{"id":"https://openalex.org/W1924363611","doi":"https://doi.org/10.1371/journal.pcbi.1004496","title":"Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding","display_name":"Decoding Structural Properties of a Partially Unfolded Protein Substrate: En Route to Chaperone Binding","publication_year":2015,"publication_date":"2015-09-22","ids":{"openalex":"https://openalex.org/W1924363611","doi":"https://doi.org/10.1371/journal.pcbi.1004496","mag":"1924363611","pmid":"https://pubmed.ncbi.nlm.nih.gov/26394388"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004496","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004496&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004496&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081892612","display_name":"Suhani Nagpal","orcid":"https://orcid.org/0000-0002-6336-1570"},"institutions":[{"id":"https://openalex.org/I177828482","display_name":"Institute of Genomics and Integrative Biology","ror":"https://ror.org/05ef28661","country_code":"IN","type":"facility","lineage":["https://openalex.org/I177828482","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Suhani Nagpal","raw_affiliation_strings":["CSIR-Institute of Genomics and Integrative Biology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Institute of Genomics and Integrative Biology, New Delhi, India","institution_ids":["https://openalex.org/I177828482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062181294","display_name":"Satyam Tiwari","orcid":"https://orcid.org/0000-0003-3618-3497"},"institutions":[{"id":"https://openalex.org/I177828482","display_name":"Institute of Genomics and Integrative Biology","ror":"https://ror.org/05ef28661","country_code":"IN","type":"facility","lineage":["https://openalex.org/I177828482","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I99364266","display_name":"Academy of Scientific and Innovative Research","ror":"https://ror.org/053rcsq61","country_code":"IN","type":"education","lineage":["https://openalex.org/I99364266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Satyam Tiwari","raw_affiliation_strings":["CSIR-Institute of Genomics and Integrative Biology, New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India","CSIR-Institute of Genomics and Integrative Biology, New Delhi, India","Academy of Scientific and Innovative Research (AcSIR), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Institute of Genomics and Integrative Biology, New Delhi, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India","institution_ids":[]},{"raw_affiliation_string":"CSIR-Institute of Genomics and Integrative Biology, New Delhi, India","institution_ids":["https://openalex.org/I177828482"]},{"raw_affiliation_string":"Academy of Scientific and Innovative Research (AcSIR), New Delhi, India","institution_ids":["https://openalex.org/I99364266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050691055","display_name":"Koyeli Mapa","orcid":"https://orcid.org/0000-0002-0080-9243"},"institutions":[{"id":"https://openalex.org/I26604189","display_name":"Shiv Nadar University","ror":"https://ror.org/05aqahr97","country_code":"IN","type":"education","lineage":["https://openalex.org/I26604189"]},{"id":"https://openalex.org/I177828482","display_name":"Institute of Genomics and Integrative Biology","ror":"https://ror.org/05ef28661","country_code":"IN","type":"facility","lineage":["https://openalex.org/I177828482","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Koyeli Mapa","raw_affiliation_strings":["CSIR-Institute of Genomics and Integrative Biology, New Delhi, India; Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Dadri, Uttar Pradesh, India","CSIR-Institute of Genomics and Integrative Biology, New Delhi, India","Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Dadri, Uttar Pradesh, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Institute of Genomics and Integrative Biology, New Delhi, India; Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Dadri, Uttar Pradesh, India","institution_ids":[]},{"raw_affiliation_string":"CSIR-Institute of Genomics and Integrative Biology, New Delhi, India","institution_ids":["https://openalex.org/I177828482"]},{"raw_affiliation_string":"Department of Life Sciences, School of Natural Sciences, Shiv Nadar University, Dadri, Uttar Pradesh, India","institution_ids":["https://openalex.org/I26604189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018966703","display_name":"Lipi Thukral","orcid":"https://orcid.org/0000-0002-1961-039X"},"institutions":[{"id":"https://openalex.org/I177828482","display_name":"Institute of Genomics and Integrative Biology","ror":"https://ror.org/05ef28661","country_code":"IN","type":"facility","lineage":["https://openalex.org/I177828482","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Lipi Thukral","raw_affiliation_strings":["CSIR-Institute of Genomics and Integrative Biology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIR-Institute of Genomics and Integrative Biology, New