{"id":"https://openalex.org/W2235371662","doi":"https://doi.org/10.1371/journal.pcbi.1004696","title":"A Network Model to Describe the Terminal Differentiation of B Cells","display_name":"A Network Model to Describe the Terminal Differentiation of B Cells","publication_year":2016,"publication_date":"2016-01-11","ids":{"openalex":"https://openalex.org/W2235371662","doi":"https://doi.org/10.1371/journal.pcbi.1004696","mag":"2235371662","pmid":"https://pubmed.ncbi.nlm.nih.gov/26751566"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004696","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004696","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004696&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004696&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009381673","display_name":"Akram M\u00e9ndez","orcid":null},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Akram M\u00e9ndez","raw_affiliation_strings":["Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico","Programa de Doctorado en Ciencias Bioqu\u00edmicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]},{"raw_affiliation_string":"Programa de Doctorado en Ciencias Bioqu\u00edmicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072755654","display_name":"Luis Mendoza","orcid":"https://orcid.org/0000-0002-3321-3083"},"institutions":[{"id":"https://openalex.org/I8961855","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25","country_code":"MX","type":"education","lineage":["https://openalex.org/I8961855"]},{"id":"https://openalex.org/I167724894","display_name":"Universidad Aut\u00f3noma de la Ciudad de M\u00e9xico","ror":"https://ror.org/04q0r6m34","country_code":"MX","type":"education","lineage":["https://openalex.org/I167724894"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"Luis Mendoza","raw_affiliation_strings":["C3, Centro de Ciencias de la Complejidad, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico","Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C3, Centro de Ciencias de la Complejidad, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I167724894","https://openalex.org/I8961855"]},{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico","institution_ids":["https://openalex.org/I8961855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5072755654"],"corresponding_institution_ids":["https://openalex.org/I167724894","https://openalex.org/I8961855"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.2696,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.9184835,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"e1004696","last_page":"e1004696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-differentiation","display_name":"Cellular differentiation","score":0.6759586930274963},{"id":"https://openalex.org/keywords/bcl6","display_name":"BCL6","score":0.6368159651756287},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5335111618041992},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5262507796287537},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5074054598808289},{"id":"https://openalex.org/keywords/b-cell","display_name":"B cell","score":0.4054940342903137},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3601072430610657},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.24247807264328003},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10242849588394165},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.08916690945625305}],"concepts":[{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.6759586930274963},{"id":"https://openalex.org/C2777537477","wikidata":"https://www.wikidata.org/wiki/Q17847411","display_name":"BCL6","level":5,"score":0.6368159651756287},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5335111618041992},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5262507796287537},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5074054598808289},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4054940342903137},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3601072430610657},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24247807264328003},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10242849588394165},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.08916690945625305},{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006377","descriptor_name":"T-Lymphocytes, Helper-Inducer","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004696","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004696","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004696&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26751566","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26751566","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1004696","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004696","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:32ca2dc32ec24f9ea1ed51bf59f78ee5","is_oa":false,"landing_page_url":"https://doaj.org/article/32ca2dc32ec24f9ea1ed51bf59f78ee5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 1, p e1004696 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1636545","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_A_Network_Model_to_Describe_the_Terminal_Differentiation_of_B_Cells_/1636545","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4720151","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4720151","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004696","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004696","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004696&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321739","display_name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","ror":"https://ror.org/059ex5q34"},{"id":"https://openalex.org/F4320323401","display_name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"},{"id":"https://openalex.org/F4320335100","display_name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","ror":"https://ror.org/01tmp8f25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2235371662.pdf","grobid_xml":"https://content.openalex.org/works/W2235371662.grobid-xml"},"referenced_works_count":107,"referenced_works":["https://openalex.org/W1485900506","https://openalex.org/W1492892881","https://openalex.org/W1550072509","https://openalex.org/W1566926046","https://openalex.org/W1568951543","https://openalex.org/W1599839677","