{"id":"https://openalex.org/W2225675378","doi":"https://doi.org/10.1371/journal.pcbi.1004431","title":"Coordinating Role of RXR\u03b1 in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling","display_name":"Coordinating Role of RXR\u03b1 in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling","publication_year":2016,"publication_date":"2016-01-04","ids":{"openalex":"https://openalex.org/W2225675378","doi":"https://doi.org/10.1371/journal.pcbi.1004431","mag":"2225675378","pmid":"https://pubmed.ncbi.nlm.nih.gov/26727233"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004431","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004431","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004431&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004431&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111558148","display_name":"Roland Keller","orcid":null},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Roland Keller","raw_affiliation_strings":["Center for Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102871851","display_name":"Marcus Klein","orcid":"https://orcid.org/0000-0001-5077-8302"},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marcus Klein","raw_affiliation_strings":["Dr. Margarete Fischer Bosch-Institute of Clinical Pharmacology, Stuttgart","University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer Bosch-Institute of Clinical Pharmacology, Stuttgart","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064898960","display_name":"Maria Thomas","orcid":"https://orcid.org/0000-0001-6394-8710"},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Maria Thomas","raw_affiliation_strings":["Dr. Margarete Fischer Bosch-Institute of Clinical Pharmacology, Stuttgart","University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer Bosch-Institute of Clinical Pharmacology, Stuttgart","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065854572","display_name":"Andreas Dr\u00e4ger","orcid":"https://orcid.org/0000-0002-1240-5553"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Andreas Dr\u00e4ger","raw_affiliation_strings":["Center for Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tuebingen, Germany","Systems Biology Research Group, University of California, San Diego, La Jolla, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Systems Biology Research Group, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023700781","display_name":"Ute Metzger","orcid":null},"institutions":[{"id":"https://openalex.org/I4210111828","display_name":"Natural and Medical Sciences Institute","ror":"https://ror.org/01th1p123","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210111828"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ute Metzger","raw_affiliation_strings":["NMI Institute of Natural and Medical Sciences, Reutlingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NMI Institute of Natural and Medical Sciences, Reutlingen, Germany","institution_ids":["https://openalex.org/I4210111828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058234708","display_name":"Markus F. Templin","orcid":"https://orcid.org/0000-0002-6569-6489"},"institutions":[{"id":"https://openalex.org/I4210111828","display_name":"Natural and Medical Sciences Institute","ror":"https://ror.org/01th1p123","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210111828"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus F. Templin","raw_affiliation_strings":["NMI Institute of Natural and Medical Sciences, Reutlingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NMI Institute of Natural and Medical Sciences, Reutlingen, Germany","institution_ids":["https://openalex.org/I4210111828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080106313","display_name":"Thomas Joos","orcid":"https://orcid.org/0000-0003-3042-8174"},"institutions":[{"id":"https://openalex.org/I4210111828","display_name":"Natural and Medical Sciences Institute","ror":"https://ror.org/01th1p123","country_code":"DE","type":"other","lineage":["https://openalex.org/I4210111828"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas O. Joos","raw_affiliation_strings":["NMI Institute of Natural and Medical Sciences, Reutlingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NMI Institute of Natural and Medical Sciences, Reutlingen, Germany","institution_ids":["https://openalex.org/I4210111828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109159555","display_name":"Wolfgang E. Thasler","orcid":null},"institutions":[{"id":"https://openalex.org/I4210121101","display_name":"M\u00fcnchen Klinik","ror":"https://ror.org/03pfshj32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210121101"]},{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfgang E. Thasler","raw_affiliation_strings":["Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Hospital of the University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Hospital of the University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I4210121101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004958444","display_name":"Andreas Zell","orcid":"https://orcid.org/0000-0003-3299-2211"},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Zell","raw_affiliation_strings":["Center for Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics Tuebingen (ZBIT), University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044688765","display_name":"Ulrich