{"id":"https://openalex.org/W2151233921","doi":"https://doi.org/10.1371/journal.pcbi.1003935","title":"Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin","display_name":"Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin","publication_year":2014,"publication_date":"2014-11-06","ids":{"openalex":"https://openalex.org/W2151233921","doi":"https://doi.org/10.1371/journal.pcbi.1003935","mag":"2151233921","pmid":"https://pubmed.ncbi.nlm.nih.gov/25375667"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003935","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003935","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003935&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003935&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065641764","display_name":"Thomas R. Caulfield","orcid":"https://orcid.org/0000-0002-1055-3069"},"institutions":[{"id":"https://openalex.org/I2801572250","display_name":"Jacksonville College","ror":"https://ror.org/03a9t7g49","country_code":"US","type":"education","lineage":["https://openalex.org/I2801572250"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas R. Caulfield","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I2801572250","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047826493","display_name":"Fabienne C. Fiesel","orcid":"https://orcid.org/0000-0002-1919-9676"},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I2801572250","display_name":"Jacksonville College","ror":"https://ror.org/03a9t7g49","country_code":"US","type":"education","lineage":["https://openalex.org/I2801572250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fabienne C. Fiesel","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I2801572250","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037545837","display_name":"Elisabeth L. Moussaud-Lamodi\u00e8re","orcid":null},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I2801572250","display_name":"Jacksonville College","ror":"https://ror.org/03a9t7g49","country_code":"US","type":"education","lineage":["https://openalex.org/I2801572250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabeth L. Moussaud-Lamodi\u00e8re","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I2801572250","https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054958411","display_name":"Daniel F. A. R. Dourado","orcid":"https://orcid.org/0000-0001-7977-6722"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Daniel F. A. R. Dourado","raw_affiliation_strings":["Department of Cell & Molecular Biology, Computational & Systems Biology, Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Cell & Molecular Biology, Computational & Systems Biology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087934243","display_name":"Samuel Coulbourn Flores","orcid":"https://orcid.org/0000-0002-3869-8147"},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Samuel C. Flores","raw_affiliation_strings":["Department of Cell & Molecular Biology, Computational & Systems Biology, Uppsala University, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Cell & Molecular Biology, Computational & Systems Biology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083674000","display_name":"Wolfdieter Springer","orcid":"https://orcid.org/0000-0002-1178-3149"},"institutions":[{"id":"https://openalex.org/I2801572250","display_name":"Jacksonville College","ror":"https://ror.org/03a9t7g49","country_code":"US","type":"education","lineage":["https://openalex.org/I2801572250"]},{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wolfdieter Springer","raw_affiliation_strings":["Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America; Mayo Graduate School, Neurobiology of Disease, Mayo Clinic, Jacksonville, Florida, United States of America","Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America","Mayo Graduate School, Neurobiology of Disease, Mayo Clinic, Jacksonville, Florida, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America; Mayo Graduate School, Neurobiology of Disease, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Neuroscience, Mayo Clinic Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I2801572250","https://openalex.org/I4210146710"]},{"raw_affiliation_string":"Mayo Graduate School, Neurobiology of Disease, Mayo Clinic, Jacksonville, Florida, United States of America","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065641764","https://openalex.org/A5083674000"],"corresponding_institution_ids":["https://openalex.org/I2801572250","https://openalex.org/I4210146710"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.5506,"has_fulltext":true,"cited_by_count":112,"citation_normalized_percentile":{"value":0.96013149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"10","issue":"11","first_page":"e1003935","last_page":"e1003935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkin","display_name":"Parkin","score":0.9855715036392212},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.8953558206558228},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"Ubiquitin ligase","score":0.8341293334960938},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.6257588863372803},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"Ubiquitin","score":0.6104883551597595},{"id":"https://openalex.org/keywords/dna-ligase","display_name":"DNA