{"id":"https://openalex.org/W2037072074","doi":"https://doi.org/10.1371/journal.pcbi.1003957","title":"Live Imaging-Based Model Selection Reveals Periodic Regulation of the Stochastic G1/S Phase Transition in Vertebrate Axial Development","display_name":"Live Imaging-Based Model Selection Reveals Periodic Regulation of the Stochastic G1/S Phase Transition in Vertebrate Axial Development","publication_year":2014,"publication_date":"2014-12-04","ids":{"openalex":"https://openalex.org/W2037072074","doi":"https://doi.org/10.1371/journal.pcbi.1003957","mag":"2037072074","pmid":"https://pubmed.ncbi.nlm.nih.gov/25474567"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003957","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003957","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003957&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003957&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081718599","display_name":"Mayu Sugiyama","orcid":null},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mayu Sugiyama","raw_affiliation_strings":["Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan"],"affiliations":[{"raw_affiliation_string":"Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000535326","display_name":"Takashi Saitou","orcid":"https://orcid.org/0000-0003-0532-8112"},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Saitou","raw_affiliation_strings":["Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-city, Ehime, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-city, Ehime, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103630411","display_name":"Hiroshi Kurokawa","orcid":null},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kurokawa","raw_affiliation_strings":["Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan"],"affiliations":[{"raw_affiliation_string":"Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022938409","display_name":"Asako Sakaue\u2010Sawano","orcid":"https://orcid.org/0000-0002-6975-0390"},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Asako Sakaue-Sawano","raw_affiliation_strings":["Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan"],"affiliations":[{"raw_affiliation_string":"Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101774377","display_name":"Takeshi Imamura","orcid":"https://orcid.org/0000-0001-5101-4304"},"institutions":[{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]},{"id":"https://openalex.org/I4210110672","display_name":"Ehime University Hospital","ror":"https://ror.org/01vpa9c32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210110672"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takeshi Imamura","raw_affiliation_strings":["Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-city, Ehime, Japan; Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan; Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan","Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan","Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-city, Ehime, Japan","Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-city, Ehime, Japan; Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan; Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan","institution_ids":[]},{"raw_affiliation_string":"Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan","institution_ids":["https://openalex.org/I43545212","https://openalex.org/I4210110672"]},{"raw_affiliation_string":"Department of Molecular Medicine for Pathogenesis, Graduate School of Medicine, Ehime University, Shitsukawa, Toon-city, Ehime, Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan","institution_ids":["https://openalex.org/I43545212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005075596","display_name":"Atsushi Miyawaki","orcid":"https://orcid.org/0000-0002-0671-4376"},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Miyawaki","raw_affiliation_strings":["Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan"],"affiliations":[{"raw_affiliation_string":"Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077363607","display_name":"Tadahiro Iimura","orcid":"https://orcid.org/0000-0002-1431-0689"},"institutions":[{"id":"https://openalex.org/I2800939219","display_name":"RIKEN Center for Brain Science","ror":"https://ror.org/04j1n1c04","country_code":"JP","type":"facility","lineage":["https://openalex.org/I2800939219","https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I4210110672","display_name":"Ehime University Hospital","ror":"https://ror.org/01vpa9c32","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210110672"]},{"id":"https://openalex.org/I43545212","display_name":"Ehime University","ror":"https://ror.org/017hkng22","country_code":"JP","type":"education","lineage":["https://openalex.org/I43545212"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tadahiro Iimura","raw_affiliation_strings":["Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan; Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan; Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan","Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan","Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan","Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan"],"affiliations":[{"raw_affiliation_string":"Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan; Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan; Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan","institution_ids":[]},{"raw_affiliation_string":"Division of Bio-Imaging, Proteo-Science Center (PROS), Ehime University, Shitsukawa, Toon-city, Ehime, Japan","institution_ids":["https://openalex.org/I43545212"]},{"raw_affiliation_string":"Laboratory for Cell Function and Dynamics, Advanced Technology Development Group, Brain Science Institute, RIKEN, Wako-city, Saitama, Japan","institution_ids":["https://openalex.org/I2800939219"]},{"raw_affiliation_string":"Translational Research Center, Ehime University Hospital, Shitsukawa, Toon-city, Ehime, Japan","institution_ids":["https://openalex.org/I43545212","https://openalex.org/I4210110672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5005075596","https://openalex.org/A5077363607","https://openalex.org/A5101774377"],"corresponding_institution_ids":["https://openalex.org/I2800939219","https://openalex.org/I4210110672","https://openalex.org/I43545212"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2809,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.79067233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"12","first_page":"e1003957","last_page":"e1003957"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6391861438751221},{"id":"https://openalex.org/keywords/notochord","display_name":"Notochord","score":0.6299224495887756},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.5973450541496277},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47304195165634155},{"id":"https://openalex.org/keywords/zebrafish","display_name":"Zebrafish","score":0.462605357170105},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.46044763922691345},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"Live