{"id":"https://openalex.org/W2189730870","doi":"https://doi.org/10.1371/journal.pcbi.1004504","title":"Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks","display_name":"Automated Identification of Core Regulatory Genes in Human Gene Regulatory Networks","publication_year":2015,"publication_date":"2015-09-22","ids":{"openalex":"https://openalex.org/W2189730870","doi":"https://doi.org/10.1371/journal.pcbi.1004504","mag":"2189730870"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004504","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004504&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004504&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047474735","display_name":"Vipin Narang","orcid":"https://orcid.org/0000-0001-8669-9964"},"institutions":[{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Vipin Narang","raw_affiliation_strings":["Singapore Immunology Network, Singapore,","Singapore Immunology Network, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Singapore,","institution_ids":["https://openalex.org/I2800824516"]},{"raw_affiliation_string":"Singapore Immunology Network, Singapore","institution_ids":["https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034581488","display_name":"Muhamad Azfar Ramli","orcid":"https://orcid.org/0000-0002-6321-0828"},"institutions":[{"id":"https://openalex.org/I3004594783","display_name":"Institute of High Performance Computing","ror":"https://ror.org/02n0ejh50","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3004594783","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Muhamad Azfar Ramli","raw_affiliation_strings":["Institute of High Performance Computing, Singapore"],"affiliations":[{"raw_affiliation_string":"Institute of High Performance Computing, Singapore","institution_ids":["https://openalex.org/I3004594783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032337999","display_name":"Amit Singhal","orcid":"https://orcid.org/0000-0003-3913-8798"},"institutions":[{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Amit Singhal","raw_affiliation_strings":["Singapore Immunology Network, Singapore,","Singapore Immunology Network, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Singapore,","institution_ids":["https://openalex.org/I2800824516"]},{"raw_affiliation_string":"Singapore Immunology Network, Singapore","institution_ids":["https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038230511","display_name":"Pavanish Kumar","orcid":"https://orcid.org/0000-0003-1832-4436"},"institutions":[{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Pavanish Kumar","raw_affiliation_strings":["Singapore Immunology Network, Singapore,","Singapore Immunology Network, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Singapore,","institution_ids":["https://openalex.org/I2800824516"]},{"raw_affiliation_string":"Singapore Immunology Network, Singapore","institution_ids":["https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018674182","display_name":"Gennaro De Libero","orcid":"https://orcid.org/0000-0003-0853-7868"},"institutions":[{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Gennaro de Libero","raw_affiliation_strings":["Singapore Immunology Network, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Singapore","institution_ids":["https://openalex.org/I2800824516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050267398","display_name":"Michael Poidinger","orcid":"https://orcid.org/0000-0002-1047-2277"},"institutions":[{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Michael Poidinger","raw_affiliation_strings":["Singapore Immunology Network, Singapore,","Singapore Immunology Network, Singapore"],"affiliations":[{"raw_affiliation_string":"Singapore Immunology Network, Singapore,","institution_ids":["https://openalex.org/I2800824516"]},{"raw_affiliation_string":"Singapore Immunology Network, Singapore","institution_ids":["https://openalex.org/I2800824516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019471916","display_name":"Christopher Monterola","orcid":"https://orcid.org/0000-0003-2094-1433"},"institutions":[{"id":"https://openalex.org/I2800824516","display_name":"Singapore Immunology Network","ror":"https://ror.org/03vmmgg57","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2800824516","https://openalex.org/I2801752549"]},{"id":"https://openalex.org/I3004594783","display_name":"Institute of High Performance Computing","ror":"https://ror.org/02n0ejh50","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I3004594783","https://openalex.org/I91275662"]}],"countries":["SG"],"is_corresponding":true,"raw_author_name":"Christopher Monterola","raw_affiliation_strings":["Institute of High Performance Computing, Singapore","Singapore Immunology Network, Singapore,"],"affiliations":[{"raw_affiliation_string":"Institute of High Performance Computing, Singapore","institution_ids":["https://openalex.org/I3004594783"]},{"raw_affiliation_string":"Singapore