{"id":"https://openalex.org/W2009727747","doi":"https://doi.org/10.1371/journal.pcbi.1003655","title":"An Expanded Notch-Delta Model Exhibiting Long-Range Patterning and Incorporating MicroRNA Regulation","display_name":"An Expanded Notch-Delta Model Exhibiting Long-Range Patterning and Incorporating MicroRNA Regulation","publication_year":2014,"publication_date":"2014-06-19","ids":{"openalex":"https://openalex.org/W2009727747","doi":"https://doi.org/10.1371/journal.pcbi.1003655","mag":"2009727747","pmid":"https://pubmed.ncbi.nlm.nih.gov/24945987"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003655","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003655","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003655&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003655&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030785276","display_name":"Jerry S. Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry S. Chen","raw_affiliation_strings":["Computational Science Research Center, San Diego State University, San Diego, California, United States of America; Department of Biology, San Diego State University, San Diego, California, United States of America","Department of Biology, San Diego State University, San Diego, California, United States of America","Computational Science Research Center, San Diego State University, San Diego, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Computational Science Research Center, San Diego State University, San Diego, California, United States of America; Department of Biology, San Diego State University, San Diego, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Biology, San Diego State University, San Diego, California, United States of America","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Computational Science Research Center, San Diego State University, San Diego, California, United States of America","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046842824","display_name":"Abygail M. Gumbayan","orcid":null},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abygail M. Gumbayan","raw_affiliation_strings":["Department of Biology, San Diego State University, San Diego, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biology, San Diego State University, San Diego, California, United States of America","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050682703","display_name":"Robert W. Zeller","orcid":"https://orcid.org/0000-0001-8398-513X"},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Zeller","raw_affiliation_strings":["Computational Science Research Center, San Diego State University, San Diego, California, United States of America; Department of Biology, San Diego State University, San Diego, California, United States of America","Department of Biology, San Diego State University, San Diego, California, United States of America","Computational Science Research Center, San Diego State University, San Diego, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Computational Science Research Center, San Diego State University, San Diego, California, United States of America; Department of Biology, San Diego State University, San Diego, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Biology, San Diego State University, San Diego, California, United States of America","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Computational Science Research Center, San Diego State University, San Diego, California, United States of America","institution_ids":["https://openalex.org/I26538001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111600675","display_name":"Joseph M. Mahaffy","orcid":null},"institutions":[{"id":"https://openalex.org/I26538001","display_name":"San Diego State University","ror":"https://ror.org/0264fdx42","country_code":"US","type":"education","lineage":["https://openalex.org/I26538001"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph M. Mahaffy","raw_affiliation_strings":["Computational Science Research Center, San Diego State University, San Diego, California, United States of America; Department of Mathematics and Statistics, San Diego State University, San Diego, California, United States of America","Department of Mathematics and Statistics, San Diego State University, San Diego, California, United States of America","Computational Science Research Center, San Diego State University, San Diego, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Computational Science Research Center, San Diego State University, San Diego, California, United States of America; Department of Mathematics and Statistics, San Diego State University, San Diego, California, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Mathematics and Statistics, San Diego State University, San Diego, California, United States of America","institution_ids":["https://openalex.org/I26538001"]},{"raw_affiliation_string":"Computational Science Research Center, San Diego State University, San Diego, California, United States of America","institution_ids":["https://openalex.org/I26538001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111600675"],"corresponding_institution_ids":["https://openalex.org/I26538001"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9982,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.74719545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"6","first_page":"e1003655","last_page":"e1003655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12213","display_name":"Marine Ecology and Invasive Species","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/2306","display_name":"Global and Planetary