{"id":"https://openalex.org/W2150880328","doi":"https://doi.org/10.1371/journal.pcbi.1004201","title":"Bacterial Temporal Dynamics Enable Optimal Design of Antibiotic Treatment","display_name":"Bacterial Temporal Dynamics Enable Optimal Design of Antibiotic Treatment","publication_year":2015,"publication_date":"2015-04-23","ids":{"openalex":"https://openalex.org/W2150880328","doi":"https://doi.org/10.1371/journal.pcbi.1004201","mag":"2150880328","pmid":"https://pubmed.ncbi.nlm.nih.gov/25905796"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004201","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004201","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004201&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004201&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083654258","display_name":"Hannah R. Meredith","orcid":"https://orcid.org/0000-0002-5315-7568"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah R. Meredith","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080009166","display_name":"Allison J. Lopatkin","orcid":"https://orcid.org/0000-0003-0018-9205"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allison J. Lopatkin","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017717374","display_name":"Deverick J. Anderson","orcid":"https://orcid.org/0000-0001-6882-5496"},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deverick J. Anderson","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America; Duke Infection Control Outreach Network, Duke University Medical Center, Durham, North Carolina, United States of America","Duke Infection Control Outreach Network, Duke University Medical Center, Durham, North Carolina, United States of America","Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America; Duke Infection Control Outreach Network, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":[]},{"raw_affiliation_string":"Duke Infection Control Outreach Network, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210153043","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100401842","display_name":"Lingchong You","orcid":"https://orcid.org/0000-0003-3725-4007"},"institutions":[{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lingchong You","raw_affiliation_strings":["Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America; Center for Systems Biology, Duke University, Durham, North Carolina, United States of America; Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, United States of America","Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, United States of America","Center for Systems Biology, Duke University, Durham, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America; Center for Systems Biology, Duke University, Durham, North Carolina, United States of America; Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Center for Genomic and Computational Biology, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Center for Systems Biology, Duke University, Durham, North Carolina, United States of America","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100401842"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210155419"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.6304,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.9220012,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"11","issue":"4","first_page":"e1004201","last_page":"e1004201"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.8970980644226074},{"id":"https://openalex.org/keywords/dosing","display_name":"Dosing","score":0.528436005115509},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5014698505401611},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.4245002865791321},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.33623743057250977},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.08892792463302612}],"concepts":[{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.8970980644226074},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.528436005115509},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5014698505401611},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4245002865791321},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33623743057250977},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.08892792463302612}],"mesh":[{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004360","descriptor_name":"Drug Therapy, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018407","descriptor_name":"Bacterial Physiological Phenomena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018440","descriptor_name":"beta-Lactam Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D047090","descriptor_name":"beta-Lactams","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004201","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004201","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004201&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25905796","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25905796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:95b93712dabc4d8fa6b25071abee4abc","is_oa":true,"landing_page_url":"https://doaj.org/article/95b93712dabc4d8fa6b25071abee4abc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 4, p e1004201 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3382685","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4407907","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1392350","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Bacterial_Temporal_Dynamics_Enable_Optimal_Design_of_Antibiotic_Treatment_/1392350","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004201","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004201","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004201&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5}],"awards":[{"id":"https://openalex.org/G153315454","display_name":"CAREER:Engineering Microbial Swarmbots","funder_award_id":"0953202","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1995246219","display_name":null,"funder_award_id":"CBET-0953202","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2535037955","display_name":null,"funder_award_id":"1RO1GM110494","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3101296360","display_name":null,"funder_award_id":"K23 AI095357","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3752823162","display_name":null,"funder_award_id":"R01 GM098642","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3986617250","display_name":null,"funder_award_id":"1R01GM098642","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7567051917","display_name":null,"funder_award_id":"1R01GM110494","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8552303779","display_name":null,"funder_award_id":"R01 GM110494","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2150880328.pdf","grobid_xml":"https://content.openalex.org/works/W2150880328.