Immunology Network, Singapore,","institution_ids":["https://openalex.org/I2800824516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5018674182","https://openalex.org/A5019471916","https://openalex.org/A5032337999","https://openalex.org/A5034581488","https://openalex.org/A5038230511","https://openalex.org/A5047474735","https://openalex.org/A5050267398"],"corresponding_institution_ids":["https://openalex.org/I2800824516","https://openalex.org/I3004594783"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.8076,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":{"value":0.85307143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"11","issue":"9","first_page":"e1004504","last_page":"e1004504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.7306302785873413},{"id":"https://openalex.org/keywords/betweenness-centrality","display_name":"Betweenness centrality","score":0.6779912114143372},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6274952292442322},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5904863476753235},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5406237840652466},{"id":"https://openalex.org/keywords/subnetwork","display_name":"Subnetwork","score":0.5017297267913818},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.49084073305130005},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4387264847755432},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.42513132095336914},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.42186859250068665},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.41632798314094543},{"id":"https://openalex.org/keywords/centrality","display_name":"Centrality","score":0.3986912965774536},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.35779255628585815},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35598301887512207},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.21996620297431946},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.07464087009429932}],"concepts":[{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.7306302785873413},{"id":"https://openalex.org/C117045392","wikidata":"https://www.wikidata.org/wiki/Q4899215","display_name":"Betweenness centrality","level":3,"score":0.6779912114143372},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6274952292442322},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5904863476753235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5406237840652466},{"id":"https://openalex.org/C2780186347","wikidata":"https://www.wikidata.org/wiki/Q11414","display_name":"Subnetwork","level":2,"score":0.5017297267913818},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.49084073305130005},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4387264847755432},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.42513132095336914},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.42186859250068665},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.41632798314094543},{"id":"https://openalex.org/C53811970","wikidata":"https://www.wikidata.org/wiki/Q5062194","display_name":"Centrality","level":2,"score":0.3986912965774536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35779255628585815},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35598301887512207},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21996620297431946},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.07464087009429932},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004504","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004504&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/161933","is_oa":true,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/161933","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Unpaywall 20191101","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:4636c259c95c43e2af1c2101047ecb08","is_oa":true,"landing_page_url":"https://doaj.org/article/4636c259c95c43e2af1c2101047ecb08","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 9, p e1004504 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3567192","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4578944","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1552482","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Automated_Identification_of_Core_Regulatory_Genes_in_Human_Gene_Regulatory_Networks_/1552482","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004504","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004504","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004504&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2189730870.pdf","grobid_xml":"https://content.openalex.org/works/W2189730870.