{"id":"https://openalex.org/W2019182972","doi":"https://doi.org/10.1371/journal.pcbi.1004206","title":"Three-Dimensional Gradients of Cytokine Signaling between T Cells","display_name":"Three-Dimensional Gradients of Cytokine Signaling between T Cells","publication_year":2015,"publication_date":"2015-04-29","ids":{"openalex":"https://openalex.org/W2019182972","doi":"https://doi.org/10.1371/journal.pcbi.1004206","mag":"2019182972","pmid":"https://pubmed.ncbi.nlm.nih.gov/25923703"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004206","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004206","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004206&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004206&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078612345","display_name":"Kevin Thurley","orcid":"https://orcid.org/0000-0002-7217-2755"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Kevin Thurley","raw_affiliation_strings":["Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany; Institute for Theoretical Biology, Charit\u00e9-Universit\u00e4tsmedizin, Berlin, Germany; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America","Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany","Institute for Theoretical Biology, Charit\u00e9-Universit\u00e4tsmedizin, Berlin, Germany","Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany; Institute for Theoretical Biology, Charit\u00e9-Universit\u00e4tsmedizin, Berlin, Germany; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Institute for Theoretical Biology, Charit\u00e9-Universit\u00e4tsmedizin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063848456","display_name":"Daniel Gerecht","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Daniel Gerecht","raw_affiliation_strings":["Institute for Applied Mathematics, University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Applied Mathematics, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016376676","display_name":"Elfriede Friedmann","orcid":"https://orcid.org/0000-0002-2827-6581"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Elfriede Friedmann","raw_affiliation_strings":["Institute for Applied Mathematics, University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for Applied Mathematics, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022095447","display_name":"Thomas H\u00f6fer","orcid":"https://orcid.org/0000-0003-3560-8780"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas H\u00f6fer","raw_affiliation_strings":["Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany; Bioquant Center, University of Heidelberg, Heidelberg, Germany","Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany","Bioquant Center, University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany; Bioquant Center, University of Heidelberg, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"Division of Theoretical Systems Biology, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Bioquant Center, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016376676","https://openalex.org/A5022095447","https://openalex.org/A5063848456","https://openalex.org/A5078612345"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I180670191","https://openalex.org/I223822909","https://openalex.org/I7877124"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.623,"has_fulltext":true,"cited_by_count":87,"citation_normalized_percentile":{"value":0.93577337,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"e1004206","last_page":"e1004206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.8043102025985718},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"Immunological synapse","score":0.654961347579956},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6459999680519104},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5859878063201904},{"id":"https://openalex.org/keywords/paracrine-signalling","display_name":"Paracrine signalling","score":0.5168278813362122},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.5132625102996826},{"id":"https://openalex.org/keywords/autocrine-signalling","display_name":"Autocrine signalling","score":0.4631945490837097},{"id":"https://openalex.org/keywords/suppressor-of-cytokine-signaling-1","display_name":"Suppressor of cytokine signaling 1","score":0.4422233998775482},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.43989092111587524},{"id":"https://openalex.org/keywords/suppressor-of-cytokine-signalling","display_name":"Suppressor of cytokine signalling","score":0.4295184016227722},{"id":"https://openalex.org/keywords/cytokine-receptor","display_name":"Cytokine receptor","score":0.4163365662097931},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.3226426839828491},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.3089537024497986},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2913019061088562},{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":0.17771580815315247},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.16417330503463745},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0878276526927948}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.8043102025985718},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.654961347579956},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6459999680519104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5859878063201904},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.5168278813362122},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.5132625102996826},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.4631945490837097},{"id":"https://openalex.org/C14077384","wikidata":"https://www.wikidata.org/wiki/Q18033186","display_name":"Suppressor