{"id":"https://openalex.org/W910669104","doi":"https://doi.org/10.1371/journal.pcbi.1004386","title":"A Developmental Switch for Hebbian Plasticity","display_name":"A Developmental Switch for Hebbian Plasticity","publication_year":2015,"publication_date":"2015-07-14","ids":{"openalex":"https://openalex.org/W910669104","doi":"https://doi.org/10.1371/journal.pcbi.1004386","mag":"910669104","pmid":"https://pubmed.ncbi.nlm.nih.gov/26172394"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004386","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004386","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004386&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004386&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034300310","display_name":"Marijn Bart Martens","orcid":"https://orcid.org/0000-0002-5196-5131"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Marijn B. Martens","raw_affiliation_strings":["Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neuroinformatics, Radboud University Nijmegen, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neuroinformatics, Radboud University Nijmegen, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034870531","display_name":"Tansu Celikel","orcid":"https://orcid.org/0000-0002-9629-0334"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tansu Celikel","raw_affiliation_strings":["Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurophysiology, Radboud University Nijmegen, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neurophysiology, Radboud University Nijmegen, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015482433","display_name":"Paul Tiesinga","orcid":"https://orcid.org/0000-0003-4509-6870"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul H. E. Tiesinga","raw_affiliation_strings":["Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neuroinformatics, Radboud University Nijmegen, Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Neuroinformatics, Radboud University Nijmegen, Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034300310"],"corresponding_institution_ids":["https://openalex.org/I145872427"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8867,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.72936619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"7","first_page":"e1004386","last_page":"e1004386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hebbian-theory","display_name":"Hebbian theory","score":0.9633278250694275},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7888109683990479},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"Synaptic plasticity","score":0.6004055142402649},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"Neuroplasticity","score":0.5814602375030518},{"id":"https://openalex.org/keywords/metaplasticity","display_name":"Metaplasticity","score":0.5709213018417358},{"id":"https://openalex.org/keywords/developmental-plasticity","display_name":"Developmental plasticity","score":0.5227530002593994},{"id":"https://openalex.org/keywords/homeostatic-plasticity","display_name":"Homeostatic plasticity","score":0.45620226860046387},{"id":"https://openalex.org/keywords/exocytosis","display_name":"Exocytosis","score":0.42732834815979004},{"id":"https://openalex.org/keywords/synaptic-scaling","display_name":"Synaptic scaling","score":0.4270053803920746},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3633362054824829},{"id":"https://openalex.org/keywords/plasticity","display_name":"Plasticity","score":0.29047057032585144},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1816360056400299},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.07285177707672119},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.06819641590118408},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.06488931179046631}],"concepts":[{"id":"https://openalex.org/C111437709","wikidata":"https://www.wikidata.org/wiki/Q1277874","display_name":"Hebbian theory","level":3,"score":0.9633278250694275},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7888109683990479},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.6004055142402649},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.5814602375030518},{"id":"https://openalex.org/C194973443","wikidata":"https://www.wikidata.org/wiki/Q1420291","display_name":"Metaplasticity","level":4,"score":0.5709213018417358},{"id":"https://openalex.org/C86878447","wikidata":"https://www.wikidata.org/wiki/Q5266812","display_name":"Developmental plasticity","level":3,"score":0.5227530002593994},{"id":"https://openalex.org/C5687787","wikidata":"https://www.wikidata.org/wiki/Q5889850","display_name":"Homeostatic plasticity","level":5,"score":0.45620226860046387},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.42732834815979004},{"id":"https://openalex.org/C117718741","wikidata":"https://www.wikidata.org/wiki/Q7662041","display_name":"Synaptic scaling","level":5,"score":0.4270053803920746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3633362054824829},{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.29047057032585144},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1816360056400299},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07285177707672119},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.06819641590118408},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.06488931179046631},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004386","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004386","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004386&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26172394","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26172394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:e12c425880264996a543ff2a5dcbd849","is_oa":true,"landing_page_url":"https://doaj.org/article/e12c425880264996a543ff2a5dcbd849","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 