{"id":"https://openalex.org/W2019863483","doi":"https://doi.org/10.1371/journal.pcbi.1003703","title":"Inferring Clonal Composition from Multiple Sections of a Breast Cancer","display_name":"Inferring Clonal Composition from Multiple Sections of a Breast Cancer","publication_year":2014,"publication_date":"2014-07-10","ids":{"openalex":"https://openalex.org/W2019863483","doi":"https://doi.org/10.1371/journal.pcbi.1003703","mag":"2019863483","pmid":"https://pubmed.ncbi.nlm.nih.gov/25010360"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003703","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003703","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003703&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003703&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062228773","display_name":"Habil Zare","orcid":"https://orcid.org/0000-0001-5902-6238"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habil Zare","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100377335","display_name":"Junfeng Wang","orcid":"https://orcid.org/0000-0002-9608-6851"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junfeng Wang","raw_affiliation_strings":["Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053493275","display_name":"Alex Hu","orcid":"https://orcid.org/0000-0001-6846-1776"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Hu","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042981248","display_name":"Kris Weber","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kris Weber","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008638540","display_name":"J. G. Smith","orcid":"https://orcid.org/0000-0001-6285-9935"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josh Smith","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022525919","display_name":"Debbie A. Nickerson","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debbie Nickerson","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113988085","display_name":"Chao-Zhong Song","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ChaoZhong Song","raw_affiliation_strings":["Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031682567","display_name":"Daniela Witten","orcid":"https://orcid.org/0000-0002-1764-1184"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniela Witten","raw_affiliation_strings":["Department of Biostatistics, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044817889","display_name":"C. Anthony Blau","orcid":"https://orcid.org/0000-0001-8667-6068"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Anthony Blau","raw_affiliation_strings":["Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Medicine, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057375933","display_name":"William Stafford Noble","orcid":"https://orcid.org/0000-0001-7283-4715"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William Stafford Noble","raw_affiliation_strings":["Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America; Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America","Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America; Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Computer Science and Engineering, University of Washington, Seattle, Washington, United States of America","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5031682567","https://openalex.org/A5044817889","https://openalex.org/A5057375933"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":6.4471,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.97665526,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"10","issue":"7","first_page":"e1003703","last_page":"e1003703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7059903144836426},{"id":"https://openalex.org/keywords/somatic-evolution-in-cancer","display_name":"Somatic evolution in cancer","score":0.6785399913787842},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5642781257629395},{"id":"https://openalex.org/keywords/dna-sequencing","display_name":"DNA sequencing","score":0.5603285431861877},{"id":"https://openalex.org/keywords/exome-sequencing","display_name":"Exome sequencing","score":0.5283492207527161},{"id":"https://openalex.org/keywords/deep-sequencing","display_name":"Deep sequencing","score":0.5215228199958801},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5064660310745239},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5004768371582031},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4423026740550995},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.40430164337158203},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1452627182006836},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.14276686310768127}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7059903144836426},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.6785399913787842},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5642781257629395},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.5603285431861877},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.5283492207527161},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.5215228199958801},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5064660310745239},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5004768371582031},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4423026740550995},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.40430164337158203},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1452627182006836},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.14276686310768127}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003703","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003703","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003703&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25010360","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25010360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:966e1c18193d463e897220f2d7f45c26","is_oa":true,"landing_page_url":"https://doaj.org/article/966e1c18193d463e897220f2d7f45c26","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 