{"id":"https://openalex.org/W2096524146","doi":"https://doi.org/10.1371/journal.pcbi.1003860","title":"Exploring the miRNA Regulatory Network Using Evolutionary Correlations","display_name":"Exploring the miRNA Regulatory Network Using Evolutionary Correlations","publication_year":2014,"publication_date":"2014-10-09","ids":{"openalex":"https://openalex.org/W2096524146","doi":"https://doi.org/10.1371/journal.pcbi.1003860","mag":"2096524146","pmid":"https://pubmed.ncbi.nlm.nih.gov/25299225"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003860","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003860","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003860&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003860&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041273179","display_name":"Benedikt Obermayer","orcid":"https://orcid.org/0000-0002-9116-630X"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Benedikt Obermayer","raw_affiliation_strings":["Systems Biology of Gene Regulatory Elements, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany; Department of Physics and Center for Systems Biology, Harvard University, Cambridge, United Kingdom","Systems Biology of Gene Regulatory Elements, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","Department of Physics and Center for Systems Biology, Harvard University, Cambridge, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Systems Biology of Gene Regulatory Elements, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany; Department of Physics and Center for Systems Biology, Harvard University, Cambridge, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Systems Biology of Gene Regulatory Elements, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Department of Physics and Center for Systems Biology, Harvard University, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051039938","display_name":"Erel Levine","orcid":"https://orcid.org/0000-0002-9659-6253"},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE","GB"],"is_corresponding":true,"raw_author_name":"Erel Levine","raw_affiliation_strings":["Systems Biology of Gene Regulatory Elements, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany; Department of Physics and Center for Systems Biology, Harvard University, Cambridge, United Kingdom","Department of Physics and Center for Systems Biology, Harvard University, Cambridge, United Kingdom","Systems Biology of Gene Regulatory Elements, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Systems Biology of Gene Regulatory Elements, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany; Department of Physics and Center for Systems Biology, Harvard University, Cambridge, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Department of Physics and Center for Systems Biology, Harvard University, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Systems Biology of Gene Regulatory Elements, Max-Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5041273179","https://openalex.org/A5051039938"],"corresponding_institution_ids":["https://openalex.org/I205582932","https://openalex.org/I241749"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.4446,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.64652755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"10","first_page":"e1003860","last_page":"e1003860"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7134472131729126},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6504945755004883},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.6020309329032898},{"id":"https://openalex.org/keywords/conserved-sequence","display_name":"Conserved sequence","score":0.546879231929779},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5430899858474731},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5333958268165588},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4692409336566925},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.45833900570869446},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4506906270980835},{"id":"https://openalex.org/keywords/evolutionary-dynamics","display_name":"Evolutionary dynamics","score":0.4298911690711975},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4043896198272705},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3572385609149933},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.17825421690940857},{"id":"https://openalex.org/keywords/base-sequence","display_name":"Base sequence","score":0.1135033667087555},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.08908283710479736}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7134472131729126},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6504945755004883},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.6020309329032898},{"id":"https://openalex.org/C199216141","wikidata":"https://www.wikidata.org/wiki/Q4995178","display_name":"Conserved