{"id":"https://openalex.org/W2144666467","doi":"https://doi.org/10.1371/journal.pcbi.1003965","title":"Modulation of Elementary Calcium Release Mediates a Transition from Puffs to Waves in an IP3R Cluster Model","display_name":"Modulation of Elementary Calcium Release Mediates a Transition from Puffs to Waves in an IP3R Cluster Model","publication_year":2015,"publication_date":"2015-01-08","ids":{"openalex":"https://openalex.org/W2144666467","doi":"https://doi.org/10.1371/journal.pcbi.1003965","mag":"2144666467","pmid":"https://pubmed.ncbi.nlm.nih.gov/25569772"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003965","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003965","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003965&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003965&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057916418","display_name":"Martin R\u00fcckl","orcid":null},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin R\u00fcckl","raw_affiliation_strings":["Institut f\u00fcr Physik, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Institut f\u00fcr Physik, Humboldt- Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Physik, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Institut f\u00fcr Physik, Humboldt- Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103229536","display_name":"Ian Parker","orcid":"https://orcid.org/0000-0001-8734-4081"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian Parker","raw_affiliation_strings":["Departments of Neurobiology and Behavior, Physiology and Biophysics, University of California, Irvine, Irvine, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurobiology and Behavior, Physiology and Biophysics, University of California, Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047013622","display_name":"Jonathan S. Marchant","orcid":"https://orcid.org/0000-0001-6592-0877"},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S. Marchant","raw_affiliation_strings":["Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, United States of America","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103472599","display_name":"Chamakuri Nagaiah","orcid":null},"institutions":[{"id":"https://openalex.org/I138211613","display_name":"Austrian Academy of Sciences","ror":"https://ror.org/03anc3s24","country_code":"AT","type":"funder","lineage":["https://openalex.org/I138211613"]},{"id":"https://openalex.org/I4210158379","display_name":"Johann Radon Institute for Computational and Applied Mathematics","ror":"https://ror.org/05a94k872","country_code":"AT","type":"facility","lineage":["https://openalex.org/I138211613","https://openalex.org/I4210158379"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Chamakuri Nagaiah","raw_affiliation_strings":["Johann Radon Institute for Computational and Applied Mathematics, Austrian Academy of Sciences, Linz, Austria","Johann Radon Institute for Computational and Applied Mathematics, Austrian Academy of Sciences, Linz, Austria#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johann Radon Institute for Computational and Applied Mathematics, Austrian Academy of Sciences, Linz, Austria","institution_ids":["https://openalex.org/I4210158379","https://openalex.org/I138211613"]},{"raw_affiliation_string":"Johann Radon Institute for Computational and Applied Mathematics, Austrian Academy of Sciences, Linz, Austria#TAB#","institution_ids":["https://openalex.org/I138211613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091059976","display_name":"Friedrich W. Johenning","orcid":"https://orcid.org/0000-0001-9349-4473"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friedrich W. Johenning","raw_affiliation_strings":["Neuroscience Research Center, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","Neuroscience Research Center, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroscience Research Center, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"Neuroscience Research Center, Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104362413","display_name":"Sten R\u00fcdiger","orcid":null},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sten R\u00fcdiger","raw_affiliation_strings":["Institut f\u00fcr Physik, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","Institut f\u00fcr Physik, Humboldt- Universit\u00e4t zu Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Physik, Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]},{"raw_affiliation_string":"Institut f\u00fcr Physik, Humboldt- Universit\u00e4t zu Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I39343248"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5104362413"],"corresponding_institution_ids":["https://openalex.org/I39343248"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.9558,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.91618541,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"e1003965","last_page":"e1003965"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9876999855041504,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gating","display_name":"Gating","score":0.6436012387275696},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.635068416595459},{"id":"https://openalex.org/keywords/coupling","display_name":"Coupling (piping)","score":0.577588677406311},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.5518539547920227},{"id":"https://openalex.org/keywords/modulation","display_name":"Modulation (music)","score":0.5275161862373352},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4692516326904297},{"id":"https://openalex.org/keywords/cluster","display_name":"Cluster (spacecraft)","score":0.44655999541282654},{"id":"https://openalex.org/keywords/inositol-trisphosphate","display_name":"Inositol trisphosphate","score":0.4172388017177582},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33986401557922363},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3296721577644348},{"id":"https://openalex.org/keywords/inositol","display_name":"Inositol","score":0.3191191256046295},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22853761911392212},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.2023797631263733},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.14446812868118286},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1198190450668335},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08187153935432434},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.07878455519676208}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.6436012387275696},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.635068416595459},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.577588677406311},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.5518539547920227},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.5275161862373352},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4692516326904297},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.44655999541282654},{"id":"https://openalex.org/C2781387506","wikidata":"https://www.wikidata.org/wiki/Q138145","display_name":"Inositol trisphosphate","level":4,"score":0.4172388017177582},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33986401557922363},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3296721577644348},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.3191191256046295},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22853761911392212},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2023797631263733},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14446812868118286},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1198190450668335},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08187153935432434},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.07878455519676208},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003965","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003965","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003965&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25569772","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25569772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1003965","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003965","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:183cf56ee3e94910857c49c4edd029b4","is_oa":true,"landing_page_url":"https://doaj.org/article/183cf56ee3e94910857c49c4edd029b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 1, p e1003965 (2015)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt9936m8f2","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9936m8f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 11, iss 1","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4288706","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4288706","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:refubium.fu-berlin.de:fub188/17549","is_oa":true,"landing_page_url":"https://refubium.fu-berlin.de/handle/fub188/17549","pdf_url":null,"source":{"id":"https://openalex.org/S4306402444","display_name":"Refubium (Universit\u00e4tsbibliothek der Freien Universit\u00e4t Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I75951250","host_organization_name":"Freie Universit\u00e4t Berlin","host_organization_lineage":["https://openalex.org/I75951250"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Wissenschaftlicher Artikel"},{"id":"doi:10.17169/refubium-21433","is_oa":true,"landing_page_url":"https://doi.org/10.17169/refubium-21433","pdf_url":null,"source":{"id":"https://openalex.org/S7407052913","display_name":"Universit\u00e4tsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003965","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003965","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003965&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G158468807","display_name":null,"funder_award_id":"R37 GM048071","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4572893079","display_name":null,"funder_award_id":"R01 GM088790","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5164286717","display_name":null,"funder_award_id":"GM048071","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5602471134","display_name":null,"funder_award_id":"GM048071","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G739186463","display_name":null,"funder_award_id":"R01 GM048071","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8713993438","display_name":null,"funder_award_id":"IRTG 1740","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144666467.pdf","grobid_xml":"https://content.openalex.org/works/W2144666467.