{"id":"https://openalex.org/W2079036660","doi":"https://doi.org/10.1371/journal.pcbi.1003733","title":"Analysis of the Protein Domain and Domain Architecture Content in Fungi and Its Application in the Search of New Antifungal Targets","display_name":"Analysis of the Protein Domain and Domain Architecture Content in Fungi and Its Application in the Search of New Antifungal Targets","publication_year":2014,"publication_date":"2014-07-17","ids":{"openalex":"https://openalex.org/W2079036660","doi":"https://doi.org/10.1371/journal.pcbi.1003733","mag":"2079036660","pmid":"https://pubmed.ncbi.nlm.nih.gov/25033262"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003733","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003733","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003733&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003733&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057113487","display_name":"Alejandro Barrera","orcid":"https://orcid.org/0000-0001-9244-9822"},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Alejandro Barrera","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain","European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom","National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom; National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain","institution_ids":[]},{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]},{"raw_affiliation_string":"National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025944964","display_name":"Ana Alastruey\u2010Izquierdo","orcid":"https://orcid.org/0000-0001-8651-4405"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Alastruey-Izquierdo","raw_affiliation_strings":["National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071535801","display_name":"Mar\u00eda Martin","orcid":"https://orcid.org/0000-0001-5454-2815"},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mar\u00eda J. Mart\u00edn","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001176014","display_name":"Isabel Cuesta","orcid":"https://orcid.org/0000-0002-7911-9041"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Isabel Cuesta","raw_affiliation_strings":["National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044603792","display_name":"Juan Antonio Vizca\u00edno","orcid":"https://orcid.org/0000-0002-3905-4335"},"institutions":[{"id":"https://openalex.org/I87048295","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08","country_code":"GB","type":"funder","lineage":["https://openalex.org/I87048295"]},{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Juan Antonio Vizca\u00edno","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom"],"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I87048295"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001176014","https://openalex.org/A5044603792"],"corresponding_institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I2801357902","https://openalex.org/I87048295"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.0194,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.85337332,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"7","first_page":"e1003733","last_page":"e1003733"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.7989327907562256},{"id":"https://openalex.org/keywords/architecture-domain","display_name":"Architecture domain","score":0.7114432454109192},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6485096216201782},{"id":"https://openalex.org/keywords/phylum","display_name":"Phylum","score":0.6341342926025391},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.5945818424224854},{"id":"https://openalex.org/keywords/protein-domain","display_name":"Protein domain","score":0.5444210767745972},{"id":"https://openalex.org/keywords/domain","display_name":"Domain (mathematical analysis)","score":0.4789372384548187},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46866878867149353},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.44760650396347046},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.30354082584381104},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27117085456848145},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24659180641174316},{"id":"https://openalex.org/keywords/architecture","display_name":"Architecture","score":0.14184394478797913}],"concepts":[{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.7989327907562256},{"id":"https://openalex.org/C194167682","wikidata":"https://www.wikidata.org/wiki/Q4787088","display_name":"Architecture domain","level":5,"score":0.7114432454109192},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6485096216201782},{"id":"https://openalex.org/C91066513","wikidata":"https://www.wikidata.org/wiki/Q38348","display_name":"Phylum","level":3,"score":0.6341342926025391},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5945818424224854},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.5444210767745972},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4789372384548187},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46866878867149353},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44760650396347046},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30354082584381104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27117085456848145},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24659180641174316},{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.14184394478797913},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.0},{"id":"https://openalex.org/C163352659","wikidata":"https://www.wikidata.org/wiki/Q5380367","display_name":"Enterprise