{"id":"https://openalex.org/W2093464262","doi":"https://doi.org/10.1371/journal.pcbi.1003782","title":"Specificity and Affinity Quantification of Flexible Recognition from Underlying Energy Landscape Topography","display_name":"Specificity and Affinity Quantification of Flexible Recognition from Underlying Energy Landscape Topography","publication_year":2014,"publication_date":"2014-08-21","ids":{"openalex":"https://openalex.org/W2093464262","doi":"https://doi.org/10.1371/journal.pcbi.1003782","mag":"2093464262","pmid":"https://pubmed.ncbi.nlm.nih.gov/25144525"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003782","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003782","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003782&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003782&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072626733","display_name":"Xiakun Chu","orcid":"https://orcid.org/0000-0003-3166-7070"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiakun Chu","raw_affiliation_strings":["College of Physics, Jilin University, Changchun, Jilin, P. R. China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China","College of Physics, Jilin University, Changchun, Jilin, P. R. China","State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China"],"affiliations":[{"raw_affiliation_string":"College of Physics, Jilin University, Changchun, Jilin, P. R. China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China","institution_ids":[]},{"raw_affiliation_string":"College of Physics, Jilin University, Changchun, Jilin, P. R. China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China","institution_ids":["https://openalex.org/I4210092888","https://openalex.org/I19820366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100346147","display_name":"Jin Wang","orcid":"https://orcid.org/0000-0002-2841-4913"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"funder","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210092888","display_name":"Changchun Institute of Applied Chemistry","ror":"https://ror.org/00h52n341","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210092888"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]},{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Jin Wang","raw_affiliation_strings":["College of Physics, Jilin University, Changchun, Jilin, P. R. China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China; Department of Chemistry and Physics, State University of New York at Stony Brook, Stony Brook, New York, United States of America","College of Physics, Jilin University, Changchun, Jilin, P. R. China","Department of Chemistry and Physics, State University of New York at Stony Brook, Stony Brook, New York, United States of America","State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China"],"affiliations":[{"raw_affiliation_string":"College of Physics, Jilin University, Changchun, Jilin, P. R. China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China; Department of Chemistry and Physics, State University of New York at Stony Brook, Stony Brook, New York, United States of America","institution_ids":[]},{"raw_affiliation_string":"College of Physics, Jilin University, Changchun, Jilin, P. R. China","institution_ids":["https://openalex.org/I194450716"]},{"raw_affiliation_string":"Department of Chemistry and Physics, State University of New York at Stony Brook, Stony Brook, New York, United States of America","institution_ids":["https://openalex.org/I59553526","https://openalex.org/I1327163397"]},{"raw_affiliation_string":"State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China","institution_ids":["https://openalex.org/I4210092888","https://openalex.org/I19820366"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100346147"],"corresponding_institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I194450716","https://openalex.org/I19820366","https://openalex.org/I4210092888","https://openalex.org/I59553526"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.4261,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.81300957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"8","first_page":"e1003782","last_page":"e1003782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/energy-landscape","display_name":"Energy landscape","score":0.7821745872497559},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.7708703279495239},{"id":"https://openalex.org/keywords/folding","display_name":"Folding (DSP implementation)","score":0.6576842069625854},{"id":"https://openalex.org/keywords/molecular-recognition","display_name":"Molecular recognition","score":0.5089144706726074},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45185744762420654},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.43427854776382446},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.42437613010406494},{"id":"https://openalex.org/keywords/binding-energy","display_name":"Binding