M. Zanger","orcid":"https://orcid.org/0000-0002-5276-2002"},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]},{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Ulrich M. Zanger","raw_affiliation_strings":["Dr. Margarete Fischer Bosch-Institute of Clinical Pharmacology, Stuttgart","University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer Bosch-Institute of Clinical Pharmacology, Stuttgart","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5004958444","https://openalex.org/A5023700781","https://openalex.org/A5044688765","https://openalex.org/A5058234708","https://openalex.org/A5064898960","https://openalex.org/A5065854572","https://openalex.org/A5080106313","https://openalex.org/A5102871851","https://openalex.org/A5109159555","https://openalex.org/A5111558148"],"corresponding_institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I36258959","https://openalex.org/I4210111828","https://openalex.org/I4210120009","https://openalex.org/I4210121101","https://openalex.org/I8087733"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.8864,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.86853143,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"e1004431","last_page":"e1004431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/downregulation-and-upregulation","display_name":"Downregulation and upregulation","score":0.6663186550140381},{"id":"https://openalex.org/keywords/nuclear-receptor","display_name":"Nuclear receptor","score":0.6654101610183716},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5963504910469055},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5409979820251465},{"id":"https://openalex.org/keywords/retinoid-x-receptor","display_name":"Retinoid X receptor","score":0.5308590531349182},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4812981188297272},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"Gene silencing","score":0.4528426229953766},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.433615118265152},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3967216908931732},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.3542255759239197},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.32631903886795044},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.29094743728637695},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2213454246520996}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.6663186550140381},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.6654101610183716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5963504910469055},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5409979820251465},{"id":"https://openalex.org/C128821507","wikidata":"https://www.wikidata.org/wiki/Q3454518","display_name":"Retinoid X receptor","level":5,"score":0.5308590531349182},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4812981188297272},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4528426229953766},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.433615118265152},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3967216908931732},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3542255759239197},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32631903886795044},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29094743728637695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2213454246520996}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017143","descriptor_name":"Fuzzy Logic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047490","descriptor_name":"Retinoid X Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047490","descriptor_name":"Retinoid X Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047490","descriptor_name":"Retinoid X Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004431","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004431","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004431&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26727233","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26727233","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:4990ce8acd6b4ae2990fb37d80558db9","is_oa":false,"landing_page_url":"https://doaj.org/article/4990ce8acd6b4ae2990fb37d80558db9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 1, p e1004431 (2016)","raw_type":"article"},{"id":"pmh:oai:epub.ub.uni-muenchen.de:38255","is_oa":false,"landing_page_url":"http://nbn-resolving.de/urn:nbn:de:bvb:19-epub-38255-2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401845","display_name":"Open access LMU (Ludwid Maxmilian's Universitat Munchen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I8204097","host_organization_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","host_organization_lineage":["https://openalex.org/I8204097"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS Computational Biology","raw_type":"doc-type:article"},{"id":"pmh:oai:europepmc.org:3688730","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4699813","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1632650","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Coordinating_Role_of_RXR_945_in_Downregulating_Hepatic_Detoxification_during_Inflammation_Revealed_by_Fuzzy_Logic_Modeling_/1632650","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004431","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004431","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004431&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.800000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1780967863","display_name":null,"funder_award_id":"0315755","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G6782187388","display_name":null,"funder_award_id":"0315756","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320869","display_name":"Robert Bosch Stiftung","ror":"https://ror.org/012kqkf58"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2225675378.pdf","grobid_xml":"https://content.openalex.org/works/W2225675378.