{"id":"https://openalex.org/W2149565502","doi":"https://doi.org/10.1371/journal.pcbi.1004314","title":"A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis","display_name":"A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis","publication_year":2015,"publication_date":"2015-10-15","ids":{"openalex":"https://openalex.org/W2149565502","doi":"https://doi.org/10.1371/journal.pcbi.1004314","mag":"2149565502","pmid":"https://pubmed.ncbi.nlm.nih.gov/26468651"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004314","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004314&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004314&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023166649","display_name":"Alexander D. Malkin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander D. Malkin","raw_affiliation_strings":["McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210155891","https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109064854","display_name":"Robert P. Sheehan","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Sheehan","raw_affiliation_strings":["Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035660807","display_name":"Shibin Mathew","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shibin Mathew","raw_affiliation_strings":["Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066540105","display_name":"William J. Federspiel","orcid":"https://orcid.org/0000-0002-7068-6779"},"institutions":[{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]},{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Federspiel","raw_affiliation_strings":["McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210155891","https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030343627","display_name":"Heinz Redl","orcid":"https://orcid.org/0000-0003-1654-462X"},"institutions":[{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Heinz Redl","raw_affiliation_strings":["Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUVA center, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUVA center, Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082272833","display_name":"Gilles Clermont","orcid":"https://orcid.org/0000-0002-0163-1379"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilles Clermont","raw_affiliation_strings":["CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023166649"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8681,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.76126059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"10","first_page":"e1004314","last_page":"e1004314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.6950003504753113},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5612584948539734},{"id":"https://openalex.org/keywords/extracorporeal","display_name":"Extracorporeal","score":0.5334314107894897},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5044530630111694},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.4273134171962738},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39985328912734985},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.367153525352478},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19646203517913818}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6950003504753113},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5612584948539734},{"id":"https://openalex.org/C2779915274","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal","level":2,"score":0.5334314107894897},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5044530630111694},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4273134171962738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39985328912734985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.367153525352478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19646203517913818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004314","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004314&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26468651","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26468651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1004314","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004314","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:008d049bbd7c4768bedc1c028918c1d9","is_oa":false,"landing_page_url":"https://doaj.org/article/008d049bbd7c4768bedc1c028918c1d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 10, p e1004314 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3594453","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4607502","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1577047","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_A_Neutrophil_Phenotype_Model_for_Extracorporeal_Treatment_of_Sepsis_/1577047","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004314","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004314&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8600000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G4591649018","display_name":null,"funder_award_id":"EB009403","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4679364596","display_name":null,"funder_award_id":"T32 HL076124","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7306899482","display_name":null,"funder_award_id":"T32 EB009403","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149565502.pdf","grobid_xml":"https://content.openalex.org/works/W2149565502.