{"id":"https://openalex.org/W2038727419","doi":"https://doi.org/10.1371/journal.pcbi.1003747","title":"Propagating Waves of Directionality and Coordination Orchestrate Collective Cell Migration","display_name":"Propagating Waves of Directionality and Coordination Orchestrate Collective Cell Migration","publication_year":2014,"publication_date":"2014-07-24","ids":{"openalex":"https://openalex.org/W2038727419","doi":"https://doi.org/10.1371/journal.pcbi.1003747","mag":"2038727419","pmid":"https://pubmed.ncbi.nlm.nih.gov/25058592"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003747","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003747","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003747&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003747&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021318986","display_name":"Assaf Zaritsky","orcid":"https://orcid.org/0000-0002-1477-5478"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Assaf Zaritsky","raw_affiliation_strings":["Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109101585","display_name":"Doron Kaplan","orcid":null},"institutions":[{"id":"https://openalex.org/I104146711","display_name":"Israel Institute for Biological Research","ror":"https://ror.org/05atez085","country_code":"IL","type":"facility","lineage":["https://openalex.org/I104146711"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Doron Kaplan","raw_affiliation_strings":["Israel Institute for Biological Research, Ness Ziona, Israel"],"affiliations":[{"raw_affiliation_string":"Israel Institute for Biological Research, Ness Ziona, Israel","institution_ids":["https://openalex.org/I104146711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031030154","display_name":"Inbal Hecht","orcid":null},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Inbal Hecht","raw_affiliation_strings":["School of Physics and Astronomy, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015460920","display_name":"Sari Natan","orcid":"https://orcid.org/0000-0001-9419-3808"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sari Natan","raw_affiliation_strings":["Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078102229","display_name":"Lior Wolf","orcid":"https://orcid.org/0000-0001-5578-8892"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Lior Wolf","raw_affiliation_strings":["Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077179422","display_name":"Nir S. Gov","orcid":"https://orcid.org/0000-0001-7774-1139"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nir S. Gov","raw_affiliation_strings":["Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Chemical Physics, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113524343","display_name":"Eshel Ben\u2010Jacob","orcid":null},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]},{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I4210114157","display_name":"Assaf Harofeh Medical Center","ror":"https://ror.org/02722hp10","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I4210114157"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Eshel Ben-Jacob","raw_affiliation_strings":["School of Physics and Astronomy, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel; Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America; Research & Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel","Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America","Research & Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel","School of Physics and Astronomy, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"School of Physics and Astronomy, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel; Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America; Research & Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel","institution_ids":[]},{"raw_affiliation_string":"Center for Theoretical Biological Physics, Rice University, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]},{"raw_affiliation_string":"Research & Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel","institution_ids":["https://openalex.org/I4210114157"]},{"raw_affiliation_string":"School of Physics and Astronomy, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053220727","display_name":"Ilan Tsarfaty","orcid":"https://orcid.org/0000-0002-5230-7093"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ilan Tsarfaty","raw_affiliation_strings":["Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5053220727","https://openalex.org/A5113524343"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I4210114157","https://openalex.org/I4210145836","https://openalex.org/I74775410"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.6522,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.9306789,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"7","first_page":"e1003747","last_page":"e1003747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/directionality","display_name":"Directionality","score":0.8386924266815186},{"id":"https://openalex.org/keywords/cell-migration","display_name":"Cell