of cytokine signaling 1","level":4,"score":0.4422233998775482},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43989092111587524},{"id":"https://openalex.org/C162354598","wikidata":"https://www.wikidata.org/wiki/Q7644655","display_name":"Suppressor of cytokine signalling","level":5,"score":0.4295184016227722},{"id":"https://openalex.org/C2775855021","wikidata":"https://www.wikidata.org/wiki/Q968436","display_name":"Cytokine receptor","level":3,"score":0.4163365662097931},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3226426839828491},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3089537024497986},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2913019061088562},{"id":"https://openalex.org/C126042315","wikidata":"https://www.wikidata.org/wiki/Q18033763","display_name":"SOCS3","level":4,"score":0.17771580815315247},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16417330503463745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0878276526927948},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.0},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.0},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018121","descriptor_name":"Receptors, Cytokine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054992","descriptor_name":"Immunological Synapses","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1004206","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004206","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004206&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25923703","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25923703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:3a694eb7975543ea95adc38f94fc9987","is_oa":true,"landing_page_url":"https://doaj.org/article/3a694eb7975543ea95adc38f94fc9987","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 4, p e1004206 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3391678","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4414419","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1397814","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Three_Dimensional_Gradients_of_Cytokine_Signaling_between_T_Cells_/1397814","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:oai.bibliothek.uni-kassel.de:123456789/16036","is_oa":true,"landing_page_url":"http://doi.org/doi:10.17170/kobra-2024082910751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400093","display_name":"Kobra (Universit\u00e4tsbibliothek Kassel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I106157433","host_organization_name":"University of Kassel","host_organization_lineage":["https://openalex.org/I106157433"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"status-type:publishedVersion"},{"id":"pmh:oai:pubmedcentral.nih.gov:4414419","is_oa":true,"landing_page_url":"http://doi.org/10.1371/journal.pcbi.1004206","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:refubium.fu-berlin.de:fub188/16950","is_oa":true,"landing_page_url":"https://refubium.fu-berlin.de/handle/fub188/16950","pdf_url":null,"source":{"id":"https://openalex.org/S4306402444","display_name":"Refubium (Universit\u00e4tsbibliothek der Freien Universit\u00e4t Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I75951250","host_organization_name":"Freie Universit\u00e4t Berlin","host_organization_lineage":["https://openalex.org/I75951250"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftlicher Artikel"},{"id":"doi:10.17170/kobra-2024082910751","is_oa":true,"landing_page_url":"https://doi.org/10.17170/kobra-2024082910751","pdf_url":null,"source":{"id":"https://openalex.org/S7407052891","display_name":"Universit\u00e4tsbibliothek Kassel","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004206","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004206","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004206&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019182972.pdf","grobid_xml":"https://content.openalex.org/works/W2019182972.