{"id":"https://openalex.org/W2010020189","doi":"https://doi.org/10.1371/journal.pcbi.1003984","title":"Dissecting Dynamic Genetic Variation That Controls Temporal Gene Response in Yeast","display_name":"Dissecting Dynamic Genetic Variation That Controls Temporal Gene Response in Yeast","publication_year":2014,"publication_date":"2014-12-04","ids":{"openalex":"https://openalex.org/W2010020189","doi":"https://doi.org/10.1371/journal.pcbi.1003984","mag":"2010020189","pmid":"https://pubmed.ncbi.nlm.nih.gov/25474467"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003984","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003984","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003984&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003984&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051197037","display_name":"Avital Brodt","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Avital Brodt","raw_affiliation_strings":["Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel","Department of Cell Research and Immunology Tel-Aviv University Tel-Aviv  Israel"],"affiliations":[{"raw_affiliation_string":"Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Cell Research and Immunology Tel-Aviv University Tel-Aviv  Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069112323","display_name":"Maya Botzman","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Maya Botzman","raw_affiliation_strings":["Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel","Department of Cell Research and Immunology Tel-Aviv University Tel-Aviv  Israel"],"affiliations":[{"raw_affiliation_string":"Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Cell Research and Immunology Tel-Aviv University Tel-Aviv  Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030630152","display_name":"Eyal David","orcid":"https://orcid.org/0000-0002-9020-2364"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Eyal David","raw_affiliation_strings":["Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel","Department of Cell Research and Immunology Tel-Aviv University Tel-Aviv  Israel"],"affiliations":[{"raw_affiliation_string":"Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Cell Research and Immunology Tel-Aviv University Tel-Aviv  Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016870908","display_name":"Irit Gat\u2010Viks","orcid":"https://orcid.org/0000-0002-5431-6444"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Irit Gat-Viks","raw_affiliation_strings":["Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel","Department of Cell Research and Immunology Tel-Aviv University Tel-Aviv  Israel"],"affiliations":[{"raw_affiliation_string":"Department of Cell Research and Immunology, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Cell Research and Immunology Tel-Aviv University Tel-Aviv  Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5016870908"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.07270786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"10","issue":"12","first_page":"e1003984","last_page":"e1003984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-variation","display_name":"Genetic variation","score":0.7049450874328613},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.657032310962677},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6054962873458862},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5773143172264099},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4840182960033417},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.46493691205978394},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.43168386816978455},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.4272051155567169}],"concepts":[{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.7049450874328613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.657032310962677},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6054962873458862},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5773143172264099},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4840182960033417},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.46493691205978394},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.43168386816978455},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4272051155567169}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003984","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003984","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003984&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25474467","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25474467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.7454","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.7454","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/0e/2d/pcbi.1003984.PMC4256076.