{"id":"https://openalex.org/W2081054022","doi":"https://doi.org/10.1371/journal.pcbi.1003865","title":"Natural Isotopic Signatures of Variations in Body Nitrogen Fluxes: A Compartmental Model Analysis","display_name":"Natural Isotopic Signatures of Variations in Body Nitrogen Fluxes: A Compartmental Model Analysis","publication_year":2014,"publication_date":"2014-10-02","ids":{"openalex":"https://openalex.org/W2081054022","doi":"https://doi.org/10.1371/journal.pcbi.1003865","mag":"2081054022","pmid":"https://pubmed.ncbi.nlm.nih.gov/25275306"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003865","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003865&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003865&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051880093","display_name":"Nathalie Poupin","orcid":"https://orcid.org/0000-0002-3393-1405"},"institutions":[{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210134531","display_name":"Physiologie de la Nutrition et du Comportement Alimentaire","ror":"https://ror.org/043f5vc59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210134531"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Poupin","raw_affiliation_strings":["INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France"],"affiliations":[{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":[]},{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I4210134531"]},{"raw_affiliation_string":"AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I22248866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083984584","display_name":"Fran\u00e7ois Mariotti","orcid":"https://orcid.org/0000-0002-4516-3853"},"institutions":[{"id":"https://openalex.org/I4210134531","display_name":"Physiologie de la Nutrition et du Comportement Alimentaire","ror":"https://ror.org/043f5vc59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210134531"]},{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Mariotti","raw_affiliation_strings":["INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France"],"affiliations":[{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":[]},{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I4210134531"]},{"raw_affiliation_string":"AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I22248866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014143220","display_name":"Jean\u2010Fran\u00e7ois Huneau","orcid":"https://orcid.org/0000-0001-7336-2617"},"institutions":[{"id":"https://openalex.org/I4210134531","display_name":"Physiologie de la Nutrition et du Comportement Alimentaire","ror":"https://ror.org/043f5vc59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210134531"]},{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Fran\u00e7ois Huneau","raw_affiliation_strings":["INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France"],"affiliations":[{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":[]},{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I4210134531"]},{"raw_affiliation_string":"AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I22248866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047311149","display_name":"Dominique Hermier","orcid":"https://orcid.org/0000-0001-8676-6960"},"institutions":[{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210134531","display_name":"Physiologie de la Nutrition et du Comportement Alimentaire","ror":"https://ror.org/043f5vc59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210134531"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Hermier","raw_affiliation_strings":["INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France"],"affiliations":[{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":[]},{"raw_affiliation_string":"AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I22248866"]},{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I4210134531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081453310","display_name":"H\u00e9l\u00e8ne Fouillet","orcid":"https://orcid.org/0000-0003-3932-251X"},"institutions":[{"id":"https://openalex.org/I4210134531","display_name":"Physiologie de la Nutrition et du Comportement Alimentaire","ror":"https://ror.org/043f5vc59","country_code":"FR","type":"facility","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954","https://openalex.org/I277688954","https://openalex.org/I4210088668","https://openalex.org/I4210134531"]},{"id":"https://openalex.org/I22248866","display_name":"AgroParisTech","ror":"https://ror.org/02kbmgc12","country_code":"FR","type":"education","lineage":["https://openalex.org/I22248866","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"H\u00e9l\u00e8ne Fouillet","raw_affiliation_strings":["INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France"],"affiliations":[{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France; AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":[]},{"raw_affiliation_string":"INRA, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I4210134531"]},{"raw_affiliation_string":"AgroParisTech, CRNH-IdF, UMR914 Nutrition Physiology and Ingestive Behavior, Paris, France","institution_ids":["https://openalex.org/I22248866"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5081453310"],"corresponding_institution_ids":["https://openalex.org/I22248866","https://openalex.org/I4210134531"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.5812,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.95604914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"10","first_page":"e1003865","last_page":"e1003865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12073","display_name":"Isotope Analysis in Ecology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12073","display_name":"Isotope