{"id":"https://openalex.org/W2068716083","doi":"https://doi.org/10.1371/journal.pcbi.1003997","title":"Lattice-Based Model of Ductal Carcinoma In Situ Suggests Rules for Breast Cancer Progression to an Invasive State","display_name":"Lattice-Based Model of Ductal Carcinoma In Situ Suggests Rules for Breast Cancer Progression to an Invasive State","publication_year":2014,"publication_date":"2014-12-04","ids":{"openalex":"https://openalex.org/W2068716083","doi":"https://doi.org/10.1371/journal.pcbi.1003997","mag":"2068716083","pmid":"https://pubmed.ncbi.nlm.nih.gov/25473842"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003997","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003997","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003997&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003997&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027376638","display_name":"Eline Boghaert","orcid":null},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eline Boghaert","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048587108","display_name":"Derek C. Radisky","orcid":"https://orcid.org/0000-0002-1962-8784"},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek C. Radisky","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049456828","display_name":"Celeste M. Nelson","orcid":"https://orcid.org/0000-0001-9973-8870"},"institutions":[{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Celeste M. Nelson","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, United States of America; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, United States of America","Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, United States of America; Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]},{"raw_affiliation_string":"Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America","institution_ids":["https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5049456828"],"corresponding_institution_ids":["https://openalex.org/I20089843"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6431,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.84488111,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"12","first_page":"e1003997","last_page":"e1003997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ductal-carcinoma","display_name":"Ductal carcinoma","score":0.7490687370300293},{"id":"https://openalex.org/keywords/comedo","display_name":"Comedo","score":0.6410647630691528},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5656082630157471},{"id":"https://openalex.org/keywords/cribriform","display_name":"Cribriform","score":0.5605676770210266},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.5540890097618103},{"id":"https://openalex.org/keywords/carcinoma-in-situ","display_name":"Carcinoma in situ","score":0.5003187656402588},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.4589143991470337},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.451151043176651},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.4484729766845703},{"id":"https://openalex.org/keywords/in-situ","display_name":"In situ","score":0.43592217564582825},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.4347497820854187},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.41645336151123047},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4065927267074585},{"id":"https://openalex.org/keywords/carcinoma","display_name":"Carcinoma","score":0.34555676579475403},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3146069645881653},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.28138381242752075},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17552262544631958}],"concepts":[{"id":"https://openalex.org/C2780862961","wikidata":"https://www.wikidata.org/wiki/Q5311598","display_name":"Ductal carcinoma","level":4,"score":0.7490687370300293},{"id":"https://openalex.org/C2780045663","wikidata":"https://www.wikidata.org/wiki/Q1146379","display_name":"Comedo","level":5,"score":0.6410647630691528},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5656082630157471},{"id":"https://openalex.org/C2909818935","wikidata":"https://www.wikidata.org/wiki/Q5184902","display_name":"Cribriform","level":3,"score":0.5605676770210266},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5540890097618103},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.5003187656402588},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4589143991470337},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.451151043176651},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4484729766845703},{"id":"https://openalex.org/C2777822432","wikidata":"https://www.wikidata.org/wiki/Q216681","display_name":"In situ","level":2,"score":0.43592217564582825},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4347497820854187},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41645336151123047},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4065927267074585},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.34555676579475403},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3146069645881653},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28138381242752075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17552262544631958},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002285","descriptor_name":"Carcinoma, Intraductal, Noninfiltrating","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003997","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003997","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003997&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25473842","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25473842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.782.7847","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.782.7847","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a4/4a/pcbi.1003997.PMC4256017.