{"id":"https://openalex.org/W1980881263","doi":"https://doi.org/10.1371/journal.pcbi.1003794","title":"Stochastic Dynamics of Interacting Haematopoietic Stem Cell Niche Lineages","display_name":"Stochastic Dynamics of Interacting Haematopoietic Stem Cell Niche Lineages","publication_year":2014,"publication_date":"2014-09-04","ids":{"openalex":"https://openalex.org/W1980881263","doi":"https://doi.org/10.1371/journal.pcbi.1003794","mag":"1980881263","pmid":"https://pubmed.ncbi.nlm.nih.gov/25188267"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003794","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003794&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003794&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063077232","display_name":"Tam\u00e1s Sz\u00e9kely","orcid":"https://orcid.org/0000-0003-2093-0056"},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tam\u00e1s Sz\u00e9kely","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003330950","display_name":"Kevin Burrage","orcid":"https://orcid.org/0000-0002-8111-1137"},"institutions":[{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Kevin Burrage","raw_affiliation_strings":["Department of Computer Science, University of Oxford, Oxford, United Kingdom; Department of Mathematics, Queensland University of Technology, Brisbane, Queensland, Australia","Department of Computer Science, University of Oxford, Oxford, United Kingdom","Department of Mathematics, Queensland University of Technology, Brisbane, Queensland, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, United Kingdom; Department of Mathematics, Queensland University of Technology, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I160993911"]},{"raw_affiliation_string":"Department of Computer Science, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Mathematics, Queensland University of Technology, Brisbane, Queensland, Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060725859","display_name":"Marc Mangel","orcid":"https://orcid.org/0000-0002-9406-697X"},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO","US"],"is_corresponding":false,"raw_author_name":"Marc Mangel","raw_affiliation_strings":["Department of Applied Mathematics and Statistics, University of California Santa Cruz, Santa Cruz, California, United States of America; Department of Biology, University of Bergen, Bergen, Norway","Department of Biology, University of Bergen, Bergen, Norway","Department of Applied Mathematics and Statistics, University of California Santa Cruz, Santa Cruz, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, University of California Santa Cruz, Santa Cruz, California, United States of America; Department of Biology, University of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I185103710"]},{"raw_affiliation_string":"Department of Biology, University of Bergen, Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]},{"raw_affiliation_string":"Department of Applied Mathematics and Statistics, University of California Santa Cruz, Santa Cruz, California, United States of America","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034662688","display_name":"Michael B. Bonsall","orcid":"https://orcid.org/0000-0003-0250-0423"},"institutions":[{"id":"https://openalex.org/I2802123492","display_name":"Oxford Research Group","ror":"https://ror.org/00z4w4f29","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802123492"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael B. Bonsall","raw_affiliation_strings":["Mathematical Ecology Research Group, Department of Zoology, University of Oxford, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Ecology Research Group, Department of Zoology, University of Oxford, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2802123492","https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5063077232"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2917,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79697489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"9","first_page":"e1003794","last_page":"e1003794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9847999811172485,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niche","display_name":"Niche","score":0.826730489730835},{"id":"https://openalex.org/keywords/metapopulation","display_name":"Metapopulation","score":0.7708548307418823},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7655894160270691},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.6838780045509338},{"id":"https://openalex.org/keywords/ecological-niche","display_name":"Ecological