energy","score":0.4127580523490906},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.39836233854293823},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3813840448856354},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31801629066467285},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18589091300964355},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.1804875135421753},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.17244726419448853},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11731332540512085}],"concepts":[{"id":"https://openalex.org/C119621388","wikidata":"https://www.wikidata.org/wiki/Q5377166","display_name":"Energy landscape","level":2,"score":0.7821745872497559},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.7708703279495239},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.6576842069625854},{"id":"https://openalex.org/C179303850","wikidata":"https://www.wikidata.org/wiki/Q4300362","display_name":"Molecular recognition","level":3,"score":0.5089144706726074},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45185744762420654},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.43427854776382446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42437613010406494},{"id":"https://openalex.org/C93282013","wikidata":"https://www.wikidata.org/wiki/Q420754","display_name":"Binding energy","level":2,"score":0.4127580523490906},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39836233854293823},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3813840448856354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31801629066467285},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18589091300964355},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.1804875135421753},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17244726419448853},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11731332540512085},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018583","descriptor_name":"Pliability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018583","descriptor_name":"Pliability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018583","descriptor_name":"Pliability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1003782","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003782","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003782&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25144525","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25144525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:34938163280f4ee0b0faaf2590c8b181","is_oa":true,"landing_page_url":"https://doaj.org/article/34938163280f4ee0b0faaf2590c8b181","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 8, p e1003782 (2014)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4140643","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4140643","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003782","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003782","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003782&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7300000190734863,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G1131331748","display_name":null,"funder_award_id":"91227114","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5421120092","display_name":null,"funder_award_id":"2010CB933600","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5492191759","display_name":null,"funder_award_id":"11174105","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6926952570","display_name":null,"funder_award_id":"21190040","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2093464262.pdf","grobid_xml":"https://content.openalex.org/works/W2093464262.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W45157614","https://openalex.org/W337785430","https://openalex.org/W1524608481","https://openalex.org/W1587498640","https://openalex.org/W1965127482","https://openalex.org/W1965800037","https://openalex.org/W1966078827","https://openalex.org/W1967203779","https://openalex.org/W1968751855","https://openalex.org/W1969765360","https://openalex.org/W1971803615","https://openalex.org/W1978842345","https://openalex.org/W1979795840","https://openalex.org/W1980593789","https://openalex.org/W1985023530","https://openalex.org/W1985581386","https://openalex.org/W1985953075","https://openalex.org/W1987159249","https://openalex.org/W1987434495","https://openalex.org/W1991906934","https://openalex.org/W1992787746","https://openalex.org/W1994296030","https://openalex.org/W1994296819","https://openalex.org/W1994756593","https://openalex.org/W1998767084","https://openalex.org/W2000149219","https://openalex.org/W2004698009","https://openalex.org/W2005474992","https://openalex.org/W2006192061","https://openalex.org/W2007016963","https://openalex.org/W2010004274","https://openalex.org/W2011246315","https://openalex.org/W2011983814","https://openalex.org/W2013354180","https://openalex.org/W2013593586","https://openalex.org/W2013638533","https://openalex.org/W2015117663","https://openalex.org/W2016170088","https://openalex.org/W2016408686","https://openalex.org/W2021059897","https://openalex.org/W2021664957","https://openalex.org/W2023231003","https://openalex.org/W2024052331","https://openalex.org/W2026924192","https://openalex.