7, p e1003703 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3071488","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4091710","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1099168","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Inferring_Clonal_Composition_from_Multiple_Sections_of_a_Breast_Cancer_/1099168","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003703","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003703","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003703&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8700000047683716}],"awards":[{"id":"https://openalex.org/G5411062805","display_name":null,"funder_award_id":"DP5OD009145","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019863483.pdf","grobid_xml":"https://content.openalex.org/works/W2019863483.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W78747592","https://openalex.org/W601713258","https://openalex.org/W613054787","https://openalex.org/W775925344","https://openalex.org/W1499861606","https://openalex.org/W1543429635","https://openalex.org/W1550376883","https://openalex.org/W1663973292","https://openalex.org/W1747464137","https://openalex.org/W1786620475","https://openalex.org/W1972701998","https://openalex.org/W1976618413","https://openalex.org/W1984227596","https://openalex.org/W1986888627","https://openalex.org/W1987754412","https://openalex.org/W2002456838","https://openalex.org/W2004834404","https://openalex.org/W2005051528","https://openalex.org/W2005895632","https://openalex.org/W2009474665","https://openalex.org/W2009569945","https://openalex.org/W2011438897","https://openalex.org/W2011832962","https://openalex.org/W2012753533","https://openalex.org/W2015182193","https://openalex.org/W2021341670","https://openalex.org/W2027246028","https://openalex.org/W2032518018","https://openalex.org/W2034629821","https://openalex.org/W2043736118","https://openalex.org/W2049633694","https://openalex.org/W2063382533","https://openalex.org/W2068040216","https://openalex.org/W2072974424","https://openalex.org/W2077658674","https://openalex.org/W2080660780","https://openalex.org/W2093144236","https://openalex.org/W2097749765","https://openalex.org/W2098290597","https://openalex.org/W2103441770","https://openalex.org/W2112997276","https://openalex.org/W2117131162","https://openalex.org/W2123019231","https://openalex.org/W2123094878","https://openalex.org/W2124715997","https://openalex.org/W2126903025","https://openalex.org/W2127214385","https://openalex.org/W2129136620","https://openalex.org/W2144847592","https://openalex.org/W2147354890","https://openalex.org/W2148561513","https://openalex.org/W2150575159","https://openalex.org/W2155085787","https://openalex.org/W2157783208","https://openalex.org/W2159760729","https://openalex.org/W2161055995","https://openalex.org/W2161724277","https://openalex.org/W2161815151","https://openalex.org/W2162232643","https://openalex.org/W2168175751","https://openalex.org/W2169895148","https://openalex.org/W2170490448","https://openalex.org/W3104577407","https://openalex.org/W4247053599"],"related_works":["https://openalex.org/W3029015202","https://openalex.org/W3031411603","https://openalex.org/W2104595023","https://openalex.org/W1539933040","https://openalex.org/W2894247673","https://openalex.org/W3006152679","https://openalex.org/W2802247229","https://openalex.org/W2413391814","https://openalex.org/W2396249381","https://openalex.org/W2054261324"],"abstract_inverted_index":{"Cancers":[0],"arise":[1],"from":[2,41,74],"successive":[3],"rounds":[4],"of":[5,25,77,104,117,162,187,196],"mutation":[6],"and":[7,18,34,38,81,92,107,122,152,178,200],"selection,":[8],"generating":[9],"clonal":[10,23,49,59,90,115,172,194],"populations":[11],"that":[12,168,174],"vary":[13],"in":[14,198],"size,":[15],"mutational":[16,142],"content":[17],"drug":[19],"responsiveness.":[20],"Ascertaining":[21],"the":[22,89,102,105,114,129,160,193],"composition":[24,116],"a":[26,47,57,62,67,78,118],"tumor":[27,130],"is":[28],"therefore":[29],"important":[30],"both":[31,176],"for":[32,70,87,137],"prognosis":[33],"therapy.":[35],"Mutation":[36],"counts":[37],"frequencies":[39,94,161],"resulting":[40],"next-generation":[42],"sequencing":[43,136,147],"(NGS)":[44],"potentially":[45],"reflect":[46],"tumor's":[48,58],"composition;":[50],"however,":[51],"deconvolving":[52],"NGS":[53,71],"data":[54,72],"to":[55,112,140,148,184],"infer":[56],"structure":[60],"presents":[61],"major":[63],"challenge.":[64],"We":[65,98],"propose":[66],"generative":[68],"model":[69],"derived":[73],"multiple":[75],"subsections":[76],"single":[79],"tumor,":[80],"we":[82,133,166],"describe":[83],"an":[84],"expectation-maximization":[85],"procedure":[86],"estimating":[88],"genotypes":[91],"relative":[93],"using":[95],"this":[96,182],"model.":[97],"demonstrate,":[99],"via":[100],"simulation,":[101],"validity":[103],"approach,":[106],"then":[108],"use":[109],"our":[110,169],"algorithm":[111,170],"assess":[113,141],"primary":[119],"breast":[120],"cancer":[121],"associated":[123],"metastatic":[124],"lymph":[125],"node.":[126],"After":[127],"dividing":[128],"into":[131],"subsections,":[132],"perform":[134],"exome":[135],"each":[138,156],"subsection":[139],"content,":[143],"followed":[144],"by":[145],"deep":[146],"precisely":[149],"count":[150],"normal":[151],"variant":[153],"alleles":[154],"within":[155],"subsection.":[157],"By":[158],"quantifying":[159],"17":[163],"somatic":[164],"variants,":[165],"demonstrate":[167],"predicts":[171],"relationships":[173],"are":[175],"phylogenetically":[177],"spatially":[179],"plausible.":[180],"Applying":[181],"method":[183],"larger":[185],"numbers":[186],"tumors":[188],"should":[189],"cast":[190],"light":[191],"on":[192],"evolution":[195],"cancers":[197],"space":[199],"time.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":4}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}