cell imaging","score":0.4558391273021698},{"id":"https://openalex.org/keywords/transition","display_name":"Transition (genetics)","score":0.4221126139163971},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.39290857315063477},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3086817264556885},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.28203532099723816},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20378392934799194},{"id":"https://openalex.org/keywords/embryo","display_name":"Embryo","score":0.17780905961990356},{"id":"https://openalex.org/keywords/embryogenesis","display_name":"Embryogenesis","score":0.13723763823509216},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10440817475318909}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6391861438751221},{"id":"https://openalex.org/C2776133846","wikidata":"https://www.wikidata.org/wiki/Q243469","display_name":"Notochord","level":4,"score":0.6299224495887756},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.5973450541496277},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47304195165634155},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.462605357170105},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.46044763922691345},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.4558391273021698},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.4221126139163971},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39290857315063477},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3086817264556885},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28203532099723816},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20378392934799194},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.17780905961990356},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.13723763823509216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10440817475318909},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003957","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003957","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003957&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25474567","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25474567","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1003957","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003957","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:487e8814582240289f76001fc947dc0e","is_oa":true,"landing_page_url":"https://doaj.org/article/487e8814582240289f76001fc947dc0e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 12, p e1003957 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1261105","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Live_Imaging_Based_Model_Selection_Reveals_Periodic_Regulation_of_the_Stochastic_G1_S_Phase_Transition_in_Vertebrate_Axial_Development_/1261105","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4256085","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4256085","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003957","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003957","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003957&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.5600000023841858,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G12401395","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G1874785657","display_name":"\u300c\u52b4\u50cd\u306e\u5f93\u5c5e\u6027\u300d\u7406\u8ad6\u306e\u518d\u691c\u8a0e","funder_award_id":"21130","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2920681495","display_name":null,"funder_award_id":"(CREST)","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G2966587221","display_name":null,"funder_award_id":"No. 22113002","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G2983449479","display_name":null,"funder_award_id":"Scientific Research","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3236194794","display_name":null,"funder_award_id":"Grant-in-Aid","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3459562248","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3857676562","display_name":null,"funder_award_id":"Grant-in-Aid for Scientific Research on Innovative","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4874944895","display_name":null,"funder_award_id":"-in-Aid","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5256887504","display_name":null,"funder_award_id":"Japan Society for the Promotion of Science (JSPS)","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5755530080","display_name":null,"funder_award_id":"Scientific Research on Innovative A","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5934877227","display_name":null,"funder_award_id":"Innovative Areas","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6267471473","display_name":null,"funder_award_id":"Grant-in-Aid","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G6718509927","display_name":null,"funder_award_id":"CREST","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7167128334","display_name":null,"funder_award_id":"Grant-in-Aid for Scientific Researc","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7337825077","display_name":null,"funder_award_id":"Grant-in-Aid for Sc","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7392006656","display_name":null,"funder_award_id":"22113002","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7567012397","display_name":null,"funder_award_id":"a Grant-in-Aid for Scientific Research on Innovati","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7599130655","display_name":null,"funder_award_id":"Grant","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7634616218","display_name":"\u5317\u6d77\u9053\u6771\u5317\u90e8\u306b\u304a\u3051\u308b\u7e04\u6587\u6587\u5316\u306e\u7de8\u5e74\u7684\u7814\u7a76","funder_award_id":"13002","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7693551792","display_name":null,"funder_award_id":"(MEXT)","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7748302082","display_name":null,"funder_award_id":"Scientific Research on Innovative Areas","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7752643416","display_name":null,"funder_award_id":"Japan","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7879866177","display_name":null,"funder_award_id":"CREST","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G8044579487","display_name":null,"funder_award_id":"Japan","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G8759943101","display_name":null,"funder_award_id":"rant-in-Aid for Scientific Research","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G987876312","display_name":null,"funder_award_id":"22113002","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037072074.pdf","grobid_xml":"https://content.openalex.org/works/W2037072074.