niche","score":0.44161751866340637},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.4335811734199524},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.42304107546806335},{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.4132625460624695},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.2604061961174011},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.241804301738739},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.19432750344276428},{"id":"https://openalex.org/keywords/biological-dispersal","display_name":"Biological dispersal","score":0.1309443712234497}],"concepts":[{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.826730489730835},{"id":"https://openalex.org/C189569837","wikidata":"https://www.wikidata.org/wiki/Q954495","display_name":"Metapopulation","level":4,"score":0.7708548307418823},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7655894160270691},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6838780045509338},{"id":"https://openalex.org/C102715595","wikidata":"https://www.wikidata.org/wiki/Q172861","display_name":"Ecological niche","level":3,"score":0.44161751866340637},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.4335811734199524},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.42304107546806335},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4132625460624695},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2604061961174011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.241804301738739},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.19432750344276428},{"id":"https://openalex.org/C47559259","wikidata":"https://www.wikidata.org/wiki/Q778143","display_name":"Biological dispersal","level":3,"score":0.1309443712234497},{"id":"https://openalex.org/C185933670","wikidata":"https://www.wikidata.org/wiki/Q52105","display_name":"Habitat","level":2,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003794","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003794&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25188267","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25188267","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1003794","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003794","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b6f0691e28b44844a282e81d76b51d71","is_oa":true,"landing_page_url":"https://doaj.org/article/b6f0691e28b44844a282e81d76b51d71","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 9, p e1003794 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3126935","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4154659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1162402","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Stochastic_Dynamics_of_Interacting_Haematopoietic_Stem_Cell_Niche_Lineages_/1162402","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003794","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003794","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003794&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G1672966807","display_name":null,"funder_award_id":"EF-0924195","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4029663021","display_name":"Towards a theory linking hematopoietic stem cells, foraging ecology, antipredator behavior, and immune defense","funder_award_id":"0924195","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320290","display_name":"University of Oxford","ror":"https://ror.org/052gg0110"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1980881263.pdf","grobid_xml":"https://content.openalex.org/works/W1980881263.grobid-xml"},"referenced_works_count":72,"referenced_works":["https://openalex.org/W126539919","https://openalex.org/W571673367","https://openalex.org/W1836124358","https://openalex.org/W1966455261","https://openalex.org/W1966644300","https://openalex.org/W1968541478","https://openalex.org/W1970291858","https://openalex.org/W1972766500","https://openalex.org/W1973876898","https://openalex.org/W1977905227","https://openalex.org/W1982296995","https://openalex.org/W1989019426","https://openalex.org/W1990574061","https://openalex.org/W1996884864","https://openalex.org/W1999501108","https://openalex.org/W2004783314","https://openalex.org/W2007627399","https://openalex.org/W2010221405","https://openalex.org/W2011375480","https://openalex.org/W2011432832","https://openalex.org/W2017828716","https://openalex.org/W2022176539","https://openalex.org/W2025268465","https://openalex.org/W2027309262","https://openalex.org/W2027927113","https://openalex.org/W2034689973","https://openalex.org/W2037046279","https://openalex.org/W2037736150","https://openalex.org/W2045490693","https://openalex.org/W2047515584","https://openalex.org/W2050395164","https://openalex.org/W2050948440","https://openalex.org/W2056160976","https://openalex.org/W2062217218","https://openalex.org/W2062945