{"id":"https://openalex.org/W2072982744","doi":"https://doi.org/10.1371/journal.pcbi.1003613","title":"Pierced Lasso Bundles Are a New Class of Knot-like Motifs","display_name":"Pierced Lasso Bundles Are a New Class of Knot-like Motifs","publication_year":2014,"publication_date":"2014-06-19","ids":{"openalex":"https://openalex.org/W2072982744","doi":"https://doi.org/10.1371/journal.pcbi.1003613","mag":"2072982744","pmid":"https://pubmed.ncbi.nlm.nih.gov/24945798"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003613","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003613","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003613&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003613&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000559334","display_name":"Ellinor Haglund","orcid":"https://orcid.org/0000-0002-6629-2793"},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellinor Haglund","raw_affiliation_strings":["Center for Theoretical Biological Physics (CTBP) and Department of Physics, University of California at San Diego (UCSD), La Jolla, California, United States of America; Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America","Center for Theoretical Biological Physics (CTBP) and Department of Physics, University of California at San Diego (UCSD), La Jolla, California, United States of America","Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics (CTBP) and Department of Physics, University of California at San Diego (UCSD), La Jolla, California, United States of America; Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America","institution_ids":[]},{"raw_affiliation_string":"Center for Theoretical Biological Physics (CTBP) and Department of Physics, University of California at San Diego (UCSD), La Jolla, California, United States of America","institution_ids":["https://openalex.org/I4210145836"]},{"raw_affiliation_string":"Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013867366","display_name":"Joanna I. Su\u0142kowska","orcid":"https://orcid.org/0000-0003-2452-0724"},"institutions":[{"id":"https://openalex.org/I4654613","display_name":"University of Warsaw","ror":"https://ror.org/039bjqg32","country_code":"PL","type":"education","lineage":["https://openalex.org/I4654613"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna I. Sulkowska","raw_affiliation_strings":["Laboratory of Theory of Biopolymers, University of Warsaw, Warsaw, Poland"],"affiliations":[{"raw_affiliation_string":"Laboratory of Theory of Biopolymers, University of Warsaw, Warsaw, Poland","institution_ids":["https://openalex.org/I4654613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088083389","display_name":"Jeffrey K. Noel","orcid":"https://orcid.org/0000-0003-3168-6036"},"institutions":[{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey K. Noel","raw_affiliation_strings":["Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086271777","display_name":"Heiko Lammert","orcid":null},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]},{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heiko Lammert","raw_affiliation_strings":["Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030987631","display_name":"Jos\u00e9 N. Onuchic","orcid":"https://orcid.org/0000-0002-9448-0388"},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]},{"id":"https://openalex.org/I4210145836","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/04hfg7v94","country_code":"US","type":"facility","lineage":["https://openalex.org/I12912129","https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4210145836","https://openalex.org/I44461941","https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 N. Onuchic","raw_affiliation_strings":["Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Theoretical Biological Physics (CTBP) and Departments of Physics and Astronomy, Chemistry and Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America","institution_ids":["https://openalex.org/I4210145836","https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053680151","display_name":"Patricia A. Jennings","orcid":"https://orcid.org/0000-0002-7478-2223"},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia A. Jennings","raw_affiliation_strings":["Departments of Chemistry and Biochemistry, University of California at San Diego (UCSD), La Jolla, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Chemistry and Biochemistry, University of California at San Diego (UCSD), La Jolla, California, United States of America","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5053680151"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.2816,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.88392537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"10","issue":"6","first_page":"e1003613","last_page":"e1003613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9803000092506409,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/threading","display_name":"Threading (protein sequence)","score":0.5585470795631409},{"id":"https://openalex.org/keywords/covalent-bond","display_name":"Covalent bond","score":0.5069072842597961},{"id":"https://openalex.org/keywords/bundle","display_name":"Bundle","score":0.5057158470153809},{"id":"https://openalex.org/keywords/protein-folding","display_name":"Protein