architecture management","level":4,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C10590034","wikidata":"https://www.wikidata.org/wiki/Q1048431","display_name":"Enterprise architecture","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001230","descriptor_name":"Aspergillus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005658","descriptor_name":"Fungi","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003733","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003733","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003733&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25033262","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25033262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dnet:repisalud___::c2de1d16dd9e54b9cbe0abc5a98c3a49","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.12105/7451","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:fab5c6a5879a446aad2df406f14cd103","is_oa":true,"landing_page_url":"https://doaj.org/article/fab5c6a5879a446aad2df406f14cd103","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 7, p e1003733 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3074077","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4102429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1109125","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Analysis_of_the_Protein_Domain_and_Domain_Architecture_Content_in_Fungi_and_Its_Application_in_the_Search_of_New_Antifungal_Targets_/1109125","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003733","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003733","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003733&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8600000143051147}],"awards":[{"id":"https://openalex.org/G1123387284","display_name":null,"funder_award_id":"RD06/0008","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G1443135587","display_name":null,"funder_award_id":"WT101477MA","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2182312841","display_name":null,"funder_award_id":"RD12/0015","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G3912468130","display_name":null,"funder_award_id":"REIPI","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4531677044","display_name":null,"funder_award_id":"grant","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G4677042605","display_name":null,"funder_award_id":"REIPI RD12/0015","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G4704457972","display_name":null,"funder_award_id":"2008-2011","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5046430597","display_name":null,"funder_award_id":"WT101477MA","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G537177302","display_name":null,"funder_award_id":"REIPI RD12/0015","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5634928892","display_name":null,"funder_award_id":"101477","funder_id":"https://openalex.org/F4320307874","funder_display_name":"Wellcome"},{"id":"https://openalex.org/G62621495","display_name":null,"funder_award_id":"RD12/0015","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6660225447","display_name":null,"funder_award_id":"co-financed","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7120927785","display_name":null,"funder_award_id":"I+D+i","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G7800705679","display_name":null,"funder_award_id":"I+D+i","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G7891398668","display_name":null,"funder_award_id":"REIPI RD12/0015","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G993539107","display_name":null,"funder_award_id":"RD12/0015","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"}],"funders":[{"id":"https://openalex.org/F4320307874","display_name":"Wellcome","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2079036660.pdf","grobid_xml":"https://content.openalex.org/works/W2079036660.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W80140380","https://openalex.org/W1491063910","https://openalex.org/W1546472944","https://openalex.org/W1587026990","https://openalex.org/W1587822751","https://openalex.org/W1823566177","https://openalex.org/W1871466069","https://openalex.org/W1933881136","https://openalex.org/W1948733660","https://openalex.org/W1969460352","https://openalex.org/W1970614280","https://openalex.org/W1979051131","https://openalex.org/W1980095813","https://openalex.org/W1980357487","https://openalex.org/W1985512202","https://openalex.org/W1987741628","https://openalex.org/W1988725811","https://openalex.org/W1989509003","https://openalex.org/W1994957997","https://openalex.org/W1998437697","https://openalex.org/W2002622959","https://openalex.org/W2009969961","https://openalex.org/W2010670537","https://openalex.org/W2010958487","https://openalex.org/W2020179762","https://openalex.org/W2020336239","https://openalex