{"id":"https://openalex.org/W2008158683","doi":"https://doi.org/10.1371/journal.pcbi.1003802","title":"The Protective Role of Symmetric Stem Cell Division on the Accumulation of Heritable Damage","display_name":"The Protective Role of Symmetric Stem Cell Division on the Accumulation of Heritable Damage","publication_year":2014,"publication_date":"2014-08-14","ids":{"openalex":"https://openalex.org/W2008158683","doi":"https://doi.org/10.1371/journal.pcbi.1003802","mag":"2008158683","pmid":"https://pubmed.ncbi.nlm.nih.gov/25121484"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003802","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003802","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003802&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003802&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080056847","display_name":"Peter McHale","orcid":"https://orcid.org/0000-0001-6452-1786"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter T. McHale","raw_affiliation_strings":["Center for Complex Biological Systems & Department of Cell and Developmental Biology, University of California Irvine, Irvine, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Complex Biological Systems & Department of Cell and Developmental Biology, University of California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030125759","display_name":"Arthur D. Lander","orcid":"https://orcid.org/0000-0002-4380-5525"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arthur D. Lander","raw_affiliation_strings":["Center for Complex Biological Systems & Department of Cell and Developmental Biology, University of California Irvine, Irvine, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Complex Biological Systems & Department of Cell and Developmental Biology, University of California Irvine, Irvine, California, United States of America","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030125759","https://openalex.org/A5080056847"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0008,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.85195571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"8","first_page":"e1003802","last_page":"e1003802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.8526726961135864},{"id":"https://openalex.org/keywords/cell-division","display_name":"Cell division","score":0.7346643805503845},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6782022714614868},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6554389595985413},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.6334047317504883},{"id":"https://openalex.org/keywords/asymmetric-cell-division","display_name":"Asymmetric cell division","score":0.623430609703064},{"id":"https://openalex.org/keywords/stem-cell-theory-of-aging","display_name":"Stem cell theory of aging","score":0.5075138807296753},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.46347862482070923},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.4197622537612915},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.3726692795753479},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3456329107284546},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"Stem cell factor","score":0.2880200147628784},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.08554190397262573},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07821452617645264}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8526726961135864},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.7346643805503845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6782022714614868},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6554389595985413},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6334047317504883},{"id":"https://openalex.org/C2778977658","wikidata":"https://www.wikidata.org/wiki/Q4812070","display_name":"Asymmetric cell division","level":4,"score":0.623430609703064},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.5075138807296753},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.46347862482070923},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.4197622537612915},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.3726692795753479},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3456329107284546},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.2880200147628784},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.08554190397262573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07821452617645264}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003802","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003802","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003802&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25121484","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25121484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:escholarship.org/ark:/13030/qt7m96g141","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7m96g141","pdf_url":"https://escholarship.org/content/qt7m96g141/qt7m96g141.