Delhi, India","institution_ids":["https://openalex.org/I177828482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018966703","https://openalex.org/A5050691055"],"corresponding_institution_ids":["https://openalex.org/I177828482","https://openalex.org/I26604189"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4434,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.64674297,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":"9","first_page":"e1004496","last_page":"e1004496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chaperone","display_name":"Chaperone (clinical)","score":0.5549203753471375},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.5263268351554871},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.5193575620651245},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.5162193775177002},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.47756248712539673},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"Unfolded protein response","score":0.47636792063713074},{"id":"https://openalex.org/keywords/substrate-specificity","display_name":"Substrate specificity","score":0.4722565710544586},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4640447497367859},{"id":"https://openalex.org/keywords/decoding-methods","display_name":"Decoding methods","score":0.44495925307273865},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4154413938522339},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.4104781746864319},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3701320290565491},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.36129480600357056},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32125723361968994},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.15721997618675232},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.15511620044708252},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.10748133063316345},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"Endoplasmic reticulum","score":0.0811956524848938}],"concepts":[{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5549203753471375},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.5263268351554871},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.5193575620651245},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5162193775177002},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47756248712539673},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.47636792063713074},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.4722565710544586},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4640447497367859},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.44495925307273865},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4154413938522339},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.4104781746864319},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3701320290565491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36129480600357056},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32125723361968994},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15721997618675232},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15511620044708252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10748133063316345},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.0811956524848938},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004496","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004496&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26394388","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26394388","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:cd5c7527031c4cd59e6898183c50c87e","is_oa":true,"landing_page_url":"https://doaj.org/article/cd5c7527031c4cd59e6898183c50c87e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 9, p e1004496 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3567187","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4578939","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1552928","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Decoding_Structural_Properties_of_a_Partially_Unfolded_Protein_Substrate_En_Route_to_Chaperone_Binding_/1552928","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004496","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004496","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004496&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.6000000238418579,"display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1924363611.pdf","grobid_xml":"https://content.openalex.org/works/W1924363611.grobid-xml"},"referenced_works_count":88,"referenced_works":["https://openalex.org/W1499817490","https://openalex.org/W1533808701","https://openalex.org/W1552392580","https://openalex.org/W1966891645","https://openalex.org/W1971899575","https://openalex.org/W1972505318","https://openalex.org/W1972885447","https://openalex.org/W1974347829","https://openalex.org/W1975721001","https://openalex.org/W1976499671","https://openalex.org/W1977428203","https://openalex.org/W1978033776","https://openalex.org/W1978675310","https://openalex.org/W1980934601","https://openalex.org/W1985732252","https://openalex.org/W1986918984","https://openalex.org/W1986934575","https://openalex.org/W1988840545","https://openalex.org/W1988985785","https://openalex.org/W1993639331","https://openalex.org/W1996139069","https://openalex.org/W2000069699","https://openalex.org/W2000777346","https://openalex.org/W2005341355","https://openalex.org/W2005834965","https