{"id":"https://openalex.org/W2149565502","doi":"https://doi.org/10.1371/journal.pcbi.1004314","title":"A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis","display_name":"A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis","publication_year":2015,"publication_date":"2015-10-15","ids":{"openalex":"https://openalex.org/W2149565502","doi":"https://doi.org/10.1371/journal.pcbi.1004314","mag":"2149565502","pmid":"https://pubmed.ncbi.nlm.nih.gov/26468651"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004314","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004314&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004314&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023166649","display_name":"Alexander D. Malkin","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander D. Malkin","raw_affiliation_strings":["McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I4210155891"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109064854","display_name":"Robert P. Sheehan","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Sheehan","raw_affiliation_strings":["Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035660807","display_name":"Shibin Mathew","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shibin Mathew","raw_affiliation_strings":["Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066540105","display_name":"William J. Federspiel","orcid":"https://orcid.org/0000-0002-7068-6779"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Federspiel","raw_affiliation_strings":["McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]},{"raw_affiliation_string":"Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030343627","display_name":"Heinz Redl","orcid":"https://orcid.org/0000-0003-1654-462X"},"institutions":[{"id":"https://openalex.org/I4210096363","display_name":"Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA","ror":"https://ror.org/00a8zdv13","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210096363"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Heinz Redl","raw_affiliation_strings":["Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUVA center, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in AUVA center, Vienna, Austria","institution_ids":["https://openalex.org/I4210096363"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082272833","display_name":"Gilles Clermont","orcid":"https://orcid.org/0000-0002-0163-1379"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilles Clermont","raw_affiliation_strings":["CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CRISMA Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023166649"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8199,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.74492608,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"10","first_page":"e1004314","last_page":"e1004314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sepsis","display_name":"Sepsis","score":0.6950003504753113},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5612584948539734},{"id":"https://openalex.org/keywords/extracorporeal","display_name":"Extracorporeal","score":0.5334314107894897},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5044530630111694},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.4273134171962738},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39985328912734985},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.367153525352478},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19646203517913818}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6950003504753113},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5612584948539734},{"id":"https://openalex.org/C2779915274","wikidata":"https://www.wikidata.org/wiki/Q1115882","display_name":"Extracorporeal","level":2,"score":0.5334314107894897},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5044530630111694},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4273134171962738},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39985328912734985},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.367153525352478},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19646203517913818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001781","descriptor_name":"Blood Component Removal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005112","descriptor_name":"Extracorporeal