{"id":"https://openalex.org/W2295996937","doi":"https://doi.org/10.1371/journal.pcbi.1004752","title":"Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces","display_name":"Simulation and Theory of Antibody Binding to Crowded Antigen-Covered Surfaces","publication_year":2016,"publication_date":"2016-03-11","ids":{"openalex":"https://openalex.org/W2295996937","doi":"https://doi.org/10.1371/journal.pcbi.1004752","mag":"2295996937","pmid":"https://pubmed.ncbi.nlm.nih.gov/26967624"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004752","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004752","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004752&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004752&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063297991","display_name":"Cristiano De Michele","orcid":"https://orcid.org/0000-0002-8367-0610"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Cristiano De Michele","raw_affiliation_strings":["Dipartimento di Fisica, \"Sapienza\" Universit\u00e0 di Roma, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Fisica, \"Sapienza\" Universit\u00e0 di Roma, Roma, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055873619","display_name":"Paolo De Los Rios","orcid":"https://orcid.org/0000-0002-5394-5062"},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Paolo De Los Rios","raw_affiliation_strings":["Institute of Theoretical Physics, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Theoretical Physics, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058768020","display_name":"Giuseppe Foffi","orcid":"https://orcid.org/0000-0002-7444-1453"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I2799857465","display_name":"Laboratoire de physique des Solides","ror":"https://ror.org/02dyaew97","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I277688954","https://openalex.org/I2799857465"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Giuseppe Foffi","raw_affiliation_strings":["Laboratoire de Physique des Solides (LPS), UMR8502, Universit\u00e9 Paris sud, Orsay, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physique des Solides (LPS), UMR8502, Universit\u00e9 Paris sud, Orsay, France","institution_ids":["https://openalex.org/I102197404","https://openalex.org/I2799857465"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004758092","display_name":"Francesco Piazza","orcid":"https://orcid.org/0000-0003-0205-3790"},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I4210118525","display_name":"Centre de Biophysique Mol\u00e9culaire","ror":"https://ror.org/02dpqcy73","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I4210096427","https://openalex.org/I4210118525","https://openalex.org/I4210128300"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Francesco Piazza","raw_affiliation_strings":["Universit\u00e9 d'Orl\u00e9ans, Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, Orl\u00e9ans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 d'Orl\u00e9ans, Centre de Biophysique Mol\u00e9culaire, CNRS-UPR4301, Orl\u00e9ans, France","institution_ids":["https://openalex.org/I4210118525","https://openalex.org/I1294671590","https://openalex.org/I12449238"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063297991"],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.8235,"has_fulltext":true,"cited_by_count":69,"citation_normalized_percentile":{"value":0.9601841,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"12","issue":"3","first_page":"e1004752","last_page":"e1004752"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hapten","display_name":"Hapten","score":0.7441914677619934},{"id":"https://openalex.org/keywords/surface-plasmon-resonance","display_name":"Surface plasmon resonance","score":0.6404388546943665},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.4494487941265106},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4436279535293579},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.43321818113327026},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.40763503313064575},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.37128421664237976},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3668045997619629},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.3663550615310669},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3103107213973999},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3011147379875183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19198590517044067},{"id":"https://openalex.org/keywords/nanoparticle","display_name":"Nanoparticle","score":0.13348734378814697},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.11816656589508057}],"concepts":[{"id":"https://openalex.org/C29144244","wikidata":"https://www.wikidata.org/wiki/Q506441","display_name":"Hapten","level":3,"score":0.7441914677619934},{"id":"https://openalex.org/C106847996","wikidata":"https://www.wikidata.org/wiki/Q898756","display_name":"Surface plasmon resonance","level":3,"score":0.6404388546943665},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.4494487941265106},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4436279535293579},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.43321818113327026},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40763503313064575},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.37128421664237976},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3668045997619629},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3663550615310669},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3103107213973999},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3011147379875183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19198590517044067},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.13348734378814697},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11816656589508057},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000936","descriptor_name":"Antigen-Antibody Complex","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000937","descriptor_name":"Antigen-Antibody Reactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1004752","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004752","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004752&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26967624","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26967624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:iris.uniroma1.it:11573/952042","is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/952042","pdf_url":"http://hdl.handle.net/11573/952042","source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-01406916v1","is_oa":false,"landing_page_url":"https://hal.science/hal-01406916","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2016, 