{"id":"https://openalex.org/W2076544181","doi":"https://doi.org/10.1371/journal.pcbi.1003765","title":"Identification of Allelic Imbalance with a Statistical Model for Subtle Genomic Mosaicism","display_name":"Identification of Allelic Imbalance with a Statistical Model for Subtle Genomic Mosaicism","publication_year":2014,"publication_date":"2014-08-28","ids":{"openalex":"https://openalex.org/W2076544181","doi":"https://doi.org/10.1371/journal.pcbi.1003765","mag":"2076544181","pmid":"https://pubmed.ncbi.nlm.nih.gov/25166618"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003765","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003765","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003765&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003765&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022494657","display_name":"Rui Xia","orcid":"https://orcid.org/0000-0003-2409-1181"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rui Xia","raw_affiliation_strings":["Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America","Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008131059","display_name":"Selina Vattathil","orcid":"https://orcid.org/0000-0001-5616-4184"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selina Vattathil","raw_affiliation_strings":["Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Human & Molecular Genetics Program, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America","Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","Human & Molecular Genetics Program, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Human & Molecular Genetics Program, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Human & Molecular Genetics Program, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054223849","display_name":"Paul Scheet","orcid":"https://orcid.org/0000-0002-5173-7497"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Scheet","raw_affiliation_strings":["Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America; Human & Molecular Genetics Program, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America","Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America","Human & Molecular Genetics Program, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America; Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America; Human & Molecular Genetics Program, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Division of Biostatistics, The University of Texas School of Public Health, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Human & Molecular Genetics Program, The University of Texas Graduate School of Biomedical Sciences, Houston, Texas, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022494657"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.8529,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76554345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"8","first_page":"e1003765","last_page":"e1003765"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7003383040428162},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6551757454872131},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"Loss of heterozygosity","score":0.5970796346664429},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.5570545196533203},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5336865186691284},{"id":"https://openalex.org/keywords/comparative-genomic-hybridization","display_name":"Comparative genomic hybridization","score":0.521439254283905},{"id":"https://openalex.org/keywords/germline","display_name":"Germline","score":0.49490994215011597},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.470117449760437},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.45108091831207275},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.447814017534256},{"id":"https://openalex.org/keywords/snp-array","display_name":"SNP array","score":0.42449912428855896},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.3311241865158081},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.1983712613582611},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1488170027732849},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.09426620602607727}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7003383040428162},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6551757454872131},{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.5970796346664429},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.5570545196533203},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5336865186691284},{"id":"https://openalex.org/C124942203","wikidata":"https://www.wikidata.org/wiki/Q656638","display_name":"Comparative genomic hybridization","level":4,"score":0.521439254283905},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.49490994215011597},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.470117449760437},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.45108091831207275},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.447814017534256},{"id":"https://openalex.org/C122060243","wikidata":"https://www.wikidata.org/wiki/Q7391885","display_name":"SNP array","level":5,"score":0.42449912428855896},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.3311241865158081},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1983712613582611},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1488170027732849},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.09426620602607727},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009030","descriptor_name":"Mosaicism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009030","descriptor_name":"Mosaicism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009030","descriptor_name":"Mosaicism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009030","descriptor_name":"Mosaicism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022981","descriptor_name":"Allelic Imbalance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022981","descriptor_name":"Allelic Imbalance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022981","descriptor_name":"Allelic Imbalance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022981","descriptor_name":"Allelic Imbalance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003765","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003765","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003765&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25166618","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25166618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.783.8557","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.783.8557","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/09/2a/pcbi.1003765.PMC4148184.