org/W2028968631","https://openalex.org/W2029998417","https://openalex.org/W2030207939","https://openalex.org/W2030718808","https://openalex.org/W2030776726","https://openalex.org/W2033215069","https://openalex.org/W2034299708","https://openalex.org/W2034655166","https://openalex.org/W2040680919","https://openalex.org/W2040809566","https://openalex.org/W2044730187","https://openalex.org/W2045393768","https://openalex.org/W2045664610","https://openalex.org/W2049888624","https://openalex.org/W2050352485","https://openalex.org/W2052606462","https://openalex.org/W2053960740","https://openalex.org/W2058353811","https://openalex.org/W2058527555","https://openalex.org/W2059324308","https://openalex.org/W2059521474","https://openalex.org/W2059947046","https://openalex.org/W2062792348","https://openalex.org/W2062845058","https://openalex.org/W2063702932","https://openalex.org/W2065864578","https://openalex.org/W2068751599","https://openalex.org/W2073745520","https://openalex.org/W2074455942","https://openalex.org/W2076231220","https://openalex.org/W2079212311","https://openalex.org/W2084333983","https://openalex.org/W2085656056","https://openalex.org/W2086642544","https://openalex.org/W2086801849","https://openalex.org/W2090393756","https://openalex.org/W2094600324","https://openalex.org/W2094624643","https://openalex.org/W2097891553","https://openalex.org/W2099345838","https://openalex.org/W2107677817","https://openalex.org/W2109475802","https://openalex.org/W2109685531","https://openalex.org/W2112154906","https://openalex.org/W2113353838","https://openalex.org/W2115273980","https://openalex.org/W2115570685","https://openalex.org/W2119693327","https://openalex.org/W2120881407","https://openalex.org/W2124037948","https://openalex.org/W2125022522","https://openalex.org/W2126303237","https://openalex.org/W2127921600","https://openalex.org/W2134544170","https://openalex.org/W2144562104","https://openalex.org/W2149472608","https://openalex.org/W2149744037","https://openalex.org/W2154335467","https://openalex.org/W2162685411","https://openalex.org/W2162720882","https://openalex.org/W2168239703","https://openalex.org/W2968636733","https://openalex.org/W4210968583","https://openalex.org/W4248357178","https://openalex.org/W4252035015","https://openalex.org/W4298261323"],"related_works":["https://openalex.org/W2186061937","https://openalex.org/W2113188411","https://openalex.org/W1974862140","https://openalex.org/W2083241011","https://openalex.org/W1919653159","https://openalex.org/W2970203514","https://openalex.org/W2080251448","https://openalex.org/W2145920789","https://openalex.org/W3013460560","https://openalex.org/W2111515598"],"abstract_inverted_index":{"Flexibility":[0],"in":[1,22,44,237],"biomolecular":[2,45,59,239],"recognition":[3,13,46,60],"is":[4,47],"essential":[5],"and":[6,31,64,88,100,125,133,155,163,177,217,235],"critical":[7],"for":[8],"many":[9],"cellular":[10],"activities.":[11],"Flexible":[12],"often":[14],"leads":[15,148],"to":[16,149,231],"moderate":[17],"affinity":[18,30,113,132,154,176,234],"but":[19,117],"high":[20,29,32],"specificity,":[21],"contradiction":[23],"with":[24,63,138,191],"the":[25,40,53,57,68,75,80,83,89,98,122,126,139,167,172,184,199,205,214,233],"conventional":[26],"wisdom":[27],"that":[28,97,109,183,194,204],"specificity":[33,78,91,102,120,134,236],"are":[34,103,135,188],"coupled.":[35],"Furthermore,":[36,106],"quantitative":[37,164],"understanding":[38],"of":[39,42,71,82,131,141,166],"role":[41],"flexibility":[43,66,110,147],"still":[48],"challenging.":[49],"Here,":[50],"we":[51,107,181,202],"meet":[52],"challenge":[54],"by":[55,79,92,213],"quantifying":[56],"intrinsic":[58,77,84],"energy":[61,86,186,208,220],"landscapes":[62,187,209,221],"without":[65],"through":[67],"underlying":[69],"density":[70],"states.":[72],"We":[73,95],"quantified":[74],"thermodynamic":[76,99],"topography":[81],"binding":[85,112,119,195,216],"landscape":[87],"kinetic":[90,101],"association":[93],"rate.":[94],"found":[96,108,182],"strongly":[104,136],"correlated.":[105],"decreases":[111],"on":[114,121,171],"one":[115],"hand,":[116,124],"increases":[118],"other":[123],"decreasing":[127],"or":[128],"increasing":[129],"proportion":[130],"correlated":[137],"degree":[140],"flexibility.":[142,224],"This":[143],"shows":[144],"more":[145,189],"(less)":[146],"weaker":[150],"(stronger)":[151],"coupling":[152],"between":[153],"specificity.":[156,178],"Our":[157,225],"work":[158],"provides":[159],"a":[160,228],"theoretical":[161],"foundation":[162],"explanation":[165],"previous":[168],"qualitative":[169],"studies":[170],"relationship":[173],"among":[174],"flexibility,":[175],"In":[179],"addition,":[180],"folding":[185,197,219],"funneled":[190],"binding,":[192],"indicating":[193],"helps":[196],"during":[198],"recognition.":[200,240],"Finally,":[201],"demonstrated":[203],"whole":[206],"binding-folding":[207],"can":[210],"be":[211],"integrated":[212],"rigid":[215],"isolated":[218],"under":[222],"weak":[223],"results":[226],"provide":[227],"novel":[229],"way":[230],"quantify":[232],"flexible":[238]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
