{"id":"https://openalex.org/W1791990521","doi":"https://doi.org/10.1371/journal.pcbi.1004284","title":"Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module","display_name":"Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module","publication_year":2015,"publication_date":"2015-07-23","ids":{"openalex":"https://openalex.org/W1791990521","doi":"https://doi.org/10.1371/journal.pcbi.1004284","mag":"1791990521","pmid":"https://pubmed.ncbi.nlm.nih.gov/26204520"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004284","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004284","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004284&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004284&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027992807","display_name":"John Walmsley","orcid":"https://orcid.org/0000-0001-9171-7530"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"John Walmsley","raw_affiliation_strings":["Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019378102","display_name":"Theo Arts","orcid":"https://orcid.org/0000-0003-0223-8496"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Theo Arts","raw_affiliation_strings":["Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053571962","display_name":"Nicolas Derval","orcid":"https://orcid.org/0000-0002-6189-1308"},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210086115","display_name":"Electrophysiology and Heart Modeling Institute","ror":"https://ror.org/00jsv7j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210086115"]},{"id":"https://openalex.org/I4210120975","display_name":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque","ror":"https://ror.org/02bf3a828","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210120975"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Derval","raw_affiliation_strings":["H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210086115","https://openalex.org/I4210120975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072424721","display_name":"Pierre Bordachar","orcid":null},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210086115","display_name":"Electrophysiology and Heart Modeling Institute","ror":"https://ror.org/00jsv7j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210086115"]},{"id":"https://openalex.org/I4210120975","display_name":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque","ror":"https://ror.org/02bf3a828","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210120975"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Bordachar","raw_affiliation_strings":["H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210086115","https://openalex.org/I4210120975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026485672","display_name":"Hubert Cochet","orcid":"https://orcid.org/0000-0001-7772-5331"},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210086115","display_name":"Electrophysiology and Heart Modeling Institute","ror":"https://ror.org/00jsv7j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210086115"]},{"id":"https://openalex.org/I4210120975","display_name":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque","ror":"https://ror.org/02bf3a828","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210120975"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hubert Cochet","raw_affiliation_strings":["H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210086115","https://openalex.org/I4210120975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030282021","display_name":"Sylvain Ploux","orcid":"https://orcid.org/0000-0003-4355-2967"},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I4210086115","display_name":"Electrophysiology and Heart Modeling Institute","ror":"https://ror.org/00jsv7j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210086115"]},{"id":"https://openalex.org/I4210120975","display_name":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque","ror":"https://ror.org/02bf3a828","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210120975"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvain Ploux","raw_affiliation_strings":["H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210086115","https://openalex.org/I4210120975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049901772","display_name":"Frits W. Prinzen","orcid":"https://orcid.org/0000-0001-8917-9032"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frits W. Prinzen","raw_affiliation_strings":["Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080175953","display_name":"Tammo Delhaas","orcid":"https://orcid.org/0000-0001-6897-9700"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tammo Delhaas","raw_affiliation_strings":["Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034213745","display_name":"Joost Lumens","orcid":"https://orcid.org/0000-0001-8129-7384"},"institutions":[{"id":"https://openalex.org/I3018323443","display_name":"Centre Hospitalier Universitaire de Bordeaux","ror":"https://ror.org/01hq89f96","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4210086115","display_name":"Electrophysiology and Heart Modeling Institute","ror":"https://ror.org/00jsv7j98","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I3018323443","https://openalex.org/I4210086115"]},{"id":"https://openalex.org/I4210120975","display_name":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque","ror":"https://ror.org/02bf3a828","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018323443","https://openalex.org/I4210120975"]}],"countries":["FR","NL"],"is_corresponding":false,"raw_author_name":"Joost