{"id":"https://openalex.org/W2151684398","doi":"https://doi.org/10.1371/journal.pcbi.1004147","title":"Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations","display_name":"Protein Domain-Level Landscape of Cancer-Type-Specific Somatic Mutations","publication_year":2015,"publication_date":"2015-03-20","ids":{"openalex":"https://openalex.org/W2151684398","doi":"https://doi.org/10.1371/journal.pcbi.1004147","mag":"2151684398","pmid":"https://pubmed.ncbi.nlm.nih.gov/25794154"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004147","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004147","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004147&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004147&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031025260","display_name":"Fan Yang","orcid":"https://orcid.org/0000-0002-0520-5254"},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Fan Yang","raw_affiliation_strings":["Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada","Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I210557978"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067492324","display_name":"Evangelia Petsalaki","orcid":"https://orcid.org/0000-0002-8294-2995"},"institutions":[{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Evangelia Petsalaki","raw_affiliation_strings":["Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada","Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063781036","display_name":"Thomas Rolland","orcid":"https://orcid.org/0000-0001-6468-8391"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas Rolland","raw_affiliation_strings":["Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America","Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":[]},{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074302961","display_name":"David E. Hill","orcid":"https://orcid.org/0000-0001-5192-0921"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David E. Hill","raw_affiliation_strings":["Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040546953","display_name":"Marc Vidal","orcid":"https://orcid.org/0000-0003-3391-5410"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc Vidal","raw_affiliation_strings":["Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090936599","display_name":"Frederick P. Roth","orcid":"https://orcid.org/0000-0002-6628-649X"},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I109736498","display_name":"Canadian Institute for Advanced Research","ror":"https://ror.org/01sdtdd95","country_code":"CA","type":"facility","lineage":["https://openalex.org/I109736498"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Frederick P. Roth","raw_affiliation_strings":["Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Canadian Institute for Advanced Research, Toronto, Ontario, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada","Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","Canadian Institute for Advanced Research, Toronto, Ontario, Canada","Department of Computer Science, University of Toronto, Toronto, Ontario, Canada","Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada; Donnelly Centre, University of Toronto, Toronto, Ontario, Canada; Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada; Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America; Canadian Institute for Advanced Research, Toronto, Ontario, Canada; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada","institution_ids":[]},{"raw_affiliation_string":"Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Canadian Institute for Advanced Research, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I109736498"]},{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Donnelly Centre, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I210557978"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5031025260","https://openalex.org/A5040546953","https://openalex.org/A5063781036","https://openalex.org/A5067492324","https://openalex.org/A5074302961","https://openalex.org/A5090936599"],"corresponding_institution_ids":["https://openalex.org/I109736498","https://openalex.org/I136199984","https://openalex.org/I185261750","https://openalex.org/I210557978","https://openalex.org/I4210117453"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.0117,"has_fulltext":true,"cited_by_count":81,"citation_normalized_percentile":{"value":0.94631539,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"11","issue":"3","first_page":"e1004147","last_page":"e1004147"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6843826770782471},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5846239328384399},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5195491909980774},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.4832195043563843},{"id":"https://openalex.org/keywords/germline-mutation","display_name":"Germline mutation","score":0.4798980951309204},{"id":"https://openalex.org/keywords/protein-kinase-domain","display_name":"Protein kinase domain","score":0.45924901962280273},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.45748794078826904},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.4534861445426941},{"id":"https://openalex.org/keywords/somatic-cell","display_name":"Somatic