{"id":"https://openalex.org/W2195182558","doi":"https://doi.org/10.1371/journal.pcbi.1004653","title":"MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells","display_name":"MiR-192-Mediated Positive Feedback Loop Controls the Robustness of Stress-Induced p53 Oscillations in Breast Cancer Cells","publication_year":2015,"publication_date":"2015-12-07","ids":{"openalex":"https://openalex.org/W2195182558","doi":"https://doi.org/10.1371/journal.pcbi.1004653","mag":"2195182558","pmid":"https://pubmed.ncbi.nlm.nih.gov/26642352"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004653","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004653","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004653&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004653&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063664464","display_name":"Richard Moore","orcid":"https://orcid.org/0000-0002-1313-2577"},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Moore","raw_affiliation_strings":["Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","Center for Systems Biology, University of Texas at Dallas, Richardson, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319"]},{"raw_affiliation_string":"Center for Systems Biology, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020837149","display_name":"Hsu Kiang Ooi","orcid":"https://orcid.org/0000-0001-7934-4866"},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsu Kiang Ooi","raw_affiliation_strings":["Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103072952","display_name":"Taek Kang","orcid":"https://orcid.org/0000-0002-8661-2328"},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taek Kang","raw_affiliation_strings":["Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","Center for Systems Biology, University of Texas at Dallas, Richardson, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319"]},{"raw_affiliation_string":"Center for Systems Biology, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319","https://openalex.org/I4210155419"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036972388","display_name":"Leonidas Bleris","orcid":"https://orcid.org/0000-0002-6610-9020"},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leonidas Bleris","raw_affiliation_strings":["Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","Center for Systems Biology, University of Texas at Dallas, Richardson, Texas, United States of America","Electrical Engineering Department, University of Texas at Dallas, Richardson, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319"]},{"raw_affiliation_string":"Center for Systems Biology, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Electrical Engineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100699235","display_name":"Lan Ma","orcid":"https://orcid.org/0000-0001-7945-8708"},"institutions":[{"id":"https://openalex.org/I162577319","display_name":"The University of Texas at Dallas","ror":"https://ror.org/049emcs32","country_code":"US","type":"education","lineage":["https://openalex.org/I162577319"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lan Ma","raw_affiliation_strings":["Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, University of Texas at Dallas, Richardson, Texas, United States of America","institution_ids":["https://openalex.org/I162577319"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036972388","https://openalex.org/A5100699235"],"corresponding_institution_ids":["https://openalex.org/I162577319","https://openalex.org/I4210155419"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0662,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.87287518,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"12","first_page":"e1004653","last_page":"e1004653"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.988099992275238,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7883856296539307},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.6692801713943481},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.599294126033783},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.597318172454834},{"id":"https://openalex.org/keywords/positive-feedback","display_name":"Positive feedback","score":0.5901011824607849},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5290650129318237},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4838051199913025},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4786580801010132},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4755244553089142},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.4641602635383606},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.44879475235939026},{"id":"https://openalex.org/keywords/feedback-loop","display_name":"Feedback loop","score":0.42976099252700806},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.4166754186153412},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4097968637943268},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.35790717601776123},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3575130105018616},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25867295265197754},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.20416751503944397},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16558268666267395},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12763085961341858},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1059177815914154}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7883856296539307},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.6692801713943481},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.599294126033783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.597318172454834},{"id":"https://openalex.org/C48207687","wikidata":"https://www.wikidata.org/wiki/Q918004","display_name":"Positive feedback","level":2,"score":0.5901011824607849},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5290650129318237},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4838051199913025},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4786580801010132},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4755244553089142},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4641602635383606},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44879475235939026},{"id":"https://openalex.org/C186886427","wikidata":"https://www.wikidata.org/wiki/Q5441213","display_name":"Feedback loop","level":2,"score":0.42976099252700806},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4166754186153412},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4097968637943268},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35790717601776123},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3575130105018616},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25867295265197754},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20416751503944397},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16558268666267395},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12763085961341858},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1059177815914154},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004653","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004653","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004653&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26642352","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26642352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1004653","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004653","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:11d32adc01534508817dcbad817a8ac5","is_oa":true,"landing_page_url":"https://doaj.org/article/11d32adc01534508817dcbad817a8ac5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 