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003984","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003984","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c861759bc24a47afa9e9f0c8432d1907","is_oa":true,"landing_page_url":"https://doaj.org/article/c861759bc24a47afa9e9f0c8432d1907","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 12, p e1003984 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1259977","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Dissecting_Dynamic_Genetic_Variation_That_Controls_Temporal_Gene_Response_in_Yeast_/1259977","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4256076","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4256076","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003984","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003984","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003984&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1699706384","display_name":null,"funder_award_id":"I-CORE","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G4791905715","display_name":null,"funder_award_id":"41/11","funder_id":"https://openalex.org/F4320335016","funder_display_name":"Israeli Centers for Research Excellence"},{"id":"https://openalex.org/G6967680648","display_name":null,"funder_award_id":"41/11","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"},{"id":"https://openalex.org/F4320335016","display_name":"Israeli Centers for Research Excellence","ror":"https://ror.org/03w2v9593"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2010020189.pdf","grobid_xml":"https://content.openalex.org/works/W2010020189.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1835754911","https://openalex.org/W1944381374","https://openalex.org/W1963554221","https://openalex.org/W1970390603","https://openalex.org/W1970964234","https://openalex.org/W1996184324","https://openalex.org/W1996952375","https://openalex.org/W2000186580","https://openalex.org/W2007268871","https://openalex.org/W2011677751","https://openalex.org/W2019312328","https://openalex.org/W2024052061","https://openalex.org/W2034162523","https://openalex.org/W2034541289","https://openalex.org/W2038225430","https://openalex.org/W2048244826","https://openalex.org/W2053126761","https://openalex.org/W2058454627","https://openalex.org/W2060384181","https://openalex.org/W2062018774","https://openalex.org/W2070302210","https://openalex.org/W2083380010","https://openalex.org/W2086699924","https://openalex.org/W2094248448","https://openalex.org/W2100707780","https://openalex.org/W2114548349","https://openalex.org/W2116901181","https://openalex.org/W2117007075","https://openalex.org/W2126415488","https://openalex.org/W2141711435","https://openalex.org/W2149640531","https://openalex.org/W2149681218","https://openalex.org/W2167120442","https://openalex.org/W2171863224","https://openalex.org/W2171915236"],"related_works":["https://openalex.org/W4315558101","https://openalex.org/W3200271510","https://openalex.org/W63366483","https://openalex.org/W1516770101","https://openalex.org/W1897466773","https://openalex.org/W2357011584","https://openalex.org/W4380882399","https://openalex.org/W2623087137","https://openalex.org/W3005242175","https://openalex.org/W2115260093"],"abstract_inverted_index":{"Inter-individual":[0],"variation":[1,173,194],"in":[2,59,75,125,152,174,201,220],"regulatory":[3],"circuits":[4],"controlling":[5],"gene":[6,23,85],"expression":[7,24],"is":[8],"a":[9,52,81,98,112,131,135,159,163,202,207],"powerful":[10],"source":[11],"of":[12,17,47,70,84,88,108,147,162,180],"functional":[13],"information.":[14],"The":[15,104],"study":[16],"associations":[18],"among":[19],"genetic":[20,42,60,94,101,106,123,148,164,198,209],"variants":[21,38],"and":[22,35,62,96,195],"provides":[25,206],"important":[26],"insights":[27],"about":[28],"cell":[29],"circuitry":[30],"but":[31],"cannot":[32],"specify":[33],"whether":[34],"when":[36],"potential":[37],"dynamically":[39],"alter":[40],"their":[41],"effect":[43,102,165,199],"during":[44,68],"the":[45,71,92,126,153,175,186,196,213],"course":[46],"response.":[48,181],"Here":[49],"we":[50],"develop":[51],"computational":[53],"procedure":[54],"that":[55,185,216],"captures":[56],"temporal":[57,100,105,197],"changes":[58,219],"effects,":[61],"apply":[63],"it":[64],"to":[65,134,191,211],"analyze":[66],"transcription":[67],"inhibition":[69],"TOR":[72],"signaling":[73],"pathway":[74],"segregating":[76],"yeast":[77],"cells.":[78],"We":[79],"found":[80],"high-order":[82],"coordination":[83],"modules:":[86],"sets":[87],"genes":[89],"co-associated":[90],"with":[91],"same":[93,187],"variant":[95],"sharing":[97],"common":[99],"pattern.":[103],"effects":[107,124],"some":[109],"modules":[110],"represented":[111],"single":[113],"state-transitioning":[114],"pattern;":[115],"for":[116,150],"example,":[117,151],"at":[118,166],"10-30":[119],"minutes":[120,168],"following":[121,169],"stimulation,":[122],"phosphate":[127],"utilization":[128,157],"module":[129,142],"attained":[130],"characteristic":[132],"transition":[133],"new":[136],"steady":[137],"state.":[138],"In":[139],"contrast,":[140],"another":[141],"showed":[143],"an":[144],"impulse":[145],"pattern":[146,200],"effects;":[149],"poor":[154],"nitrogen":[155],"sources":[156],"module,":[158],"spike":[160],"up":[161],"10-20":[167],"stimulation":[170],"reflected":[171],"inter-individual":[172,193],"timing":[176],"(rather":[177],"than":[178],"magnitude)":[179],"Our":[182,204],"analysis":[183],"suggests":[184],"mechanism":[188],"typically":[189],"leads":[190],"both":[192],"module.":[203],"methodology":[205],"quantitative":[208],"approach":[210],"studying":[212],"molecular":[214],"mechanisms":[215],"shape":[217],"dynamic":[218],"transcriptional":[221],"responses.":[222]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
