{"id":"https://openalex.org/W2071689070","doi":"https://doi.org/10.1371/journal.pcbi.1003801","title":"Revealing Molecular Mechanisms by Integrating High-Dimensional Functional Screens with Protein Interaction Data","display_name":"Revealing Molecular Mechanisms by Integrating High-Dimensional Functional Screens with Protein Interaction Data","publication_year":2014,"publication_date":"2014-09-04","ids":{"openalex":"https://openalex.org/W2071689070","doi":"https://doi.org/10.1371/journal.pcbi.1003801","mag":"2071689070","pmid":"https://pubmed.ncbi.nlm.nih.gov/25188415"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003801","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003801","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003801&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003801&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034823559","display_name":"Angela Simeone","orcid":null},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Angela Simeone","raw_affiliation_strings":["Biotechnology Center, TU Dresden, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Biotechnology Center, TU Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056778425","display_name":"Giovanni Marsico","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Giovanni Marsico","raw_affiliation_strings":["Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057529723","display_name":"Claudio Collinet","orcid":"https://orcid.org/0000-0002-8532-2601"},"institutions":[{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudio Collinet","raw_affiliation_strings":["Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067424620","display_name":"Thierry Galvez","orcid":"https://orcid.org/0000-0003-2800-3732"},"institutions":[{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thierry Galvez","raw_affiliation_strings":["Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078646809","display_name":"Yannis Kalaidzidis","orcid":"https://orcid.org/0000-0002-6137-1193"},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["DE","RU"],"is_corresponding":false,"raw_author_name":"Yannis Kalaidzidis","raw_affiliation_strings":["Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany; Belozersky Institute of Physico-Chemical Biology & Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia","Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany","Belozersky Institute of Physico-Chemical Biology & Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany; Belozersky Institute of Physico-Chemical Biology & Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia","institution_ids":[]},{"raw_affiliation_string":"Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany","institution_ids":["https://openalex.org/I4210159854"]},{"raw_affiliation_string":"Belozersky Institute of Physico-Chemical Biology & Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012441246","display_name":"Marino Zerial","orcid":"https://orcid.org/0000-0002-7490-4235"},"institutions":[{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marino Zerial","raw_affiliation_strings":["Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022041947","display_name":"Andreas Beyer","orcid":"https://orcid.org/0000-0002-3891-2123"},"institutions":[{"id":"https://openalex.org/I4210127521","display_name":"Berlin-Brandenburger Centrum f\u00fcr Regenerative Therapien","ror":"https://ror.org/03781zn34","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210127521"]},{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]},{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Andreas Beyer","raw_affiliation_strings":["Biotechnology Center, TU Dresden, Dresden, Germany; Center for Regenerative Therapy, Dresden, Germany; University of Cologne, Cologne, Germany","University of Cologne, Cologne, Germany","Biotechnology Center, TU Dresden, Dresden, Germany","Center for Regenerative Therapy, Dresden, Germany"],"affiliations":[{"raw_affiliation_string":"Biotechnology Center, TU Dresden, Dresden, Germany; Center for Regenerative Therapy, Dresden, Germany; University of Cologne, Cologne, Germany","institution_ids":[]},{"raw_affiliation_string":"University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Biotechnology Center, TU Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Center for Regenerative