.org/W2024209638","https://openalex.org/W2030877267","https://openalex.org/W2037212236","https://openalex.org/W2038816853","https://openalex.org/W2041351200","https://openalex.org/W2041511979","https://openalex.org/W2044561613","https://openalex.org/W2045193818","https://openalex.org/W2051335660","https://openalex.org/W2054154091","https://openalex.org/W2056171217","https://openalex.org/W2058276503","https://openalex.org/W2080698851","https://openalex.org/W2080764633","https://openalex.org/W2087561016","https://openalex.org/W2091848990","https://openalex.org/W2094201044","https://openalex.org/W2096525273","https://openalex.org/W2096541451","https://openalex.org/W2101220662","https://openalex.org/W2102633320","https://openalex.org/W2103104057","https://openalex.org/W2107190860","https://openalex.org/W2107644675","https://openalex.org/W2108929776","https://openalex.org/W2109814431","https://openalex.org/W2117733018","https://openalex.org/W2119631996","https://openalex.org/W2131908664","https://openalex.org/W2133070552","https://openalex.org/W2134063387","https://openalex.org/W2136280642","https://openalex.org/W2141563676","https://openalex.org/W2141885858","https://openalex.org/W2143452187","https://openalex.org/W2150499428","https://openalex.org/W2151459176","https://openalex.org/W2159455600","https://openalex.org/W2161033884","https://openalex.org/W2161211166","https://openalex.org/W2161409682","https://openalex.org/W2164883151","https://openalex.org/W2169175266","https://openalex.org/W2170949917","https://openalex.org/W2172191429","https://openalex.org/W2605068739","https://openalex.org/W4210623056","https://openalex.org/W4212920271","https://openalex.org/W4230096730","https://openalex.org/W4250297812"],"related_works":["https://openalex.org/W2288906059","https://openalex.org/W4376862128","https://openalex.org/W4296966554","https://openalex.org/W2030530458","https://openalex.org/W2546159719","https://openalex.org/W2296132555","https://openalex.org/W2087903152","https://openalex.org/W2068850418","https://openalex.org/W2079036660","https://openalex.org/W1984316389"],"abstract_inverted_index":{"Over":[0],"the":[1,13,31,50,58,92,110,132,156,163,219,239,252,266,283],"past":[2],"several":[3],"years":[4],"fungal":[5,60,96,166,185,268],"infections":[6],"have":[7],"shown":[8],"an":[9,136],"increasing":[10],"incidence":[11],"in":[12,27,67,87,114,131,177,187,222,229,238,282],"susceptible":[14],"population,":[15],"and":[16,53,79,82,103,158,165,168,172,209,246,270],"caused":[17],"high":[18],"mortality":[19],"rates.":[20],"In":[21,120],"parallel,":[22],"multi-resistant":[23],"fungi":[24,221],"are":[25],"emerging":[26],"human":[28,164],"infections.":[29],"Therefore,":[30],"identification":[32],"of":[33,44,57,77,95,116,138,162,211,218,249,265,285],"new":[34,286],"potential":[35,148,253],"antifungal":[36,151,287],"targets":[37,149],"is":[38,85],"a":[39,203,216,262,279],"priority.":[40],"The":[41,74,105],"first":[42,280],"task":[43],"this":[45,88,139,259],"study":[46,260],"was":[47],"to":[48,63,146,254],"analyse":[49],"protein":[51],"domain":[52,54,81,83,118,157,159,173],"architecture":[55,160],"content":[56,161],"137":[59],"proteomes":[61,269],"(corresponding":[62],"111":[64],"species)":[65],"available":[66,267],"UniProtKB":[68],"(UniProt":[69],"KnowledgeBase)":[70],"by":[71],"January":[72],"2013.":[73],"resulting":[75],"list":[76],"core":[78],"exclusive":[80,117,236],"architectures":[84,174],"provided":[86],"paper.":[89],"It":[90],"delineates":[91],"different":[93,133,144],"levels":[94],"taxonomic":[97],"classification:":[98],"phylum,":[99],"subphylum,":[100],"order,":[101],"genus":[102,113],"species.":[104],"analysis":[106,264],"highlighted":[107],"Aspergillus":[108],"as":[109,202,278],"most":[111],"diverse":[112],"terms":[115],"content.":[119],"addition,":[121],"we":[122,141,154,180,214],"also":[123],"investigated":[124],"which":[125,248],"domains":[126,171,194,237],"could":[127,195],"be":[128,196,276],"considered":[129],"promiscuous":[130,193],"organisms.":[134],"As":[135],"application":[137],"analysis,":[140],"explored":[142],"three":[143,272],"ways":[145],"detect":[147],"for":[150,182,235],"drugs.":[152],"First,":[153],"compared":[155],"proteomes,":[167],"identified":[169,201],"those":[170],"only":[175],"present":[176],"fungi.":[178],"Secondly,":[179],"looked":[181,234],"information":[183],"regarding":[184],"pathways":[186,199],"public":[188],"repositories,":[189],"where":[190],"proteins":[191],"containing":[192],"involved.":[197],"Three":[198],"were":[200,242],"result:":[204],"lovastatin":[205],"biosynthesis,":[206],"xylan":[207],"degradation":[208],"biosynthesis":[210],"siroheme.":[212],"Finally,":[213],"classified":[215],"subset":[217],"studied":[220],"five":[223],"groups":[224,240],"depending":[225],"on":[226],"their":[227],"occurrence":[228],"clinical":[230],"samples.":[231],"We":[232],"then":[233],"that":[241,274],"more":[243],"relevant":[244],"clinically":[245],"determined":[247],"them":[250],"had":[251],"bind":[255],"small":[256],"molecules.":[257],"Overall,":[258],"provides":[261],"comprehensive":[263],"shows":[271],"approaches":[273],"can":[275],"used":[277],"step":[281],"detection":[284],"targets.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