Analysis in Ecology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urea","display_name":"Urea","score":0.6632975935935974},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.6174777150154114},{"id":"https://openalex.org/keywords/nitrogen-balance","display_name":"Nitrogen balance","score":0.5900137424468994},{"id":"https://openalex.org/keywords/nitrogen","display_name":"Nitrogen","score":0.5835109353065491},{"id":"https://openalex.org/keywords/isotopes-of-nitrogen","display_name":"Isotopes of nitrogen","score":0.5610207915306091},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.5528294444084167},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5001707077026367},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"Protein turnover","score":0.4740345776081085},{"id":"https://openalex.org/keywords/stable-isotope-ratio","display_name":"Stable isotope ratio","score":0.467875212430954},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4458749294281006},{"id":"https://openalex.org/keywords/isotope","display_name":"Isotope","score":0.4185444116592407},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3473111689090729},{"id":"https://openalex.org/keywords/protein-biosynthesis","display_name":"Protein biosynthesis","score":0.27055060863494873}],"concepts":[{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.6632975935935974},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6174777150154114},{"id":"https://openalex.org/C8101879","wikidata":"https://www.wikidata.org/wiki/Q175343","display_name":"Nitrogen balance","level":3,"score":0.5900137424468994},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.5835109353065491},{"id":"https://openalex.org/C99649442","wikidata":"https://www.wikidata.org/wiki/Q470479","display_name":"Isotopes of nitrogen","level":3,"score":0.5610207915306091},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5528294444084167},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5001707077026367},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.4740345776081085},{"id":"https://openalex.org/C22117777","wikidata":"https://www.wikidata.org/wiki/Q17148629","display_name":"Stable isotope ratio","level":2,"score":0.467875212430954},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4458749294281006},{"id":"https://openalex.org/C164304813","wikidata":"https://www.wikidata.org/wiki/Q25276","display_name":"Isotope","level":2,"score":0.4185444116592407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3473111689090729},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.27055060863494873},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009587","descriptor_name":"Nitrogen Isotopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009587","descriptor_name":"Nitrogen Isotopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009587","descriptor_name":"Nitrogen Isotopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009587","descriptor_name":"Nitrogen Isotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009587","descriptor_name":"Nitrogen Isotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009587","descriptor_name":"Nitrogen Isotopes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003865","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003865&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25275306","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25275306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.794.4766","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.794.4766","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/49/d2/pcbi.1003865.PMC4183419.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-01186909v1","is_oa":true,"landing_page_url":"https://hal.science/hal-01186909","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2014, 10 (10), ⟨10.1371/journal.pcbi.1003865⟩","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003865","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003865","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:d6e1696595dd46b1981a806d23091e18","is_oa":true,"landing_page_url":"https://doaj.org/article/d6e1696595dd46b1981a806d23091e18","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 10, p e1003865 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3159378","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4183419","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1191415","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Natural_Isotopic_Signatures_of_Variations_in_Body_Nitrogen_Fluxes_A_Compartmental_Model_Analysis_/1191415","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003865","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003865","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003865&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330399","display_name":"Nestec","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2081054022.pdf","grobid_xml":"https://content.openalex.org/works/W2081054022.