{"id":"https://openalex.org/W2286184197","doi":"https://doi.org/10.1371/journal.pcbi.1004701","title":"Evolutionary and Functional Relationships in the Truncated Hemoglobin Family","display_name":"Evolutionary and Functional Relationships in the Truncated Hemoglobin Family","publication_year":2016,"publication_date":"2016-01-20","ids":{"openalex":"https://openalex.org/W2286184197","doi":"https://doi.org/10.1371/journal.pcbi.1004701","mag":"2286184197","pmid":"https://pubmed.ncbi.nlm.nih.gov/26788940"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004701&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019127813","display_name":"Juan P. Bustamante","orcid":"https://orcid.org/0000-0001-6546-2562"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Juan P. Bustamante","raw_affiliation_strings":["Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica, INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica, INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I53241121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018949466","display_name":"Leandro Radusky","orcid":"https://orcid.org/0000-0001-5841-1273"},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Leandro Radusky","raw_affiliation_strings":["Departamento de Qu\u00edmica Biol\u00f3gica e Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Biol\u00f3gica e Instituto de Qu\u00edmica Biol\u00f3gica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I53241121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019388904","display_name":"Leonardo Boechi","orcid":null},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Leonardo Boechi","raw_affiliation_strings":["Instituto de C\u00e1lculo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de C\u00e1lculo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I53241121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027457760","display_name":"Dar\u00edo A. Estr\u0131\u0301n","orcid":"https://orcid.org/0000-0002-5006-7225"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Dar\u00edo A. Estrin","raw_affiliation_strings":["Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica, INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Inorg\u00e1nica, Anal\u00edtica y Qu\u00edmica F\u00edsica, INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I24354313","https://openalex.org/I53241121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001387245","display_name":"Arjen ten Have","orcid":"https://orcid.org/0000-0001-6210-5017"},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]},{"id":"https://openalex.org/I189075073","display_name":"National University of Mar del Plata","ror":"https://ror.org/055eqsb67","country_code":"AR","type":"education","lineage":["https://openalex.org/I189075073"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Arjen ten Have","raw_affiliation_strings":["Instituto de Investigaci\u00f3n Biol\u00f3gica, CONICET, Universidad Nacional de Mar del Plata. Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Biol\u00f3gica, CONICET, Universidad Nacional de Mar del Plata. Buenos Aires, Argentina","institution_ids":["https://openalex.org/I151201029","https://openalex.org/I189075073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089022257","display_name":"Marcelo A. Mart\u00ed","orcid":"https://orcid.org/0000-0002-7911-9340"},"institutions":[{"id":"https://openalex.org/I24354313","display_name":"Universidad de Buenos Aires","ror":"https://ror.org/0081fs513","country_code":"AR","type":"education","lineage":["https://openalex.org/I24354313"]},{"id":"https://openalex.org/I53241121","display_name":"Fundaci\u00f3n Ciencias Exactas y Naturales","ror":"https://ror.org/05rxmkq09","country_code":"AR","type":"nonprofit","lineage":["https://openalex.org/I53241121"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Marcelo A. Mart\u00ed","raw_affiliation_strings":["Instituto de C\u00e1lculo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de C\u00e1lculo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina","institution_ids":["https://openalex.org/I24354313","https://openalex.org/I53241121"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089022257"],"corresponding_institution_ids":["https://openalex.org/I24354313","https://openalex.org/I53241121"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.6311,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.88304784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"e1004701","last_page":"e1004701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5517603158950806},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.53034907579422},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5045632123947144},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.46896588802337646},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4544338583946228},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.43849706649780273},{"id":"https://openalex.org/keywords/sequence-alignment","display_name":"Sequence