folding","score":0.4427572190761566},{"id":"https://openalex.org/keywords/structural-motif","display_name":"Structural motif","score":0.430569589138031},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4149532616138458},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38937148451805115},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.37590736150741577},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3596869707107544},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.3353714942932129},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3234550356864929},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2719511091709137},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.19509398937225342}],"concepts":[{"id":"https://openalex.org/C200307862","wikidata":"https://www.wikidata.org/wiki/Q7797175","display_name":"Threading (protein sequence)","level":3,"score":0.5585470795631409},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.5069072842597961},{"id":"https://openalex.org/C2778134712","wikidata":"https://www.wikidata.org/wiki/Q1047307","display_name":"Bundle","level":2,"score":0.5057158470153809},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.4427572190761566},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.430569589138031},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4149532616138458},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38937148451805115},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37590736150741577},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3596869707107544},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3353714942932129},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3234550356864929},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2719511091709137},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19509398937225342},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040681","descriptor_name":"Structural Homology, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003613","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003613","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003613&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24945798","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24945798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.779.1664","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.779.1664","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/02/19/pcbi.1003613.PMC4063663.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0b1317bdbf2b483687a4e26c0b16044b","is_oa":true,"landing_page_url":"https://doaj.org/article/0b1317bdbf2b483687a4e26c0b16044b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 6, p e1003613 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3041830","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4063663","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1062517","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Pierced_Lasso_Bundles_Are_a_New_Class_of_Knot_like_Motifs_/1062517","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:figshare.com:article/1063896","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Pierced_Lasso_Bundles_Are_a_New_Class_of_Knot_like_Motifs_/1063896","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:scholarship.rice.edu:1911/76171","is_oa":true,"landing_page_url":"http://hdl.handle.net/1911/76171","pdf_url":null,"source":{"id":"https://openalex.org/S4306400220","display_name":"Rice University's digital scholarship archive (Rice University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I74775410","host_organization_name":"Rice University","host_organization_lineage":["https://openalex.org/I74775410"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003613","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003613","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003613&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.699999988079071,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G1615853200","display_name":null,"funder_award_id":"NSF-MCB-1214457","funder_id":"https://openalex.org/F4320332774","funder_display_name":"Center for Theoretical Biological Physics"},{"id":"https://openalex.org/G1922303759","display_name":"Sharing the Energy Landscape for Folding and Function: from Proteins to Biomolecular Machines.","funder_award_id":"1214457","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2554124182","display_name":null,"funder_award_id":"NSF-MCB-1214457","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2589238667","display_name":null,"funder_award_id":"PHY-1212312","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2734437460","display_name":null,"funder_award_id":"Homing","funder_id":"https://openalex.org/F4320321042","funder_display_name":"Fundacja na rzecz Nauki Polskiej"},{"id":"https://openalex.org/G3148463334","display_name":null,"funder_award_id":"PHY-1308264","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6660225447","display_name":null,"funder_award_id":"co-financed","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G703342338","display_name":null,"funder_award_id":"NSF_MCB-1214457","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7901954881","display_name":"Center for Theoretical Biological Physics","funder_award_id":"1308264","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8346390362","display_name":null,"funder_award_id":"1212312","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G84140598","display_name":null,"funder_award_id":"NSF-MCB","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320321042","display_name":"Fundacja na rzecz Nauki Polskiej","ror":"https://ror.org/048zd9m77"},{"id":"https://openalex.org/F4320332774","display_name":"Center for Theoretical Biological Physics","ror":"https://ror.org/008zs3103"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2072982744.pdf","grobid_xml":"https://content.openalex.org/works/W2072982744.