12, p e1004653 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3652102","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4671655","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/2655010","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/MiR_192_Mediated_Positive_Feedback_Loop_Controls_the_Robustness_of_Stress_Induced_p53_Oscillations_in_Breast_Cancer_Cells/2655010","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004653","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004653","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004653&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"awards":[{"id":"https://openalex.org/G7186501047","display_name":null,"funder_award_id":"R21 CA170018","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G728052449","display_name":null,"funder_award_id":"1R21CA170018-01","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2195182558.pdf","grobid_xml":"https://content.openalex.org/works/W2195182558.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W3044475","https://openalex.org/W1495609430","https://openalex.org/W1563316806","https://openalex.org/W1965581435","https://openalex.org/W1969201199","https://openalex.org/W1970431885","https://openalex.org/W1975413628","https://openalex.org/W1979634817","https://openalex.org/W1983660125","https://openalex.org/W1984104797","https://openalex.org/W1990039929","https://openalex.org/W1991663431","https://openalex.org/W1993916353","https://openalex.org/W1995427220","https://openalex.org/W1996861281","https://openalex.org/W1999266701","https://openalex.org/W2006173503","https://openalex.org/W2008887283","https://openalex.org/W2010114834","https://openalex.org/W2026452170","https://openalex.org/W2030945597","https://openalex.org/W2033853356","https://openalex.org/W2033911870","https://openalex.org/W2040244459","https://openalex.org/W2044692345","https://openalex.org/W2048601206","https://openalex.org/W2055003617","https://openalex.org/W2056406543","https://openalex.org/W2058631780","https://openalex.org/W2059053384","https://openalex.org/W2060339242","https://openalex.org/W2063052296","https://openalex.org/W2066218351","https://openalex.org/W2067230462","https://openalex.org/W2068371312","https://openalex.org/W2069500900","https://openalex.org/W2083158631","https://openalex.org/W2085418817","https://openalex.org/W2095324538","https://openalex.org/W2097651998","https://openalex.org/W2099648444","https://openalex.org/W2106043531","https://openalex.org/W2106362845","https://openalex.org/W2106469366","https://openalex.org/W2110620666","https://openalex.org/W2124595934","https://openalex.org/W2125937596","https://openalex.org/W2127793379","https://openalex.org/W2130979840","https://openalex.org/W2132828256","https://openalex.org/W2133959309","https://openalex.org/W2136605121","https://openalex.org/W2137088684","https://openalex.org/W2139193302","https://openalex.org/W2141997480","https://openalex.org/W2142484802","https://openalex.org/W2143145944","https://openalex.org/W2143297340","https://openalex.org/W2146483998","https://openalex.org/W2149181149","https://openalex.org/W2162281264","https://openalex.org/W2167921512","https://openalex.org/W2169643501","https://openalex.org/W2169895124","https://openalex.org/W2171280873","https://openalex.org/W2171296186","https://openalex.org/W2171327609"],"related_works":["https://openalex.org/W2771707358","https://openalex.org/W2773320882","https://openalex.org/W2899244556","https://openalex.org/W2106469366","https://openalex.org/W2038819846","https://openalex.org/W1603824164","https://openalex.org/W1970980747","https://openalex.org/W2051497876","https://openalex.org/W1971938644","https://openalex.org/W2017101110"],"abstract_inverted_index":{"The":[0],"p53":[1,35,56,95,137,206],"tumor":[2],"suppressor":[3],"protein":[4],"plays":[5],"a":[6,40,103,200],"critical":[7],"role":[8,49,233],"in":[9,127,141,169,176,186,223,239],"cellular":[10,28,92,155,205],"stress":[11],"and":[12,36,47,121,124,144],"cancer":[13,179],"prevention.":[14],"A":[15],"number":[16],"of":[17,43,50,71,82,94,106,136,183,196,234,246,249],"post-transcriptional":[18],"regulators,":[19],"termed":[20],"microRNAs,":[21],"are":[22,208],"closely":[23],"connected":[24],"with":[25,54,79,96,112,193,215,225],"the":[26,31,44,48,55,80,88,91,97,107,133,153,158,204,216,232,243],"p53-mediated":[27],"networks.":[29],"While":[30],"molecular":[32],"interactions":[33],"among":[34],"microRNAs":[37],"have":[38,62],"emerged,":[39],"systems-level":[41],"understanding":[42],"regulatory":[45],"mechanism":[46],"microRNAs-forming":[51],"feedback":[52,73,84,99,116,237],"loops":[53,74,117,238],"core":[57,108],"remains":[58],"elusive.":[59],"Here":[60],"we":[61,101,172],"identified":[63],"from":[64],"literature":[65],"that":[66,147,203],"there":[67],"exist":[68],"three":[69,113],"classes":[70],"microRNA-mediated":[72,114,235],"revolving":[75],"around":[76],"p53,":[77],"all":[78],"nature":[81],"positive":[83,115,236],"coincidentally.":[85],"To":[86,166],"explore":[87],"relationship":[89,128],"between":[90],"performance":[93,245],"microRNA":[98,149],"pathways,":[100],"developed":[102],"mathematical":[104],"model":[105,217],"p53-MDM2":[109],"module":[110],"coupled":[111],"involving":[118],"miR-192,":[119],"miR-34a,":[120],"miR-29a.":[122],"Simulations":[123],"bifurcation":[125],"analysis":[126],"to":[129,188,242],"extrinsic":[130],"noise":[131],"reproduce":[132],"oscillatory":[134],"behavior":[135,185],"under":[138],"DNA":[139,189],"damage":[140],"single":[142],"cells,":[143],"notably":[145],"show":[146],"specific":[148],"abrogation":[150],"can":[151],"disrupt":[152],"wild-type":[154],"phenotype":[156],"when":[157],"ubiquitous":[159],"cell-to-cell":[160],"variability":[161],"is":[162],"taken":[163],"into":[164],"account.":[165],"assess":[167],"these":[168],"silico":[170],"results":[171],"conducted":[173],"microRNA-perturbation":[174],"experiments":[175,227],"MCF7":[177],"breast":[178],"cells.":[180],"Time-lapse":[181],"microscopy":[182],"cell-population":[184],"response":[187,248],"double-strand":[190],"breaks,":[191],"together":[192],"image":[194],"classification":[195],"single-cell":[197],"phenotypes":[198],"across":[199],"population,":[201],"confirmed":[202],"oscillations":[207],"compromised":[209],"after":[210],"miR-192":[211],"perturbations,":[212],"matching":[213],"well":[214],"predictions.":[218],"Our":[219],"study":[220],"via":[221],"modeling":[222],"combination":[224],"quantitative":[226],"provides":[228],"new":[229],"evidence":[230],"on":[231],"conferring":[240],"robustness":[241],"system":[244],"stress-induced":[247],"p53.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":2}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}