{"id":"https://openalex.org/W1829180632","doi":"https://doi.org/10.1371/journal.pcbi.1004452","title":"Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via Genome-Scale Kinetic Models of Bacterial Metabolism","display_name":"Biofilm Formation Mechanisms of Pseudomonas aeruginosa Predicted via Genome-Scale Kinetic Models of Bacterial Metabolism","publication_year":2015,"publication_date":"2015-10-02","ids":{"openalex":"https://openalex.org/W1829180632","doi":"https://doi.org/10.1371/journal.pcbi.1004452","mag":"1829180632","pmid":"https://pubmed.ncbi.nlm.nih.gov/26431398"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004452","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004452","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004452&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004452&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049343634","display_name":"Francisco G Vital-Lopez","orcid":"https://orcid.org/0000-0001-5314-8373"},"institutions":[{"id":"https://openalex.org/I2800986571","display_name":"Telemedicine & Advanced Technology Research Center","ror":"https://ror.org/014pvr265","country_code":"US","type":"other","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2800986571","https://openalex.org/I2802581893"]},{"id":"https://openalex.org/I2802581893","display_name":"United States Army Medical Research and Development Command","ror":"https://ror.org/03cd02q50","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco G. Vital-Lopez","raw_affiliation_strings":["Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America","institution_ids":["https://openalex.org/I2800986571","https://openalex.org/I2802581893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020594190","display_name":"Jaques Reifman","orcid":"https://orcid.org/0000-0001-7292-2029"},"institutions":[{"id":"https://openalex.org/I2800986571","display_name":"Telemedicine & Advanced Technology Research Center","ror":"https://ror.org/014pvr265","country_code":"US","type":"other","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2800986571","https://openalex.org/I2802581893"]},{"id":"https://openalex.org/I2802581893","display_name":"United States Army Medical Research and Development Command","ror":"https://ror.org/03cd02q50","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jaques Reifman","raw_affiliation_strings":["Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America","institution_ids":["https://openalex.org/I2800986571","https://openalex.org/I2802581893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030271505","display_name":"Anders Wallqvist","orcid":"https://orcid.org/0000-0002-9775-7469"},"institutions":[{"id":"https://openalex.org/I2800986571","display_name":"Telemedicine & Advanced Technology Research Center","ror":"https://ror.org/014pvr265","country_code":"US","type":"other","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2800986571","https://openalex.org/I2802581893"]},{"id":"https://openalex.org/I2802581893","display_name":"United States Army Medical Research and Development Command","ror":"https://ror.org/03cd02q50","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anders Wallqvist","raw_affiliation_strings":["Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States of America","institution_ids":["https://openalex.org/I2800986571","https://openalex.org/I2802581893"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020594190"],"corresponding_institution_ids":["https://openalex.org/I2800986571","https://openalex.org/I2802581893"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.07,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.86742143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"11","issue":"10","first_page":"e1004452","last_page":"e1004452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biofilm","display_name":"Biofilm","score":0.9769713878631592},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.8554596304893494},{"id":"https://openalex.org/keywords/quorum-sensing","display_name":"Quorum sensing","score":0.7867972254753113},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6437593698501587},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.6135843992233276},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5534260869026184},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4250854253768921},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.42002055048942566},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.4170994460582733},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.21712785959243774},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2118677794933319}],"concepts":[{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.9769713878631592},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.8554596304893494},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.7867972254753113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6437593698501587},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6135843992233276},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5534260869026184},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4250854253768921},{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.42002055048942566},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4170994460582733},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.21712785959243774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2118677794933319}],"mesh":[{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D018441","descriptor_name":"Biofilms","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004452","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004452","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004452&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26431398","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26431398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:54a4e8d5cf4f4341bb106bdde930d47c","is_oa":true,"landing_page_url":"https://doaj.org/article/54a4e8d5cf4f4341bb106bdde930d47c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 10, p e1004452 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3575668","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4592021","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1563187","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Biofilm_Formation_Mechanisms_of_Pseudomonas_aeruginosa_Predicted_via_Genome_Scale_Kinetic_Models_of_Bacterial_Metabolism/1563187","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004452","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004452","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004452&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.6700000166893005}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320338280","display_name":"Medical Research and Materiel Command","ror":"https://ror.org/03cd02q50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1829180632.pdf","grobid_xml":"https://content.openalex.org/works/W1829180632.