{"id":"https://openalex.org/W2073511211","doi":"https://doi.org/10.1371/journal.pcbi.1004006","title":"Molecular Insights into the Dynamics of Pharmacogenetically Important N-Terminal Variants of the Human \u03b22-Adrenergic Receptor","display_name":"Molecular Insights into the Dynamics of Pharmacogenetically Important N-Terminal Variants of the Human \u03b22-Adrenergic Receptor","publication_year":2014,"publication_date":"2014-12-11","ids":{"openalex":"https://openalex.org/W2073511211","doi":"https://doi.org/10.1371/journal.pcbi.1004006","mag":"2073511211","pmid":"https://pubmed.ncbi.nlm.nih.gov/25501358"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004006","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004006","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004006&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004006&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051075689","display_name":"Ganesh Shahane","orcid":null},"institutions":[{"id":"https://openalex.org/I3125981224","display_name":"National Chemical Laboratory","ror":"https://ror.org/057mn3690","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3125981224","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ganesh Shahane","raw_affiliation_strings":["CSIR-National Chemical Laboratory, Pune, India","CSIR\u2010National Chemical Laboratory  Pune India"],"affiliations":[{"raw_affiliation_string":"CSIR-National Chemical Laboratory, Pune, India","institution_ids":["https://openalex.org/I3125981224"]},{"raw_affiliation_string":"CSIR\u2010National Chemical Laboratory  Pune India","institution_ids":["https://openalex.org/I3125981224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040581077","display_name":"Chirag Parsania","orcid":"https://orcid.org/0000-0003-4873-2385"},"institutions":[{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chirag Parsania","raw_affiliation_strings":["Bioinformatics Center, University of Pune, Pune, India"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Center, University of Pune, Pune, India","institution_ids":["https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024022206","display_name":"Durba Sengupta","orcid":"https://orcid.org/0000-0002-3138-1024"},"institutions":[{"id":"https://openalex.org/I3125981224","display_name":"National Chemical Laboratory","ror":"https://ror.org/057mn3690","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I3125981224","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Durba Sengupta","raw_affiliation_strings":["CSIR-National Chemical Laboratory, Pune, India","CSIR\u2010National Chemical Laboratory  Pune India"],"affiliations":[{"raw_affiliation_string":"CSIR-National Chemical Laboratory, Pune, India","institution_ids":["https://openalex.org/I3125981224"]},{"raw_affiliation_string":"CSIR\u2010National Chemical Laboratory  Pune India","institution_ids":["https://openalex.org/I3125981224"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101706450","display_name":"Manali Joshi","orcid":"https://orcid.org/0000-0002-4255-2474"},"institutions":[{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manali Joshi","raw_affiliation_strings":["Bioinformatics Center, University of Pune, Pune, India"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Center, University of Pune, Pune, India","institution_ids":["https://openalex.org/I878213199"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5024022206","https://openalex.org/A5101706450"],"corresponding_institution_ids":["https://openalex.org/I3125981224","https://openalex.org/I878213199"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.5687,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82665396,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"12","first_page":"e1004006","last_page":"e1004006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13338","display_name":"Pharmacological Effects and Assays","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.6545931100845337},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor","display_name":"G protein-coupled receptor","score":0.5325754284858704},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.5107145309448242},{"id":"https://openalex.org/keywords/agonist","display_name":"Agonist","score":0.49828219413757324},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42388254404067993},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.42355281114578247},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3702905476093292},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34955310821533203},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3437168300151825},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.24090850353240967}],"concepts":[{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.6545931100845337},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5325754284858704},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5107145309448242},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.49828219413757324},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42388254404067993},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.42355281114578247},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3702905476093292},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34955310821533203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3437168300151825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24090850353240967},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000420","descriptor_name":"Albuterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004006","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004006","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004006&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25501358","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25501358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1004006","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004006","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f17b4738dea5476c8c829647e0fc39c9","is_oa":true,"landing_page_url":"https://doaj.org/article/f17b4738dea5476c8c829647e0fc39c9","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 