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W22834980","https://openalex.org/W83323146","https://openalex.org/W151171476","https://openalex.org/W589439282","https://openalex.org/W1240542110","https://openalex.org/W1482258469","https://openalex.org/W1558738309","https://openalex.org/W1820140377","https://openalex.org/W1889432453","https://openalex.org/W1965846042","https://openalex.org/W1969482186","https://openalex.org/W1973760310","https://openalex.org/W1978738012","https://openalex.org/W1984199840","https://openalex.org/W1986039556","https://openalex.org/W1987635163","https://openalex.org/W1994437451","https://openalex.org/W1994972456","https://openalex.org/W2001069185","https://openalex.org/W2013030981","https://openalex.org/W2026693802","https://openalex.org/W2030152873","https://openalex.org/W2036978592","https://openalex.org/W2042326970","https://openalex.org/W2043487490","https://openalex.org/W2044878383","https://openalex.org/W2045825103","https://openalex.org/W2046526279","https://openalex.org/W2052972684","https://openalex.org/W2060816398","https://openalex.org/W2062495428","https://openalex.org/W2062546581","https://openalex.org/W2066745723","https://openalex.org/W2069250280","https://openalex.org/W2070567253","https://openalex.org/W2078881130","https://openalex.org/W2082356407","https://openalex.org/W2084805347","https://openalex.org/W2085132236","https://openalex.org/W2086516457","https://openalex.org/W2086524492","https://openalex.org/W2097999145","https://openalex.org/W2099925303","https://openalex.org/W2100096695","https://openalex.org/W2102013604","https://openalex.org/W2104344909","https://openalex.org/W2104484234","https://openalex.org/W2106729847","https://openalex.org/W2109779439","https://openalex.org/W2110232499","https://openalex.org/W2113717321","https://openalex.org/W2115682940","https://openalex.org/W2119524520","https://openalex.org/W2121560052","https://openalex.org/W2121867408","https://openalex.org/W2126484433","https://openalex.org/W2127429285","https://openalex.org/W2130704985","https://openalex.org/W2130764575","https://openalex.org/W2132963724","https://openalex.org/W2134985690","https://openalex.org/W2137467836","https://openalex.org/W2138545785","https://openalex.org/W2140040471","https://openalex.org/W2146280691","https://openalex.org/W2148323109","https://openalex.org/W2148750184","https://openalex.org/W2148964027","https://openalex.org/W2149711482","https://openalex.org/W2150319881","https://openalex.org/W2151496242","https://openalex.org/W2151946759","https://openalex.org/W2152771638","https://openalex.org/W2152968008","https://openalex.org/W2159664785","https://openalex.org/W2161755384","https://openalex.org/W2162398839","https://openalex.org/W2168764308","https://openalex.org/W2323352121","https://openalex.org/W2395367319","https://openalex.org/W2419283504","https://openalex.org/W2498645033","https://openalex.org/W2793938485","https://openalex.org/W2951067386","https://openalex.org/W4206802736","https://openalex.org/W4211157436","https://openalex.org/W4213353716","https://openalex.org/W4232506861","https://openalex.org/W4238527420","https://openalex.org/W4247449511","https://openalex.org/W4247818380","https://openalex.org/W4285719527","https://openalex.org/W4316093093","https://openalex.org/W6606191173","https://openalex.org/W6638633133","https://openalex.org/W7074066072"],"related_works":["https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2151865869","https://openalex.org/W2117258802"],"abstract_inverted_index":{"There":[0],"is":[1],"a":[2,42,121,128,147],"critical":[3],"need":[4],"to":[5,11,40,68,93,123,131],"better":[6],"use":[7,64],"existing":[8],"antibiotics":[9,29,39,151],"due":[10],"the":[12,21,33,52,63,69,125],"urgent":[13],"threat":[14],"of":[15,32,38,45,54,65,71,113,127,146,149],"antibiotic":[16],"resistant":[17],"bacteria":[18,60],"coupled":[19],"with":[20,152],"reduced":[22],"effort":[23],"in":[24],"developing":[25],"new":[26],"antibiotics.":[27,159],"\u03b2-lactam":[28],"represent":[30],"one":[31],"most":[34],"commonly":[35],"used":[36],"classes":[37],"treat":[41,106],"broad":[43],"spectrum":[44,56],"Gram-positive":[46],"and":[47,156],"-negative":[48],"bacterial":[49],"pathogens.":[50],"However,":[51],"rise":[53],"extended":[55],"\u03b2-lactamase":[57],"(ESBL)":[58],"producing":[59,108],"has":[61],"limited":[62],"\u03b2-lactams.":[66,95],"Due":[67],"concern":[70],"complex":[72],"drug":[73],"responses,":[74],"many":[75],"\u03b2-lactams":[76,102],"are":[77,84],"typically":[78],"ruled":[79],"out":[80],"if":[81,87],"ESBL-producing":[82],"pathogens":[83,89,107],"detected,":[85],"even":[86],"these":[88],"test":[90],"as":[91],"susceptible":[92],"some":[94],"Using":[96],"quantitative":[97],"modeling,":[98],"we":[99],"show":[100],"that":[101],"could":[103,143],"still":[104],"effectively":[105],"low":[109],"or":[110],"moderate":[111],"levels":[112],"ESBLs":[114],"when":[115],"administered":[116],"properly.":[117],"We":[118],"further":[119],"develop":[120],"metric":[122],"guide":[124],"design":[126],"dosing":[129,141],"protocol":[130],"optimize":[132],"treatment":[133,154],"efficiency":[134],"for":[135],"any":[136],"antibiotic-pathogen":[137],"combination.":[138],"Ultimately,":[139],"optimized":[140],"protocols":[142],"allow":[144],"reintroduction":[145],"repertoire":[148],"first-line":[150],"improved":[153],"outcomes":[155],"preserve":[157],"last-resort":[158]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