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1480858593","https://openalex.org/W1583614303","https://openalex.org/W1590056435","https://openalex.org/W1899390263","https://openalex.org/W1914847270","https://openalex.org/W1969537603","https://openalex.org/W1970927928","https://openalex.org/W1987486474","https://openalex.org/W2013198636","https://openalex.org/W2031043669","https://openalex.org/W2036748232","https://openalex.org/W2038669746","https://openalex.org/W2046973388","https://openalex.org/W2047698915","https://openalex.org/W2055294982","https://openalex.org/W2055767311","https://openalex.org/W2067849157","https://openalex.org/W2072967720","https://openalex.org/W2073611314","https://openalex.org/W2081492047","https://openalex.org/W2090437281","https://openalex.org/W2095415260","https://openalex.org/W2097744318","https://openalex.org/W2100927178","https://openalex.org/W2102707565","https://openalex.org/W2103041540","https://openalex.org/W2107969753","https://openalex.org/W2112568743","https://openalex.org/W2115801514","https://openalex.org/W2115933619","https://openalex.org/W2116854231","https://openalex.org/W2118258530","https://openalex.org/W2125603952","https://openalex.org/W2127373523","https://openalex.org/W2133172011","https://openalex.org/W2133444948","https://openalex.org/W2134053082","https://openalex.org/W2136004458","https://openalex.org/W2137890456","https://openalex.org/W2138134673","https://openalex.org/W2144922187","https://openalex.org/W2145402561","https://openalex.org/W2147229554","https://openalex.org/W2148753657","https://openalex.org/W2154061034","https://openalex.org/W2157666459","https://openalex.org/W2157927045","https://openalex.org/W2162237022","https://openalex.org/W2162666840","https://openalex.org/W2165407655","https://openalex.org/W2166359904","https://openalex.org/W2168244801","https://openalex.org/W2170382524","https://openalex.org/W4237151101"],"related_works":["https://openalex.org/W2129197708","https://openalex.org/W4206567109","https://openalex.org/W2888747144","https://openalex.org/W2197362931","https://openalex.org/W4224441266","https://openalex.org/W1603821791","https://openalex.org/W2052893160","https://openalex.org/W2277991016","https://openalex.org/W2500673925","https://openalex.org/W1905181907"],"abstract_inverted_index":{"A":[0],"hallmark":[1],"of":[2,43,63,82,141,164,177,225,228,241,261,274],"Pseudomonas":[3,150],"aeruginosa":[4,85,115,263],"is":[5,157,212,236],"its":[6],"ability":[7,199],"to":[8,15,21,52,109,184,200,204],"establish":[9],"biofilm-based":[10],"infections":[11],"that":[12,138,208,222,270],"are":[13,18,66,253],"difficult":[14],"eradicate.":[16],"Biofilms":[17],"less":[19],"susceptible":[20],"host":[22],"inflammatory":[23],"and":[24,27,88,105,130,153,234],"immune":[25],"responses":[26],"have":[28,50,196],"higher":[29],"antibiotic":[30],"tolerance":[31],"than":[32],"free-living":[33],"planktonic":[34,133],"cells.":[35],"Developing":[36],"treatments":[37],"against":[38,113],"biofilms":[39,240],"requires":[40],"an":[41,197],"understanding":[42],"bacterial":[44],"biofilm-specific":[45,175],"physiological":[46],"traits.":[47],"Research":[48],"efforts":[49],"started":[51],"elucidate":[53],"the":[54,83,106,120,139,147,154,162,174,223,226,239],"intricate":[55],"mechanisms":[56,65],"underlying":[57],"biofilm":[58,75,103,129,210,264],"development.":[59],"However,":[60],"many":[61],"aspects":[62],"these":[64,185,242,245],"still":[67],"poorly":[68],"understood.":[69],"Here,":[70],"we":[71,93,188,220],"addressed":[72],"questions":[73],"regarding":[74],"metabolism":[76,122],"using":[77],"a":[78,205,215],"genome-scale":[79,283],"kinetic":[80,250,284],"model":[81,259],"P.":[84,114,262],"metabolic":[86],"network":[87],"gene":[89,125,287],"expression":[90,126,163,176,288],"profiles.":[91,289],"Specifically,":[92],"computed":[94],"metabolite":[95],"concentration":[96],"differences":[97],"between":[98,128],"known":[99],"mutants":[100,191],"with":[101,286],"altered":[102,121],"formation":[104],"wild-type":[107],"strain":[108],"predict":[110],"drug":[111],"targets":[112],"biofilms.":[116,202],"We":[117],"also":[118,172],"simulated":[119],"driven":[123],"by":[124,214,281],"changes":[127],"stationary":[131],"growth-phase":[132],"cultures.":[134],"Our":[135,266],"analysis":[136],"suggests":[137],"synthesis":[140,169,227],"important":[142],"biofilm-related":[143],"molecules,":[144],"such":[145],"as":[146],"quorum-sensing":[148],"molecule":[149],"quinolone":[151],"signal":[152],"exopolysaccharide":[155],"Psl,":[156],"regulated":[158],"not":[159,254],"only":[160],"through":[161,173,248],"genes":[165,178],"in":[166,179,193,217],"their":[167],"own":[168],"pathway,":[170],"but":[171],"pathways":[180],"competing":[181],"for":[182],"precursors":[183],"molecules.":[186],"Finally,":[187],"investigated":[189],"why":[190],"defective":[192],"anthranilate":[194,233],"degradation":[195],"impaired":[198,238],"form":[201],"Alternative":[203],"previous":[206,257],"hypothesis":[207],"this":[209],"reduction":[211],"caused":[213],"decrease":[216],"energy":[218],"production,":[219],"proposed":[221],"dysregulation":[224],"secondary":[229],"metabolites":[230],"derived":[231],"from":[232,256],"chorismate":[235],"what":[237],"mutants.":[243],"Notably,":[244],"insights":[246],"generated":[247,280],"our":[249],"model-based":[251],"approach":[252],"accessible":[255],"constraint-based":[258],"analyses":[260],"metabolism.":[265],"simulation":[267],"results":[268],"showed":[269],"plausible,":[271],"non-intuitive":[272],"explanations":[273],"difficult-to-interpret":[275],"experimental":[276],"observations":[277],"could":[278],"be":[279],"integrating":[282],"models":[285]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}