cell","score":0.45308390259742737},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44732850790023804},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.4186254143714905},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.38952434062957764},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3638075590133667},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.09105053544044495}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6843826770782471},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5846239328384399},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5195491909980774},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4832195043563843},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.4798980951309204},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.45924901962280273},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.45748794078826904},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4534861445426941},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.45308390259742737},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44732850790023804},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4186254143714905},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38952434062957764},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3638075590133667},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.09105053544044495},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004147","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004147","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004147&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25794154","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25794154","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dash.harvard.edu:1/14351381","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351381","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8353bf4f8bbb4dbfb137a905fbf318c8","is_oa":true,"landing_page_url":"https://doaj.org/article/8353bf4f8bbb4dbfb137a905fbf318c8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 3, p e1004147 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3337948","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4368709","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1345450","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Protein_Domain_Level_Landscape_of_Cancer_Type_Specific_Somatic_Mutations_/1345450","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004147","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004147","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004147&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7799999713897705,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2387441181","display_name":null,"funder_award_id":"HG001715","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2470583414","display_name":null,"funder_award_id":"HG004233","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G331135180","display_name":null,"funder_award_id":"HG004233","funder_id":"https://openalex.org/F4320321481","funder_display_name":"Canada Excellence Research Chairs, Government of Canada"},{"id":"https://openalex.org/G3509326096","display_name":null,"funder_award_id":"U01 HG001715","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G4118909504","display_name":null,"funder_award_id":"P50 HG004233","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G4723854142","display_name":null,"funder_award_id":"R01 HG001715","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G6370580963","display_name":null,"funder_award_id":"U41 HG001715","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8178563453","display_name":null,"funder_award_id":"HG001715","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8637606780","display_name":null,"funder_award_id":"HG004233","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306109","display_name":"Avon Foundation for Women","ror":"https://ror.org/02eqe7f55"},{"id":"https://openalex.org/F4320321481","display_name":"Canada Excellence Research Chairs, Government of Canada","ror":"https://ror.org/02tvrwm90"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151684398.pdf","grobid_xml":"https://content.openalex.org/works/W2151684398.grobid-xml"},"referenced_works_count":145,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1493266094","https://openalex.org/W1494567425","https://openalex.org/W1870193477","https://openalex.org/W1964640688","https://openalex.org/W1965662201","https://openalex.org/W1966522008","https://openalex.org/W1966524014","https://openalex.org/W1974625077","https://openalex.org/W1974773495","https://openalex.org/W1975141727","https://openalex.org/W1976489901","https://openalex.org/W1979855662","https://openalex.org/W1979946545","https://openalex.org/W1981194976","https://openalex.org/W1988303870","https://openalex.org/W1989773675","https://openalex.org/W1992894543","https://openalex.org/W1993849863","https://openalex.org/W1994847090","https://openalex.org/W1995808589","https://openalex.org/W2000381516","https://openalex.org/W2003262666","https://openalex.org/W2003665515","https://openalex.org/W2004637409","https://openalex.org/W2005250386","https://openalex.org/W2009132217","https://openalex.org/W2009720434","https://openalex.org/W2010559811","https://openalex.org/W2011941471","https://openalex.org/W2015049472","https://openalex.org/W2015577159","https://openalex.org/W2015631955","https://openalex.org/W2016710415","https://openalex.org/W2019651806","https://openalex.org/W2019961381","https://openalex.org/W2020202943","https://openalex.org/W2023171799","https://openalex.org/W2023568503","https://openalex.org/W2024751825","https://openalex.org/W2024957890","https://openalex.org/W2025183726","https://openalex.org/W2027807187","https://openalex.org/W2028878627","https://openalex.org/W2034820020","https://openalex.org/W2035000040","https://openalex.org/W2035503835","https://openalex.org/W2037411879","https://openalex.org/W2040847667","https://openalex.org/W2041440766","https://openalex.org/W2042386784","https://openalex.org/W2044237973","https://openalex.org/W2044433401","https://openalex.org/W2051025