{"id":"https://openalex.org/W863411863","doi":"https://doi.org/10.1371/journal.pcbi.1004303","title":"Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA","display_name":"Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA","publication_year":2015,"publication_date":"2015-07-16","ids":{"openalex":"https://openalex.org/W863411863","doi":"https://doi.org/10.1371/journal.pcbi.1004303","mag":"863411863","pmid":"https://pubmed.ncbi.nlm.nih.gov/26181442"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004303","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004303","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004303&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004303&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091790146","display_name":"Chris Neale","orcid":"https://orcid.org/0000-0001-9912-078X"},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chris Neale","raw_affiliation_strings":["Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada","Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada","Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050035563","display_name":"Nilmadhab Chakrabarti","orcid":null},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nilmadhab Chakrabarti","raw_affiliation_strings":["Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061812118","display_name":"Pawe\u0142 Pomorski","orcid":"https://orcid.org/0000-0002-1658-7649"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]},{"id":"https://openalex.org/I4210151048","display_name":"Shared Hierarchical Academic Research Computing Network","ror":"https://ror.org/05ezsn819","country_code":"CA","type":"other","lineage":["https://openalex.org/I4210151048"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pawel Pomorski","raw_affiliation_strings":["Shared Hierarchical Academic Research Computing Network, Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shared Hierarchical Academic Research Computing Network, Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483","https://openalex.org/I4210151048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081814794","display_name":"E.F. Pai","orcid":"https://orcid.org/0000-0002-1162-7242"},"institutions":[{"id":"https://openalex.org/I112260969","display_name":"Ontario Institute for Cancer Research","ror":"https://ror.org/043q8yx54","country_code":"CA","type":"funder","lineage":["https://openalex.org/I112260969"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Emil F. Pai","raw_affiliation_strings":["Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; Ontario Cancer Institute/Princess Margaret Cancer Centre, Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada","Ontario Cancer Institute/Princess Margaret Cancer Centre, Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; Ontario Cancer Institute/Princess Margaret Cancer Centre, Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"Ontario Cancer Institute/Princess Margaret Cancer Centre, Campbell Family Institute for Cancer Research, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I112260969","https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076945305","display_name":"R\u00e9gis Pom\u00e8s","orcid":"https://orcid.org/0000-0003-3068-9833"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"R\u00e9gis Pom\u00e8s","raw_affiliation_strings":["Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada","Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada","Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5076945305"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2801317318"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3647,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.88432276,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"11","issue":"7","first_page":"e1004303","last_page":"e1004303"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12280","display_name":"Magnesium in Health and Disease","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/permeation","display_name":"Permeation","score":0.7693069577217102},{"id":"https://openalex.org/keywords/magnesium","display_name":"Magnesium","score":0.7339532375335693},{"id":"https://openalex.org/keywords/gating","display_name":"Gating","score":0.6637445092201233},{"id":"https://openalex.org/keywords/wetting","display_name":"Wetting","score":0.5817261934280396},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5452991724014282},{"id":"https://openalex.org/keywords/ionic-bonding","display_name":"Ionic bonding","score":0.5441589951515198},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5323132872581482},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.5143238306045532},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.502690315246582},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.49003469944000244},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.452612966299057},{"id":"https://openalex.org/keywords/chemical-engineering","display_name":"Chemical engineering","score":0.31655287742614746},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.11241698265075684},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.11191165447235107},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09617915749549866}],"concepts":[{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.7693069577217102},{"id":"https://openalex.org/C543218039","wikidata":"https://www.wikidata.org/wiki/Q660","display_name":"Magnesium","level":2,"score":0.7339532375335693},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.6637445092201233},{"id":"https://openalex.org/C134514944","wikidata":"https://www.wikidata.org/wiki/Q817136","display_name":"Wetting","level":2,"score":0.5817261934280396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5452991724014282},{"id":"https://openalex.org/C2182769","wikidata":"https://www.wikidata.org/wiki/Q62500","display_name":"Ionic bonding","level":3,"score":0.5441589951515198},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5323132872581482},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5143238306045532},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.502690315246582},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.49003469944000244},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.452612966299057},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.31655287742614746},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11241698265075684},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.11191165447235107},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09617915749549866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015640","descriptor_name":"Ion Channel