12, p e1004006 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1268274","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Molecular_Insights_into_the_Dynamics_of_Pharmacogenetically_Important_N_Terminal_Variants_of_the_Human_2_Adrenergic_Receptor/1268274","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4263363","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4263363","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004006","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004006","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004006&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2073511211.pdf","grobid_xml":"https://content.openalex.org/works/W2073511211.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W35537551","https://openalex.org/W1601495365","https://openalex.org/W1603274157","https://openalex.org/W1825353903","https://openalex.org/W1965984853","https://openalex.org/W1968682237","https://openalex.org/W1970613671","https://openalex.org/W1975732928","https://openalex.org/W1976198657","https://openalex.org/W1980374511","https://openalex.org/W1988097700","https://openalex.org/W1990813403","https://openalex.org/W1991387062","https://openalex.org/W1994816216","https://openalex.org/W1995816895","https://openalex.org/W1997340548","https://openalex.org/W2004334951","https://openalex.org/W2006998486","https://openalex.org/W2012959970","https://openalex.org/W2018762866","https://openalex.org/W2020601776","https://openalex.org/W2029667189","https://openalex.org/W2035266068","https://openalex.org/W2035687084","https://openalex.org/W2035939859","https://openalex.org/W2039812658","https://openalex.org/W2049617698","https://openalex.org/W2050199670","https://openalex.org/W2060874643","https://openalex.org/W2067805628","https://openalex.org/W2069677629","https://openalex.org/W2073110681","https://openalex.org/W2078876572","https://openalex.org/W2080231167","https://openalex.org/W2081645999","https://openalex.org/W2086946786","https://openalex.org/W2095237667","https://openalex.org/W2102377211","https://openalex.org/W2105850024","https://openalex.org/W2117003397","https://openalex.org/W2122671870","https://openalex.org/W2125399699","https://openalex.org/W2141920771","https://openalex.org/W2157226274","https://openalex.org/W2158076215","https://openalex.org/W2160544821","https://openalex.org/W2167857702","https://openalex.org/W2168966210","https://openalex.org/W2170033400","https://openalex.org/W2172509713","https://openalex.org/W3100271906","https://openalex.org/W4249658209"],"related_works":["https://openalex.org/W2609050007","https://openalex.org/W3011298851","https://openalex.org/W4224216382","https://openalex.org/W3195483439","https://openalex.org/W2444295418","https://openalex.org/W416861399","https://openalex.org/W2171194536","https://openalex.org/W1967231335","https://openalex.org/W2042405111","https://openalex.org/W2141926683"],"abstract_inverted_index":{"The":[0,33,83],"human":[1],"\u03b22-adrenergic":[2],"receptor":[3,11],"(\u03b22AR),":[4],"a":[5,45,189],"member":[6],"of":[7,36,47,66,85,114,134,173],"the":[8,39,62,67,70,91,96,111,115,122,130,135,140,151,160,165,170,176,186,194],"G-protein":[9],"coupled":[10],"(GPCR)":[12],"family,":[13],"is":[14,51,64,76,156],"expressed":[15],"in":[16,30,55,78,159,169,198],"bronchial":[17],"smooth":[18],"muscle":[19],"cells.":[20],"Upon":[21],"activation":[22],"by":[23],"agonists,":[24],"\u03b22AR":[25,37,63],"causes":[26],"bronchodilation":[27],"and":[28,102,132],"relief":[29],"asthma":[31,199],"patients.":[32,200],"N-terminal":[34,97,112,136],"polymorphism":[35],"at":[38,150],"16th":[40],"position,":[41],"Arg16Gly,":[42],"has":[43],"warranted":[44],"lot":[46],"attention":[48],"since":[49],"it":[50],"linked":[52],"to":[53,57,89,126,164,175],"variations":[54],"response":[56,197],"albuterol":[58,174],"(agonist)":[59],"treatment.":[60],"Although":[61],"one":[65],"well-studied":[68],"GPCRs,":[69],"N-terminus":[71],"which":[72,155],"harbors":[73],"this":[74,86],"mutation,":[75],"absent":[77],"all":[79],"available":[80],"experimental":[81],"structures.":[82],"goal":[84],"work":[87],"was":[88],"study":[90,180],"molecular":[92,104,190],"level":[93],"differences":[94,184],"between":[95,185],"variants":[98,187],"using":[99],"structural":[100],"modeling":[101],"atomistic":[103],"dynamics":[105,120,133],"simulations.":[106],"Our":[107],"simulations":[108],"reveal":[109],"that":[110],"region":[113],"Arg":[116,166],"variant":[117,167],"shows":[118],"greater":[119],"than":[121],"Gly":[123,161,177],"variant,":[124],"leading":[125],"differential":[127],"placement.":[128],"Further,":[129],"position":[131],"region,":[137],"further,":[138],"affects":[139],"ligand":[141,152],"binding-site":[142],"accessibility.":[143],"Interestingly,":[144],"long-range":[145],"effects":[146],"are":[147],"also":[148],"seen":[149],"binding":[153],"site,":[154],"marginally":[157],"larger":[158],"as":[162],"compared":[163],"resulting":[168],"preferential":[171],"docking":[172],"variant.":[178],"This":[179],"thus":[181],"reveals":[182],"key":[183],"providing":[188],"framework":[191],"towards":[192],"understanding":[193],"variable":[195],"drug":[196]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