migration","score":0.7726175785064697},{"id":"https://openalex.org/keywords/motility","display_name":"Motility","score":0.6989787817001343},{"id":"https://openalex.org/keywords/wound-healing","display_name":"Wound healing","score":0.5673301815986633},{"id":"https://openalex.org/keywords/acceleration","display_name":"Acceleration","score":0.4416259825229645},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43509641289711},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4168859124183655},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.40096351504325867},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.36941996216773987},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3315296471118927},{"id":"https://openalex.org/keywords/classical-mechanics","display_name":"Classical mechanics","score":0.11600932478904724},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11548319458961487}],"concepts":[{"id":"https://openalex.org/C29648211","wikidata":"https://www.wikidata.org/wiki/Q1995607","display_name":"Directionality","level":2,"score":0.8386924266815186},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.7726175785064697},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.6989787817001343},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.5673301815986633},{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.4416259825229645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43509641289711},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4168859124183655},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40096351504325867},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36941996216773987},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3315296471118927},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.11600932478904724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11548319458961487}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061985","descriptor_name":"Madin Darby Canine Kidney Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003747","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003747","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003747&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25058592","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25058592","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.5549","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.5549","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/8d/92/pcbi.1003747.PMC4109844.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c5ca338c76ac4485841bae480e309223","is_oa":true,"landing_page_url":"https://doaj.org/article/c5ca338c76ac4485841bae480e309223","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 7, p e1003747 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3080902","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4109844","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003747","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003747","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003747&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10"}],"awards":[{"id":"https://openalex.org/G3747673514","display_name":null,"funder_award_id":"PHY-0822283","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6200803884","display_name":null,"funder_award_id":"PHY-0822283","funder_id":"https://openalex.org/F4320332774","funder_display_name":"Center for Theoretical Biological Physics"},{"id":"https://openalex.org/G6776192592","display_name":"Center for Theoretical Biological Physics","funder_award_id":"0822283","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320310133","display_name":"Rice University","ror":"https://ror.org/008zs3103"},{"id":"https://openalex.org/F4320316503","display_name":"Federico and Elvia Faggin Foundation","ror":null},{"id":"https://openalex.org/F4320322596","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49"},{"id":"https://openalex.org/F4320332774","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/008zs3103"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2038727419.pdf","grobid_xml":"https://content.openalex.org/works/W2038727419.