Gating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017155","descriptor_name":"Wettability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017155","descriptor_name":"Wettability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017155","descriptor_name":"Wettability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D027682","descriptor_name":"Cation Transport Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004303","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004303","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004303&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26181442","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26181442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:27f8707424024a6680df32ff0553317f","is_oa":true,"landing_page_url":"https://doaj.org/article/27f8707424024a6680df32ff0553317f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 7, p e1004303 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1486144","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Hydrophobic_Gating_of_Ion_Permeation_in_Magnesium_Channel_CorA_/1486144","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4504495","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4504495","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004303","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004303","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004303&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Clean water and sanitation","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/6"}],"awards":[{"id":"https://openalex.org/G3816129549","display_name":null,"funder_award_id":"MOP-86548","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G4086027587","display_name":null,"funder_award_id":"MOP-43949","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G6096675853","display_name":null,"funder_award_id":"43998","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320314000","display_name":"Compute Canada","ror":"https://ror.org/03ty8yr27"},{"id":"https://openalex.org/F4320314607","display_name":"Government of Ontario","ror":"https://ror.org/015pzp858"},{"id":"https://openalex.org/F4320322015","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087"},{"id":"https://openalex.org/F4320323654","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W863411863.pdf","grobid_xml":"https://content.openalex.org/works/W863411863.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1963480981","https://openalex.org/W1964784760","https://openalex.org/W1966078827","https://openalex.org/W1976499671","https://openalex.org/W1980171423","https://openalex.org/W1983234151","https://openalex.org/W1986668651","https://openalex.org/W1993177346","https://openalex.org/W1994803160","https://openalex.org/W1999838269","https://openalex.org/W2005843451","https://openalex.org/W2006053894","https://openalex.org/W2010518893","https://openalex.org/W2015574221","https://openalex.org/W2015870127","https://openalex.org/W2016467021","https://openalex.org/W2018312454","https://openalex.org/W2021649251","https://openalex.org/W2031272029","https://openalex.org/W2035576583","https://openalex.org/W2035747346","https://openalex.org/W2039835476","https://openalex.org/W2040923822","https://openalex.org/W2051381895","https://openalex.org/W2052365569","https://openalex.org/W2052553094","https://openalex.org/W2054881399","https://openalex.org/W2056331631","https://openalex.org/W2056816531","https://openalex.org/W2058382319","https://openalex.org/W2058811491","https://openalex.org/W2068770352","https://openalex.org/W2073623394","https://openalex.org/W2074698050","https://openalex.org/W2077082977","https://openalex.org/W2079984660","https://openalex.org/W2081260116","https://openalex.org/W2081484203","https://openalex.org/W2084304818","https://openalex.org/W2085408488","https://openalex.org/W2085434575","https://openalex.org/W2087238735","https://openalex.org/W2094122219","https://openalex.org/W2097951193","https://openalex.org/W2102521379","https://openalex.org/W2104129019","https://openalex.org/W2113181545","https://openalex.org/W2114431583","https://openalex.org/W2117563536","https://openalex.org/W2122056204","https://openalex.org/W2124416706","https://openalex.org/W2131609458","https://openalex.org/W2131754023","https://openalex.org/W2143674731","https://openalex.org/W2145586921","https://openalex.org/W2146906572","https://openalex.org/W2159760243","https://openalex.org/W2161773548","https://openalex.org/W2162011510","https://openalex.org/W2164997453","https://openalex.org/W2171699191","https://openalex.org/W2337120805","https://openalex.org/W3105134109"],"related_works":["https://openalex.org/W2087572532","https://openalex.org/W2378716748","https://openalex.org/W2031449089","https://openalex.org/W2598708838","https://openalex.org/W3024832472","https://openalex.org/W2350544349","https://openalex.org/W2325080826","https://openalex.org/W2112596406","https://openalex.org/W1169125209","https://openalex.org/W1544389072"],"abstract_inverted_index":{"Ion":[0],"channels":[1],"catalyze":[2],"ionic":[3,153],"permeation":[4,114],"across":[5],"membranes":[6],"via":[7],"water-filled":[8],"pores.":[9],"To":[10],"understand":[11],"how":[12],"changes":[13,144],"in":[14,29,64,77,145],"intracellular":[15,146],"magnesium":[16,147],"concentration":[17,148],"regulate":[18],"the":[19,30,85,126,150],"influx":[20],"of":[21,32,54,87,128,139,152],"Mg2+":[22,33,113],"into":[23],"cells,":[24],"we":[25],"examine":[26],"early":[27],"events":[28,72],"relaxation":[31],"channel":[34],"CorA":[35,55],"toward":[36],"its":[37],"open":[38],"state":[39,99],"using":[40],"massively-repeated":[41],"molecular":[42],"dynamics":[43],"simulations":[44],"conducted":[45],"either":[46],"with":[47,74],"or":[48,70],"without":[49],"regulatory":[50,88],"ions.":[51],"The":[52,108],"pore":[53,78,123],"contains":[56],"a":[57,97,116,140],"2-nm-long":[58],"hydrophobic":[59,129,141],"bottleneck":[60],"which":[61],"remained":[62],"dehydrated":[63],"most":[65],"simulations.":[66],"However,":[67],"rapid":[68],"hydration":[69],"\"wetting\"":[71],"concurrent":[73],"small-amplitude":[75],"fluctuations":[76],"diameter":[79,124],"occurred":[80],"spontaneously":[81],"and":[82,95,105,125],"reversibly.":[83],"In":[84],"absence":[86],"ions,":[89],"wetting":[90,138],"transitions":[91],"are":[92],"more":[93,103,106],"likely":[94],"include":[96],"wet":[98],"that":[100],"is":[101,120],"significantly":[102],"stable":[104],"hydrated.":[107],"free":[109],"energy":[110],"profile":[111],"for":[112],"presents":[115],"barrier":[117],"whose":[118],"magnitude":[119],"anticorrelated":[121],"to":[122,149],"extent":[127],"hydration.":[130],"These":[131],"findings":[132],"support":[133],"an":[134],"allosteric":[135],"mechanism":[136],"whereby":[137],"gate":[142],"couples":[143],"onset":[151],"conduction.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-13T07:31:44.756512","created_date":"2025-10-10T00:00:00"}
