{"id":"https://openalex.org/W2019032212","doi":"https://doi.org/10.1371/journal.pcbi.1003625","title":"In-Vivo Real-Time Control of Protein Expression from Endogenous and Synthetic Gene Networks","display_name":"In-Vivo Real-Time Control of Protein Expression from Endogenous and Synthetic Gene Networks","publication_year":2014,"publication_date":"2014-05-15","ids":{"openalex":"https://openalex.org/W2019032212","doi":"https://doi.org/10.1371/journal.pcbi.1003625","mag":"2019032212","pmid":"https://pubmed.ncbi.nlm.nih.gov/24831205"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003625","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003625","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003625&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003625&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083704013","display_name":"Filippo Menolascina","orcid":"https://orcid.org/0000-0002-4937-7912"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Filippo Menolascina","raw_affiliation_strings":["TeleThon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"affiliations":[{"raw_affiliation_string":"TeleThon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102936915","display_name":"Gianfranco Fiore","orcid":"https://orcid.org/0000-0002-5713-5323"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianfranco Fiore","raw_affiliation_strings":["TeleThon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"affiliations":[{"raw_affiliation_string":"TeleThon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053314179","display_name":"Emanuele Orabona","orcid":null},"institutions":[{"id":"https://openalex.org/I4210165120","display_name":"Institute for Microelectronics and Microsystems","ror":"https://ror.org/05vk2g845","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210165120"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuele Orabona","raw_affiliation_strings":["Institute of Microelectronics and Microsystems (IMM), CNR, Naples, Italy"],"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics and Microsystems (IMM), CNR, Naples, Italy","institution_ids":["https://openalex.org/I4210165120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090734088","display_name":"Luca De Stefano","orcid":"https://orcid.org/0000-0002-9442-4175"},"institutions":[{"id":"https://openalex.org/I4210165120","display_name":"Institute for Microelectronics and Microsystems","ror":"https://ror.org/05vk2g845","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210165120"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca De Stefano","raw_affiliation_strings":["Institute of Microelectronics and Microsystems (IMM), CNR, Naples, Italy"],"affiliations":[{"raw_affiliation_string":"Institute of Microelectronics and Microsystems (IMM), CNR, Naples, Italy","institution_ids":["https://openalex.org/I4210165120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108199928","display_name":"Mike Ferry","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Ferry","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America","Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052945096","display_name":"Jeff Hasty","orcid":null},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Hasty","raw_affiliation_strings":["Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America","Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California, San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034953482","display_name":"Mario di Bernardo","orcid":"https://orcid.org/0000-0002-2171-4745"},"institutions":[{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario di Bernardo","raw_affiliation_strings":["Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy; Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom","Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy, Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy; Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy, Department of Engineering Mathematics, University of Bristol, Bristol, United Kingdom","institution_ids":["https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001896455","display_name":"Diego di Bernardo","orcid":"https://orcid.org/0000-0002-1911-7407"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Diego di Bernardo","raw_affiliation_strings":["TeleThon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy"],"affiliations":[{"raw_affiliation_string":"TeleThon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Department of Electrical Engineering and Information Technology, University of Naples Federico II, Naples, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5001896455"],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.1426,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.53634914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"5","first_page":"e1003625","last_page":"e1003625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9912999868392944,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9886999726295471,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/green-fluorescent-protein","display_name":"Green fluorescent protein","score":0.672017514705658},{"id":"https://openalex.org/keywords/inducer","display_name":"Inducer","score":0.6088203191757202},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5839727520942688},{"id":"https://openalex.org/keywords/protein-expression","display_name":"Protein expression","score":0.500669002532959},{"id":"https://openalex.org/keywords/reporter-gene","display_name":"Reporter gene","score":0.4985356330871582},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.46491628885269165},{"id":"https://openalex.org/keywords/protein-biosynthesis","display_name":"Protein biosynthesis","score":0.444114089012146},{"id":"https://openalex.org/keywords/fluorescent-protein","display_name":"Fluorescent protein","score":0.43255701661109924},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.4202512502670288},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.4146687388420105},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4135192632675171},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.41328173875808716},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4125509560108185},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39444467425346375},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.372035413980484},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.35145604610443115},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3346134424209595},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.32116782665252686},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19890376925468445},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16326582431793213},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07661285996437073}],"concepts":[{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.672017514705658},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.6088203191757202},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5839727520942688},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.500669002532959},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4985356330871582},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46491628885269165},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.444114089012146},{"id":"https://openalex.org/C3019336641","wikidata":"https://www.wikidata.org/wiki/Q55643886","display_name":"Fluorescent