{"id":"https://openalex.org/W1988041251","doi":"https://doi.org/10.1371/journal.pcbi.1003993","title":"SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies","display_name":"SteatoNet: The First Integrated Human Metabolic Model with Multi-layered Regulation to Investigate Liver-Associated Pathologies","publication_year":2014,"publication_date":"2014-12-11","ids":{"openalex":"https://openalex.org/W1988041251","doi":"https://doi.org/10.1371/journal.pcbi.1003993","mag":"1988041251","pmid":"https://pubmed.ncbi.nlm.nih.gov/25500563"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003993","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003993","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003993&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003993&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012297491","display_name":"Adviti Naik","orcid":"https://orcid.org/0000-0001-5147-3869"},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Adviti Naik","raw_affiliation_strings":["Faculty of Computer Sciences and Informatics, University of Ljubljana, Ljubljana, Slovenia; Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia","Faculty of Computer Sciences and Informatics, University of Ljubljana, Ljubljana, Slovenia","Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia"],"affiliations":[{"raw_affiliation_string":"Faculty of Computer Sciences and Informatics, University of Ljubljana, Ljubljana, Slovenia; Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]},{"raw_affiliation_string":"Faculty of Computer Sciences and Informatics, University of Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]},{"raw_affiliation_string":"Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018486258","display_name":"Damjana Rozman","orcid":"https://orcid.org/0000-0002-6501-2163"},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Damjana Rozman","raw_affiliation_strings":["Centre for Functional Genomics and Bio-Chips, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"],"affiliations":[{"raw_affiliation_string":"Centre for Functional Genomics and Bio-Chips, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ale\u0161 Beli\u010d","orcid":null},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Ale\u0161 Beli\u010d","raw_affiliation_strings":["Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia"],"affiliations":[{"raw_affiliation_string":"Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012297491"],"corresponding_institution_ids":["https://openalex.org/I153976015"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.6443,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.70297812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"12","first_page":"e1003993","last_page":"e1003993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.793676495552063},{"id":"https://openalex.org/keywords/steatosis","display_name":"Steatosis","score":0.671111524105072},{"id":"https://openalex.org/keywords/fatty-liver","display_name":"Fatty liver","score":0.6359480619430542},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6170043349266052},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4955812692642212},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.4670592248439789},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.40647515654563904},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3289692997932434},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1937054693698883},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1843121349811554},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.16561827063560486},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16404277086257935},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.153530091047287},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13475322723388672},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.1030949056148529}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.793676495552063},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.671111524105072},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6359480619430542},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6170043349266052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4955812692642212},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.4670592248439789},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40647515654563904},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3289692997932434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1937054693698883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1843121349811554},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.16561827063560486},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16404277086257935},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.153530091047287},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13475322723388672},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1030949056148529},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003993","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003993","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003993&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25500563","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25500563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.782.6826","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.782.6826","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/34/ac/pcbi.1003993.PMC4263370.