https://openalex.org/W1886819223","https://openalex.org/W1963761129","https://openalex.org/W1966384388","https://openalex.org/W1968758858","https://openalex.org/W1970054115","https://openalex.org/W1970149027","https://openalex.org/W1970728276","https://openalex.org/W1970854602","https://openalex.org/W1971224531","https://openalex.org/W1973587254","https://openalex.org/W1975213528","https://openalex.org/W1977123213","https://openalex.org/W1978567176","https://openalex.org/W1980268334","https://openalex.org/W1981403111","https://openalex.org/W1990376783","https://openalex.org/W1991311051","https://openalex.org/W1995204178","https://openalex.org/W1995344003","https://openalex.org/W1997989189","https://openalex.org/W2000982470","https://openalex.org/W2001283453","https://openalex.org/W2001777890","https://openalex.org/W2005377557","https://openalex.org/W2015632708","https://openalex.org/W2016729216","https://openalex.org/W2016932039","https://openalex.org/W2018427441","https://openalex.org/W2019447967","https://openalex.org/W2019904704","https://openalex.org/W2021301407","https://openalex.org/W2022687427","https://openalex.org/W2026549568","https://openalex.org/W2035502959","https://openalex.org/W2043948827","https://openalex.org/W2045067923","https://openalex.org/W2045715956","https://openalex.org/W2048438929","https://openalex.org/W2053937978","https://openalex.org/W2054414479","https://openalex.org/W2056521686","https://openalex.org/W2056939983","https://openalex.org/W2057379398","https://openalex.org/W2060871248","https://openalex.org/W2062109421","https://openalex.org/W2065906324","https://openalex.org/W2066285349","https://openalex.org/W2066554568","https://openalex.org/W2067111018","https://openalex.org/W2068975867","https://openalex.org/W2069047496","https://openalex.org/W2071959000","https://openalex.org/W2081613377","https://openalex.org/W2081870862","https://openalex.org/W2084825289","https://openalex.org/W2086504474","https://openalex.org/W2087170380","https://openalex.org/W2089478119","https://openalex.org/W2091213817","https://openalex.org/W2096592094","https://openalex.org/W2097843798","https://openalex.org/W2101755826","https://openalex.org/W2101974006","https://openalex.org/W2102978939","https://openalex.org/W2103454055","https://openalex.org/W2103454590","https://openalex.org/W2104039751","https://openalex.org/W2104601806","https://openalex.org/W2105254505","https://openalex.org/W2109164629","https://openalex.org/W2111480476","https://openalex.org/W2113963915","https://openalex.org/W2116031853","https://openalex.org/W2117189326","https://openalex.org/W2125310129","https://openalex.org/W2128243696","https://openalex.org/W2128410841","https://openalex.org/W2131723671","https://openalex.org/W2135782683","https://openalex.org/W2136616777","https://openalex.org/W2136829296","https://openalex.org/W2139237097","https://openalex.org/W2141545875","https://openalex.org/W2143470489","https://openalex.org/W2143952529","https://openalex.org/W2148152782","https://openalex.org/W2148654292","https://openalex.org/W2149737545","https://openalex.org/W2149794922","https://openalex.org/W2153131914","https://openalex.org/W2157929457","https://openalex.org/W2159518203","https://openalex.org/W2160521571","https://openalex.org/W2163150086","https://openalex.org/W2165608602","https://openalex.org/W2167437179","https://openalex.org/W2170267675","https://openalex.org/W2397677784","https://openalex.org/W2748723614","https://openalex.org/W3013110774","https://openalex.org/W4246504300"],"related_works":["https://openalex.org/W3028044956","https://openalex.org/W2951366684","https://openalex.org/W2993630476","https://openalex.org/W2937775576","https://openalex.org/W4313354602","https://openalex.org/W2007314562","https://openalex.org/W1975420246","https://openalex.org/W2060127911","https://openalex.org/W2015632708","https://openalex.org/W2163970349"],"abstract_inverted_index":{"Terminal":[0],"differentiation":[1,87,157,206,221,226],"of":[2,23,44,68,81,88,93,127,135,156,164,178,193,203,217],"B":[3,89,204,219,235],"cells":[4],"is":[5,17,41,58,210],"an":[6],"essential":[7],"process":[8],"for":[9,138],"the":[10,20,48,63,69,82,94,103,113,133,139,148,154,159,165,191,214],"humoral":[11],"immune":[12],"response":[13,28,173],"in":[14,27,54,102,172],"vertebrates":[15],"and":[16,32,50,65,105,119,143,187,198,222],"achieved":[18],"by":[19,36,111],"concerted":[21],"action":[22],"several":[24],"transcription":[25],"factors":[26],"to":[29,152,162,174,212,232],"antigen":[30],"recognition":[31],"extracellular":[33,179],"signals":[34,52],"provided":[35],"T-helper":[37],"cells.":[38,90,236],"While":[39],"there":[40,57],"a":[42,78,117,120,175,229],"wealth":[43],"experimental":[45,99],"data":[46,100],"regarding":[47,62],"molecular":[49],"cellular":[51],"involved":[53],"this":[55,74],"process,":[56],"no":[59],"general":[60],"consensus":[61],"structure":[64,92],"dynamical":[66,79,107,122],"properties":[67],"underlying":[70],"regulatory":[71,83],"network":[72,84,95,114],"controlling":[73,85],"process.":[75,207],"We":[76,181],"developed":[77],"model":[80,209],"terminal":[86,218],"The":[91,124,208],"was":[96,109],"inferred":[97],"from":[98,158,228],"available":[101],"literature,":[104],"its":[106],"behavior":[108],"analyzed":[110],"modeling":[112],"both":[115],"as":[116,200],"discrete":[118],"continuous":[121],"systems.":[123],"steady":[125],"states":[126],"these":[128],"models":[129,149],"are":[130,150],"consistent":[131],"with":[132],"patterns":[134,155],"activation":[136],"reported":[137],"Naive,":[140],"GC,":[141,166],"Mem,":[142,167],"PC":[144,169],"cell":[145,170,205,220,231],"types.":[146],"Moreover,":[147],"able":[151,211],"describe":[153],"precursor":[160,230],"Naive":[161],"any":[163],"or":[168],"types":[171],"specific":[176],"set":[177],"signals.":[180],"simulated":[182],"all":[183],"possible":[184],"single":[185],"loss-":[186],"gain-of-function":[188],"mutants,":[189],"corroborating":[190],"importance":[192],"Pax5,":[194],"Bcl6,":[195],"Bach2,":[196],"Irf4,":[197],"Blimp1":[199],"key":[201,225],"regulators":[202],"represent":[213],"directional":[215],"nature":[216],"qualitatively":[223],"describes":[224],"events":[227],"terminally":[233],"differentiated":[234]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2}],"updated_date":"2026-05-29T09:21:14.243279","created_date":"2025-10-10T00:00:00"}