protein","level":4,"score":0.43255701661109924},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.4202512502670288},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.4146687388420105},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4135192632675171},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.41328173875808716},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4125509560108185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39444467425346375},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.372035413980484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35145604610443115},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3346134424209595},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32116782665252686},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19890376925468445},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16326582431793213},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07661285996437073},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003199","descriptor_name":"Computer Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005813","descriptor_name":"Genes, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005813","descriptor_name":"Genes, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005813","descriptor_name":"Genes, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005813","descriptor_name":"Genes, Synthetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015003","descriptor_name":"Yeasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1003625","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003625","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003625&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24831205","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24831205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1003625","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003625","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f0782acf6d92454a822d2c97710010f3","is_oa":true,"landing_page_url":"https://doaj.org/article/f0782acf6d92454a822d2c97710010f3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 5, p e1003625 (2014)","raw_type":"article"},{"id":"pmh:oai:dspace.mit.edu:1721.1/89224","is_oa":true,"landing_page_url":"http://hdl.handle.net/1721.1/89224","pdf_url":null,"source":{"id":"https://openalex.org/S4306400425","display_name":"DSpace@MIT (Massachusetts Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63966007","host_organization_name":"Massachusetts Institute of Technology","host_organization_lineage":["https://openalex.org/I63966007"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Public Library of Science","raw_type":"http://purl.org/eprint/type/JournalArticle"},{"id":"pmh:oai:pubmedcentral.nih.gov:4022480","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4022480","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/ea797f28-cc9d-4406-9d59-ede361ec2661","is_oa":false,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/ea797f28-cc9d-4406-9d59-ede361ec2661","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Menolascina, F, Fiore, G, Orabona, E, De Stefano, L, Ferry, M, Hasty, J, di Bernardo, M & di Bernardo, D 2014, 'In-Vivo Real-Time Control of Protein Expression from Endogenous and Synthetic Gene Networks', PLOS Computational Biology, vol. 10, no. 5, e1003625. https://doi.org/10.1371/journal.pcbi.1003625","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:research-information.bris.ac.uk:publications/ea797f28-cc9d-4406-9d59-ede361ec2661","is_oa":false,"landing_page_url":"https://hdl.handle.net/1983/ea797f28-cc9d-4406-9d59-ede361ec2661","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Menolascina, F, Fiore, G, Orabona, E, De Stefano, L, Ferry, M, Hasty, J, di Bernardo, M & di Bernardo, D 2014, 'In-Vivo Real-Time Control of Protein Expression from Endogenous and Synthetic Gene Networks', PLOS Computational Biology, vol. 10, no. 5, e1003625. https://doi.org/10.1371/journal.pcbi.1003625","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"mag:2019032212","is_oa":false,"landing_page_url":"https://dspace.mit.edu/openaccess-disseminate/1721.1/89224","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003625","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003625","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003625&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019032212.pdf","grobid_xml":"https://content.openalex.org/works/W2019032212.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W58805225","https://openalex.org/W338168858","https://openalex.org/W1964213976","https://openalex.org/W1976484445","https://openalex.org/W1994794118","https://openalex.org/W2015745168","https://openalex.org/W2022507599","https://openalex.org/W2037298848","https://openalex.org/W2039808072","https://openalex.org/W2051594535","https://openalex.org/W2057013484","https://openalex.org/W2083329762","https://openalex.org/W2094052071","https://openalex.org/W2101420429","https://openalex.org/W2106411386","https://openalex.org/W2106927126","https://openalex.org/W2111165959","https://openalex.org/W2114790553","https://openalex.org/W2125300189","https://openalex.org/W2136498480","https://openalex.org/W2160803964","https://openalex.org/W2166447119","https://openalex.org/W2166499263","https://openalex.org/W2171340202","https://openalex.org/W2171419763","https://openalex.org/W2484469314","https://openalex.org/W4243369158"],"related_works":["https://openalex.org/W2068367947","https://openalex.org/W2558144529","https://openalex.org/W2570500702","https://openalex.org/W2304563860","https://openalex.org/W2624976294","https://openalex.org/W1501371299","https://openalex.org/W2949854146","https://openalex.org/W2898473670","https://openalex.org/W2935973494","https://openalex.org/W1561439742","https://openalex.org/W3199685212","https://openalex.org/W1529805656","https://openalex.org/W2600198595","https://openalex.org/W2121553505","https://openalex.org/W2121998297","https://openalex.org/W1603032454","https://openalex.org/W2979384205","https://openalex.org/W2607217819","https://openalex.org/W2043908740","https://openalex.org/W2982563748"],"abstract_inverted_index":{"We":[0,21,54,80],"describe":[1],"an":[2,57,144],"innovative":[3],"experimental":[4],"and":[5,69,118],"computational":[6],"approach":[7,127],"to":[8,27,35,84,88,113,122,131,138,148],"control":[9,25,124,132],"the":[10,30,36,40,46,50,82,108,114,123],"expression":[11,43,52,133],"of":[12,18,32,72,96,102,110,134],"a":[13,16,23,62,65,70,78,90,97,139],"protein":[14,42,99],"in":[15,45],"population":[17,48],"yeast":[19,86],"cells.":[20],"designed":[22],"simple":[24],"algorithm":[26],"automatically":[28,106],"regulate":[29],"administration":[31],"inducer":[33],"molecules":[34],"cells":[37,87],"by":[38,77],"comparing":[39],"actual":[41],"level":[44],"cell":[47],"with":[49],"desired":[51,91],"level.":[53],"then":[55],"built":[56],"automated":[58],"platform":[59,83],"based":[60],"on":[61],"microfluidic":[63],"device,":[64],"time-lapse":[66],"microscopy":[67],"apparatus,":[68],"set":[71],"motorized":[73],"syringes,":[74],"all":[75],"controlled":[76],"computer.":[79],"tested":[81],"force":[85],"express":[89],"fixed,":[92],"or":[93],"time-varying,":[94],"amount":[95],"reporter":[98],"over":[100],"thousands":[101],"minutes.":[103],"The":[104],"computer":[105],"switched":[107],"type":[109],"sugar":[111],"administered":[112],"cells,":[115],"its":[116,119,151],"concentration":[117],"duration,":[120],"according":[121],"algorithm.":[125],"Our":[126],"can":[128],"be":[129],"used":[130],"any":[135],"protein,":[136],"fused":[137],"fluorescent":[140],"reporter,":[141],"provided":[142],"that":[143],"external":[145],"molecule":[146],"known":[147],"(indirectly)":[149],"affect":[150],"promoter":[152],"activity":[153],"is":[154],"available.":[155]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