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1500474910","https://openalex.org/W1510241967","https://openalex.org/W1533335653","https://openalex.org/W1546952499","https://openalex.org/W1797459856","https://openalex.org/W1964034855","https://openalex.org/W1968286256","https://openalex.org/W1978650654","https://openalex.org/W1981704956","https://openalex.org/W2000515602","https://openalex.org/W2001554877","https://openalex.org/W2003998314","https://openalex.org/W2007070249","https://openalex.org/W2009405916","https://openalex.org/W2013326913","https://openalex.org/W2017426710","https://openalex.org/W2032200433","https://openalex.org/W2033105784","https://openalex.org/W2040847667","https://openalex.org/W2044832480","https://openalex.org/W2050869737","https://openalex.org/W2060501224","https://openalex.org/W2062057057","https://openalex.org/W2062533676","https://openalex.org/W2065663455","https://openalex.org/W2070412833","https://openalex.org/W2083381199","https://openalex.org/W2084668738","https://openalex.org/W2086595847","https://openalex.org/W2087194317","https://openalex.org/W2089865437","https://openalex.org/W2090247362","https://openalex.org/W2095521407","https://openalex.org/W2101296410","https://openalex.org/W2105280376","https://openalex.org/W2109108939","https://openalex.org/W2110503722","https://openalex.org/W2112741367","https://openalex.org/W2118258530","https://openalex.org/W2124064920","https://openalex.org/W2124491835","https://openalex.org/W2124590058","https://openalex.org/W2127372456","https://openalex.org/W2127387319","https://openalex.org/W2128551987","https://openalex.org/W2130674065","https://openalex.org/W2132022337","https://openalex.org/W2133131640","https://openalex.org/W2135030836","https://openalex.org/W2136518208","https://openalex.org/W2137910529","https://openalex.org/W2139719208","https://openalex.org/W2140636685","https://openalex.org/W2141781797","https://openalex.org/W2144675661","https://openalex.org/W2149680578","https://openalex.org/W2151465627","https://openalex.org/W2152296813","https://openalex.org/W2153635508","https://openalex.org/W2158217645","https://openalex.org/W2161409973","https://openalex.org/W2162808198","https://openalex.org/W2164683872","https://openalex.org/W2169318796","https://openalex.org/W2170276985","https://openalex.org/W2259938310","https://openalex.org/W2616543068","https://openalex.org/W2912889105","https://openalex.org/W2917702074","https://openalex.org/W2949793923","https://openalex.org/W3098374147","https://openalex.org/W3120421331","https://openalex.org/W3141829038","https://openalex.org/W4401946675","https://openalex.org/W6665738843"],"related_works":["https://openalex.org/W1973509935","https://openalex.org/W4389076551","https://openalex.org/W2097992793","https://openalex.org/W2107855069","https://openalex.org/W2611574733","https://openalex.org/W2241641394","https://openalex.org/W2140653560","https://openalex.org/W2348831795","https://openalex.org/W2514739320","https://openalex.org/W4312461432"],"abstract_inverted_index":{"Human":[0],"gene":[1,158],"regulatory":[2,62,87,148],"networks":[3],"(GRN)":[4],"can":[5],"be":[6],"difficult":[7],"to":[8,11,110,120,141],"interpret":[9,142],"due":[10],"a":[12,22,39],"tangle":[13],"of":[14,18,41,50,98,118,122,131],"edges":[15],"interconnecting":[16],"thousands":[17],"genes.":[19,125],"We":[20],"constructed":[21],"general":[23],"human":[24,157],"GRN":[25,43,137],"from":[26,35],"extensive":[27],"transcription":[28],"factor":[29],"and":[30,66,76,159,162],"microRNA":[31],"target":[32],"data":[33],"obtained":[34],"public":[36],"databases.":[37],"In":[38],"subnetwork":[40],"this":[42,166,176],"that":[44],"is":[45],"active":[46],"during":[47],"estrogen":[48],"stimulation":[49],"MCF-7":[51,102],"breast":[52],"cancer":[53],"cells,":[54],"we":[55,71,127],"benchmarked":[56],"automated":[57],"algorithms":[58,79],"for":[59,84,134],"identifying":[60],"core":[61,86],"genes":[63,88,100,149],"(transcription":[64],"factors":[65],"microRNAs).":[67],"Among":[68],"these":[69,99],"algorithms,":[70],"identified":[72],"K-core":[73,132],"decomposition,":[74],"pagerank":[75],"betweenness":[77],"centrality":[78],"as":[80,104,106,170],"the":[81,90,112,123,129,136,152],"most":[82],"effective":[83],"discovering":[85],"in":[89,101,107,138,165],"network":[91,161],"evaluated":[92],"based":[93],"on":[94],"previously":[95],"known":[96],"roles":[97],"biology":[103],"well":[105],"their":[108],"ability":[109],"explain":[111],"up":[113,119],"or":[114],"down":[115],"expression":[116],"status":[117],"70%":[121],"remaining":[124],"Finally,":[126],"validated":[128],"use":[130],"algorithm":[133],"organizing":[135],"an":[139],"easier":[140],"layered":[143],"hierarchy":[144],"where":[145],"more":[146],"influential":[147],"percolate":[150],"towards":[151],"inner":[153],"layers.":[154],"The":[155],"integrated":[156],"miRNA":[160],"software":[163],"used":[164],"study":[167],"are":[168],"provided":[169],"supplementary":[171],"materials":[172],"(S1":[173],"Data)":[174],"accompanying":[175],"manuscript.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3}],"updated_date":"2026-03-25T14:56:36.534964","created_date":"2016-06-24T00:00:00"}