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:42ce778403744c218887341935d7a13d","is_oa":true,"landing_page_url":"https://doaj.org/article/42ce778403744c218887341935d7a13d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 12, p e1003997 (2014)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4256017","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4256017","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003997","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003997","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003997&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G105322576","display_name":null,"funder_award_id":"HL110335","funder_id":"https://openalex.org/F4320306079","funder_display_name":"David and Lucile Packard Foundation"},{"id":"https://openalex.org/G1369097202","display_name":null,"funder_award_id":"HL110335","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1832599177","display_name":null,"funder_award_id":"HL110335","funder_id":"https://openalex.org/F4320306151","funder_display_name":"Alfred P. Sloan Foundation"},{"id":"https://openalex.org/G2403458452","display_name":null,"funder_award_id":"HL120142","funder_id":"https://openalex.org/F4320306151","funder_display_name":"Alfred P. Sloan Foundation"},{"id":"https://openalex.org/G2440329253","display_name":null,"funder_award_id":"GM083997","funder_id":"https://openalex.org/F4320306133","funder_display_name":"Burroughs Wellcome Fund"},{"id":"https://openalex.org/G2584202007","display_name":null,"funder_award_id":"GM083997","funder_id":"https://openalex.org/F4320306315","funder_display_name":"Camille and Henry Dreyfus Foundation"},{"id":"https://openalex.org/G3388447281","display_name":null,"funder_award_id":"GM083997","funder_id":"https://openalex.org/F4320306079","funder_display_name":"David and Lucile Packard Foundation"},{"id":"https://openalex.org/G347915573","display_name":null,"funder_award_id":"CA116201","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3558499978","display_name":null,"funder_award_id":"HL118532","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3834165267","display_name":null,"funder_award_id":"HL118532","funder_id":"https://openalex.org/F4320306315","funder_display_name":"Camille and Henry Dreyfus Foundation"},{"id":"https://openalex.org/G3863030043","display_name":null,"funder_award_id":"GM083997","funder_id":"https://openalex.org/F4320306151","funder_display_name":"Alfred P. Sloan Foundation"},{"id":"https://openalex.org/G4372826676","display_name":null,"funder_award_id":"GM083997, HL110335, HL118532, HL120142","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4641068160","display_name":null,"funder_award_id":"Packard","funder_id":"https://openalex.org/F4320306079","funder_display_name":"David and Lucile Packard Foundation"},{"id":"https://openalex.org/G5709455999","display_name":null,"funder_award_id":"HL118532","funder_id":"https://openalex.org/F4320306151","funder_display_name":"Alfred P. Sloan Foundation"},{"id":"https://openalex.org/G5794020386","display_name":null,"funder_award_id":"HL118532","funder_id":"https://openalex.org/F4320306133","funder_display_name":"Burroughs Wellcome Fund"},{"id":"https://openalex.org/G5827685195","display_name":null,"funder_award_id":"HL110335","funder_id":"https://openalex.org/F4320306133","funder_display_name":"Burroughs Wellcome Fund"},{"id":"https://openalex.org/G6238009587","display_name":null,"funder_award_id":"GM083997","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6390186846","display_name":null,"funder_award_id":"HL118532","funder_id":"https://openalex.org/F4320306079","funder_display_name":"David and Lucile Packard Foundation"},{"id":"https://openalex.org/G6455371844","display_name":null,"funder_award_id":"HL120142","funder_id":"https://openalex.org/F4320306079","funder_display_name":"David and Lucile Packard Foundation"},{"id":"https://openalex.org/G6513087666","display_name":null,"funder_award_id":"HL120142","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7030140753","display_name":null,"funder_award_id":"HL110335","funder_id":"https://openalex.org/F4320306315","funder_display_name":"Camille and Henry Dreyfus Foundation"},{"id":"https://openalex.org/G7249173304","display_name":null,"funder_award_id":"HL120142","funder_id":"https://openalex.org/F4320306133","funder_display_name":"Burroughs Wellcome Fund"},{"id":"https://openalex.org/G7350824931","display_name":null,"funder_award_id":"HL120142","funder_id":"https://openalex.org/F4320306315","funder_display_name":"Camille and Henry Dreyfus Foundation"}],"funders":[{"id":"https://openalex.org/F4320306079","display_name":"David and Lucile Packard Foundation","ror":"https://ror.org/032atxq54"},{"id":"https://openalex.org/F4320306133","display_name":"Burroughs Wellcome Fund","ror":"https://ror.org/01d35cw23"},{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320306315","display_name":"Camille and Henry Dreyfus