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1505887721","https://openalex.org/W1972514043","https://openalex.org/W1983923147","https://openalex.org/W1984634839","https://openalex.org/W1989676138","https://openalex.org/W1990039283","https://openalex.org/W1992172233","https://openalex.org/W2004042002","https://openalex.org/W2009150565","https://openalex.org/W2009337022","https://openalex.org/W2012376126","https://openalex.org/W2012789793","https://openalex.org/W2023968415","https://openalex.org/W2030204150","https://openalex.org/W2034082312","https://openalex.org/W2038224401","https://openalex.org/W2047303997","https://openalex.org/W2048242269","https://openalex.org/W2049471028","https://openalex.org/W2060525515","https://openalex.org/W2065186923","https://openalex.org/W2065890885","https://openalex.org/W2066098137","https://openalex.org/W2066604159","https://openalex.org/W2069421644","https://openalex.org/W2081118262","https://openalex.org/W2088392532","https://openalex.org/W2091389429","https://openalex.org/W2094098398","https://openalex.org/W2094337993","https://openalex.org/W2097642044","https://openalex.org/W2098210520","https://openalex.org/W2100592123","https://openalex.org/W2101778925","https://openalex.org/W2111960078","https://openalex.org/W2116852953","https://openalex.org/W2122857604","https://openalex.org/W2126306109","https://openalex.org/W2130430747","https://openalex.org/W2132971099","https://openalex.org/W2136390065","https://openalex.org/W2137031731","https://openalex.org/W2140436344","https://openalex.org/W2145013849","https://openalex.org/W2152632881","https://openalex.org/W2160780620","https://openalex.org/W2164358503","https://openalex.org/W2166045155","https://openalex.org/W2166082766","https://openalex.org/W2167928913","https://openalex.org/W2167948024","https://openalex.org/W2168191922","https://openalex.org/W2328659017"],"related_works":["https://openalex.org/W2201991444","https://openalex.org/W2391617054","https://openalex.org/W2950752483","https://openalex.org/W2483359251","https://openalex.org/W4323029873","https://openalex.org/W2324018797","https://openalex.org/W2575770495","https://openalex.org/W2402845798","https://openalex.org/W3142081545","https://openalex.org/W4283809963"],"abstract_inverted_index":{"The":[0,62,270],"ability":[1],"of":[2,69,83,86,92,106,109,121,123,172,183,188,198,214,265],"cells":[3,96,126],"to":[4,11,14,49,79,139,168,230,237,243,253],"coordinately":[5,58,124],"migrate":[6],"in":[7,59,97,146,178],"groups":[8],"is":[9,46,153,209],"crucial":[10],"enable":[12],"them":[13],"travel":[15],"long":[16],"distances":[17],"during":[18,32,89,288],"embryonic":[19],"development,":[20],"wound":[21,98,116,134],"healing":[22,99],"and":[23,52,65,94,136,149,152,175,221,239,262,275,285],"tumorigenesis,":[24],"but":[25],"the":[26,81,104,115,133,140,181,199,202,212,249,254,258],"fundamental":[27],"mechanisms":[28],"underlying":[29],"intercellular":[30,286],"coordination":[31],"collective":[33,90,289],"cell":[34,54,283,290],"migration":[35,91,111,190,208],"remain":[36],"elusive":[37],"despite":[38],"considerable":[39],"research":[40],"efforts.":[41],"A":[42],"novel":[43],"analytical":[44],"framework":[45],"introduced":[47],"here":[48],"explicitly":[50],"detect":[51],"quantify":[53],"clusters":[55,122],"that":[56,127,205,226,241],"move":[57],"a":[60,107,184,277],"monolayer.":[61],"analysis":[63],"combines":[64],"associates":[66],"vast":[67],"amount":[68],"spatiotemporal":[70],"data":[71,220],"across":[72],"multiple":[73],"experiments":[74],"into":[75],"transparent":[76],"quantitative":[77],"measures":[78],"report":[80],"emergence":[82,105,182,213],"new":[84,273],"modes":[85],"organized":[87],"behavior":[88],"tumor":[93,150],"epithelial":[95],"assays.":[100],"First,":[101],"we":[102],"discovered":[103],"wave":[108,144,187],"coordinated":[110,207],"propagating":[112,186],"backward":[113,185],"from":[114,132],"front,":[117],"which":[118,177],"reflects":[119],"formation":[120],"migrating":[125],"are":[128],"generated":[129],"further":[130],"away":[131],"edge":[135],"disintegrate":[137],"close":[138],"advancing":[141],"front.":[142],"This":[143],"emerges":[145],"both":[147],"normal":[148],"cells,":[151],"amplified":[154,206],"by":[155,246,257],"Met":[156,164],"activation":[157,165],"with":[158,191,211],"hepatocyte":[159],"growth":[160],"factor/scatter":[161],"factor.":[162],"Second,":[163],"was":[166],"found":[167],"induce":[169],"coinciding":[170],"waves":[171,203],"cellular":[173,279],"acceleration":[174,238],"stretching,":[176],"turn":[179],"trigger":[180],"directional":[189,215],"about":[192],"an":[193],"hour":[194],"phase":[195],"lag.":[196],"Assessments":[197],"relations":[200],"between":[201],"revealed":[204],"associated":[210],"migration.":[216,291],"Taken":[217],"together,":[218],"our":[219],"simplified":[222],"modeling-based":[223],"assessments":[224],"suggest":[225,276],"increased":[227],"velocity":[228,250],"leads":[229],"enhanced":[231],"coordination:":[232],"higher":[233],"motility":[234],"arises":[235],"due":[236],"stretching":[240],"seems":[242],"increase":[244],"directionality":[245,266],"temporarily":[247],"diminishing":[248],"components":[251],"orthogonal":[252],"direction":[255],"defined":[256],"monolayer":[259],"geometry.":[260],"Spatial":[261],"temporal":[263],"accumulation":[264],"thus":[267],"defines":[268],"coordination.":[269],"findings":[271],"offer":[272],"insight":[274],"basic":[278],"mechanism":[280],"for":[281],"long-term":[282],"guidance":[284],"communication":[287]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}