Therapy, Dresden, Germany","institution_ids":["https://openalex.org/I4210127521"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5022041947"],"corresponding_institution_ids":["https://openalex.org/I180923762","https://openalex.org/I4210127521","https://openalex.org/I78650965"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.2852,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60054582,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"10","issue":"9","first_page":"e1003801","last_page":"e1003801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.7121475338935852},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.650031328201294},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.643744945526123},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6368920803070068},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.49640709161758423},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4834507405757904},{"id":"https://openalex.org/keywords/endocytosis","display_name":"Endocytosis","score":0.45492687821388245},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4547703266143799},{"id":"https://openalex.org/keywords/bottleneck","display_name":"Bottleneck","score":0.4291209578514099},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.42170530557632446},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1827557384967804},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.10346314311027527},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.07298249006271362}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7121475338935852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.650031328201294},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.643744945526123},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6368920803070068},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.49640709161758423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4834507405757904},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.45492687821388245},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4547703266143799},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.4291209578514099},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.42170530557632446},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1827557384967804},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10346314311027527},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07298249006271362},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1003801","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003801","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003801&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25188415","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25188415","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:43140","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.4623","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.4623","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f5/bf/pcbi.1003801.PMC4154648.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:78fbf104473246ef95cd5584349bfdb4","is_oa":true,"landing_page_url":"https://doaj.org/article/78fbf104473246ef95cd5584349bfdb4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 9, p e1003801 (2014)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:705693","is_oa":false,"landing_page_url":"http://edoc.mpg.de/705693","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, v.10 (2014)","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:3126924","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4154648","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1161206","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Revealing_Molecular_Mechanisms_by_Integrating_High_Dimensional_Functional_Screens_with_Protein_Interaction_Data_/1161206","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pure.mpg.de:item_2567653","is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0001-0602-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003801","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003801","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003801&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071689070.pdf","grobid_xml":"https://content.openalex.org/works/W2071689070.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1876024155","https://openalex.org/W1963899959","https://openalex.org/W1965440903","https://openalex.org/W1965601708","https://openalex.org/W1966311581","https://openalex.org/W1968410036","https://openalex.org/W1972637758","https://openalex.org/W1973260880","https://openalex.org/W1974683325","https://openalex.org/W1998202992","https://openalex.org/W2001447115","https://openalex.org/W2001623365","https://openalex.org/W2006617902","https://openalex.org/W2016324935","https://openalex.org/W2023119588","https://openalex.org/W2025145799","https://openalex.org/W2027954222","https://openalex.org/W2030052455","https://openalex.org/W2041058556","https://openalex.org/W2069981183","https://openalex.org/W2074325696","https://openalex.org/W2076883893","https://openalex.org/W2077275724","https://openalex.org/W2083752219","https://openalex.org/W2096081010","https://openalex.org/W2099826569","https://openalex.org/W2100327770","https://openalex.org/W2101807845","https://openalex.org/W2102150