12 (3), &#x27E8;10.1371/journal.pcbi.1004752&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1004752","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004752","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:29da38d6675e44d28d976c349a463ac4","is_oa":true,"landing_page_url":"https://doaj.org/article/29da38d6675e44d28d976c349a463ac4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 3, p e1004752 (2016)","raw_type":"article"},{"id":"pmh:oai:flore.unifi.it:2158/1265406","is_oa":false,"landing_page_url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-84962109465&doi=10.1371/journal.pcbi.1004752&partnerID=40&md5=413f165cb63394aa8ca904478d55f98e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:infoscience.epfl.ch:219428","is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/219428","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4788199","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4788199","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004752","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004752","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004752&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5562135935","display_name":null,"funder_award_id":"2010-11","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G6026305304","display_name":null,"funder_award_id":"2010LKE4CC","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2295996937.pdf","grobid_xml":"https://content.openalex.org/works/W2295996937.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W24013980","https://openalex.org/W1813667297","https://openalex.org/W1979351627","https://openalex.org/W1980906531","https://openalex.org/W1984899070","https://openalex.org/W1984909504","https://openalex.org/W1991822827","https://openalex.org/W2004732798","https://openalex.org/W2006712680","https://openalex.org/W2015753430","https://openalex.org/W2025497179","https://openalex.org/W2026737855","https://openalex.org/W2028601571","https://openalex.org/W2041377518","https://openalex.org/W2043149936","https://openalex.org/W2051662988","https://openalex.org/W2054655080","https://openalex.org/W2058206198","https://openalex.org/W2059435741","https://openalex.org/W2071557478","https://openalex.org/W2076078915","https://openalex.org/W2083445427","https://openalex.org/W2084443622","https://openalex.org/W2085709924","https://openalex.org/W2094792002","https://openalex.org/W2106988671","https://openalex.org/W2108348023","https://openalex.org/W2113017790","https://openalex.org/W2113994268","https://openalex.org/W2119182831","https://openalex.org/W2119267663","https://openalex.org/W2119812267","https://openalex.org/W2124866200","https://openalex.org/W2139468467","https://openalex.org/W2139960862","https://openalex.org/W2142694980","https://openalex.org/W2144646547","https://openalex.org/W2156115459","https://openalex.org/W2158885585","https://openalex.org/W2162504516","https://openalex.org/W2164379005","https://openalex.org/W2265060724","https://openalex.org/W2896296657","https://openalex.org/W3098311515"],"related_works":["https://openalex.org/W1976832055","https://openalex.org/W1990058423","https://openalex.org/W2395449481","https://openalex.org/W2063245208","https://openalex.org/W2044309065","https://openalex.org/W1517487682","https://openalex.org/W2332468522","https://openalex.org/W4313309038","https://openalex.org/W2076131152","https://openalex.org/W1507849322"],"abstract_inverted_index":{"In":[0],"this":[1],"paper":[2],"we":[3,38,222],"introduce":[4],"a":[5,32,41,74,128,144,244],"fully":[6],"flexible":[7,88],"coarse-grained":[8],"model":[9,43,242],"of":[10,25,76,135,155,190,236,256,262],"immunoglobulin":[11],"G":[12],"(IgG)":[13],"antibodies":[14,257],"parametrized":[15],"directly":[16],"on":[17,31,161],"cryo-EM":[18],"data":[19,68],"and":[20,58,69,172,211],"simulate":[21],"the":[22,49,53,94,111,156,170,177,188,200,204,208,215,234],"binding":[23,178,216,258],"dynamics":[24],"many":[26,266],"IgGs":[27,89,123,136],"to":[28,46,72,84,92,115,125,139,166,252,259],"antigens":[29,152],"adsorbed":[30],"surface":[33,95,209],"at":[34,143,217],"increasing":[35],"densities.":[36,220],"Moreover,":[37],"work":[39],"out":[40],"theoretical":[42,59,247],"that":[44,175,199,224],"allows":[45,70],"explain":[47],"all":[48],"features":[50],"observed":[51],"in":[52,62,100,229,265],"simulations.":[54],"Our":[55],"combined":[56],"computational":[57],"framework":[60],"is":[61,82,107,137],"excellent":[63],"agreement":[64],"with":[65,96,117],"surface-plasmon":[66],"resonance":[67],"us":[71],"establish":[73],"number":[75],"important":[77],"results.":[78],"(i)":[79],"Internal":[80],"flexibility":[81],"key":[83,181],"maximize":[85],"bivalent":[86],"binding,":[87],"being":[90],"able":[91],"explore":[93],"their":[97],"second":[98,157],"arm":[99],"search":[101],"for":[102,169],"an":[103],"available":[104],"hapten.":[105],"This":[106],"made":[108],"clear":[109],"by":[110,121,193],"strongly":[112],"reduced":[113],"ability":[114],"bind":[116],"both":[118],"arms":[119],"displayed":[120],"artificial":[122],"designed":[124],"rigidly":[126],"keep":[127,140],"prescribed":[129],"shape.":[130],"(ii)":[131],"The":[132,180],"large":[133],"size":[134],"instrumental":[138],"neighboring":[141,194],"molecules":[142],"certain":[145],"distance":[146],"(surface":[147],"repulsion),":[148],"which":[149],"essentially":[150],"makes":[151],"within":[153],"reach":[154],"Fab":[158],"always":[159],"unoccupied":[160],"average.":[162],"(iii)":[163],"One":[164],"needs":[165],"account":[167],"independently":[168],"thermodynamic":[171,201],"geometric":[173],"factors":[174],"regulate":[176],"equilibrium.":[179],"geometrical":[182],"parameters,":[183],"besides":[184],"excluded-volume":[185],"repulsion,":[186],"describe":[187],"screening":[189,210,225],"free":[191],"haptens":[192],"bound":[195,238],"antibodies.":[196,239],"We":[197],"prove":[198,223],"parameters":[202],"govern":[203],"low-antigen-concentration":[205],"regime,":[206],"while":[207],"repulsion":[212],"only":[213],"affect":[214],"high":[218],"hapten":[219],"Importantly,":[221],"effects":[226],"are":[227],"concealed":[228],"relative":[230],"measures,":[231],"such":[232],"as":[233],"fraction":[235],"bivalently":[237],"Overall,":[240],"our":[241],"provides":[243],"valuable,":[245],"accurate":[246],"paradigm":[248],"beyond":[249],"existing":[250],"frameworks":[251],"interpret":[253],"experimental":[254],"profiles":[255],"multi-valent":[260],"surfaces":[261],"different":[263],"sorts":[264],"contexts.":[267]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5}],"updated_date":"2026-05-07T13:39:58.223016","created_date":"2025-10-10T00:00:00"}
