{"id":"https://openalex.org/W2265495650","doi":"https://doi.org/10.1371/journal.pcbi.1004685","title":"Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia","display_name":"Implementation of Complex Biological Logic Circuits Using Spatially Distributed Multicellular Consortia","publication_year":2016,"publication_date":"2016-02-01","ids":{"openalex":"https://openalex.org/W2265495650","doi":"https://doi.org/10.1371/journal.pcbi.1004685","mag":"2265495650","pmid":"https://pubmed.ncbi.nlm.nih.gov/26829588"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004685","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004685&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004685&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080642556","display_name":"Javier Mac\u00eda","orcid":"https://orcid.org/0000-0002-6705-5554"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Javier Macia","raw_affiliation_strings":["ICREA-Complex Systems Laboratory, Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICREA-Complex Systems Laboratory, Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I11932220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075780758","display_name":"Romilde Manzoni","orcid":null},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Romilde Manzoni","raw_affiliation_strings":["Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029775011","display_name":"N\u00faria Conde\u2013Pueyo","orcid":"https://orcid.org/0000-0001-5766-309X"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"N\u00faria Conde","raw_affiliation_strings":["Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain","ICREA-Complex Systems Laboratory, Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]},{"raw_affiliation_string":"ICREA-Complex Systems Laboratory, Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I11932220"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029066330","display_name":"Arturo Urrios","orcid":"https://orcid.org/0000-0002-5698-8359"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Arturo Urrios","raw_affiliation_strings":["Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077934558","display_name":"Eul\u00e0lia de Nadal","orcid":"https://orcid.org/0000-0003-0039-5607"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eul\u00e0lia de Nadal","raw_affiliation_strings":["Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046878011","display_name":"Ricard V. Sol\u00e9","orcid":"https://orcid.org/0000-0001-6974-1008"},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I1308548392","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35","country_code":"US","type":"funder","lineage":["https://openalex.org/I1308548392"]},{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Ricard Sol\u00e9","raw_affiliation_strings":["ICREA-Complex Systems Laboratory, Universitat Pompeu Fabra (UPF), Barcelona, Spain","Santa Fe Institute, Santa Fe, New Mexico, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ICREA-Complex Systems Laboratory, Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I11932220"]},{"raw_affiliation_string":"Santa Fe Institute, Santa Fe, New Mexico, United States of America","institution_ids":["https://openalex.org/I1308548392"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045012079","display_name":"Francesc Posas","orcid":"https://orcid.org/0000-0002-4164-7076"},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Francesc Posas","raw_affiliation_strings":["Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signaling Research Group, Departament de Ci\u00e8ncies Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045012079","https://openalex.org/A5046878011"],"corresponding_institution_ids":["https://openalex.org/I11932220","https://openalex.org/I1308548392","https://openalex.org/I170486558"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.3519,"has_fulltext":true,"cited_by_count":82,"citation_normalized_percentile":{"value":0.94533198,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"12","issue":"2","first_page":"e1004685","last_page":"e1004685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12784","display_name":"Modular Robots and Swarm Intelligence","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.7581926584243774},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6980290412902832},{"id":"https://openalex.org/keywords/reusability","display_name":"Reusability","score":0.6845489144325256},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.6688470840454102},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.647658109664917},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.600014865398407},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.557628870010376},{"id":"https://openalex.org/keywords/biomedicine","display_name":"Biomedicine","score":0.5245728492736816},{"id":"https://openalex.org/keywords/computer-architecture","display_name":"Computer architecture","score":0.507379949092865},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.486524760723114},{"id":"https://openalex.org/keywords/distributed-computing","display_name":"Distributed computing","score":0.4803836941719055},{"id":"https://openalex.org/keywords/computer-engineering","display_name":"Computer engineering","score":0.3208984136581421},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.17862975597381592},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1734728217124939},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1717103123664856},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11517259478569031},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09365031123161316}],"concepts":[{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.7581926584243774},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6980290412902832},{"id":"https://openalex.org/C137981799","wikidata":"https://www.wikidata.org/wiki/Q1369184","display_name":"Reusability","level":3,"score":0.6845489144325256},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.6688470840454102},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.647658109664917},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.600014865398407},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.557628870010376},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.5245728492736816},{"id":"https://openalex.org/C118524514","wikidata":"https://www.wikidata.org/wiki/Q173212","display_name":"Computer architecture","level":1,"score":0.507379949092865},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.486524760723114},{"id":"https://openalex.org/C120314980","wikidata":"https://www.wikidata.org/wiki/Q180634","display_name":"Distributed computing","level":1,"score":0.4803836941719055},{"id":"https://openalex.org/C113775141","wikidata":"https://www.wikidata.org/wiki/Q428691","display_name":"Computer