727","https://openalex.org/W2063854986","https://openalex.org/W2064412759","https://openalex.org/W2069565851","https://openalex.org/W2071490795","https://openalex.org/W2077330278","https://openalex.org/W2084924279","https://openalex.org/W2086057553","https://openalex.org/W2087849201","https://openalex.org/W2090629368","https://openalex.org/W2093470850","https://openalex.org/W2093818708","https://openalex.org/W2099631900","https://openalex.org/W2105241495","https://openalex.org/W2105998918","https://openalex.org/W2107307011","https://openalex.org/W2117376536","https://openalex.org/W2118077148","https://openalex.org/W2119511363","https://openalex.org/W2119584141","https://openalex.org/W2119704135","https://openalex.org/W2124295081","https://openalex.org/W2125291586","https://openalex.org/W2127403997","https://openalex.org/W2129375080","https://openalex.org/W2131387288","https://openalex.org/W2132898564","https://openalex.org/W2134651634","https://openalex.org/W2149053153","https://openalex.org/W2154699417","https://openalex.org/W2155418451","https://openalex.org/W2155653301","https://openalex.org/W2155721087","https://openalex.org/W2163192588","https://openalex.org/W2170223994","https://openalex.org/W4240660124","https://openalex.org/W6650401418","https://openalex.org/W6683959616"],"related_works":["https://openalex.org/W3102059334","https://openalex.org/W3045983630","https://openalex.org/W2774948409","https://openalex.org/W2981567463","https://openalex.org/W2777552974","https://openalex.org/W4388745874","https://openalex.org/W3114103876","https://openalex.org/W1985545421","https://openalex.org/W2095253586","https://openalex.org/W3183539837"],"abstract_inverted_index":{"Since":[0],"we":[1,72,160],"still":[2],"know":[3],"very":[4],"little":[5],"about":[6],"stem":[7,31,46,83,247],"cells":[8,58,150],"in":[9],"their":[10,18],"natural":[11,43],"environment,":[12],"it":[13,119,219],"is":[14,50,63,112,116,220],"useful":[15],"to":[16,66,122,138,184,193,205,225,244],"explore":[17,161],"dynamics":[19,163],"through":[20],"modelling":[21],"and":[22,59,254],"simulation,":[23],"as":[24,26,118,189,191,259],"well":[25],"experimentally.":[27],"Most":[28],"models":[29],"of":[30,45,56,82,142,164,211,262,265],"cell":[32,47,84,187,248],"systems":[33],"are":[34,151],"based":[35],"on":[36],"deterministic":[37],"differential":[38],"equations":[39],"that":[40,87,91,108,176,218,236],"ignore":[41],"the":[42,54,101,109,140,162,165,182,194,209,252],"heterogeneity":[44],"populations.":[48],"This":[49,115,215],"not":[51],"appropriate":[52],"at":[53],"level":[55],"individual":[57],"niches,":[60],"when":[61],"randomness":[62],"more":[64],"likely":[65],"affect":[67],"dynamics.":[68],"In":[69],"this":[70,158],"paper,":[71],"introduce":[73,123],"a":[74,80,94,169,237,260,263],"fast":[75],"stochastic":[76],"method":[77,106,137],"for":[78,222],"simulating":[79],"metapopulation":[81,111],"niche":[85,127,146,155,179,229,253],"lineages,":[86,128],"is,":[88],"many":[89,143],"sub-populations":[90],"together":[92,178,227],"form":[93],"heterogeneous":[95],"metapopulation,":[96],"over":[97],"time.":[98],"By":[99],"selecting":[100],"common":[102],"limiting":[103],"timestep,":[104],"our":[105,136],"ensures":[107],"entire":[110],"simulated":[113],"synchronously.":[114],"important,":[117],"allows":[120,181],"us":[121],"interactions":[124],"between":[125],"separate":[126],"which":[129],"would":[130],"otherwise":[131],"be":[132,243],"impossible.":[133],"We":[134,174],"expand":[135],"enable":[139],"coupling":[141,177],"lineages":[144,180,199,230],"into":[145,231],"groups,":[147],"where":[148],"differentiated":[149],"pooled":[152],"within":[153],"each":[154],"group.":[156],"Using":[157],"method,":[159],"haematopoietic":[166],"system":[167,172],"from":[168],"demand":[170],"control":[171],"perspective.":[173],"find":[175],"organism":[183,224],"regulate":[185],"blood":[186],"numbers":[188],"closely":[190],"possible":[192],"homeostatic":[195],"optimum.":[196],"Furthermore,":[197],"coupled":[198],"respond":[200],"better":[201],"than":[202],"uncoupled":[203],"ones":[204],"random":[206],"perturbations,":[207],"here":[208],"loss":[210],"some":[212],"myeloid":[213],"cells.":[214],"could":[216],"imply":[217],"advantageous":[221],"an":[223],"connect":[226],"its":[228],"groups.":[232],"Our":[233],"results":[234],"suggest":[235],"potential":[238],"fruitful":[239],"empirical":[240],"direction":[241],"will":[242],"understand":[245],"how":[246,255],"descendants":[249],"communicate":[250],"with":[251],"cancer":[256],"may":[257],"arise":[258],"result":[261],"failure":[264],"such":[266],"communication.":[267]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-07-25T09:21:30.201066","created_date":"2025-10-10T00:00:00"}