ligase","score":0.5998150706291199},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.5100536942481995},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4893602728843689},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.46520644426345825},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.40507200360298157},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4043501019477844},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3575550317764282},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.34722816944122314},{"id":"https://openalex.org/keywords/mitophagy","display_name":"Mitophagy","score":0.25623467564582825},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.14442139863967896},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07717457413673401}],"concepts":[{"id":"https://openalex.org/C2777668072","wikidata":"https://www.wikidata.org/wiki/Q2472777","display_name":"Parkin","level":4,"score":0.9855715036392212},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.8953558206558228},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.8341293334960938},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6257588863372803},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6104883551597595},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.5998150706291199},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5100536942481995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4893602728843689},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46520644426345825},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.40507200360298157},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4043501019477844},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3575550317764282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34722816944122314},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.25623467564582825},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.14442139863967896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07717457413673401},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000099202","descriptor_name":"PTEN-Induced Putative Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003935","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003935","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003935&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25375667","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25375667","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:DiVA.org:uu-240135","is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-240135","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f7354ae969fb4bd9aa4f52cf1971f172","is_oa":true,"landing_page_url":"https://doaj.org/article/f7354ae969fb4bd9aa4f52cf1971f172","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 11, p e1003935 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1232079","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Phosphorylation_by_PINK1_Releases_the_UBL_Domain_and_Initializes_the_Conformational_Opening_of_the_E3_Ubiquitin_Ligase_Parkin_/1232079","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4222639","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4222639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003935","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003935","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003935&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2525221511","display_name":null,"funder_award_id":"NS085070","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320306550","display_name":"Wenner-Gren Foundation","ror":"https://ror.org/04qvvhf62"},{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320336376","display_name":"Uppsala Multidisciplinary Center for Advanced Computational Science","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151233921.pdf","grobid_xml":"https://content.openalex.org/works/W2151233921.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W100416791","https://openalex.org/W150175414","https://openalex.org/W241954630","https://openalex.org/W1528471367","https://openalex.org/W1550876205","https://openalex.org/W1559288865","https://openalex.org/W1904531393","https://openalex.org/W1964670587","https://openalex.org/W1969403212","https://openalex.org/W1969723894","https://openalex.org/W1975580333","https://openalex.org/W1976499671","https://openalex.org/W1983470920","https://openalex.org/W1983509809","https://openalex.org/W1983580560","https://openalex.org/W1986191025","https://openalex.org/W1990496517","https://openalex.org/W1991679616","https://openalex.org/W1992899488","https://openalex.org/W2001555590","https://openalex.org/W2004146034","https://openalex.org/W2004908477","https://openalex.org/W2015403140","https://openalex.org/W2015758704","https://openalex.org/W2017269420","https://openalex.org/W2018267310","https://openalex.org/W2021312899","https://openalex.org/W2021620380","https://openalex.org/W2023634870","https://openalex.org/W2026247887","https://openalex.org/W2026540198","https://openalex.org/W2029087609","https://openalex.org/W2029667189","https://openalex.org/W2032476721","https://openalex.org/W2033178483","https://openalex.org/W2034087770","https://openalex.org/W2037487430","https://openalex.org/W2043276141","https://openalex.org/W2045679430","https://openalex.org/W2045914731","https://openalex.org/W2047507923","https://openalex.org/W2052329232","https://openalex.org/W2052889619","https://openalex.org/W2053260890","https://openalex.org/W2059194853","https://openalex.org/W2060542273","https://openalex.org/W2065565793","https://openalex.org/W2069644249","https://openalex.org/W2081120309","https