engineering","level":1,"score":0.3208984136581421},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.17862975597381592},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1734728217124939},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1717103123664856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11517259478569031},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09365031123161316},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005818","descriptor_name":"Genetic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008128","descriptor_name":"Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1004685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004685","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004685&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26829588","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26829588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:recercat.cat:2072/314358","is_oa":true,"landing_page_url":"http://hdl.handle.net/10230/25979","pdf_url":null,"source":{"id":"https://openalex.org/S4306402147","display_name":"RECERCAT (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1004685","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004685","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:digital.csic.es:10261/151818","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/151818","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:doaj.org/article:b96b1633368642f887aaa97f61081173","is_oa":true,"landing_page_url":"https://doaj.org/article/b96b1633368642f887aaa97f61081173","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 2, p e1004685 (2016)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/2622292","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Implementation_of_Complex_Biological_Logic_Circuits_Using_Spatially_Distributed_Multicellular_Consortia/2622292","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4734778","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4734778","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004685","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004685","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004685&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.8100000023841858,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G968323567","display_name":null,"funder_award_id":"2014 SGR 599","funder_id":"https://openalex.org/F4320321505","funder_display_name":"Generalitat de Catalunya"}],"funders":[{"id":"https://openalex.org/F4320312331","display_name":"Banco Santander","ror":"https://ror.org/017d1hs72"},{"id":"https://openalex.org/F4320312777","display_name":"Santa Fe Institute","ror":"https://ror.org/01arysc35"},{"id":"https://openalex.org/F4320321505","display_name":"Generalitat de Catalunya","ror":"https://ror.org/01bg62x04"},{"id":"https://openalex.org/F4320322121","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230"},{"id":"https://openalex.org/F4320323816","display_name":"Fundaci\u00f3n Bot\u00edn","ror":"https://ror.org/03zefme93"},{"id":"https://openalex.org/F4320330256","display_name":"Fundaci\u00f3n Bancaria Caixa d'Estalvis i Pensions de Barcelona","ror":null},{"id":"https://openalex.org/F4320330616","display_name":"Santander Universities","ror":null},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2265495650.pdf","grobid_xml":"https://content.openalex.org/works/W2265495650.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W182590847","https://openalex.org/W420455788","https://openalex.org/W585964221","https://openalex.org/W1527441981","https://openalex.org/W1557270760","https://openalex.org/W1574957724","https://openalex.org/W1584397582","https://openalex.org/W1645305843","https://openalex.org/W1785874214","https://openalex.org/W1973577260","https://openalex.org/W1974190927","https://openalex.org/W1977624796","https://openalex.org/W1977943300","https://openalex.org/W1980570931","https://openalex.org/W1981538345","https://openalex.org/W1985190908","https://openalex.org/W1986562649","https://openalex.org/W1988246924","https://openalex.org/W1993700348","https://openalex.org/W2000484783","https://openalex.org/W2007696147","https://openalex.org/W2013310157","https://openalex.org/W2016830368","https://openalex.org/W2017862866","https://openalex.org/W2023525048","https://openalex.org/W2027576577","https://openalex.org/W2031369606","https://openalex.org/W2039140951","https://openalex.org/W2041985017","https://openalex.org/W2042352676","https://openalex.org/W2062573403","https://openalex.org/W2070876566","https://openalex.org/W2076053527","https://openalex.org/W2076425379","https://openalex.org/W2076800072","https://openalex.org/W2082398508","https://openalex.org/W2083456183","https://openalex.org/W2090876232","https://openalex.org/W2091491561","https://openalex.org/W2099090468","https://openalex.org/W2101576896","https://openalex.org/W2113464341","https://openalex.org/W2115286109","https://openalex.org/W2121005425","https://openalex.org/W2125340100","https://openalex.org/W2128427912","https://openalex.org/W2130912501","https://openalex.org/W2132108550","https://openalex.org/W2134759932","https://openalex.org/W2139629468","https://openalex.org/W2141170384","https://openalex.org/W2143205144","https://openalex.org/W2152278776","https://openalex.org/W2158075875","https://openalex.org/W2161466984","https://openalex.org/W2506613447","https://openalex.org/W3011891279","https://openalex.org/W3122885786","https://openalex.org/W4242005639","https://openalex.org/W4253795631"],"related_works":["https://openalex.org/W4282938614","https://openalex.org/W2017899917","https://openalex.org/W2080571363","https://openalex.org/W2522472446","https://openalex.org/W1963836821","https://openalex.org/W2145740829","https://openalex.org/W2099755394","https://openalex.org/W4281994149","https://openalex.org/W2166797439","https://openalex.org/W4384277189"],"abstract_inverted_index":{"Engineered":[0],"synthetic":[1],"biological":[2],"devices":[3,50,69],"have":[4],"been":[5],"designed":[6],"to":[7,18,36,65,122],"perform":[8],"a":[9,24],"variety":[10],"of":[11,27,39,48,91,109,116,131,137],"functions":[12,119],"from":[13],"sensing":[14],"molecules":[15],"and":[16,21,58,73,98,129],"bioremediation":[17],"energy":[19],"production":[20],"biomedicine.":[22],"Notwithstanding,":[23],"major":[25],"limitation":[26],"in":[28],"vivo":[29],"circuit":[30,43],"implementation":[31,115],"is":[32,89,112],"the":[33,37,92,127],"constraint":[34],"associated":[35],"use":[38,108],"standard":[40],"methodologies":[41],"for":[42],"design.":[44],"Thus,":[45],"future":[46],"success":[47],"these":[49],"depends":[51],"on":[52],"obtaining":[53],"circuits":[54],"with":[55,102,120],"scalable":[56],"complexity":[57],"reusable":[59],"parts.":[60],"Here":[61],"we":[62],"show":[63],"how":[64],"build":[66],"complex":[67,117],"computational":[68,77],"using":[70],"multicellular":[71],"consortia":[72],"space":[74],"as":[75],"key":[76],"elements.":[78],"This":[79],"spatial":[80],"modular":[81],"design":[82],"grants":[83],"scalability":[84,128],"since":[85],"its":[86],"general":[87],"architecture":[88],"independent":[90],"circuit's":[93],"complexity,":[94],"minimizes":[95],"wiring":[96],"requirements":[97],"allows":[99],"component":[100],"reusability":[101],"minimal":[103],"genetic":[104],"engineering.":[105],"The":[106,134],"potential":[107,135],"this":[110,132],"approach":[111],"demonstrated":[113],"by":[114],"logical":[118],"up":[121],"six":[123],"inputs,":[124],"thus":[125],"demonstrating":[126],"flexibility":[130],"method.":[133],"implications":[136],"our":[138],"results":[139],"are":[140],"outlined.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}