382","https://openalex.org/W2054051862","https://openalex.org/W2054607545","https://openalex.org/W2057224174","https://openalex.org/W2058620780","https://openalex.org/W2059437408","https://openalex.org/W2061658069","https://openalex.org/W2062005062","https://openalex.org/W2062312459","https://openalex.org/W2062807784","https://openalex.org/W2063382533","https://openalex.org/W2067405757","https://openalex.org/W2068124730","https://openalex.org/W2068127752","https://openalex.org/W2069329627","https://openalex.org/W2071480068","https://openalex.org/W2071734901","https://openalex.org/W2077393203","https://openalex.org/W2077858999","https://openalex.org/W2081375228","https://openalex.org/W2083457841","https://openalex.org/W2085382072","https://openalex.org/W2092892924","https://openalex.org/W2093144236","https://openalex.org/W2094122486","https://openalex.org/W2095698093","https://openalex.org/W2096460732","https://openalex.org/W2097889307","https://openalex.org/W2099459640","https://openalex.org/W2102005789","https://openalex.org/W2102140136","https://openalex.org/W2105666596","https://openalex.org/W2107384304","https://openalex.org/W2108643617","https://openalex.org/W2109860416","https://openalex.org/W2110065044","https://openalex.org/W2112612051","https://openalex.org/W2113834377","https://openalex.org/W2114023704","https://openalex.org/W2114715773","https://openalex.org/W2116031174","https://openalex.org/W2117180730","https://openalex.org/W2117521607","https://openalex.org/W2118071133","https://openalex.org/W2120627772","https://openalex.org/W2121906867","https://openalex.org/W2123696077","https://openalex.org/W2124558732","https://openalex.org/W2124662474","https://openalex.org/W2126062698","https://openalex.org/W2128339707","https://openalex.org/W2128537223","https://openalex.org/W2128799219","https://openalex.org/W2129136620","https://openalex.org/W2133051701","https://openalex.org/W2133586252","https://openalex.org/W2134471382","https://openalex.org/W2135184154","https://openalex.org/W2135640980","https://openalex.org/W2136280642","https://openalex.org/W2137284086","https://openalex.org/W2137297899","https://openalex.org/W2139216037","https://openalex.org/W2140349867","https://openalex.org/W2140929811","https://openalex.org/W2141885858","https://openalex.org/W2142630775","https://openalex.org/W2143600397","https://openalex.org/W2143881980","https://openalex.org/W2143965359","https://openalex.org/W2148351505","https://openalex.org/W2150271494","https://openalex.org/W2150575159","https://openalex.org/W2150677022","https://openalex.org/W2151831732","https://openalex.org/W2152061559","https://openalex.org/W2152556045","https://openalex.org/W2153056550","https://openalex.org/W2154225779","https://openalex.org/W2155173231","https://openalex.org/W2159202225","https://openalex.org/W2159715390","https://openalex.org/W2159940473","https://openalex.org/W2164683872","https://openalex.org/W2166337170","https://openalex.org/W2167532631","https://openalex.org/W2171965424","https://openalex.org/W2172142216","https://openalex.org/W2262414037","https://openalex.org/W4210623056","https://openalex.org/W4238448376","https://openalex.org/W4240237951"],"related_works":["https://openalex.org/W4296060409","https://openalex.org/W3111064715","https://openalex.org/W2623784472","https://openalex.org/W1972248466","https://openalex.org/W824391999","https://openalex.org/W2065180810","https://openalex.org/W2940468410","https://openalex.org/W2054270613","https://openalex.org/W4200456173","https://openalex.org/W2913740063"],"abstract_inverted_index":{"Identifying":[0],"driver":[1],"mutations":[2,79,119,170,185],"and":[3,17,65,68,116,129,153,186],"their":[4],"functional":[5,22,67,173],"consequences":[6],"is":[7,146],"critical":[8],"to":[9,47,76,167],"our":[10],"understanding":[11],"of":[12,24,33,59,108,139,144],"cancer.":[13,165],"Towards":[14],"this":[15],"goal,":[16],"because":[18],"domains":[19,49],"are":[20,80],"the":[21,29,57,66,105,135,140,159,190],"units":[23],"a":[25,148],"protein,":[26,142],"we":[27,38,84,103,125,181],"explored":[28],"protein":[30,191],"domain-level":[31],"landscape":[32],"cancer-type-specific":[34],"somatic":[35],"mutations.":[36],"Specifically,":[37],"systematically":[39,183],"examined":[40],"tumor":[41,87,121],"genomes":[42],"from":[43],"21":[44],"cancer":[45,132,169,179,187],"types":[46,188],"identify":[48],"with":[50,110],"high":[51],"mutational":[52,60],"density":[53],"in":[54,97,134,150,158,163],"specific":[55,77],"tissues,":[56],"positions":[58,113],"hotspots":[61,74,133,157],"within":[62],"these":[63],"domains,":[64,101],"structural":[69],"context":[70],"where":[71],"possible.":[72],"While":[73],"corresponding":[75],"gain-of-function":[78],"expected":[81,106],"for":[82,114,120,171],"oncoproteins,":[83],"found":[85,154],"that":[86],"suppressor":[88],"proteins":[89],"also":[90,147],"exhibit":[91],"strong":[92],"biases":[93],"toward":[94],"being":[95],"mutated":[96,112],"particular":[98],"domains.":[99],"Within":[100],"however,":[102],"observed":[104],"patterns":[107],"mutation,":[109],"recurrently":[111],"oncogenes":[115],"evenly":[117],"distributed":[118],"suppressors.":[122],"For":[123],"example,":[124],"identified":[126],"both":[127],"known":[128],"new":[130,155],"endometrial":[131],"tyrosine":[136],"kinase":[137],"domain":[138,162,192],"FGFR2":[141],"one":[143],"which":[145],"hotspot":[149],"breast":[151],"cancer,":[152],"two":[156],"Immunoglobulin":[160],"I-set":[161],"colon":[164],"Thus,":[166],"prioritize":[168],"further":[172],"studies":[174],"aimed":[175],"at":[176,189],"more":[177],"precise":[178],"treatments,":[180],"have":[182],"correlated":[184],"level.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}