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, vol 10, iss 8","raw_type":"article"},{"id":"pmh:ark:/13030/qt7m96g141","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:doaj.org/article:fe4da6bde15547b49570bf2875a9bbad","is_oa":true,"landing_page_url":"https://doaj.org/article/fe4da6bde15547b49570bf2875a9bbad","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 8, p e1003802 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3105692","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4133021","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1139131","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_The_Protective_Role_of_Symmetric_Stem_Cell_Division_on_the_Accumulation_of_Heritable_Damage_/1139131","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:qt7m96g141","is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/7m96g141","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"McHale, PT; & Lander, AD. (2014). The Protective Role of Symmetric Stem Cell Division on the Accumulation of Heritable Damage. PLoS Computational Biology, 10(8), e1003802. doi: 10.1371/journal.pcbi.1003802. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/7m96g141","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003802","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003802","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003802&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5199999809265137}],"awards":[{"id":"https://openalex.org/G6345853531","display_name":null,"funder_award_id":"unknown","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2008158683.pdf","grobid_xml":"https://content.openalex.org/works/W2008158683.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1617597216","https://openalex.org/W1874198492","https://openalex.org/W1894632965","https://openalex.org/W1965766641","https://openalex.org/W1967658333","https://openalex.org/W1968407767","https://openalex.org/W1975373973","https://openalex.org/W1977905227","https://openalex.org/W1978626016","https://openalex.org/W1978628782","https://openalex.org/W1978871519","https://openalex.org/W1979812265","https://openalex.org/W1982603620","https://openalex.org/W1985444222","https://openalex.org/W1989413259","https://openalex.org/W1991327249","https://openalex.org/W1994874018","https://openalex.org/W1997768471","https://openalex.org/W1998170462","https://openalex.org/W1999777663","https://openalex.org/W2009031936","https://openalex.org/W2009720434","https://openalex.org/W2011912935","https://openalex.org/W2016500868","https://openalex.org/W2022937116","https://openalex.org/W2036831253","https://openalex.org/W2036986058","https://openalex.org/W2042397019","https://openalex.org/W2044433401","https://openalex.org/W2054345991","https://openalex.org/W2062093164","https://openalex.org/W2063728375","https://openalex.org/W2064236697","https://openalex.org/W2065220128","https://openalex.org/W2075743485","https://openalex.org/W2080308138","https://openalex.org/W2080480789","https://openalex.org/W2080856070","https://openalex.org/W2080873513","https://openalex.org/W2085217863","https://openalex.org/W2088766753","https://openalex.org/W2091523930","https://openalex.org/W2094901567","https://openalex.org/W2099334597","https://openalex.org/W2100050856","https://openalex.org/W2105372361","https://openalex.org/W2105670702","https://openalex.org/W2105754268","https://openalex.org/W2105986617","https://openalex.org/W2109860416","https://openalex.org/W2116233619","https://openalex.org/W2118077148","https://openalex.org/W2118643513","https://openalex.org/W2119799188","https://openalex.org/W2120627772","https://openalex.org/W2132373340","https://openalex.org/W2145606954","https://openalex.org/W2146542392","https://openalex.org/W2158195820","https://openalex.org/W2167543384","https://openalex.org/W2168901267","https://openalex.org/W2262414037","https://openalex.org/W2593596205","https://openalex.org/W4240237951"],"related_works":["https://openalex.org/W2057143267","https://openalex.org/W2088461774","https://openalex.org/W2942732239","https://openalex.org/W2963011660","https://openalex.org/W2297254013","https://openalex.org/W1987384599","https://openalex.org/W4311268005","https://openalex.org/W2091412371","https://openalex.org/W4313311740","https://openalex.org/W2891394911"],"abstract_inverted_index":{"Stem":[0],"cell":[1,9,13,44,138],"divisions":[2],"are":[3,47],"either":[4,28],"asymmetric-in":[5],"which":[6,20],"one":[7,15],"daughter":[8,22],"remains":[10],"a":[11,110],"stem":[12,29,43,91,137],"and":[14],"does":[16],"not-or":[17],"symmetric,":[18],"in":[19,36,89,97,121],"both":[21],"cells":[23],"adopt":[24],"the":[25,51,55,75,114,122],"same":[26],"fate,":[27],"or":[30,85],"non-stem.":[31],"Recent":[32],"studies":[33],"show":[34,65],"that":[35,66,112],"many":[37,117],"tissues":[38,100],"operating":[39],"under":[40],"homeostatic":[41],"conditions":[42],"division":[45],"patterns":[46,135],"strongly":[48],"biased":[49],"toward":[50],"symmetric":[52,134],"outcome,":[53],"raising":[54],"question":[56],"of":[57,70,78,105,116,124,136],"whether":[58],"symmetry":[59],"confers":[60],"some":[61],"benefit.":[62],"Here,":[63],"we":[64],"symmetry,":[67],"via":[68],"extinction":[69],"damaged":[71],"stem-cell":[72],"clones,":[73],"reduces":[74],"lifetime":[76],"risk":[77],"accumulating":[79],"phenotypically":[80],"silent":[81],"heritable":[82],"damage":[83,106,126],"(mutations":[84],"aberrant":[86],"epigenetic":[87],"changes)":[88],"individual":[90],"cells.":[92],"This":[93],"effect":[94],"is":[95],"greatest":[96],"rapidly":[98],"cycling":[99],"subject":[101],"to":[102],"accelerating":[103],"rates":[104],"accumulation":[107,127],"over":[108],"time,":[109],"scenario":[111],"describes":[113],"progression":[115],"cancers.":[118],"A":[119],"decrease":[120],"rate":[123],"cellular":[125],"may":[128],"be":[129],"an":[130],"important":[131],"factor":[132],"favoring":[133],"division.":[139]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}