Lumens","raw_affiliation_strings":["Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France","Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I34352273","https://openalex.org/I4210120975"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"H\u00f4pital Cardiologique du Haut-L\u00e9v\u00eaque, IHU-LIRYC, CHU de Bordeaux, Bordeaux, France","institution_ids":["https://openalex.org/I3018323443","https://openalex.org/I4210086115","https://openalex.org/I4210120975"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5027992807"],"corresponding_institution_ids":["https://openalex.org/I34352273"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.1956,"has_fulltext":true,"cited_by_count":117,"citation_normalized_percentile":{"value":0.94704039,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"11","issue":"7","first_page":"e1004284","last_page":"e1004284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10598","display_name":"Cardiac pacing and defibrillation studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.5720854997634888},{"id":"https://openalex.org/keywords/mechanobiology","display_name":"Mechanobiology","score":0.4955037832260132},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.4780469536781311},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.44524309039115906},{"id":"https://openalex.org/keywords/cardiac-cycle","display_name":"Cardiac cycle","score":0.43427759408950806},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3641519844532013},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.2663908302783966},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.1866680383682251},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1519097089767456}],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.5720854997634888},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.4955037832260132},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.4780469536781311},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44524309039115906},{"id":"https://openalex.org/C99398487","wikidata":"https://www.wikidata.org/wiki/Q257319","display_name":"Cardiac cycle","level":2,"score":0.43427759408950806},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3641519844532013},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2663908302783966},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1866680383682251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1519097089767456}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002037","descriptor_name":"Bundle-Branch Block","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002037","descriptor_name":"Bundle-Branch Block","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002037","descriptor_name":"Bundle-Branch Block","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002037","descriptor_name":"Bundle-Branch Block","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002037","descriptor_name":"Bundle-Branch Block","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002037","descriptor_name":"Bundle-Branch Block","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009200","descriptor_name":"Myocardial Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056966","descriptor_name":"Excitation Contraction Coupling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1004284","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004284","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004284&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26204520","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26204520","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/8f27c139-2079-4151-9bee-a6a397674507","is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/8f27c139-2079-4151-9bee-a6a397674507","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Walmsley, J, Arts, T, Derval, N, Bordachar, P, Cochet, H, Ploux, S, Prinzen, F W, Delhaas, T & Lumens, J 2015, 'Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module', PLoS Computational Biology, vol. 11, no. 7, e1004284. https://doi.org/10.1371/journal.pcbi.1004284","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:europepmc.org:3489615","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4512705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1004284","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004284","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9ddfebb44e9c4f468114337b24a599df","is_oa":true,"landing_page_url":"https://doaj.org/article/9ddfebb44e9c4f468114337b24a599df","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 7, p e1004284 (2015)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1492619","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Fast_Simulation_of_Mechanical_Heterogeneity_in_the_Electrically_Asynchronous_Heart_Using_the_MultiPatch_Module_/1492619","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004284","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004284","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004284&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.550000011920929,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G133457142","display_name":null,"funder_award_id":"ANR-10-IAHU-04)","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G1864516712","display_name":null,"funder_award_id":"2012T010","funder_id":"https://openalex.org/F4320321642","funder_display_name":"Hartstichting"},{"id":"https://openalex.org/G3273634535","display_name":null,"funder_award_id":"10\u2010IAHU\u201004","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5497420254","display_name":null,"funder_award_id":"ANR-10-IAHU-04","funder_id":"https://openalex.org/F4320321642","funder_display_name":"Hartstichting"},{"id":"https://openalex.org/G7240651115","display_name":null,"funder_award_id":"ANR-10","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321642","display_name":"Hartstichting","ror":"https://ror.org/05nxhgm70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1791990521.pdf","grobid_xml":"https://content.openalex.org/works/W1791990521.