://openalex.org/W2087592289","https://openalex.org/W2088933990","https://openalex.org/W2091264505","https://openalex.org/W2092387745","https://openalex.org/W2093242149","https://openalex.org/W2095348121","https://openalex.org/W2097271989","https://openalex.org/W2097777783","https://openalex.org/W2099099776","https://openalex.org/W2102697248","https://openalex.org/W2104412320","https://openalex.org/W2106383417","https://openalex.org/W2106415502","https://openalex.org/W2106444069","https://openalex.org/W2108326484","https://openalex.org/W2108627006","https://openalex.org/W2110498021","https://openalex.org/W2113440807","https://openalex.org/W2115864800","https://openalex.org/W2116836989","https://openalex.org/W2120689690","https://openalex.org/W2123252124","https://openalex.org/W2129750781","https://openalex.org/W2130979925","https://openalex.org/W2132717858","https://openalex.org/W2135309234","https://openalex.org/W2138311396","https://openalex.org/W2140654974","https://openalex.org/W2141087520","https://openalex.org/W2143233657","https://openalex.org/W2143739717","https://openalex.org/W2147542927","https://openalex.org/W2147993766","https://openalex.org/W2157046483","https://openalex.org/W2157151871","https://openalex.org/W2160311330","https://openalex.org/W2161644181","https://openalex.org/W2162798718","https://openalex.org/W2163052596","https://openalex.org/W2163854178","https://openalex.org/W2164045406","https://openalex.org/W2164122903","https://openalex.org/W2166904711","https://openalex.org/W2167867141","https://openalex.org/W2168466878","https://openalex.org/W2171213306","https://openalex.org/W2480573065","https://openalex.org/W4242855320"],"related_works":["https://openalex.org/W2008201895","https://openalex.org/W2074357173","https://openalex.org/W2088002295","https://openalex.org/W3004501979","https://openalex.org/W3002172210","https://openalex.org/W2557944616","https://openalex.org/W4386997297","https://openalex.org/W2022997027","https://openalex.org/W4281611459","https://openalex.org/W2026540198"],"abstract_inverted_index":{"Loss-of-function":[0],"mutations":[1],"in":[2,31,106,124,140,193],"PINK1":[3,22,39],"or":[4],"PARKIN":[5],"are":[6],"the":[7,19,24,57,69,73,100,144,203,227,235,238,248,257,267],"most":[8],"common":[9],"causes":[10],"of":[11,49,62,75,90,149,190,195,202,218,226,230,237,256,269],"autosomal":[12],"recessive":[13],"Parkinson's":[14],"disease.":[15],"Both":[16],"gene":[17],"products,":[18],"Ser/Thr":[20],"kinase":[21],"and":[23,42,47,142,163,178,186,200,254],"E3":[25],"Ubiquitin":[26],"ligase":[27,102],"Parkin,":[28],"functionally":[29],"cooperate":[30],"a":[32,86,107,132,153,196],"mitochondrial":[33],"quality":[34],"control":[35],"pathway.":[36],"Upon":[37],"stress,":[38],"activates":[40],"Parkin":[41,92,117,150,272],"enables":[43],"its":[44,128,160,165],"translocation":[45],"to":[46,52,119,126,241,250],"ubiquitination":[48],"damaged":[50],"mitochondria":[51],"facilitate":[53,234],"their":[54],"clearance":[55],"from":[56,113],"cell.":[58],"Though":[59],"PINK1-dependent":[60,137],"phosphorylation":[61,139],"Ser65":[63,138,191],"is":[64,103],"an":[65,219],"important":[66],"initial":[67],"step,":[68],"molecular":[70,82,146,172],"mechanisms":[71,253],"underlying":[72],"activation":[74],"Parkin's":[76],"enzymatic":[77],"functions":[78],"remain":[79],"unclear.":[80],"Using":[81],"modeling,":[83],"we":[84,134],"generated":[85],"complete":[87],"structural":[88,122],"model":[89],"human":[91],"at":[93],"all":[94],"atom":[95],"resolution.":[96],"At":[97],"steady":[98],"state,":[99],"Ub":[101,239],"maintained":[104],"inactive":[105],"closed,":[108],"auto-inhibited":[109],"conformation":[110],"that":[111,157,215],"results":[112,192],"intra-molecular":[114],"interactions.":[115],"Evidently,":[116],"has":[118],"undergo":[120],"major":[121],"rearrangements":[123],"order":[125],"unleash":[127],"catalytic":[129,166,228],"activity.":[130,167],"As":[131],"spark,":[133],"have":[135],"modeled":[136],"silico":[141],"provide":[143],"first":[145],"dynamics":[147,173],"simulation":[148],"conformations":[151,214],"along":[152],"sequential":[154],"unfolding":[155],"pathway":[156],"could":[158],"release":[159],"intertwined":[161],"domains":[162],"enable":[164],"We":[168],"combined":[169],"free":[170],"(unbiased)":[171],"simulation,":[174],"Monte":[175],"Carlo":[176],"algorithms,":[177],"minimal-biasing":[179],"methods":[180],"with":[181],"cell-based":[182],"high":[183],"content":[184],"imaging":[185],"biochemical":[187],"assays.":[188],"Phosphorylation":[189],"widening":[194],"newly":[197],"defined":[198],"cleft":[199],"dissociation":[201],"regulatory":[204,252],"N-terminal":[205],"UBL":[206],"domain.":[207],"This":[208,260],"motion":[209],"propagates":[210],"through":[211,274],"further":[212],"opening":[213],"allow":[216],"binding":[217],"Ub-loaded":[220],"E2":[221],"co-enzyme.":[222],"Subsequent":[223],"spatial":[224],"reorientation":[225],"centers":[229],"both":[231],"enzymes":[232],"might":[233],"transfer":[236],"moiety":[240],"charge":[242],"Parkin.":[243,259],"Our":[244],"structure-function":[245],"study":[246],"provides":[247],"basis":[249],"elucidate":[251],"activity":[255],"neuroprotective":[258],"may":[261],"open":[262],"up":[263],"new":[264],"avenues":[265],"for":[266],"development":[268],"small":[270],"molecule":[271],"activators":[273],"targeted":[275],"drug":[276],"design.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":14}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}