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003765","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003765","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:3a1db0336f5f4e07ac61fce4b87fd340","is_oa":true,"landing_page_url":"https://doaj.org/article/3a1db0336f5f4e07ac61fce4b87fd340","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 8, p e1003765 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3113736","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4148184","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1154094","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Identification_of_Allelic_Imbalance_with_a_Statistical_Model_for_Subtle_Genomic_Mosaicism_/1154094","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003765","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003765","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003765&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G46020690","display_name":null,"funder_award_id":"U01 GM092666","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4755611226","display_name":null,"funder_award_id":"R01 HG005855","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8143886224","display_name":null,"funder_award_id":"U01 GM92666","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8969677841","display_name":null,"funder_award_id":"R01 HG005859","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076544181.pdf","grobid_xml":"https://content.openalex.org/works/W2076544181.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1966026613","https://openalex.org/W1979617384","https://openalex.org/W2006288875","https://openalex.org/W2050886653","https://openalex.org/W2058401000","https://openalex.org/W2063311473","https://openalex.org/W2068127752","https://openalex.org/W2076918641","https://openalex.org/W2081093887","https://openalex.org/W2109991075","https://openalex.org/W2114553186","https://openalex.org/W2115837368","https://openalex.org/W2128351693","https://openalex.org/W2149681218","https://openalex.org/W2159595235","https://openalex.org/W2161356785","https://openalex.org/W2165790514","https://openalex.org/W2168122333","https://openalex.org/W2217809488"],"related_works":["https://openalex.org/W2353484916","https://openalex.org/W2414346359","https://openalex.org/W2001734836","https://openalex.org/W2007389278","https://openalex.org/W2414485083","https://openalex.org/W2470127854","https://openalex.org/W2355979292","https://openalex.org/W1533773610","https://openalex.org/W2041604481","https://openalex.org/W2966739945"],"abstract_inverted_index":{"Genetic":[0],"heterogeneity":[1],"in":[2,27,57,65,173,235],"a":[3,50,90,118,137,177,202,236,246],"mixed":[4],"sample":[5],"of":[6,14,37,89,92,113,126,144,160,176,205,251],"tumor":[7,16,31,40,103,178,180,255],"and":[8,32,99,111,169,195,210,213,218,254,266],"normal":[9,33],"DNA":[10,28,145,197],"can":[11],"confound":[12],"characterization":[13,159],"the":[15,58,66,78,97,102,107,123,147,151,158,186,252],"genome.":[17],"Numerous":[18],"computational":[19],"methods":[20,276],"have":[21,117],"been":[22],"proposed":[23],"to":[24,42,53,184,228,257],"detect":[25],"aberrations":[26,234],"samples":[29],"from":[30,70,271],"tissue":[34],"mixtures.":[35],"Most":[36],"these":[38,132],"require":[39],"purities":[41],"be":[43,229],"at":[44],"least":[45],"10-15%.":[46],"Here,":[47],"we":[48,225],"present":[49],"statistical":[51],"model":[52,81,87,191,223,244],"capture":[54],"information,":[55],"contained":[56],"individual's":[59,128],"germline":[60,98,193,253],"haplotypes,":[61],"about":[62],"expected":[63],"patterns":[64,112],"B":[67],"allele":[68],"frequencies":[69],"SNP":[71,83],"microarrays":[72],"while":[73],"fully":[74],"modeling":[75],"their":[76],"magnitude,":[77],"first":[79],"such":[80],"for":[82,96,101,140,157,170,192,231,248],"microarray":[84],"data.":[85],"Our":[86,189],"consists":[88],"pair":[91],"hidden":[93,133],"Markov":[94,134],"models--one":[95],"one":[100],"genome--which,":[104],"conditional":[105],"on":[106],"observed":[108],"array":[109],"data":[110],"population":[114],"haplotype":[115],"variation,":[116],"dependence":[119],"structure":[120],"induced":[121],"by":[122],"relative":[124],"imbalance":[125],"an":[127],"inherited":[129],"haplotypes.":[130],"Together,":[131],"models":[135],"offer":[136],"powerful":[138],"approach":[139],"dealing":[141],"with":[142,261],"mixtures":[143],"where":[146,274],"main":[148],"component":[149],"represents":[150],"germline,":[152],"thus":[153,267],"suggesting":[154],"natural":[155],"applications":[156],"primary":[161,187],"clones":[162],"when":[163,179],"stromal":[164],"contamination":[165],"is":[166,182,199],"extremely":[167],"high,":[168],"identifying":[171],"lesions":[172],"rare":[174,233],"subclones":[175],"purity":[181],"sufficient":[183],"characterize":[185],"lesions.":[188],"joint":[190],"haplotypes":[194],"acquired":[196],"aberration":[198],"flexible,":[200],"allowing":[201],"large":[203],"number":[204],"chromosomal":[206],"alterations,":[207],"including":[208],"balanced":[209],"imbalanced":[211],"losses":[212],"gains,":[214],"copy-neutral":[215],"loss-of-heterozygosity":[216],"(LOH)":[217],"tetraploidy.":[219],"We":[220],"found":[221],"our":[222,243],"(which":[224],"term":[226],"J-LOH)":[227],"superior":[230],"localizing":[232],"simulated":[237],"3%":[238],"mixture":[239],"sample.":[240],"More":[241],"generally,":[242],"provides":[245],"framework":[247],"full":[249],"integration":[250],"genomes":[256],"deal":[258],"more":[259],"effectively":[260],"missing":[262],"or":[263],"uncertain":[264],"features,":[265],"extract":[268],"maximal":[269],"information":[270],"difficult":[272],"scenarios":[273],"existing":[275],"fail.":[277]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2025-10-10T00:00:00"}
