{"id":"https://openalex.org/W632061114","doi":"https://doi.org/10.1371/journal.pcbi.1004158","title":"Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model","display_name":"Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model","publication_year":2015,"publication_date":"2015-06-12","ids":{"openalex":"https://openalex.org/W632061114","doi":"https://doi.org/10.1371/journal.pcbi.1004158","mag":"632061114","pmid":"https://pubmed.ncbi.nlm.nih.gov/26067165"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004158","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004158","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004158&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004158&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012363916","display_name":"Lindsay E. Clegg","orcid":"https://orcid.org/0000-0001-8558-9341"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lindsay Wendel Clegg","raw_affiliation_strings":["Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045576072","display_name":"Feilim Mac Gabhann","orcid":"https://orcid.org/0000-0003-3481-7740"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Feilim Mac Gabhann","raw_affiliation_strings":["Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":[]},{"raw_affiliation_string":"Institute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012363916"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.7293,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.95548899,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"11","issue":"6","first_page":"e1004158","last_page":"e1004158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.7641428709030151},{"id":"https://openalex.org/keywords/kinase-insert-domain-receptor","display_name":"Kinase insert domain receptor","score":0.7054556012153625},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6311022043228149},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase","display_name":"Receptor tyrosine kinase","score":0.545702338218689},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"Vascular endothelial growth factor","score":0.5236173272132874},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.5232778191566467},{"id":"https://openalex.org/keywords/neuropilin-1","display_name":"Neuropilin 1","score":0.5018348693847656},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.47223612666130066},{"id":"https://openalex.org/keywords/gene-isoform","display_name":"Gene isoform","score":0.435463547706604},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.42811572551727295},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.40873926877975464},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4073863625526428},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor-a","display_name":"Vascular endothelial growth factor A","score":0.3764111399650574},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.2094654142856598},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19155192375183105}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7641428709030151},{"id":"https://openalex.org/C14858245","wikidata":"https://www.wikidata.org/wiki/Q18028241","display_name":"Kinase insert domain receptor","level":5,"score":0.7054556012153625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6311022043228149},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.545702338218689},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5236173272132874},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5232778191566467},{"id":"https://openalex.org/C34425596","wikidata":"https://www.wikidata.org/wiki/Q18033463","display_name":"Neuropilin 1","level":4,"score":0.5018348693847656},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.47223612666130066},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.435463547706604},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42811572551727295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40873926877975464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4073863625526428},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.3764111399650574},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2094654142856598},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19155192375183105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039942","descriptor_name":"Neuropilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039942","descriptor_name":"Neuropilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D039942","descriptor_name":"Neuropilin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004158","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004158","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004158&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26067165","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26067165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:cd5ede5c144f40d197dd06c63d0d384a","is_oa":true,"landing_page_url":"https://doaj.org/article/cd5ede5c144f40d197dd06c63d0d384a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 6, p e1004158 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3436307","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4466579","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1448397","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Site_Specific_Phosphorylation_of_VEGFR2_Is_Mediated_by_Receptor_Trafficking_Insights_from_a_Computational_Model_/1448397","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004158","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004158","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004158&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2418842759","display_name":null,"funder_award_id":"R00HL093219","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3299266224","display_name":null,"funder_award_id":"R01HL101200","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5274348335","display_name":null,"funder_award_id":"R01 HL101200","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G576433839","display_name":null,"funder_award_id":"R01HL101200","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6024433419","display_name":null,"funder_award_id":"R00 HL093219","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6244576378","display_name":null,"funder_award_id":"R00HL093219","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333566","display_name":"National Defense Science and Engineering Graduate","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W632061114.pdf","grobid_xml":"https://content.openalex.org/works/W632061114.