://openalex.org/W2005870641","https://openalex.org/W2007268492","https://openalex.org/W2007363410","https://openalex.org/W2008708467","https://openalex.org/W2009645251","https://openalex.org/W2014216299","https://openalex.org/W2015027474","https://openalex.org/W2016094489","https://openalex.org/W2016351987","https://openalex.org/W2017196167","https://openalex.org/W2020275234","https://openalex.org/W2020622784","https://openalex.org/W2025448067","https://openalex.org/W2032363535","https://openalex.org/W2034351413","https://openalex.org/W2035266068","https://openalex.org/W2037551643","https://openalex.org/W2038053444","https://openalex.org/W2040809566","https://openalex.org/W2044483297","https://openalex.org/W2048063313","https://openalex.org/W2049277949","https://openalex.org/W2049341496","https://openalex.org/W2051381895","https://openalex.org/W2055285495","https://openalex.org/W2065362324","https://openalex.org/W2065504621","https://openalex.org/W2067174909","https://openalex.org/W2067697545","https://openalex.org/W2070696305","https://openalex.org/W2079021559","https://openalex.org/W2082612432","https://openalex.org/W2084607551","https://openalex.org/W2090264443","https://openalex.org/W2092432276","https://openalex.org/W2095202824","https://openalex.org/W2096966529","https://openalex.org/W2098731951","https://openalex.org/W2100408989","https://openalex.org/W2101247857","https://openalex.org/W2105463652","https://openalex.org/W2110515879","https://openalex.org/W2112374350","https://openalex.org/W2113701866","https://openalex.org/W2119999468","https://openalex.org/W2120698736","https://openalex.org/W2128072247","https://openalex.org/W2128572087","https://openalex.org/W2129214482","https://openalex.org/W2133903155","https://openalex.org/W2136918199","https://openalex.org/W2138749342","https://openalex.org/W2141809319","https://openalex.org/W2143575872","https://openalex.org/W2144272172","https://openalex.org/W2147289825","https://openalex.org/W2149038136","https://openalex.org/W2153953580","https://openalex.org/W2159923313","https://openalex.org/W2160709701","https://openalex.org/W2164243919","https://openalex.org/W2171268876","https://openalex.org/W2996377354"],"related_works":["https://openalex.org/W337913160","https://openalex.org/W1978188507","https://openalex.org/W2773112660","https://openalex.org/W2986473802","https://openalex.org/W3048040205","https://openalex.org/W1679521832","https://openalex.org/W2337198407","https://openalex.org/W2800742684","https://openalex.org/W2604320595","https://openalex.org/W4313655631"],"abstract_inverted_index":{"Many":[0],"proteins":[1],"comprising":[2],"of":[3,25,45,51,77,85,118,153,178,192],"complex":[4],"topologies":[5],"require":[6],"molecular":[7,70],"chaperones":[8],"to":[9,31,62,73,139,148,190],"achieve":[10],"their":[11],"unique":[12],"three-dimensional":[13],"folded":[14,29],"structure.":[15],"The":[16],"E.coli":[17],"chaperone,":[18],"GroEL":[19,46,80],"binds":[20],"with":[21,91],"a":[22],"large":[23],"number":[24],"unfolded":[26],"and":[27,35,38,68,109,133,155],"partially":[28],"proteins,":[30],"facilitate":[32],"proper":[33],"folding":[34,58],"prevent":[36],"misfolding":[37],"aggregation.":[39],"Although":[40],"the":[41,52,115,175],"major":[42],"structural":[43,93,116],"components":[44],"are":[47,102],"well":[48],"defined,":[49],"scaffolds":[50],"non-native":[53,75,110],"substrates":[54],"that":[55,97,160,169],"determine":[56],"chaperone-mediated":[57,187],"have":[59],"been":[60],"difficult":[61],"recognize.":[63],"Here":[64],"we":[65,144],"performed":[66],"all-atomistic":[67],"replica-exchange":[69],"dynamics":[71],"simulations":[72,87],"dissect":[74],"ensemble":[76],"an":[78],"obligate":[79],"folder,":[81],"DapA.":[82],"Thermodynamics":[83],"analyses":[84],"unfolding":[86],"revealed":[88],"populated":[89],"intermediates":[90],"distinct":[92,176],"characteristics.":[94],"We":[95,113],"found":[96],"surface":[98],"exposed":[99],"hydrophobic":[100],"patches":[101],"significantly":[103],"increased,":[104],"primarily":[105],"contributed":[106],"from":[107],"native":[108,154],"\u03b2-sheet":[111],"elements.":[112],"validate":[114],"properties":[117],"these":[119,183],"conformers":[120],"using":[121],"experimental":[122],"data,":[123],"including":[124],"circular":[125],"dichroism":[126],"(CD),":[127],"1-anilinonaphthalene-8-sulfonic":[128],"acid":[129],"(ANS)":[130],"binding":[131],"measurements":[132],"previously":[134],"reported":[135],"hydrogen-deutrium":[136],"exchange":[137],"coupled":[138],"mass":[140],"spectrometry":[141],"(HDX-MS).":[142],"Further,":[143],"constructed":[145],"network":[146],"graphs":[147],"elucidate":[149],"long-range":[150],"intra-protein":[151],"connectivity":[152],"intermediate":[156],"topologies,":[157],"demonstrating":[158],"regions":[159,177],"serve":[161],"as":[162],"central":[163],"\"hubs\".":[164],"Overall,":[165],"our":[166],"results":[167],"implicate":[168],"genomic":[170],"variations":[171],"(or":[172],"mutations)":[173],"in":[174],"protein":[179],"structures":[180],"might":[181],"disrupt":[182],"topological":[184],"signatures":[185],"disabling":[186],"folding,":[188],"leading":[189],"formation":[191],"aggregates.":[193]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