alignment","score":0.43082165718078613},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.4289812445640564},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3071463108062744},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.13656869530677795}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5517603158950806},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.53034907579422},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5045632123947144},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.46896588802337646},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4544338583946228},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.43849706649780273},{"id":"https://openalex.org/C45484198","wikidata":"https://www.wikidata.org/wiki/Q827246","display_name":"Sequence alignment","level":4,"score":0.43082165718078613},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.4289812445640564},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3071463108062744},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.13656869530677795},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1004701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26788940","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26788940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4720485","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4720485","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:americanae.aecid.es:3129026","is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3129026","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:9c3063aefec5462aa27f667a2d235e86","is_oa":true,"landing_page_url":"https://doaj.org/article/9c3063aefec5462aa27f667a2d235e86","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 1, p e1004701 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1639468","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Evolutionary_and_Functional_Relationships_in_the_Truncated_Hemoglobin_Family_/1639468","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:ri.conicet.gov.ar:11336/49640","is_oa":true,"landing_page_url":"http://hdl.handle.net/11336/49640","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:CONICET Digital (CONICET)","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2286184197.pdf","grobid_xml":"https://content.openalex.org/works/W2286184197.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W2619506","https://openalex.org/W1507703835","https://openalex.org/W1798483425","https://openalex.org/W1929077523","https://openalex.org/W1964634787","https://openalex.org/W1964755391","https://openalex.org/W1965616467","https://openalex.org/W1965668388","https://openalex.org/W1966041739","https://openalex.org/W1967386630","https://openalex.org/W1970186817","https://openalex.org/W1970895529","https://openalex.org/W1972539459","https://openalex.org/W1976213145","https://openalex.org/W1978504467","https://openalex.org/W1980235315","https://openalex.org/W1980664105","https://openalex.org/W1981368803","https://openalex.org/W1983014323","https://openalex.org/W1983029440","https://openalex.org/W1984698654","https://openalex.org/W1990768518","https://openalex.org/W1993957411","https://openalex.org/W1996602549","https://openalex.org/W2003623826","https://openalex.org/W2003772761","https://openalex.org/W2004436328","https://openalex.org/W2005755199","https://openalex.org/W2006742766","https://openalex.org/W2009047341","https://openalex.org/W2012704342","https://openalex.org/W2020350008","https://openalex.org/W2025427988","https://openalex.org/W2027091658","https://openalex.org/W2028883491","https://openalex.org/W2033487092","https://openalex.org/W2034807847","https://openalex.org/W2035896188","https://openalex.org/W2037056437","https://openalex.org/W2037151845","https://openalex.org/W2040881232","https://openalex.org/W2044068107","https://openalex.org/W2044100153","https://openalex.org/W2044898140","https://openalex.org/W2046050119","https://openalex.org/W2047189088","https://openalex.org/W2052596157","https://openalex.org/W2052773830","https://openalex.org/W2053875523","https://openalex.org/W2055043387","https://openalex.org/W2058849821","https://openalex.org/W2060727751","https://openalex.org/W2062897375","https://openalex.org/W2064930425","https://openalex.org/W2069879369","https://openalex.org/W2073305482","https://openalex.org/W2075513232","https://openalex.org/W2075563069","https://openalex.org/W2077297253","https://openalex.org/W2077547350","https://openalex.org/W2079680194","https://openalex.org/W2080347313","https://openalex.org/W2081299490","https://openalex.org/W2081820041","https://openalex.org/W2082841430","https://openalex.org/W2089337124","https://openalex.org/W2093381148","https://openalex.org/W2097606916","https://openalex.org/W2102931666","https://openalex.org/W2104666616","https://openalex.org/W2106146431","https://openalex.org/W2111211467","https://openalex.org/W2112880344","https://openalex.org/W2115458478","https://openalex.org/W2120772351","https://openalex.org/W2125252235","https://openalex.org/W2130060890","https://openalex.org/W2130257576","https://openalex.org/W2131288855","https://openalex.org/W2137597742","https://openalex.org/W2138122982","https://openalex.org/W2141885858","https://openalex.org/W2144654387","https://openalex.org/W2147361716","https://openalex.org/W2168327701","https://openalex.org/W2275884748","https://openalex.org/W2320809262","https://openalex.org/W2322963079","https://openalex.org/W2324976525","https://openalex.org/W2406347693","https://openalex.org/W2521298622","https://openalex.org/W3145289798","https://openalex.org/W4251113642","https://openalex.org/W4252166161","https://openalex.org/W7073783078"],"related_works":["https://openalex.org/W2144958703","https://openalex.org/W2080410528","https://openalex.org/W2529820324","https://openalex.org/W2905004610","https://openalex.org/W2181549235","https://openalex.org/W4290667473","https://openalex.org/W1973727281","https://openalex.org/W2046212479","https://openalex.org/W3209520725","https://openalex.org/W3192190452"],"abstract_inverted_index":{"Predicting":[0],"function":[1,36,65,149],"from":[2,180],"sequence":[3,52,81],"is":[4,17,22,32,37,173],"an":[5,73,156],"important":[6],"goal":[7],"in":[8,59,66,83,155,185],"current":[9],"biological":[10],"research,":[11],"and":[12,43,90,104,111,121,147,198],"although,":[13],"broad":[14],"functional":[15,28,218,240],"assignment":[16],"possible":[18,62],"when":[19],"a":[20,25,87,134,186],"protein":[21],"assigned":[23],"to":[24,63,78,101,145,176,182,194],"family,":[26],"predicting":[27],"specificity":[29],"with":[30,140],"accuracy":[31],"not":[33,222],"straightforward.":[34],"If":[35],"provided":[38],"by":[39,108],"key":[40],"structural":[41,229],"properties":[42,46],"the":[44,51,54,84,91,109,128,178,212,228],"relevant":[45],"can":[47,118],"be":[48,61,119],"computed":[49],"using":[50,123],"as":[53,106],"starting":[55],"point,":[56],"it":[57],"should":[58],"principle":[60],"predict":[64,146],"detail.":[67],"The":[68],"truncated":[69,153,163],"hemoglobin":[70],"family":[71,167],"presents":[72],"interesting":[74,239],"benchmark":[75],"study":[76],"due":[77],"their":[79],"ubiquity,":[80],"diversity":[82],"context":[85],"of":[86,93,116,150,227],"conserved":[88,166],"fold":[89],"number":[92],"characterized":[94],"members.":[95],"Their":[96],"functions":[97],"are":[98],"tightly":[99],"related":[100],"O2":[102],"affinity":[103,184],"reactivity,":[105],"determined":[107],"association":[110],"dissociation":[112],"rate":[113],"constants,":[114],"both":[115],"which":[117,136],"predicted":[120],"analyzed":[122],"in-silico":[124],"based":[125,142],"tools.":[126],"In":[127],"present":[129,165],"work":[130],"we":[131],"have":[132],"applied":[133],"strategy,":[135],"combines":[137],"homology":[138],"modeling":[139],"molecular":[141],"energy":[143],"calculations,":[144],"analyze":[148],"all":[151],"known":[152],"hemoglobins":[154,164],"evolutionary":[157,188,241],"context.":[158],"Our":[159,220],"results":[160],"show":[161,208],"that":[162,170],"features,":[168],"but":[169,234],"its":[171],"structure":[172],"flexible":[174],"enough":[175],"allow":[177],"switch":[179],"high":[181,195],"low":[183],"few":[187],"steps.":[189],"Most":[190],"proteins":[191],"display":[192],"moderate":[193],"oxygen":[196],"affinities":[197],"multiple":[199],"ligand":[200,232],"migration":[201],"paths,":[202],"which,":[203],"besides":[204],"some":[205,238],"minor":[206],"trends,":[207],"heterogeneous":[209],"distributions":[210],"throughout":[211],"phylogenetic":[213],"tree,":[214],"again":[215],"suggesting":[216],"fast":[217],"adaptation.":[219],"data":[221],"only":[223],"deepens":[224],"our":[225],"comprehension":[226],"basis":[230],"governing":[231],"affinity,":[233],"they":[235],"also":[236],"highlight":[237],"trends.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2}],"updated_date":"2026-08-14T07:06:38.338062","created_date":"2025-10-10T00:00:00"}