Change"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10643","display_name":"Marine and coastal plant biology","score":0.967199981212616,"subfield":{"id":"https://openalex.org/subfields/1910","display_name":"Oceanography"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling-pathway","display_name":"Notch signaling pathway","score":0.8319258689880371},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.552652895450592},{"id":"https://openalex.org/keywords/lateral-inhibition","display_name":"Lateral inhibition","score":0.5520122051239014},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.5275900959968567},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5156922936439514},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.4998321533203125},{"id":"https://openalex.org/keywords/delta","display_name":"Delta","score":0.44025328755378723},{"id":"https://openalex.org/keywords/pattern-formation","display_name":"Pattern formation","score":0.43603354692459106},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.38016122579574585},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.35586145520210266},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.30661261081695557},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2918739914894104},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.28945112228393555},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12151449918746948},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08078530430793762},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.07247459888458252}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.8319258689880371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.552652895450592},{"id":"https://openalex.org/C72064307","wikidata":"https://www.wikidata.org/wiki/Q1141237","display_name":"Lateral inhibition","level":2,"score":0.5520122051239014},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5275900959968567},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5156922936439514},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4998321533203125},{"id":"https://openalex.org/C5072461","wikidata":"https://www.wikidata.org/wiki/Q49506","display_name":"Delta","level":2,"score":0.44025328755378723},{"id":"https://openalex.org/C207016750","wikidata":"https://www.wikidata.org/wiki/Q1955627","display_name":"Pattern formation","level":2,"score":0.43603354692459106},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38016122579574585},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.35586145520210266},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30661261081695557},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2918739914894104},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.28945112228393555},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12151449918746948},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08078530430793762},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.07247459888458252},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002938","descriptor_name":"Ciona intestinalis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011984","descriptor_name":"Sensory Receptor Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003655","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003655","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003655&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24945987","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24945987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.776.3491","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.776.3491","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f4/d1/pcbi.1003655.PMC4063677.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003655","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003655","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:0a1951373fb24549b5017a99bd436b9d","is_oa":true,"landing_page_url":"https://doaj.org/article/0a1951373fb24549b5017a99bd436b9d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 6, p e1003655 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3041844","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4063677","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1063127","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_An_Expanded_Notch_Delta_Model_Exhibiting_Long_Range_Patterning_and_Incorporating_MicroRNA_Regulation_/1063127","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003655","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003655","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003655&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6505093993","display_name":"The regulation and function of miR-124 in ascidian neural development","funder_award_id":"0951347","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2009727747.pdf","grobid_xml":"https://content.openalex.org/works/W2009727747.grobid-xml"},"referenced_works_count":87,"referenced_works":["https://openalex.org/W569716420","https://openalex.org/W1547150431","https://openalex.org/W1607933147","https://openalex.org/W1658681964","https://openalex.org/W1813788325","https://openalex.org/W1904789024","https://openalex.org/W1963771011","https://openalex.org/W1966828612","https://openalex.org/W1970661255","https://openalex.org/W1970978593","https://openalex.org/W1971291306","https://openalex.org/W1971766851","https://openalex.org/W1977962361","https://openalex.org/W1980661496","https://openalex.org/W1981563641","https://openalex.org/W1983611264","https://openalex.org/W1985579134","https://openalex.org/W1985657116","https://openalex.org/W1987748653","https://openalex.org/W1998176858","https://openalex.org/W2000387440","https://openalex.org/W2001657041","https://openalex.org/W2003553411","https://openalex.org/W2009371644","https://openalex.org/W2009495925","https://openalex.org/W2009687189","https://openalex.org/W2010564301","https://openalex.org/W2012319310","https://openalex.org/W2018682447","https://openalex.org/W2019056838","https://openalex.org/W2031842788","https://openalex.org/W2032544386","https://openalex.org/W2037494606","https://openalex.org/W2038370619","https://openalex.org/W2040362901","https://openalex.org/W2041905033","https://openalex.org/W2043472151","https://openalex.org/W2043655216","https://openalex.org/W2043854809","https://openalex.org/W2043913581","https://openalex.org/W2047578520","https://openalex.org/W2052438956","https://openalex.org/W2055623626","https://openalex.org/W2055874497","https://openalex.org/W2063317702","https://openalex.org/W2064214007","https://openalex.org/W2065602100","https://openalex.org/W2068432076","https://openalex.org/W2076984671","https://openalex.org/W2078271662","https://openalex.org/W2078451104","https://openalex.org/W2081870559","https://openalex.org/W2083280774","https://openalex.org/W2083425643","https://openalex.org/W2087966784","https://openalex.org/W2091719870","https://openalex.org/W2095125813","https://openalex.org/W2098272219","https://openalex.org/W2099530148","https://openalex.org/W2102988868","https://openalex.org/W2106085645","https://openalex.org/W2108558044","https://openalex.org/W2131291113","https://openalex.org/W2132995761","https://openalex.org/W2137708006","https://openalex.org/W2140962377","https://openalex.org/W2142507929","https://openalex.org/W2142916161","https://openalex.org/W2147664526","https://openalex.org/W2152197503","https://openalex.org/W2152804884","https://openalex.org/W2154861644","https://openalex.org/W2156615417","https://openalex.org/W2159767268","https://openalex.org/W2162346791","https://openalex.org/W2162573472","https://openalex.org/W2162674813","https://openalex.org/W2166509920","https://openalex.org/W2171142519","https://openalex.org/W2181933303","https://openalex.org/W2185719995","https://openalex.org/W2188357884","https://openalex.org/W2316231559","https://openalex.org/W2323658858","https://openalex.org/W2484837953","https://openalex.org/W4234164547","https://openalex.org/W4300199570"],"related_works":["https://openalex.org/W1999400525","https://openalex.org/W2039980882","https://openalex.org/W2012660316","https://openalex.org/W2076754613","https://openalex.org/W4236113312","https://openalex.org/W2142843400","https://openalex.org/W2055949004","https://openalex.org/W122015403","https://openalex.org/W2125640651","https://openalex.org/W2050753752"],"abstract_inverted_index":{"Notch-Delta":[0,21,72,93,146,234,245,268],"signaling":[1,22,73,147,235,246,269],"is":[2,86,119,137,180,270],"a":[3,26,44,64,83,101,114,153,164],"fundamental":[4],"cell-cell":[5],"communication":[6],"mechanism":[7],"that":[8,71,77,95,130,177,207,242],"governs":[9],"the":[10,111,125,131,142,149,187,208,216,227],"differentiation":[11],"of":[12,20,37,54,67,113,145,196,210,221,230,261],"many":[13],"cell":[14,61,249],"types.":[15],"Most":[16],"existing":[17],"mathematical":[18],"models":[19,41],"are":[23,78],"based":[24],"on":[25],"feedback":[27],"loop":[28],"between":[29],"Notch":[30,55,103,217],"and":[31,56,81,110,148,172,175,185,254],"Delta":[32],"leading":[33,58],"to":[34,59,182,233],"lateral":[35],"inhibition":[36],"neighboring":[38],"cells.":[39],"These":[40],"result":[42],"in":[43,124,138,190,236,247,251,258,265],"checkerboard":[45],"spatial":[46,155,263],"pattern":[47,156,189],"whereby":[48,157],"adjacent":[49],"cells":[50,166],"express":[51],"opposing":[52],"levels":[53],"Delta,":[57],"alternate":[60],"fates.":[62],"However,":[63],"growing":[65],"body":[66],"biological":[68],"evidence":[69,241,257],"suggests":[70],"produces":[74],"other":[75,237,252,259],"patterns":[76,264],"not":[79],"checkerboard,":[80],"therefore":[82],"new":[84],"model":[85,94,118,179,198,232],"needed.":[87],"Here,":[88],"we":[89,205,225],"present":[90],"an":[91],"expanded":[92],"builds":[96],"upon":[97],"previous":[98],"models,":[99],"adding":[100],"local":[102],"activity":[104,112,144,209],"gradient,":[105],"which":[106],"affects":[107],"long-range":[108],"patterning,":[109],"regulatory":[115],"microRNA.":[116],"This":[117],"motivated":[120],"by":[121,141,239,255],"our":[122,178,197,222,231],"experiments":[123],"ascidian":[126],"Ciona":[127],"intestinalis":[128],"showing":[129],"peripheral":[132],"sensory":[133],"neurons,":[134],"whose":[135],"specification":[136],"part":[139],"regulated":[140],"coordinate":[143],"microRNA":[150],"miR-124,":[151],"exhibit":[152],"sparse":[154,262],"consecutive":[158],"neurons":[159],"may":[160],"be":[161,213],"spaced":[162],"over":[163],"dozen":[165],"apart.":[167],"We":[168],"perform":[169],"rigorous":[170],"stability":[171],"bifurcation":[173],"analyses,":[174],"demonstrate":[176,206],"able":[181],"accurately":[183],"explain":[184],"reproduce":[186],"neuronal":[188],"Ciona.":[191],"Using":[192],"Monte":[193],"Carlo":[194],"simulations":[195],"along":[199],"with":[200],"miR-124":[201,211],"transgene":[202],"over-expression":[203],"assays,":[204],"can":[212],"incorporated":[214],"into":[215],"decay":[218],"rate":[219],"parameter":[220],"model.":[223],"Finally,":[224],"motivate":[226],"general":[228],"applicability":[229],"animals":[238],"providing":[240],"microRNAs":[243],"regulate":[244],"analogous":[248],"types":[250],"organisms,":[253],"discussing":[256],"organisms":[260],"tissues":[266],"where":[267],"active.":[271]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}