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W90239176","https://openalex.org/W191098488","https://openalex.org/W1485267442","https://openalex.org/W1895626940","https://openalex.org/W1897761460","https://openalex.org/W1908806204","https://openalex.org/W1927272310","https://openalex.org/W1948615647","https://openalex.org/W1957253419","https://openalex.org/W1962365375","https://openalex.org/W1966791720","https://openalex.org/W1967076364","https://openalex.org/W1967851204","https://openalex.org/W1969884434","https://openalex.org/W1970594231","https://openalex.org/W1971217334","https://openalex.org/W1978301789","https://openalex.org/W1981280549","https://openalex.org/W1983827336","https://openalex.org/W1983874139","https://openalex.org/W1987196911","https://openalex.org/W2003614202","https://openalex.org/W2013036663","https://openalex.org/W2013424998","https://openalex.org/W2015000855","https://openalex.org/W2017399838","https://openalex.org/W2021452224","https://openalex.org/W2025492293","https://openalex.org/W2026280025","https://openalex.org/W2035469940","https://openalex.org/W2037174783","https://openalex.org/W2038202363","https://openalex.org/W2043872109","https://openalex.org/W2048003222","https://openalex.org/W2049429223","https://openalex.org/W2052404114","https://openalex.org/W2063020698","https://openalex.org/W2063624820","https://openalex.org/W2067183494","https://openalex.org/W2084840364","https://openalex.org/W2085199314","https://openalex.org/W2087531923","https://openalex.org/W2098256919","https://openalex.org/W2098779716","https://openalex.org/W2118294955","https://openalex.org/W2119574872","https://openalex.org/W2122518090","https://openalex.org/W2125776008","https://openalex.org/W2128583851","https://openalex.org/W2130053863","https://openalex.org/W2133033066","https://openalex.org/W2133517902","https://openalex.org/W2136006548","https://openalex.org/W2136703725","https://openalex.org/W2137236016","https://openalex.org/W2140384801","https://openalex.org/W2140759276","https://openalex.org/W2143629844","https://openalex.org/W2145960035","https://openalex.org/W2146090296","https://openalex.org/W2156602538","https://openalex.org/W2163860364","https://openalex.org/W2166477196","https://openalex.org/W2168558396","https://openalex.org/W2170172040","https://openalex.org/W2184162672","https://openalex.org/W2284242947","https://openalex.org/W2314722037","https://openalex.org/W2316241967","https://openalex.org/W2322242883","https://openalex.org/W2323963467","https://openalex.org/W2325789653","https://openalex.org/W2418932931","https://openalex.org/W4239650564","https://openalex.org/W4243259747"],"related_works":["https://openalex.org/W2278433907","https://openalex.org/W2473043814","https://openalex.org/W1019665771","https://openalex.org/W2032920636","https://openalex.org/W2126592636","https://openalex.org/W2406231556","https://openalex.org/W2122454042","https://openalex.org/W2360263305","https://openalex.org/W2116871544","https://openalex.org/W2206524326"],"abstract_inverted_index":{"Body":[0],"tissues":[1,16,240],"are":[2,38,46,127,276],"generally":[3],"15N-enriched":[4],"over":[5],"the":[6,66,71,75,82,92,143,165,180,189,215,243],"diet,":[7],"with":[8,131,204],"a":[9,20,61,146,228,267],"discrimination":[10],"factor":[11],"(\u039415N)":[12],"that":[13,43,64,105,263],"varies":[14],"among":[15],"and":[17,25,32,34,84,94,122,134,200,225,234,288,297],"individuals":[18],"as":[19],"function":[21],"of":[22,70,74,87,97,145,155,168,192,222,261,285],"their":[23,50],"nutritional":[24],"physiopathological":[26],"condition.":[27],"However,":[28],"both":[29,223],"15N":[30,138],"bioaccumulation":[31],"intra-":[33],"inter-individual":[35],"\u039415N":[36,55,77,85,144,183,236,255,264],"variations":[37,154,184,187,237],"still":[39],"poorly":[40],"understood,":[41],"so":[42],"theoretical":[44],"models":[45],"required":[47],"to":[48,91,137,164,271],"understand":[49],"underlying":[51],"mechanisms.":[52],"Using":[53],"experimental":[54],"measurements":[56,265],"in":[57,140,188,208,220,231,295],"rats,":[58],"we":[59],"developed":[60],"multi-compartmental":[62],"model":[63],"provides":[65,259],"first":[67],"detailed":[68],"representation":[69],"complex":[72],"functioning":[73],"body's":[76],"system,":[78],"by":[79,153],"explicitly":[80],"linking":[81],"sizes":[83],"values":[86],"21":[88],"nitrogen":[89,99,193,209],"pools":[90],"rates":[93],"isotope":[95,132],"effects":[96],"49":[98],"metabolic":[100,111,244,274],"fluxes.":[101],"We":[102],"have":[103],"shown":[104],"(i)":[106],"besides":[107],"urea":[108,120,196,198],"production,":[109,197],"several":[110],"pathways":[112],"(e.g.,":[113,195],"protein":[114,176],"synthesis,":[115,177],"amino":[116,171,201,217],"acid":[117,202,218],"intracellular":[118],"metabolism,":[119],"recycling":[121,199],"intestinal":[123],"absorption":[124],"or":[125,205,278,281],"secretion)":[126],"most":[128],"probably":[129],"associated":[130],"fractionation":[133],"together":[135],"contribute":[136],"accumulation":[139],"tissues,":[141],"(ii)":[142],"tissue":[147,169,232],"at":[148,179],"steady-state":[149],"is":[150],"not":[151],"affected":[152],"its":[156],"P":[157],"turnover":[158],"rate,":[159],"but":[160],"can":[161,248],"vary":[162],"according":[163],"relative":[166],"orientation":[167],"free":[170],"acids":[172],"towards":[173],"oxidation":[174],"vs.":[175],"(iii)":[178],"whole-body":[181],"level,":[182],"result":[185],"from":[186,214],"body":[190],"partitioning":[191],"fluxes":[194,275],"exchanges),":[203],"without":[206],"changes":[207,245],"balance,":[210],"(iv)":[211],"any":[212],"deviation":[213],"optimal":[216],"intake,":[219],"terms":[221],"quality":[224],"quantity,":[226],"causes":[227],"global":[229],"rise":[230],"\u039415N,":[233],"(v)":[235],"differ":[238],"between":[239],"depending":[241],"on":[242],"involved,":[246],"which":[247],"therefore":[249],"be":[250],"identified":[251],"using":[252],"simultaneous":[253],"multi-tissue":[254],"measurements.":[256],"This":[257],"work":[258],"proof":[260],"concept":[262],"constitute":[266],"new":[268],"promising":[269],"tool":[270],"investigate":[272],"how":[273],"nutritionally":[277],"physiopathologically":[279],"reorganized":[280],"altered.":[282],"The":[283],"existence":[284],"such":[286],"natural":[287],"interpretable":[289],"isotopic":[290],"biomarkers":[291],"promises":[292],"interesting":[293],"applications":[294],"nutrition":[296],"health.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}