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W199757098","https://openalex.org/W646011573","https://openalex.org/W1857220019","https://openalex.org/W1964184380","https://openalex.org/W1966030580","https://openalex.org/W1982189144","https://openalex.org/W1982992637","https://openalex.org/W1988212011","https://openalex.org/W1990702248","https://openalex.org/W1995865518","https://openalex.org/W1998704074","https://openalex.org/W2008594900","https://openalex.org/W2010427019","https://openalex.org/W2013349369","https://openalex.org/W2017218687","https://openalex.org/W2019050142","https://openalex.org/W2020872262","https://openalex.org/W2021469201","https://openalex.org/W2035610264","https://openalex.org/W2044634578","https://openalex.org/W2047401805","https://openalex.org/W2052090790","https://openalex.org/W2067386680","https://openalex.org/W2068780263","https://openalex.org/W2069728939","https://openalex.org/W2071212514","https://openalex.org/W2073903631","https://openalex.org/W2086262311","https://openalex.org/W2091544680","https://openalex.org/W2100772783","https://openalex.org/W2105423509","https://openalex.org/W2106219094","https://openalex.org/W2107277218","https://openalex.org/W2112271094","https://openalex.org/W2115008851","https://openalex.org/W2116638233","https://openalex.org/W2117525838","https://openalex.org/W2123125245","https://openalex.org/W2125543544","https://openalex.org/W2127625114","https://openalex.org/W2131089732","https://openalex.org/W2131129102","https://openalex.org/W2134520937","https://openalex.org/W2134610619","https://openalex.org/W2135285532","https://openalex.org/W2138713601","https://openalex.org/W2150174523","https://openalex.org/W2152148620","https://openalex.org/W2154500836","https://openalex.org/W2154601808","https://openalex.org/W2157207950","https://openalex.org/W2159562550","https://openalex.org/W2159675211","https://openalex.org/W2161771297","https://openalex.org/W2167334954","https://openalex.org/W2170839629","https://openalex.org/W2913066018","https://openalex.org/W4286852514","https://openalex.org/W6608040595"],"related_works":["https://openalex.org/W2808794533","https://openalex.org/W4236233796","https://openalex.org/W1987040411","https://openalex.org/W2093246497","https://openalex.org/W1523820703","https://openalex.org/W2469666886","https://openalex.org/W2048744825","https://openalex.org/W2071792338","https://openalex.org/W2790674462","https://openalex.org/W2068791200"],"abstract_inverted_index":{"During":[0],"various":[1],"inflammatory":[2],"processes":[3],"circulating":[4],"cytokines":[5],"including":[6],"IL-6,":[7,52],"IL-1\u03b2,":[8],"and":[9,14,33,63,67,74,89,102,107,180],"TNF\u03b1":[10],"elicit":[11],"a":[12,41,121,136,146],"broad":[13],"clinically":[15],"relevant":[16],"impairment":[17],"of":[18,28,56,86,124,149],"hepatic":[19],"detoxification":[20,68],"that":[21,177],"is":[22,44],"based":[23],"on":[24],"the":[25,38,53,57,84,130],"simultaneous":[26],"downregulation":[27],"many":[29],"drug":[30,179],"metabolizing":[31],"enzymes":[32],"transporter":[34],"genes.":[35],"To":[36],"address":[37],"question":[39],"whether":[40],"common":[42],"mechanism":[43],"involved":[45],"we":[46],"treated":[47],"human":[48],"primary":[49],"hepatocytes":[50],"with":[51,109,129,166],"major":[54],"mediator":[55],"acute":[58,65],"phase":[59,66],"response":[60],"in":[61,70,139],"liver,":[62],"characterized":[64],"responses":[69],"quantitative":[71],"gene":[72,103,111,151,157],"expression":[73,112],"(phospho-)proteomics":[75],"data":[76,113],"sets.":[77],"Selective":[78],"inhibitors":[79],"were":[80],"used":[81],"to":[82,127],"disentangle":[83],"roles":[85],"JAK/STAT,":[87],"MAPK,":[88],"PI3K":[90],"signaling":[91],"pathways.":[92],"A":[93],"prior":[94],"knowledge-based":[95],"fuzzy":[96],"logic":[97],"model":[98,119],"comprising":[99],"signal":[100],"transduction":[101],"regulation":[104,158],"was":[105],"established":[106],"trained":[108],"perturbation-derived":[110],"from":[114],"five":[115],"hepatocyte":[116],"donors.":[117],"Our":[118],"suggests":[120],"greater":[122],"role":[123,138],"MAPK/PI3K":[125],"compared":[126],"JAK/STAT":[128],"orphan":[131],"nuclear":[132,175],"receptor":[133],"RXR\u03b1":[134,150,167],"playing":[135],"central":[137],"mediating":[140],"transcriptional":[141],"downregulation.":[142],"Validation":[143],"experiments":[144],"revealed":[145],"striking":[147],"similarity":[148],"silencing":[152],"versus":[153],"IL-6":[154],"induced":[155],"negative":[156],"(rs":[159],"=":[160],"0.79;":[161],"P<0.0001).":[162],"These":[163],"results":[164],"concur":[165],"functioning":[168],"as":[169],"obligatory":[170],"heterodimerization":[171],"partner":[172],"for":[173],"several":[174],"receptors":[176],"regulate":[178],"lipid":[181],"metabolism.":[182]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}