7, p e1004386 (2015)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4501799","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4501799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/144496","is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/144496","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plos Computational Biology, 11, 7, pp. 1-19","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004386","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004386","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004386&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3689056532","display_name":null,"funder_award_id":"62001113","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W910669104.pdf","grobid_xml":"https://content.openalex.org/works/W910669104.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1534752637","https://openalex.org/W1542782021","https://openalex.org/W1595620356","https://openalex.org/W1845163922","https://openalex.org/W1946022517","https://openalex.org/W1965210407","https://openalex.org/W1978453114","https://openalex.org/W1979941326","https://openalex.org/W1981729419","https://openalex.org/W1982782013","https://openalex.org/W1984803891","https://openalex.org/W1985392528","https://openalex.org/W1993222366","https://openalex.org/W1993868308","https://openalex.org/W2003674836","https://openalex.org/W2005454026","https://openalex.org/W2008456025","https://openalex.org/W2009839417","https://openalex.org/W2013377646","https://openalex.org/W2015276824","https://openalex.org/W2015894821","https://openalex.org/W2017722024","https://openalex.org/W2022567100","https://openalex.org/W2031779883","https://openalex.org/W2037316381","https://openalex.org/W2038511109","https://openalex.org/W2041423137","https://openalex.org/W2042920344","https://openalex.org/W2044514703","https://openalex.org/W2045095925","https://openalex.org/W2045536550","https://openalex.org/W2046104691","https://openalex.org/W2047535883","https://openalex.org/W2048465987","https://openalex.org/W2049431608","https://openalex.org/W2050638824","https://openalex.org/W2055655674","https://openalex.org/W2059288735","https://openalex.org/W2067486032","https://openalex.org/W2070515178","https://openalex.org/W2073850595","https://openalex.org/W2076658236","https://openalex.org/W2077306952","https://openalex.org/W2078420859","https://openalex.org/W2083541352","https://openalex.org/W2086664483","https://openalex.org/W2091032510","https://openalex.org/W2093514926","https://openalex.org/W2093812780","https://openalex.org/W2096681544","https://openalex.org/W2100617174","https://openalex.org/W2103594871","https://openalex.org/W2114462905","https://openalex.org/W2118706970","https://openalex.org/W2120301129","https://openalex.org/W2123940254","https://openalex.org/W2128149358","https://openalex.org/W2129456284","https://openalex.org/W2132634436","https://openalex.org/W2132653427","https://openalex.org/W2132889095","https://openalex.org/W2135208959","https://openalex.org/W2150947848","https://openalex.org/W2152807601","https://openalex.org/W2153775014","https://openalex.org/W2169505641","https://openalex.org/W2170159961","https://openalex.org/W4238614602","https://openalex.org/W7073747422"],"related_works":["https://openalex.org/W2428277761","https://openalex.org/W1504248943","https://openalex.org/W2079853249","https://openalex.org/W2799124268","https://openalex.org/W2102744370","https://openalex.org/W2335718322","https://openalex.org/W2950462296","https://openalex.org/W2595596980","https://openalex.org/W2950806340","https://openalex.org/W2578308616"],"abstract_inverted_index":{"Hebbian":[0,31,118,124,148],"forms":[1],"of":[2,11,21,30,36,43,83,88,117,147,163,179,187],"synaptic":[3,84,89],"plasticity":[4,32,125],"are":[5,18],"required":[6],"for":[7,81,123],"the":[8,15,41,92,115,136,144,185],"orderly":[9],"development":[10,50,69],"sensory":[12],"circuits":[13],"in":[14,25,58,68,91,114,157],"brain":[16,180],"and":[17,23,86,135,140],"powerful":[19],"modulators":[20],"learning":[22],"memory":[24],"adulthood.":[26],"During":[27],"development,":[28],"emergence":[29],"leads":[33],"to":[34,133,172,177,184],"formation":[35],"functional":[37],"circuits.":[38],"By":[39],"modeling":[40],"dynamics":[42],"neurotransmitter":[44,158],"release":[45,159],"during":[46],"early":[47],"postnatal":[48],"cortical":[49],"we":[51],"show":[52,152],"that":[53,99,153],"a":[54,102],"developmentally":[55],"regulated":[56],"switch":[57,156,174],"vesicle":[59,71,107],"exocytosis":[60,72,108],"mode":[61,160],"triggers":[62],"associative":[63],"(i.e.":[64],"Hebbian)":[65],"plasticity.":[66,119,149,166],"Early":[67],"spontaneous":[70],"(SVE),":[73],"often":[74],"considered":[75],"as":[76],"'synaptic":[77],"noise',":[78],"is":[79],"important":[80],"homogenization":[82],"weights":[85,90],"maintenance":[87],"appropriate":[93],"dynamic":[94],"range.":[95],"Our":[96],"results":[97],"demonstrate":[98],"SVE":[100,132,139,171],"has":[101,110],"permissive,":[103],"whereas":[104],"subsequent":[105],"evoked":[106],"(EVE)":[109],"an":[111],"instructive":[112],"role":[113],"expression":[116],"A":[120,167],"timed":[121],"onset":[122],"can":[126,142],"be":[127],"achieved":[128],"by":[129],"switching":[130],"from":[131],"EVE":[134,141,173],"balance":[137],"between":[138],"control":[143],"effective":[145],"rate":[146],"We":[150],"further":[151],"this":[154],"developmental":[155],"enables":[161],"maturation":[162],"spike-timing":[164],"dependent":[165],"mis-timed":[168],"or":[169],"inadequate":[170],"may":[175],"lead":[176],"malformation":[178],"networks":[181],"thereby":[182],"contributing":[183],"etiology":[186],"neurodevelopmental":[188],"disorders.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}