307","https://openalex.org/W2105187843","https://openalex.org/W2105924489","https://openalex.org/W2109001750","https://openalex.org/W2112811019","https://openalex.org/W2113308846","https://openalex.org/W2117701806","https://openalex.org/W2117879084","https://openalex.org/W2121665844","https://openalex.org/W2123060905","https://openalex.org/W2123186051","https://openalex.org/W2123879591","https://openalex.org/W2130561514","https://openalex.org/W2133465414","https://openalex.org/W2137412574","https://openalex.org/W2137637116","https://openalex.org/W2141287957","https://openalex.org/W2143070952","https://openalex.org/W2144087703","https://openalex.org/W2148043260","https://openalex.org/W2149232113","https://openalex.org/W2150091347","https://openalex.org/W2153463811","https://openalex.org/W2154947819","https://openalex.org/W2157825442","https://openalex.org/W2158217645","https://openalex.org/W2161732139","https://openalex.org/W2165456024","https://openalex.org/W2166155213","https://openalex.org/W2167341806","https://openalex.org/W2171662214","https://openalex.org/W2916288174","https://openalex.org/W2917375902","https://openalex.org/W4211214945","https://openalex.org/W4233437719","https://openalex.org/W6678274143"],"related_works":["https://openalex.org/W1657880117","https://openalex.org/W2595172197","https://openalex.org/W2127970246","https://openalex.org/W2084856301","https://openalex.org/W1001352512","https://openalex.org/W4382618745","https://openalex.org/W2885125400","https://openalex.org/W1989889224","https://openalex.org/W1987128138","https://openalex.org/W2748922771"],"abstract_inverted_index":{"Functional":[0],"genomics":[1],"screens":[2],"using":[3,250],"multi-parametric":[4,49],"assays":[5],"are":[6,106,133],"powerful":[7],"approaches":[8],"for":[9,34,44,189],"identifying":[10],"genes":[11,93,105,154,182],"involved":[12,111],"in":[13,112],"particular":[14],"cellular":[15],"processes.":[16],"However,":[17],"they":[18],"suffer":[19],"from":[20],"problems":[21],"like":[22],"noise,":[23],"and":[24,95,186,219],"often":[25],"provide":[26],"little":[27],"insight":[28],"into":[29],"molecular":[30,53,259],"mechanisms.":[31],"A":[32],"bottleneck":[33],"addressing":[35],"these":[36,163],"issues":[37],"is":[38,71,120,165],"the":[39,45,74,101,127,140,171,195,210,238,244,258],"lack":[40],"of":[41,48,62,69,87,91,129,147,162,170,212,237,246,253,261],"computational":[42],"methods":[43],"systematic":[46],"integration":[47],"phenotypic":[50,77,130,248],"datasets":[51],"with":[52,155,183],"interactions.":[54],"Here,":[55],"we":[56,232],"present":[57],"Integrative":[58],"Multi":[59],"Profile":[60],"Analysis":[61],"Cellular":[63],"Traits":[64],"(IMPACT).":[65],"The":[66,159],"main":[67],"goal":[68],"IMPACT":[70,173,208,242],"to":[72,109,125,199],"identify":[73],"most":[75,141],"consistent":[76,221],"profile":[78,143],"among":[79,135,144],"interacting":[80,104,136],"genes.":[81,137,149,230],"This":[82],"approach":[83],"utilizes":[84],"two":[85],"types":[86,252],"external":[88],"information:":[89],"sets":[90],"related":[92,148],"(IMPACT-sets)":[94],"network":[96,196],"information":[97],"(IMPACT-modules).":[98],"Based":[99],"on":[100,204,240],"notion":[102],"that":[103,132,207],"more":[107],"likely":[108],"be":[110],"similar":[113,134,156],"functions":[114],"than":[115],"non-interacting":[116],"genes,":[117,215],"this":[118],"data":[119],"used":[121],"as":[122],"a":[123,145,200],"prior":[124],"inform":[126],"filtering":[128],"profiles":[131,177,249],"IMPACT-sets":[138],"selects":[139],"frequent":[142],"set":[146],"IMPACT-modules":[150],"identifies":[151],"sub-networks":[152],"containing":[153],"phenotype":[157],"profiles.":[158],"statistical":[160],"significance":[161],"selections":[164],"subsequently":[166],"quantified":[167],"via":[168],"permutations":[169],"data.":[172],"(1)":[174],"handles":[175],"multiple":[176,190],"per":[178],"gene,":[179],"(2)":[180],"rescues":[181],"weak":[184],"phenotypes":[185],"(3)":[187],"accounts":[188],"biases":[191],"e.g.":[192],"caused":[193],"by":[194,227],"topology.":[197],"Application":[198],"genome-wide":[201],"RNAi":[202],"screen":[203],"endocytosis":[205],"showed":[206],"improved":[209],"recovery":[211],"known":[213],"endocytosis-related":[214],"decreased":[216],"off-target":[217],"effects,":[218],"detected":[220],"phenotypes.":[222],"Those":[223],"findings":[224],"were":[225],"confirmed":[226],"rescreening":[228],"468":[229],"Additionally":[231],"validated":[233],"an":[234],"unexpected":[235],"influence":[236],"IGF-receptor":[239],"EGF-endocytosis.":[241],"facilitates":[243],"selection":[245],"high-quality":[247],"different":[251],"independent":[254],"information,":[255],"thereby":[256],"supporting":[257],"interpretation":[260],"functional":[262],"screens.":[263]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}