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W1503636374","https://openalex.org/W1509581155","https://openalex.org/W1552592481","https://openalex.org/W1738124305","https://openalex.org/W1955498245","https://openalex.org/W1965555277","https://openalex.org/W1966181655","https://openalex.org/W1968357038","https://openalex.org/W1971353366","https://openalex.org/W1973131736","https://openalex.org/W1979739874","https://openalex.org/W1980845430","https://openalex.org/W1983596214","https://openalex.org/W1989830594","https://openalex.org/W1991216151","https://openalex.org/W1991339772","https://openalex.org/W1994117507","https://openalex.org/W1996435746","https://openalex.org/W1999777663","https://openalex.org/W2012986637","https://openalex.org/W2022731947","https://openalex.org/W2026211608","https://openalex.org/W2027071190","https://openalex.org/W2033797505","https://openalex.org/W2043807089","https://openalex.org/W2044692345","https://openalex.org/W2044852019","https://openalex.org/W2053019692","https://openalex.org/W2053825702","https://openalex.org/W2059053384","https://openalex.org/W2065782380","https://openalex.org/W2077505983","https://openalex.org/W2078140686","https://openalex.org/W2078689192","https://openalex.org/W2083573714","https://openalex.org/W2089743009","https://openalex.org/W2091198609","https://openalex.org/W2091445050","https://openalex.org/W2097706279","https://openalex.org/W2099878990","https://openalex.org/W2102787760","https://openalex.org/W2105057212","https://openalex.org/W2105176031","https://openalex.org/W2106803522","https://openalex.org/W2109067263","https://openalex.org/W2125607576","https://openalex.org/W2126452184","https://openalex.org/W2128103940","https://openalex.org/W2129260097","https://openalex.org/W2131655260","https://openalex.org/W2134358521","https://openalex.org/W2136977672","https://openalex.org/W2140300773","https://openalex.org/W2143592315","https://openalex.org/W2146198038","https://openalex.org/W2146227053","https://openalex.org/W2152293062","https://openalex.org/W2155707987","https://openalex.org/W2158469604","https://openalex.org/W2169129330","https://openalex.org/W2171280873","https://openalex.org/W2171327609","https://openalex.org/W2177489649","https://openalex.org/W2361838659","https://openalex.org/W3022585649","https://openalex.org/W4211017114","https://openalex.org/W4253283596"],"related_works":["https://openalex.org/W1829204658","https://openalex.org/W2462989114","https://openalex.org/W4289528651","https://openalex.org/W2013879043","https://openalex.org/W2144817739","https://openalex.org/W2021927618","https://openalex.org/W2039682539","https://openalex.org/W2017320319","https://openalex.org/W3134091640","https://openalex.org/W2784692733"],"abstract_inverted_index":{"In":[0],"multicellular":[1],"organism":[2],"development,":[3],"a":[4,12,35,47,55,66,82,120,138,144,148,192,207,219,228,233,265],"stochastic":[5,49,145,255],"cellular":[6,32],"response":[7],"is":[8,16,34,46],"observed,":[9],"even":[10],"when":[11],"population":[13,150,174],"of":[14,54,70,80,98,151,175,187,195,198,206,212,222,272,286],"cells":[15,93,118,155,165],"exposed":[17],"to":[18,64,113,126],"the":[19,24,30,95,99,103,109,178,196,199,204,213,238,242,247,254,260,270,273,284,287],"same":[20],"environmental":[21],"conditions.":[22],"Retrieving":[23],"spatiotemporal":[25],"regulatory":[26,68,210,224],"mode":[27,69],"hidden":[28,67],"in":[29,42,74,108,137,259,264],"heterogeneous":[31],"behavior":[33],"challenging":[36],"task.":[37],"The":[38],"G1/S":[39,129,132,179,200,214,256],"transition":[40,133,180,215,257],"observed":[41],"cell":[43,57,71],"cycle":[44,58,72],"progression":[45,73],"highly":[48],"process.":[50],"By":[51],"taking":[52],"advantage":[53],"fluorescence":[56,106,121],"indicator,":[59],"Fucci":[60],"technology,":[61],"we":[62,226],"aimed":[63],"unveil":[65],"developing":[75,110],"zebrafish.":[76],"Fluorescence":[77],"live":[78,188],"imaging":[79,189],"Cecyil,":[81],"zebrafish":[83],"line":[84],"genetically":[85],"expressing":[86],"Fucci,":[87],"demonstrated":[88,203,252],"that":[89,253],"newly":[90,160],"formed":[91,161],"notochordal":[92,164,176],"from":[94,124,241,246],"posterior":[96],"tip":[97],"embryonic":[100],"mesoderm":[101,276],"exhibited":[102,143],"red":[104,125,152,162],"(G1)":[105,163],"signal":[107],"notochord.":[111],"Prior":[112],"their":[114],"initial":[115],"vacuolation,":[116],"these":[117],"showed":[119],"color":[122],"switch":[123],"green,":[127],"indicating":[128],"transitions.":[130],"This":[131,278],"did":[134],"not":[135],"occur":[136],"synchronous":[139],"manner,":[140],"but":[141],"rather":[142],"process,":[146],"since":[147],"mixed":[149,173],"and":[153,166,191,231],"green":[154,168],"was":[156],"always":[157],"inserted":[158],"between":[159],"vacuolating":[167],"cells.":[169],"We":[170,182],"termed":[171],"this":[172,223],"cells,":[177],"window.":[181,216],"first":[183],"performed":[184,232],"quantitative":[185],"analyses":[186,251],"data":[190],"numerical":[193],"estimation":[194],"probability":[197],"transition,":[201],"which":[202],"existence":[205],"posteriorly":[208,263],"traveling":[209],"wave":[211],"To":[217],"obtain":[218],"better":[220],"understanding":[221],"mode,":[225],"constructed":[227],"mathematical":[229],"model":[230,234],"selection":[235],"by":[236],"comparing":[237],"results":[239],"obtained":[240],"models":[243],"with":[244,268],"those":[245],"experimental":[248],"data.":[249],"Our":[250],"window":[258],"notochord":[261],"travels":[262],"periodic":[266],"fashion,":[267],"doubled":[269],"periodicity":[271],"neighboring":[274],"paraxial":[275],"segmentation.":[277],"approach":[279],"may":[280],"have":[281],"implications":[282],"for":[283],"characterization":[285],"pathophysiological":[288],"tissue":[289],"growth":[290],"mode.":[291]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