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W147326039","https://openalex.org/W950991549","https://openalex.org/W1518120013","https://openalex.org/W1530464904","https://openalex.org/W1599277155","https://openalex.org/W1650401181","https://openalex.org/W1970693441","https://openalex.org/W1973040508","https://openalex.org/W1986876467","https://openalex.org/W1990153078","https://openalex.org/W1991002565","https://openalex.org/W1991424184","https://openalex.org/W1997778815","https://openalex.org/W1998052338","https://openalex.org/W1998143771","https://openalex.org/W2003197964","https://openalex.org/W2011619431","https://openalex.org/W2017843168","https://openalex.org/W2021984772","https://openalex.org/W2034310820","https://openalex.org/W2037231034","https://openalex.org/W2037321354","https://openalex.org/W2047338488","https://openalex.org/W2051435374","https://openalex.org/W2056087726","https://openalex.org/W2061163650","https://openalex.org/W2063993145","https://openalex.org/W2065099255","https://openalex.org/W2067144876","https://openalex.org/W2068066123","https://openalex.org/W2072129783","https://openalex.org/W2075447040","https://openalex.org/W2085964566","https://openalex.org/W2093582209","https://openalex.org/W2095213718","https://openalex.org/W2096199252","https://openalex.org/W2096513562","https://openalex.org/W2102635728","https://openalex.org/W2106279167","https://openalex.org/W2108411628","https://openalex.org/W2122025785","https://openalex.org/W2126917206","https://openalex.org/W2128513164","https://openalex.org/W2133461732","https://openalex.org/W2147823849","https://openalex.org/W2148131152","https://openalex.org/W2150792480","https://openalex.org/W2150942343","https://openalex.org/W2151839418","https://openalex.org/W2152888284","https://openalex.org/W2153535183","https://openalex.org/W2160452160","https://openalex.org/W2168230449","https://openalex.org/W2170006809","https://openalex.org/W2171437709","https://openalex.org/W2334027583","https://openalex.org/W2337073629","https://openalex.org/W2400922497","https://openalex.org/W2496288020","https://openalex.org/W2612743911","https://openalex.org/W4211132321"],"related_works":["https://openalex.org/W2063903820","https://openalex.org/W2064525306","https://openalex.org/W2004075277","https://openalex.org/W2074993713","https://openalex.org/W2401644871","https://openalex.org/W2000588255","https://openalex.org/W2071584448","https://openalex.org/W1973264426","https://openalex.org/W172917184","https://openalex.org/W2199396374"],"abstract_inverted_index":{"The":[0],"oscillating":[1],"concentration":[2],"of":[3,8,21,25,50,55,63,72,96,120,143,163],"intracellular":[4],"calcium":[5,22,34,39],"is":[6,57,132],"one":[7],"the":[9,47,61,112,147,178],"most":[10],"important":[11],"examples":[12],"for":[13],"collective":[14],"dynamics":[15],"in":[16],"cell":[17],"biology.":[18],"Localized":[19],"releases":[20,43,125],"through":[23],"clusters":[24],"inositol":[26],"1,4,5-trisphosphate":[27],"receptor":[28],"channels":[29,74],"constitute":[30],"elementary":[31],"signals":[32],"called":[33],"puffs.":[35,129],"Coupling":[36],"by":[37,157],"diffusing":[38],"leads":[40],"to":[41,102,172],"global":[42],"and":[44,53,65,86,105,141,174],"waves,":[45,66],"but":[46,99,160],"exact":[48],"mechanism":[49],"inter-cluster":[51],"coupling":[52],"triggering":[54],"waves":[56,154],"unknown.":[58],"To":[59],"elucidate":[60],"relation":[62],"puffs":[64,91],"we":[67,137],"here":[68],"model":[69],"a":[70,76,118,158,169],"cluster":[71],"IP3R":[73],"using":[75],"gating":[77],"scheme":[78],"with":[79,122,127,134],"variable":[80],"non-equilibrium":[81],"IP3":[82,110],"binding.":[83],"Hybrid":[84],"stochastic":[85],"deterministic":[87],"simulations":[88],"show":[89],"that":[90,153],"are":[92,100,155],"not":[93],"stereotyped":[94],"events":[95,114],"constant":[97],"duration":[98],"sensitive":[101],"stimulation":[103],"strength":[104],"residual":[106],"calcium.":[107],"For":[108],"increasing":[109],"concentration,":[111],"release":[113,165],"become":[115],"modulated":[116],"at":[117],"timescale":[119],"minutes,":[121],"repetitive":[123],"wave-like":[124],"interspersed":[126],"several":[128],"This":[130],"modulation":[131],"consistent":[133],"experimental":[135],"observations":[136],"present,":[138],"including":[139],"refractoriness":[140],"increase":[142],"puff":[144],"frequency":[145],"during":[146],"inter-wave":[148],"interval.":[149],"Our":[150],"results":[151],"suggest":[152],"established":[156],"random":[159],"time-modulated":[161],"appearance":[162],"sustained":[164],"events,":[166],"which":[167],"have":[168],"high":[170],"potential":[171],"trigger":[173],"synchronize":[175],"activity":[176],"throughout":[177],"cell.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