Circulation","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023062","descriptor_name":"Receptors, Interleukin-8A","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004314","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004314&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26468651","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26468651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:europepmc.org:3594453","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4607502","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1004314","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004314","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:008d049bbd7c4768bedc1c028918c1d9","is_oa":false,"landing_page_url":"https://doaj.org/article/008d049bbd7c4768bedc1c028918c1d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 10, p e1004314 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1577047","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_A_Neutrophil_Phenotype_Model_for_Extracorporeal_Treatment_of_Sepsis_/1577047","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004314","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004314","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004314&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"awards":[{"id":"https://openalex.org/G1039939978","display_name":null,"funder_award_id":"#T32-HL076124","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1491056404","display_name":null,"funder_award_id":"GM105728-02","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1617879204","display_name":null,"funder_award_id":"T32AI089443","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2057815157","display_name":null,"funder_award_id":"R01 GM105728","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G492458726","display_name":"Integrated Interdisciplinary, inter-university PhD Program Computational Biology (T32)","funder_award_id":"5t32eb009403-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G599996245","display_name":"Cardiovascular Bioengineering Training Program","funder_award_id":"5t32hl076124-17","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6271261405","display_name":null,"funder_award_id":"T32EB009403","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320310174","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149565502.pdf","grobid_xml":"https://content.openalex.org/works/W2149565502.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W115452890","https://openalex.org/W580209411","https://openalex.org/W1516476380","https://openalex.org/W1547259510","https://openalex.org/W1550111394","https://openalex.org/W1555165785","https://openalex.org/W1953891123","https://openalex.org/W1975622213","https://openalex.org/W1976646654","https://openalex.org/W1988540551","https://openalex.org/W1993753754","https://openalex.org/W1994803737","https://openalex.org/W1995715636","https://openalex.org/W1995887867","https://openalex.org/W2002661807","https://openalex.org/W2004125965","https://openalex.org/W2008633581","https://openalex.org/W2013145865","https://openalex.org/W2013591251","https://openalex.org/W2019294202","https://openalex.org/W2019952254","https://openalex.org/W2025238477","https://openalex.org/W2025904060","https://openalex.org/W2026546599","https://openalex.org/W2026927834","https://openalex.org/W2030911724","https://openalex.org/W2040513455","https://openalex.org/W2043276874","https://openalex.org/W2044809386","https://openalex.org/W2045272841","https://openalex.org/W2047120142","https://openalex.org/W2047988689","https://openalex.org/W2048674276","https://openalex.org/W2049820468","https://openalex.org/W2049927822","https://openalex.org/W2050940395","https://openalex.org/W2056419421","https://openalex.org/W2063867274","https://openalex.org/W2071629571","https://openalex.org/W2074401358","https://openalex.org/W2075161553","https://openalex.org/W2076122670","https://openalex.org/W2077399951","https://openalex.org/W2081610661","https://openalex.org/W2085029046","https://openalex.org/W2093223772","https://openalex.org/W2101780675","https://openalex.org/W2104415072","https://openalex.org/W2104709352","https://openalex.org/W2105981152","https://openalex.org/W2107360959","https://openalex.org/W2110759872","https://openalex.org/W2118138330","https://openalex.org/W2123884323","https://openalex.org/W2125886217","https://openalex.org/W2127774299","https://openalex.org/W2130091936","https://openalex.org/W2131837548","https://openalex.org/W2133990480","https://openalex.org/W2134999083","https://openalex.org/W2136836360","https://openalex.org/W2142093121","https://openalex.org/W2143886761","https://openalex.org/W2145577370","https://openalex.org/W2146936549","https://openalex.org/W2148534890","https://openalex.org/W2159750628","https://openalex.org/W2161304688","https://openalex.org/W2161771297","https