sequence","level":4,"score":0.546879231929779},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5430899858474731},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5333958268165588},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4692409336566925},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.45833900570869446},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4506906270980835},{"id":"https://openalex.org/C171578705","wikidata":"https://www.wikidata.org/wiki/Q5418700","display_name":"Evolutionary dynamics","level":3,"score":0.4298911690711975},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4043896198272705},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3572385609149933},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17825421690940857},{"id":"https://openalex.org/C3017666073","wikidata":"https://www.wikidata.org/wiki/Q1764062","display_name":"Base sequence","level":3,"score":0.1135033667087555},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.08908283710479736},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1003860","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003860","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003860&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25299225","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25299225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:edoc.mdc-berlin.de:14387","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:dash.harvard.edu:1/13347480","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:13347480","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1004.6913","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1004.6913","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://dash.harvard.edu/bitstream/handle/1/13347480/4191876.pdf?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.982.5247","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.982.5247","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://europepmc.org/backend/ptpmcrender.fcgi?accid%3DPMC4191876%26blobtype%3Dpdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5ccaf5e1ea78435db37b82187f11c8bf","is_oa":true,"landing_page_url":"https://doaj.org/article/5ccaf5e1ea78435db37b82187f11c8bf","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 10, p e1003860 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1199034","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Exploring_the_miRNA_Regulatory_Network_Using_Evolutionary_Correlations_/1199034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4191876","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4191876","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003860","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003860","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003860&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7200000286102295,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G5115255069","display_name":"Dynamics, Plasticity and Evolvability of bacterial small regulatory RNAs","funder_award_id":"1121057","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G688430214","display_name":null,"funder_award_id":"MCB-1121057","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2096524146.pdf","grobid_xml":"https://content.openalex.org/works/W2096524146.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W1597226907","https://openalex.org/W1920303762","https://openalex.org/W1921457844","https://openalex.org/W1930635754","https://openalex.org/W1963906441","https://openalex.org/W1965835990","https://openalex.org/W1971623350","https://openalex.org/W1975981804","https://openalex.org/W1978337436","https://openalex.org/W1979259341","https://openalex.org/W1983804343","https://openalex.org/W1988163167","https://openalex.org/W1990868443","https://openalex.org/W1993900316","https://openalex.org/W1994900589","https://openalex.org/W2001706442","https://openalex.org/W2003952411","https://openalex.org/W2008545402","https://openalex.org/W2009777681","https://openalex.org/W2010461414","https://openalex.org/W2011368877","https://openalex.org/W2011913607","https://openalex.org/W2017270642","https://openalex.org/W2021769301","https://openalex.org/W2022231987","https://openalex.org/W2026570544","https://openalex.org/W2029747700","https://openalex.org/W2030816054","https://openalex.org/W2037691883","https://openalex.org/W2038212727","https://openalex.org/W2038622868","https://openalex.org/W2039415806","https://openalex.org/W2043946672","https://openalex.org/W2045685910","https://openalex.org/W2046621435","https://openalex.org/W2048728930","https://openalex.org/W2049334016","https://openalex.org/W2049868101","https://openalex.org/W2050099686","https://openalex.org/W2050869737","https://openalex.org/W2053003053","https://openalex.org/W2057885377","https://openalex.org/W2058835062","https://openalex.org/W2059073003","https