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1517726421","https://openalex.org/W1518539840","https://openalex.org/W1534336889","https://openalex.org/W1691509152","https://openalex.org/W1892261914","https://openalex.org/W1902251032","https://openalex.org/W1963899067","https://openalex.org/W1966453354","https://openalex.org/W1966646357","https://openalex.org/W1966824782","https://openalex.org/W1972640719","https://openalex.org/W1973730600","https://openalex.org/W1976088660","https://openalex.org/W1976692199","https://openalex.org/W1986135071","https://openalex.org/W1987955440","https://openalex.org/W1988114488","https://openalex.org/W1997504990","https://openalex.org/W2000869878","https://openalex.org/W2001809800","https://openalex.org/W2001924137","https://openalex.org/W2007888464","https://openalex.org/W2009644403","https://openalex.org/W2015371995","https://openalex.org/W2024184910","https://openalex.org/W2036309095","https://openalex.org/W2039480619","https://openalex.org/W2047679538","https://openalex.org/W2049020751","https://openalex.org/W2051601355","https://openalex.org/W2055522356","https://openalex.org/W2056318117","https://openalex.org/W2056766936","https://openalex.org/W2061185864","https://openalex.org/W2062878033","https://openalex.org/W2064253793","https://openalex.org/W2064625208","https://openalex.org/W2067975406","https://openalex.org/W2068698296","https://openalex.org/W2077238267","https://openalex.org/W2078052068","https://openalex.org/W2080086146","https://openalex.org/W2081072737","https://openalex.org/W2084035178","https://openalex.org/W2086121828","https://openalex.org/W2086595653","https://openalex.org/W2093052922","https://openalex.org/W2102295719","https://openalex.org/W2102642734","https://openalex.org/W2105085783","https://openalex.org/W2107770435","https://openalex.org/W2116967305","https://openalex.org/W2125791822","https://openalex.org/W2129239355","https://openalex.org/W2129627612","https://openalex.org/W2133147107","https://openalex.org/W2136443584","https://openalex.org/W2137086195","https://openalex.org/W2147632178","https://openalex.org/W2148226248","https://openalex.org/W2150792480","https://openalex.org/W2151958354","https://openalex.org/W2611037613","https://openalex.org/W2653059336","https://openalex.org/W4211207469","https://openalex.org/W6616350262","https://openalex.org/W6857832209"],"related_works":["https://openalex.org/W4249822360","https://openalex.org/W2089127654","https://openalex.org/W2740633825","https://openalex.org/W2172147573","https://openalex.org/W1846474778","https://openalex.org/W2086249186","https://openalex.org/W3009815687","https://openalex.org/W2072488504","https://openalex.org/W2014067834","https://openalex.org/W2098223746"],"abstract_inverted_index":{"Immune":[0],"responses":[1],"are":[2,59,157,228],"regulated":[3],"by":[4,134,183,210],"diffusible":[5],"mediators,":[6],"the":[7,52,70,97,113,135,138,154,172,234],"cytokines,":[8],"which":[9,55,146],"act":[10],"at":[11,75],"sub-nanomolar":[12],"concentrations.":[13],"The":[14],"spatial":[15,94],"range":[16],"of":[17,30,72,137,163,203],"cytokine":[18,31,73,98,116,121,149,197,204,220,241],"communication":[19],"is":[20,131],"a":[21,107,200,217],"crucial,":[22],"yet":[23],"poorly":[24],"understood,":[25],"functional":[26],"property.":[27],"Both":[28],"containment":[29],"action":[32],"in":[33,79,83,216],"narrow":[34,144],"junctions":[35],"between":[36,222],"immune":[37],"cells":[38,102,185],"(immunological":[39],"synapses)":[40],"and":[41,82,123,224],"global":[42],"signaling":[43,74,128,167,198],"throughout":[44],"entire":[45],"lymph":[46],"nodes":[47],"have":[48],"been":[49],"proposed,":[50],"but":[51,174],"conditions":[53],"under":[54],"they":[56],"might":[57],"occur":[58],"not":[60,225],"clear.":[61],"Here":[62],"we":[63,91,118],"analyze":[64],"spatially":[65,237],"three-dimensional":[66],"reaction-diffusion":[67],"models":[68],"for":[69,143,230,236],"dynamics":[71],"two":[76],"successive":[77],"scales:":[78],"immunological":[80,139],"synapses":[81],"dense":[84],"multicellular":[85],"environments.":[86],"For":[87],"realistic":[88],"parameter":[89],"values,":[90],"observe":[92],"local":[93],"gradients,":[95],"with":[96],"concentration":[99],"around":[100],"secreting":[101],"decaying":[103],"sharply":[104],"across":[105],"only":[106],"few":[108],"cell":[109],"diameters.":[110],"Focusing":[111],"on":[112,240],"well-characterized":[114],"T-cell":[115],"interleukin-2,":[117],"show":[119],"how":[120],"secretion":[122],"competitive":[124],"uptake":[125,182],"determine":[126],"this":[127],"range.":[129],"Uptake":[130],"shaped":[132],"locally":[133],"geometry":[136],"synapse.":[140],"However,":[141],"even":[142],"synapses,":[145],"favor":[147],"intrasynaptic":[148],"consumption,":[150],"escape":[151],"fluxes":[152],"into":[153],"extrasynaptic":[155],"space":[156],"expected":[158],"to":[159,178],"be":[160,176],"substantial":[161],"(\u226520%":[162],"secretion).":[164],"Hence":[165],"paracrine":[166],"will":[168],"generally":[169],"extend":[170],"beyond":[171],"synapse":[173],"can":[175],"limited":[177],"cellular":[179],"microenvironments":[180],"through":[181],"target":[184,213],"or":[186,206],"strong":[187],"competitors,":[188],"such":[189],"as":[190],"regulatory":[191],"T":[192],"cells.":[193],"By":[194],"contrast,":[195],"long-range":[196],"requires":[199],"high":[201],"density":[202],"producers":[205],"weak":[207],"consumption":[208],"(e.g.,":[209],"sparsely":[211],"distributed":[212],"cells).":[214],"Thus":[215],"physiological":[218],"setting,":[219],"gradients":[221],"cells,":[223],"bulk-phase":[226],"concentrations,":[227],"crucial":[229],"cell-to-cell":[231],"communication,":[232],"emphasizing":[233],"need":[235],"resolved":[238],"data":[239],"signaling.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