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:87a6dbb2d40b4511b8a89273bcdeb1ec","is_oa":true,"landing_page_url":"https://doaj.org/article/87a6dbb2d40b4511b8a89273bcdeb1ec","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 12, p e1003993 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1268015","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_SteatoNet_The_First_Integrated_Human_Metabolic_Model_with_Multi_layered_Regulation_to_Investigate_Liver_Associated_Pathologies_/1268015","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4263370","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4263370","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003993","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003993","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003993&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1323923008","display_name":null,"funder_award_id":"P1-0104","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G8939856523","display_name":null,"funder_award_id":"J7-4053","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"}],"funders":[{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988041251.pdf","grobid_xml":"https://content.openalex.org/works/W1988041251.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W136063145","https://openalex.org/W230942789","https://openalex.org/W1570155932","https://openalex.org/W1841906170","https://openalex.org/W1963683487","https://openalex.org/W1965367951","https://openalex.org/W1969067437","https://openalex.org/W1971429756","https://openalex.org/W1973866760","https://openalex.org/W1983144305","https://openalex.org/W1985139805","https://openalex.org/W1985592156","https://openalex.org/W1990640778","https://openalex.org/W1995173266","https://openalex.org/W2000233729","https://openalex.org/W2006041438","https://openalex.org/W2006357599","https://openalex.org/W2011437165","https://openalex.org/W2012201311","https://openalex.org/W2014213104","https://openalex.org/W2017511982","https://openalex.org/W2020512565","https://openalex.org/W2021747008","https://openalex.org/W2023512757","https://openalex.org/W2023841187","https://openalex.org/W2024639496","https://openalex.org/W2032919119","https://openalex.org/W2042981158","https://openalex.org/W2049965571","https://openalex.org/W2058668243","https://openalex.org/W2067094344","https://openalex.org/W2075151302","https://openalex.org/W2080269770","https://openalex.org/W2092530793","https://openalex.org/W2093976705","https://openalex.org/W2094253343","https://openalex.org/W2099110406","https://openalex.org/W2103116278","https://openalex.org/W2108629423","https://openalex.org/W2113743121","https://openalex.org/W2114991545","https://openalex.org/W2118728926","https://openalex.org/W2124038922","https://openalex.org/W2128331079","https://openalex.org/W2131256997","https://openalex.org/W2134823147","https://openalex.org/W2138202978","https://openalex.org/W2139318977","https://openalex.org/W2141727688","https://openalex.org/W2144178804","https://openalex.org/W2144275312","https://openalex.org/W2144754434","https://openalex.org/W2156760391","https://openalex.org/W2159043569","https://openalex.org/W2160216804","https://openalex.org/W2161304688","https://openalex.org/W2162236808","https://openalex.org/W2164561653","https://openalex.org/W2170539205","https://openalex.org/W2171088462","https://openalex.org/W2555995017","https://openalex.org/W6602949234"],"related_works":["https://openalex.org/W2994642861","https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2109444927","https://openalex.org/W2101501829","https://openalex.org/W4294123679","https://openalex.org/W2985427592","https://openalex.org/W2003194288","https://openalex.org/W2419316219","https://openalex.org/W2060263731"],"abstract_inverted_index":{"Current":[0],"state-of-the-art":[1],"mathematical":[2],"models":[3,129],"to":[4,42,70,76,135,193],"investigate":[5,43],"complex":[6,199],"biological":[7,138],"processes,":[8],"in":[9,39,61,124,154,190],"particular":[10],"liver-associated":[11],"pathologies,":[12],"have":[13,120],"limited":[14],"expansiveness,":[15],"flexibility,":[16],"representation":[17],"of":[18,26,85,95,116,133,146,167],"integrated":[19],"regulation":[20],"and":[21,38,46,63,92,97,114,127,149,174],"rely":[22],"on":[23,53],"the":[24,32,83,93,107,131,158,164],"availability":[25],"detailed":[27],"kinetic":[28,111],"data.":[29],"We":[30],"generated":[31],"SteatoNet,":[33],"a":[34],"multi-pathway,":[35],"multi-tissue":[36],"model":[37],"silico":[40,191],"platform":[41,192],"hepatic":[44,80,86,162,200],"metabolism":[45,173],"its":[47,175],"associated":[48,197],"deregulations.":[49],"SteatoNet":[50,100,134,140,184],"is":[51],"based":[52],"object-oriented":[54],"modelling,":[55],"an":[56,188],"approach":[57],"most":[58],"commonly":[59],"applied":[60],"automotive":[62],"process":[64],"industries,":[65],"whereby":[66],"individual":[67],"objects":[68],"correspond":[69],"functional":[71],"entities.":[72],"Objects":[73],"were":[74],"compiled":[75],"feature":[77],"two":[78],"novel":[79,181],"modelling":[81],"aspects:":[82],"interaction":[84],"metabolic":[87,201],"pathways":[88],"with":[89,198],"extra-hepatic":[90],"tissues":[91],"inclusion":[94],"transcriptional":[96],"post-transcriptional":[98],"regulation.":[99],"identification":[101,115],"at":[102],"normalised":[103],"steady":[104],"state":[105],"circumvents":[106],"need":[108],"for":[109],"constraining":[110],"parameters.":[112],"Validation":[113],"flux":[117,155],"disturbances":[118],"that":[119],"been":[121],"proven":[122],"experimentally":[123],"liver":[125,160,170],"patients":[126],"animal":[128],"highlights":[130],"ability":[132],"effectively":[136],"describe":[137],"behaviour.":[139],"identifies":[141],"crucial":[142],"pathway":[143],"branches":[144],"(transport":[145],"glucose,":[147],"lipids":[148],"ketone":[150],"bodies)":[151],"where":[152],"changes":[153,196],"distribution":[156],"drive":[157],"healthy":[159],"towards":[161],"steatosis,":[163],"primary":[165],"stage":[166],"non-alcoholic":[168],"fatty":[169],"disease.":[171],"Cholesterol":[172],"transcription":[176],"regulators":[177],"are":[178],"highlighted":[179],"as":[180,187],"steatosis":[182],"factors.":[183],"thus":[185],"serves":[186],"intuitive":[189],"identify":[194],"systemic":[195],"disorders.":[202]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