://openalex.org/W2163814324","https://openalex.org/W2164979145","https://openalex.org/W2164990391","https://openalex.org/W2166162509","https://openalex.org/W2169174676","https://openalex.org/W2170171286","https://openalex.org/W2170775692","https://openalex.org/W2174934515","https://openalex.org/W2495039162","https://openalex.org/W3098919389","https://openalex.org/W3149695318","https://openalex.org/W6616800437"],"related_works":["https://openalex.org/W3215560449","https://openalex.org/W3030236844","https://openalex.org/W2138714377","https://openalex.org/W2832459556","https://openalex.org/W4237737355","https://openalex.org/W1520457732","https://openalex.org/W2794721326","https://openalex.org/W2563391002","https://openalex.org/W4385384888","https://openalex.org/W1998617258"],"abstract_inverted_index":{"Neutrophils":[0],"play":[1],"a":[2,20,38,57,121,130,141,237],"central":[3],"role":[4],"in":[5,16],"eliminating":[6],"bacterial":[7],"pathogens,":[8],"but":[9,291],"may":[10,273],"also":[11,292],"contribute":[12],"to":[13,44,89,146,222,247,276],"end-organ":[14],"damage":[15,107,183],"sepsis.":[17],"Interleukin-8":[18],"(IL-8),":[19],"key":[21,163],"modulator":[22],"of":[23,62,66,93,124,132,136,165,175,184,194,200,206,234,259,298],"neutrophil":[24,28,87,212],"function,":[25],"signals":[26],"through":[27],"specific":[29],"surface":[30],"receptors":[31,68],"CXCR-1":[32],"and":[33,46,74,80,127,190,203,308],"CXCR-2.":[34],"In":[35,278],"this":[36],"study":[37],"mechanistic":[39,59],"computational":[40,60,300],"model":[41,61,112,148,160,301],"was":[42,69,113],"used":[43],"evaluate":[45,187],"deploy":[47],"an":[48,207,281],"extracorporeal":[49,208,282],"sepsis":[50],"treatment":[51,266,283],"which":[52,96,103,272,284,310],"modulates":[53,285],"CXCR-1/2":[54,67,286],"levels.":[55],"First,":[56],"simplified":[58],"IL-8":[63],"mediated":[64],"activation":[65],"developed,":[70],"containing":[71],"16":[72],"ODEs":[73],"43":[75],"parameters.":[76],"Receptor":[77],"level":[78,174],"dynamics":[79],"systemic":[81,182],"parameters":[82,137,161,171],"were":[83,138,214],"coupled":[84],"with":[85,265],"multiple":[86],"phenotypes":[88],"generate":[90],"dynamic":[91],"populations":[92,312],"activated":[94],"neutrophils":[95,102,178],"reduce":[97,274],"pathogen":[98],"load,":[99],"and/or":[100],"primed":[101],"cause":[104],"adverse":[105],"tissue":[106],"when":[108],"misdirected.":[109],"The":[110],"mathematical":[111],"calibrated":[114],"using":[115,140],"experimental":[116,153],"data":[117],"from":[118,245,269],"baboons":[119],"administered":[120],"two-hour":[122],"infusion":[123],"E":[125],"coli":[126],"followed":[128],"for":[129,236,294],"maximum":[131],"28":[133],"days.":[134],"Ensembles":[135],"generated":[139],"Bayesian":[142],"parallel":[143],"tempering":[144],"approach":[145],"produce":[147],"fits":[149],"that":[150,170,210,219],"could":[151],"recreate":[152],"outcomes.":[154],"Stepwise":[155],"logistic":[156],"regression":[157],"identified":[158],"seven":[159],"as":[162],"determinants":[164],"mortality.":[166],"Sensitivity":[167],"analysis":[168],"showed":[169],"controlling":[172],"the":[173,180,241,299],"killer":[176],"cell":[177],"affected":[179],"overall":[181],"individuals.":[185],"To":[186],"rescue":[188],"strategies":[189],"provide":[191],"probabilistic":[192],"predictions":[193],"their":[195],"impact":[196],"on":[197],"mortality,":[198],"time":[199,227],"onset,":[201],"duration,":[202,240],"capture":[204],"efficacy":[205,250],"device":[209,306],"modulated":[211],"phenotype":[213],"explored.":[215],"Our":[216],"findings":[217],"suggest":[218],"interventions":[220],"aiming":[221],"modulate":[223],"phenotypic":[224],"composition":[225],"are":[226],"sensitive.":[228],"When":[229],"introduced":[230,255],"between":[231],"3-6":[232],"hours":[233,258],"infection":[235],"72":[238],"hour":[239],"survivor":[242],"population":[243],"increased":[244],"31%":[246],"40-80%.":[248],"Treatment":[249],"quickly":[251],"diminishes":[252],"if":[253],"not":[254],"within":[256],"15":[257],"infection.":[260],"Significant":[261],"harm":[262],"is":[263],"possible":[264],"durations":[267],"ranging":[268],"5-24":[270],"hours,":[271],"survival":[275],"13%.":[277],"severe":[279],"sepsis,":[280],"levels":[287],"has":[288],"therapeutic":[289],"potential,":[290],"potential":[293],"harm.":[295],"Further":[296],"development":[297,307],"will":[302],"help":[303],"guide":[304],"optimal":[305],"determine":[309],"patient":[311],"should":[313],"be":[314],"targeted":[315],"by":[316],"treatment.":[317]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-08-15T07:11:24.734988","created_date":"2025-10-10T00:00:00"}