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W115452890","https://openalex.org/W580209411","https://openalex.org/W1516476380","https://openalex.org/W1547259510","https://openalex.org/W1550111394","https://openalex.org/W1555165785","https://openalex.org/W1953891123","https://openalex.org/W1975622213","https://openalex.org/W1976646654","https://openalex.org/W1988540551","https://openalex.org/W1993753754","https://openalex.org/W1994803737","https://openalex.org/W1995715636","https://openalex.org/W1995887867","https://openalex.org/W2002661807","https://openalex.org/W2004125965","https://openalex.org/W2008633581","https://openalex.org/W2013145865","https://openalex.org/W2013591251","https://openalex.org/W2019294202","https://openalex.org/W2019952254","https://openalex.org/W2025238477","https://openalex.org/W2025904060","https://openalex.org/W2026546599","https://openalex.org/W2026927834","https://openalex.org/W2030911724","https://openalex.org/W2040513455","https://openalex.org/W2043276874","https://openalex.org/W2044809386","https://openalex.org/W2045272841","https://openalex.org/W2047120142","https://openalex.org/W2047988689","https://openalex.org/W2048674276","https://openalex.org/W2049820468","https://openalex.org/W2049927822","https://openalex.org/W2050940395","https://openalex.org/W2056419421","https://openalex.org/W2063867274","https://openalex.org/W2071629571","https://openalex.org/W2074401358","https://openalex.org/W2075161553","https://openalex.org/W2076122670","https://openalex.org/W2077399951","https://openalex.org/W2081610661","https://openalex.org/W2085029046","https://openalex.org/W2093223772","https://openalex.org/W2101780675","https://openalex.org/W2104415072","https://openalex.org/W2104709352","https://openalex.org/W2105981152","https://openalex.org/W2107360959","https://openalex.org/W2110759872","https://openalex.org/W2118138330","https://openalex.org/W2123884323","https://openalex.org/W2125886217","https://openalex.org/W2127774299","https://openalex.org/W2130091936","https://openalex.org/W2131837548","https://openalex.org/W2133990480","https://openalex.org/W2134999083","https://openalex.org/W2136836360","https://openalex.org/W2142093121","https://openalex.org/W2143886761","https://openalex.org/W2145577370","https://openalex.org/W2146936549","https://openalex.org/W2148534890","https://openalex.org/W2159750628","https://openalex.org/W2161304688","https://openalex.org/W2161771297","https://openalex.org/W2163814324","https://openalex.org/W2164979145","https://openalex.org/W2164990391","https://openalex.org/W2166162509","https://openalex.org/W2169174676","https://openalex.org/W2170171286","https://openalex.org/W2170775692","https://openalex.org/W2174934515","https://openalex.org/W2495039162","https://openalex.org/W3098919389","https://openalex.org/W3149695318","https://openalex.org/W6616800437"],"related_works":["https://openalex.org/W3215560449","https://openalex.org/W3030236844","https://openalex.org/W2138714377","https://openalex.org/W2832459556","https://openalex.org/W4237737355","https://openalex.org/W1520457732","https://openalex.org/W2794721326","https://openalex.org/W2563391002","https://openalex.org/W4385384888","https://openalex.org/W1998617258"],"abstract_inverted_index":{"Neutrophils":[0],"play":[1],"a":[2,20,38,57,121,130,141,237],"central":[3],"role":[4],"in":[5,16],"eliminating":[6],"bacterial":[7],"pathogens,":[8],"but":[9,291],"may":[10,273],"also":[11,292],"contribute":[12],"to":[13,44,89,146,222,247,276],"end-organ":[14],"damage":[15,107,183],"sepsis.":[17],"Interleukin-8":[18],"(IL-8),":[19],"key":[21,163],"modulator":[22],"of":[23,62,66,93,124,132,136,165,175,184,194,200,206,234,259,298],"neutrophil":[24,28,87,212],"function,":[25],"signals":[26],"through":[27],"specific":[29],"surface":[30],"receptors":[31,68],"CXCR-1":[32],"and":[33,46,74,80,127,190,203,308],"CXCR-2.":[34],"In":[35,278],"this":[36],"study":[37],"mechanistic":[39,59],"computational":[40,60,300],"model":[41,61,112,148,160,301],"was":[42,69,113],"used":[43],"evaluate":[45,187],"deploy":[47],"an":[48,207,281],"extracorporeal":[49,208,282],"sepsis":[50],"treatment":[51,266,283],"which":[52,96,103,272,284,310],"modulates":[53,285],"CXCR-1/2":[54,67,286],"levels.":[55],"First,":[56],"simplified":[58],"IL-8":[63],"mediated":[64],"activation":[65],"developed,":[70],"containing":[71],"16":[72],"ODEs":[73],"43":[75],"parameters.":[76],"Receptor":[77],"level":[78,174],"dynamics":[79],"systemic":[81,182],"parameters":[82,137,161,171],"were":[83,138,214],"coupled":[84],"with":[85,265],"multiple":[86],"phenotypes":[88],"generate":[90],"dynamic":[91],"populations":[92,312],"activated":[94],"neutrophils":[95,102,178],"reduce":[97,274],"pathogen":[98],"load,":[99],"and/or":[100],"primed":[101],"cause":[104],"adverse":[105],"tissue":[106],"when":[108],"misdirected.":[109],"The":[110],"mathematical":[111],"calibrated":[114],"using":[115,140],"experimental":[116,153],"data":[117],"from":[118,245,269],"baboons":[119],"administered":[120],"two-hour":[122],"infusion":[123],"E":[125],"coli":[126],"followed":[128],"for":[129,236,294],"maximum":[131],"28":[133],"days.":[134],"Ensembles":[135],"generated":[139],"Bayesian":[142],"parallel":[143],"tempering":[144],"approach":[145],"produce":[147],"fits":[149],"that":[150,170,210,219],"could":[151],"recreate":[152],"outcomes.":[154],"Stepwise":[155],"logistic":[156],"regression":[157],"identified":[158],"seven":[159],"as":[162],"determinants":[164],"mortality.":[166],"Sensitivity":[167],"analysis":[168],"showed":[169],"controlling":[172],"the":[173,180,241,299],"killer":[176],"cell":[177],"affected":[179],"overall":[181],"individuals.":[185],"To":[186],"rescue":[188],"strategies":[189],"provide":[191],"probabilistic":[192],"predictions":[193],"their":[195],"impact":[196],"on":[197],"mortality,":[198],"time":[199,227],"onset,":[201],"duration,":[202,240],"capture":[204],"efficacy":[205,250],"device":[209,306],"modulated":[211],"phenotype":[213],"explored.":[215],"Our":[216],"findings":[217],"suggest":[218],"interventions":[220],"aiming":[221],"modulate":[223],"phenotypic":[224],"composition":[225],"are":[226],"sensitive.":[228],"When":[229],"introduced":[230,255],"between":[231],"3-6":[232],"hours":[233,258],"infection":[235],"72":[238],"hour":[239],"survivor":[242],"population":[243],"increased":[244],"31%":[246],"40-80%.":[248],"Treatment":[249],"quickly":[251],"diminishes":[252],"if":[253],"not":[254],"within":[256],"15":[257],"infection.":[260],"Significant":[261],"harm":[262],"is":[263],"possible":[264],"durations":[267],"ranging":[268],"5-24":[270],"hours,":[271],"survival":[275],"13%.":[277],"severe":[279],"sepsis,":[280],"levels":[287],"has":[288],"therapeutic":[289],"potential,":[290],"potential":[293],"harm.":[295],"Further":[296],"development":[297,307],"will":[302],"help":[303],"guide":[304],"optimal":[305],"determine":[309],"patient":[311],"should":[313],"be":[314],"targeted":[315],"by":[316],"treatment.":[317]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