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W1488373038","https://openalex.org/W1507337151","https://openalex.org/W1608372949","https://openalex.org/W1964621218","https://openalex.org/W1968504912","https://openalex.org/W1973262582","https://openalex.org/W1974195547","https://openalex.org/W1975911973","https://openalex.org/W1982383741","https://openalex.org/W1985498796","https://openalex.org/W1986274454","https://openalex.org/W1986335846","https://openalex.org/W1988655735","https://openalex.org/W1988864250","https://openalex.org/W1989483643","https://openalex.org/W1990368500","https://openalex.org/W1991362893","https://openalex.org/W1992049575","https://openalex.org/W1994719482","https://openalex.org/W1999358438","https://openalex.org/W2002823287","https://openalex.org/W2005575651","https://openalex.org/W2007608113","https://openalex.org/W2010641085","https://openalex.org/W2012576713","https://openalex.org/W2013166677","https://openalex.org/W2013170875","https://openalex.org/W2014606667","https://openalex.org/W2026038729","https://openalex.org/W2030128245","https://openalex.org/W2030615367","https://openalex.org/W2032009866","https://openalex.org/W2037618281","https://openalex.org/W2038818854","https://openalex.org/W2040892290","https://openalex.org/W2043416015","https://openalex.org/W2043765960","https://openalex.org/W2046525214","https://openalex.org/W2047113737","https://openalex.org/W2047991460","https://openalex.org/W2049408374","https://openalex.org/W2050893164","https://openalex.org/W2053547715","https://openalex.org/W2059229484","https://openalex.org/W2064224882","https://openalex.org/W2067020920","https://openalex.org/W2069392215","https://openalex.org/W2076601545","https://openalex.org/W2078112275","https://openalex.org/W2078359816","https://openalex.org/W2082191890","https://openalex.org/W2082240332","https://openalex.org/W2082664513","https://openalex.org/W2084587800","https://openalex.org/W2090717631","https://openalex.org/W2092364629","https://openalex.org/W2093868559","https://openalex.org/W2100909138","https://openalex.org/W2101363876","https://openalex.org/W2102478648","https://openalex.org/W2103674104","https://openalex.org/W2104257202","https://openalex.org/W2107583561","https://openalex.org/W2112078298","https://openalex.org/W2119690971","https://openalex.org/W2119748249","https://openalex.org/W2125801586","https://openalex.org/W2125907821","https://openalex.org/W2128875649","https://openalex.org/W2133809169","https://openalex.org/W2135743455","https://openalex.org/W2138992193","https://openalex.org/W2139921980","https://openalex.org/W2141801986","https://openalex.org/W2144885509","https://openalex.org/W2146293179","https://openalex.org/W2146492421","https://openalex.org/W2151280162","https://openalex.org/W2151810131","https://openalex.org/W2157200572","https://openalex.org/W2159923622","https://openalex.org/W2160518321","https://openalex.org/W2163660141","https://openalex.org/W2165536388","https://openalex.org/W2325237486","https://openalex.org/W2334759574","https://openalex.org/W6678359005"],"related_works":["https://openalex.org/W4238800710","https://openalex.org/W2049292409","https://openalex.org/W2067817921","https://openalex.org/W4229879599","https://openalex.org/W2621284822","https://openalex.org/W4246641905","https://openalex.org/W2377383000","https://openalex.org/W2777690336","https://openalex.org/W4299329059","https://openalex.org/W2004426982"],"abstract_inverted_index":{"Matrix-binding":[0],"isoforms":[1,4],"and":[2,26,32,42,55,77,103,164,211,227,236,238],"non-matrix-binding":[3],"of":[5,14,37,40,53,74,98,135,156,193,208,217,230],"vascular":[6,16],"endothelial":[7,91],"growth":[8],"factor":[9],"(VEGF)":[10],"are":[11,24,86],"both":[12],"capable":[13],"stimulating":[15],"remodeling,":[17],"but":[18],"the":[19,38,50,107,153,224],"resulting":[20],"blood":[21],"vessel":[22],"networks":[23],"structurally":[25],"functionally":[27],"different.":[28],"Here,":[29],"we":[30,176],"develop":[31],"validate":[33],"a":[34],"computational":[35],"model":[36,80,109,145,247],"binding":[39,185],"soluble":[41,126],"immobilized":[43,122],"ligands":[44],"to":[45,60,110,125,186],"VEGF":[46,68,123,127,184,202],"receptor":[47,142],"2":[48],"(VEGFR2),":[49],"endosomal":[51],"trafficking":[52,84,134],"VEGFR2,":[54],"site-specific":[56,116],"VEGFR2":[57,75,83,99,117,136,163,166,187,209,221,231],"tyrosine":[58],"phosphorylation":[59,232],"study":[61],"differences":[62,114,151],"in":[63,115,141,152,189,213],"induced":[64],"signaling":[65,76,196],"between":[66],"these":[67],"isoforms.":[69],"In":[70],"capturing":[71],"essential":[72],"features":[73],"trafficking,":[78,210],"our":[79,244],"suggests":[81],"that":[82,113,147,161,181,201],"parameters":[85],"largely":[87],"consistent":[88,246],"across":[89],"multiple":[90,178,194],"cell":[92],"lines.":[93],"Simulations":[94,158],"demonstrate":[95],"distinct":[96],"localization":[97],"phosphorylated":[100,165],"on":[101,220,233],"Y1175":[102],"Y1214.":[104],"This":[105],"is":[106],"first":[108],"clearly":[111],"show":[112,160],"activation":[118],"when":[119],"stimulated":[120],"with":[121,205],"compared":[124],"can":[128,149],"be":[129],"accounted":[130],"for":[131],"by":[132],"altered":[133],"without":[137],"an":[138],"intrinsic":[139],"difference":[140],"activation.":[143],"The":[144],"predicts":[146],"Neuropilin-1":[148],"induce":[150],"surface-to-internal":[154],"distribution":[155],"VEGFR2.":[157],"also":[159],"ligated":[162],"levels":[167],"diverge":[168],"over":[169],"time":[170],"following":[171],"stimulation.":[172],"Using":[173],"this":[174],"model,":[175],"identify":[177],"key":[179],"levers":[180],"alter":[182],"how":[183],"results":[188],"different":[190],"coordinated":[191],"patterns":[192],"downstream":[195],"pathways.":[197],"Specifically,":[198],"simulations":[199],"predict":[200],"immobilization,":[203],"interactions":[204],"Neuropilin-1,":[206],"perturbations":[207],"changes":[212],"expression":[214],"or":[215],"activity":[216],"phosphatases":[218],"acting":[219],"all":[222],"affect":[223],"magnitude,":[225],"duration,":[226],"relative":[228],"strength":[229],"tyrosines":[234],"1175":[235],"1214,":[237],"they":[239],"do":[240],"so":[241],"predictably":[242],"within":[243],"single":[245],"framework.":[248]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}