Foundation","ror":"https://ror.org/019p8h045"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2068716083.pdf","grobid_xml":"https://content.openalex.org/works/W2068716083.grobid-xml"},"referenced_works_count":79,"referenced_works":["https://openalex.org/W115452890","https://openalex.org/W172018148","https://openalex.org/W1824479450","https://openalex.org/W1893487430","https://openalex.org/W1923770335","https://openalex.org/W1963916446","https://openalex.org/W1967120404","https://openalex.org/W1973214660","https://openalex.org/W1973946053","https://openalex.org/W1974427392","https://openalex.org/W1975523864","https://openalex.org/W1980598184","https://openalex.org/W1981962653","https://openalex.org/W1983690504","https://openalex.org/W1985385254","https://openalex.org/W1987164692","https://openalex.org/W1996187477","https://openalex.org/W1996212672","https://openalex.org/W2003933044","https://openalex.org/W2007040134","https://openalex.org/W2010264613","https://openalex.org/W2010618768","https://openalex.org/W2011020623","https://openalex.org/W2018494545","https://openalex.org/W2021197729","https://openalex.org/W2022885236","https://openalex.org/W2023072510","https://openalex.org/W2029701927","https://openalex.org/W2030944887","https://openalex.org/W2032461554","https://openalex.org/W2040163651","https://openalex.org/W2049013233","https://openalex.org/W2053953532","https://openalex.org/W2059171932","https://openalex.org/W2059641178","https://openalex.org/W2061058076","https://openalex.org/W2066288526","https://openalex.org/W2070852249","https://openalex.org/W2071906932","https://openalex.org/W2072411420","https://openalex.org/W2076337068","https://openalex.org/W2086336177","https://openalex.org/W2086811477","https://openalex.org/W2088500333","https://openalex.org/W2091975893","https://openalex.org/W2097609013","https://openalex.org/W2099052265","https://openalex.org/W2099915274","https://openalex.org/W2100303404","https://openalex.org/W2101843767","https://openalex.org/W2104479723","https://openalex.org/W2115772647","https://openalex.org/W2116741675","https://openalex.org/W2127225632","https://openalex.org/W2129708422","https://openalex.org/W2130192648","https://openalex.org/W2130201056","https://openalex.org/W2131572066","https://openalex.org/W2134047171","https://openalex.org/W2138437657","https://openalex.org/W2140606720","https://openalex.org/W2141770639","https://openalex.org/W2144066197","https://openalex.org/W2147656978","https://openalex.org/W2149284057","https://openalex.org/W2154480504","https://openalex.org/W2159308794","https://openalex.org/W2166223265","https://openalex.org/W2168452260","https://openalex.org/W2169333761","https://openalex.org/W2171996376","https://openalex.org/W2172231399","https://openalex.org/W2179335453","https://openalex.org/W2216895152","https://openalex.org/W2465017664","https://openalex.org/W3021675405","https://openalex.org/W3021784366","https://openalex.org/W4211064857","https://openalex.org/W4243727397"],"related_works":["https://openalex.org/W2015184671","https://openalex.org/W4252229392","https://openalex.org/W2072225400","https://openalex.org/W2242062867","https://openalex.org/W1516109204","https://openalex.org/W2522229986","https://openalex.org/W2338637422","https://openalex.org/W2076798058","https://openalex.org/W2059053344","https://openalex.org/W2184069214"],"abstract_inverted_index":{"Ductal":[0],"carcinoma":[1],"in":[2,145,201,204,271],"situ":[3],"(DCIS)":[4],"is":[5,245],"a":[6,69],"heterogeneous":[7],"group":[8],"of":[9,12,20,46,62,66,89,96,109,178,211,217,238,265],"non-invasive":[10],"lesions":[11,148],"the":[13,37,42,56,60,63,86,97,107,123,134,175,198,209,215,236,263],"breast":[14,165],"that":[15,40,74,85,186,228,241],"result":[16],"from":[17,235],"abnormal":[18],"proliferation":[19,91,102,117,128],"mammary":[21,199],"epithelial":[22],"cells.":[23],"Pathologists":[24],"characterize":[25],"DCIS":[26,67],"by":[27,181,247],"four":[28,98],"tissue":[29,212],"morphologies":[30,48,65,99,141,163,177],"(micropapillary,":[31],"cribriform,":[32],"solid,":[33],"and":[34,44,81,92,103,111,118,129,170,240,250,261],"comedo),":[35],"but":[36],"underlying":[38],"mechanisms":[39],"distinguish":[41],"development":[43],"progression":[45,139,216],"these":[47,162],"are":[49,149,195,230],"not":[50,268],"well":[51],"understood.":[52],"Here":[53],"we":[54,207,226],"explored":[55],"conditions":[57],"leading":[58],"to":[59,122,133,173,233],"emergence":[61,108],"different":[64],"using":[68],"two-dimensional":[70],"multi-cell":[71],"lattice-based":[72],"model":[73,157,253],"incorporates":[75],"cell":[76,90,248,259],"proliferation,":[77],"apoptosis,":[78],"necrosis,":[79],"adhesion,":[80],"contractility.":[82,251],"We":[83],"found":[84,227],"relative":[87],"rates":[88],"apoptosis":[93,105,120,131],"governed":[94],"which":[95],"emerged.":[100],"High":[101],"low":[104,116],"favored":[106],"solid":[110],"comedo":[112,171],"morphologies.":[113],"In":[114,219],"contrast,":[115],"high":[119,127,130],"led":[121,132],"micropapillary":[124],"morphology,":[125],"whereas":[126],"cribriform":[135,169],"morphology.":[136],"The":[137],"natural":[138],"between":[140,161],"cannot":[142],"be":[143,174],"investigated":[144],"vivo":[146,202],"since":[147],"usually":[150],"surgically":[151],"removed":[152],"upon":[153],"detection;":[154],"however,":[155],"our":[156,222],"suggests":[158],"probable":[159],"transitions":[160,267],"during":[164],"cancer":[166],"progression.":[167],"Importantly,":[168],"appear":[172],"ultimate":[176],"DCIS.":[179,218],"Motivated":[180],"previous":[182,223],"experimental":[183,224],"studies":[184],"demonstrating":[185],"tumor":[187,258],"cells":[188,229],"behave":[189],"differently":[190],"depending":[191],"on":[192,214],"where":[193],"they":[194],"located":[196],"within":[197],"duct":[200],"or":[203],"engineered":[205],"tissues,":[206],"examined":[208],"effects":[210],"geometry":[213],"agreement":[220],"with":[221],"work,":[225],"more":[231],"likely":[232],"invade":[234],"end":[237],"ducts":[239],"this":[242],"preferential":[243],"invasion":[244],"regulated":[246],"adhesion":[249],"This":[252],"provides":[254],"additional":[255],"insight":[256],"into":[257],"behavior":[260],"allows":[262],"exploration":[264],"phenotypic":[266],"easily":[269],"monitored":[270],"vivo.":[272]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}