://openalex.org/W2061042699","https://openalex.org/W2061174980","https://openalex.org/W2064165694","https://openalex.org/W2065566217","https://openalex.org/W2070777085","https://openalex.org/W2071457420","https://openalex.org/W2080551186","https://openalex.org/W2083381199","https://openalex.org/W2094177946","https://openalex.org/W2095005830","https://openalex.org/W2097782352","https://openalex.org/W2100932663","https://openalex.org/W2102107106","https://openalex.org/W2104806799","https://openalex.org/W2105197182","https://openalex.org/W2105694586","https://openalex.org/W2108266886","https://openalex.org/W2112192177","https://openalex.org/W2115552956","https://openalex.org/W2118581428","https://openalex.org/W2120340025","https://openalex.org/W2120456037","https://openalex.org/W2127760245","https://openalex.org/W2131349713","https://openalex.org/W2133147430","https://openalex.org/W2138664009","https://openalex.org/W2145931730","https://openalex.org/W2148440440","https://openalex.org/W2149146453","https://openalex.org/W2149613147","https://openalex.org/W2150395782","https://openalex.org/W2152083180","https://openalex.org/W2161350677","https://openalex.org/W2161645441","https://openalex.org/W2162674813","https://openalex.org/W2163199119","https://openalex.org/W2166894044","https://openalex.org/W2167606024","https://openalex.org/W2171296186","https://openalex.org/W2171501215","https://openalex.org/W4252706339","https://openalex.org/W4293052541"],"related_works":["https://openalex.org/W2128583238","https://openalex.org/W2134405083","https://openalex.org/W2049907435","https://openalex.org/W2034500416","https://openalex.org/W2010571965","https://openalex.org/W2034377088","https://openalex.org/W3128451840","https://openalex.org/W2002709996","https://openalex.org/W4387092964","https://openalex.org/W2103471012"],"abstract_inverted_index":{"Post-transcriptional":[0],"regulation":[1,44,158],"by":[2,159],"miRNAs":[3],"is":[4,50,220],"a":[5,92,100,153,174,187,244],"widespread":[6],"and":[7,25,47,54,84,208,229],"highly":[8,71],"conserved":[9,19],"phenomenon":[10],"in":[11,127,141,177,186,215],"metazoans,":[12],"with":[13],"several":[14],"hundreds":[15],"to":[16,27,66,91,103,184,223,232,247],"thousands":[17],"of":[18,30,42,95,106,118,124,131,148,156,195],"binding":[20],"sites":[21,109],"for":[22,205],"each":[23],"miRNA,":[24],"up":[26],"two":[28],"thirds":[29],"all":[31],"genes":[32],"under":[33,169],"miRNA":[34,43,73,107,166],"regulation.":[35],"At":[36],"the":[37,40,67,70,128,142,178],"same":[38],"time,":[39],"effect":[41],"on":[45],"mRNA":[46],"protein":[48,206],"levels":[49],"usually":[51],"quite":[52],"modest":[53],"associated":[55],"phenotypes":[56],"are":[57,168],"often":[58],"weak":[59],"or":[60],"subtle.":[61],"This":[62],"has":[63],"given":[64],"rise":[65],"notion":[68],"that":[69,89,164,211],"interconnected":[72],"regulatory":[74,143,179,249],"network":[75,96],"exerts":[76],"its":[77],"function":[78,185],"less":[79],"through":[80],"any":[81],"individual":[82],"link":[83],"more":[85,188],"via":[86],"collective":[87,139],"effects":[88],"lead":[90],"functional":[93],"interdependence":[94],"links.":[97],"We":[98,162,241],"present":[99],"Bayesian":[101],"framework":[102],"quantify":[104],"conservation":[105,129],"target":[108,149],"using":[110],"vertebrate":[111],"whole-genome":[112],"alignments.":[113],"The":[114],"increased":[115],"statistical":[116],"power":[117],"our":[119],"phylogenetic":[120],"model":[121],"allows":[122],"detection":[123],"evolutionary":[125,203,253],"correlation":[126],"patterns":[130],"site":[132,150],"pairs.":[133],"Such":[134],"correlations":[135],"could":[136,212],"result":[137],"from":[138,251],"functions":[140],"network.":[144],"For":[145],"instance,":[146],"co-conservation":[147],"pairs":[151],"supports":[152],"selective":[154,235],"benefit":[155],"combinatorial":[157],"multiple":[160],"miRNAs.":[161],"find":[163],"some":[165],"families":[167],"pronounced":[170],"co-targeting":[171],"constraints,":[172],"indicating":[173],"high":[175],"connectivity":[176],"network,":[180],"while":[181],"others":[182],"appear":[183],"isolated":[189],"way.":[190],"By":[191],"analyzing":[192],"coordinated":[193],"targeting":[194],"different":[196],"curated":[197],"gene":[198],"sets,":[199,228],"we":[200],"observe":[201],"distinct":[202],"signatures":[204],"complexes":[207],"signaling":[209],"pathways":[210],"reflect":[213],"differences":[214],"control":[216],"strategies.":[217],"Our":[218],"method":[219,246],"easily":[221],"scalable":[222],"analyze":[224],"upcoming":[225],"larger":[226],"data":[227],"readily":[230],"adaptable":[231],"detect":[233],"high-level":[234],"constraints":[236],"between":[237],"other":[238],"genomic":[239],"loci.":[240],"thus":[242],"provide":[243],"proof-of-principle":[245],"understand":[248],"networks":[250],"an":[252],"perspective.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