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W16045677","https://openalex.org/W77580924","https://openalex.org/W1608546254","https://openalex.org/W1818584899","https://openalex.org/W1965886828","https://openalex.org/W1967892540","https://openalex.org/W1975638773","https://openalex.org/W1977098804","https://openalex.org/W1986694624","https://openalex.org/W1995281013","https://openalex.org/W2017138224","https://openalex.org/W2020146931","https://openalex.org/W2036373717","https://openalex.org/W2045749503","https://openalex.org/W2052824919","https://openalex.org/W2058817926","https://openalex.org/W2059655398","https://openalex.org/W2064151719","https://openalex.org/W2078787618","https://openalex.org/W2083132667","https://openalex.org/W2089194947","https://openalex.org/W2090501652","https://openalex.org/W2093403318","https://openalex.org/W2106490434","https://openalex.org/W2107867006","https://openalex.org/W2108256240","https://openalex.org/W2110338499","https://openalex.org/W2111834353","https://openalex.org/W2117433820","https://openalex.org/W2121317111","https://openalex.org/W2128070479","https://openalex.org/W2130860727","https://openalex.org/W2132401137","https://openalex.org/W2133130833","https://openalex.org/W2133131007","https://openalex.org/W2135421935","https://openalex.org/W2141880925","https://openalex.org/W2143925215","https://openalex.org/W2152517370","https://openalex.org/W2153797429","https://openalex.org/W2155136656","https://openalex.org/W2158361092","https://openalex.org/W2159036675","https://openalex.org/W2162872594","https://openalex.org/W2164727929","https://openalex.org/W2166777145","https://openalex.org/W2464823164","https://openalex.org/W2626091373"],"related_works":["https://openalex.org/W4291130702","https://openalex.org/W4389387458","https://openalex.org/W3025150339","https://openalex.org/W3125643364","https://openalex.org/W1990851605","https://openalex.org/W2564889688","https://openalex.org/W4383532732","https://openalex.org/W2621226137","https://openalex.org/W2887158672","https://openalex.org/W2083233080"],"abstract_inverted_index":{"Cardiac":[0,93],"electrical":[1,188],"asynchrony":[2],"occurs":[3],"as":[4,14],"a":[5,36,118,121,140,177,273],"result":[6],"of":[7,42,46,70,83,101,103,169,187,219,285,290],"cardiac":[8,31],"pacing":[9],"or":[10],"conduction":[11],"disorders":[12],"such":[13],"left":[15],"bundle-branch":[16],"block":[17],"(LBBB).":[18],"Electrically":[19],"asynchronous":[20,160,260],"activation":[21,109,147,264],"causes":[22],"myocardial":[23,170,277,292],"contraction":[24],"heterogeneity":[25],"that":[26,146,249,263],"can":[27,111],"be":[28],"detrimental":[29],"for":[30,38,155,275],"function.":[32],"Computational":[33],"models":[34],"provide":[35],"tool":[37],"understanding":[39],"pathological":[40],"consequences":[41],"dyssynchronous":[43,291],"contraction.":[44],"Simulations":[45],"mechanical":[47,157],"dyssynchrony":[48],"within":[49,117,130,272,295],"the":[50,56,79,84,90,131,144,230,242,250,259,296],"heart":[51,85,182,261],"are":[52,95],"typically":[53],"performed":[54],"using":[55,184,244],"finite":[57],"element":[58],"method,":[59],"whose":[60],"computational":[61],"intensity":[62],"may":[63],"present":[64,74],"an":[65,75,98,166],"obstacle":[66],"to":[67,136],"clinical":[68],"deployment":[69],"patient-specific":[71],"models.":[72],"We":[73,142,162,247],"alternative":[76],"based":[77],"on":[78],"CircAdapt":[80,280],"lumped-parameter":[81],"model":[82,210,281],"and":[86,108,125,176,181,192,199,206,213,221,262,287],"circulatory":[87],"system,":[88],"called":[89],"MultiPatch":[91,251],"module.":[92],"walls":[94],"subdivided":[96],"into":[97],"arbitrary":[99],"number":[100],"patches":[102,116],"homogeneous":[104],"tissue.":[105],"Tissue":[106],"properties":[107],"time":[110,148,265],"differ":[112],"between":[113,197,209],"patches.":[114],"All":[115],"wall":[119,123,132,190,274],"share":[120],"common":[122],"tension":[124],"curvature.":[126],"Consequently,":[127],"spatial":[128],"location":[129,154,271],"is":[133,149,266,282],"not":[134],"required":[135],"calculate":[137],"deformation":[138,158,171,256,293],"in":[139,159,217,229,241,258],"patch.":[141],"test":[143],"hypothesis":[145],"more":[150,267],"important":[151,268],"than":[152,269],"tissue":[153,270],"determining":[156,276],"hearts.":[161],"perform":[163],"simulations":[164,289],"representing":[165],"experimental":[167,200,214],"study":[168],"induced":[172],"by":[173],"ventricular":[174],"pacing,":[175],"patient":[178,231,243],"with":[179,236],"LBBB":[180],"failure":[183],"endocardial":[185],"recordings":[186],"activation,":[189],"volumes,":[191],"end-diastolic":[193],"volumes.":[194],"Direct":[195],"comparison":[196],"simulated":[198],"strain":[201,212,216,228,238],"patterns":[202,239,257],"shows":[203,233],"both":[204],"qualitative":[205,234],"quantitative":[207],"agreement":[208,235],"fibre":[211],"circumferential":[215,237],"terms":[218],"shortening":[220],"rebound":[222],"stretch":[223],"during":[224],"ejection.":[225],"Local":[226],"myofibre":[227],"simulation":[232],"observed":[240],"tagged":[245],"MRI.":[246],"conclude":[248],"module":[252],"produces":[253],"realistic":[254,288],"regional":[255],"deformation.":[278],"The":[279],"therefore":[283],"capable":[284],"fast":[286],"embedded":[294],"closed-loop":[297],"cardiovascular":[298],"system.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":17},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}