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W34488862","https://openalex.org/W1495825435","https://openalex.org/W1497311575","https://openalex.org/W1631449371","https://openalex.org/W1933007752","https://openalex.org/W1964236485","https://openalex.org/W1979263713","https://openalex.org/W1982134009","https://openalex.org/W1983357705","https://openalex.org/W1985555958","https://openalex.org/W1989218639","https://openalex.org/W1991194470","https://openalex.org/W1993684522","https://openalex.org/W1995819898","https://openalex.org/W1996511356","https://openalex.org/W2002003836","https://openalex.org/W2002333065","https://openalex.org/W2008768221","https://openalex.org/W2015191244","https://openalex.org/W2019218232","https://openalex.org/W2021815261","https://openalex.org/W2022652120","https://openalex.org/W2025442958","https://openalex.org/W2025864476","https://openalex.org/W2027384625","https://openalex.org/W2028612664","https://openalex.org/W2029871341","https://openalex.org/W2031643764","https://openalex.org/W2032554438","https://openalex.org/W2034418213","https://openalex.org/W2039722030","https://openalex.org/W2040248629","https://openalex.org/W2040817219","https://openalex.org/W2041769542","https://openalex.org/W2044882887","https://openalex.org/W2049381382","https://openalex.org/W2050679015","https://openalex.org/W2051039246","https://openalex.org/W2051202304","https://openalex.org/W2051302860","https://openalex.org/W2054618331","https://openalex.org/W2056245019","https://openalex.org/W2058286067","https://openalex.org/W2065864578","https://openalex.org/W2068580336","https://openalex.org/W2070349383","https://openalex.org/W2071364873","https://openalex.org/W2072622625","https://openalex.org/W2073443024","https://openalex.org/W2079665716","https://openalex.org/W2080545926","https://openalex.org/W2084362314","https://openalex.org/W2085420701","https://openalex.org/W2090265120","https://openalex.org/W2090627622","https://openalex.org/W2094795801","https://openalex.org/W2098586421","https://openalex.org/W2099405468","https://openalex.org/W2114218621","https://openalex.org/W2116509676","https://openalex.org/W2117422305","https://openalex.org/W2119207853","https://openalex.org/W2119787668","https://openalex.org/W2125138250","https://openalex.org/W2134239230","https://openalex.org/W2134815007","https://openalex.org/W2135452602","https://openalex.org/W2138981267","https://openalex.org/W2144562104","https://openalex.org/W2157455847","https://openalex.org/W2162355408","https://openalex.org/W2167686614","https://openalex.org/W2170821866","https://openalex.org/W2171268876","https://openalex.org/W2278548166","https://openalex.org/W2397728113","https://openalex.org/W2949670980","https://openalex.org/W2963939548","https://openalex.org/W3023747927","https://openalex.org/W3023923910"],"related_works":["https://openalex.org/W1741740882","https://openalex.org/W2050330741","https://openalex.org/W2253761889","https://openalex.org/W2123053169","https://openalex.org/W2181585194","https://openalex.org/W3149404221","https://openalex.org/W1493412556","https://openalex.org/W2111643578","https://openalex.org/W2802527233","https://openalex.org/W1504467230"],"abstract_inverted_index":{"A":[0],"four-helix":[1,251],"bundle":[2,38,220],"is":[3,58,140,240],"a":[4,10,22,31,45,49,71,106,153,159,174,223],"well-characterized":[5],"motif":[6,28,105],"often":[7],"used":[8],"as":[9,76,132,192,194],"target":[11],"for":[12,123,261],"designed":[13],"pharmaceutical":[14],"therapeutics":[15],"and":[16,79,100,145,207,231,272,282],"nutritional":[17],"supplements.":[18],"Recently,":[19],"we":[20,114,235],"discovered":[21,80],"new":[23,91,225,259],"structural":[24,104,162],"complexity":[25,213,234],"within":[26,217,227],"this":[27,90,265],"created":[29],"by":[30,279],"disulphide":[32,46],"bridge":[33,47],"in":[34,62,77,85,138,142,237,245,288],"the":[35,55,86,95,101,111,120,125,133,150,168,178,183,187,190,198,218,228,232,238,250,273],"long-chain":[36],"helical":[37,92,219],"cytokine":[39],"leptin.":[40],"When":[41],"oxidized,":[42],"leptin":[43,78,139],"contains":[44],"creating":[48],"covalent-loop":[50],"through":[51,167,182],"which":[52,202],"part":[53],"of":[54,152,189,214,264,268,292],"polypeptide":[56],"chain":[57],"threaded":[59,103],"(as":[60],"seen":[61],"knotted":[63],"proteins).":[64],"We":[65,88,147],"explored":[66],"whether":[67],"other":[68,246],"proteins":[69,84,216],"contain":[70],"similar":[72],"intriguing":[73],"knot-like":[74,102,215],"structure":[75],"11":[81],"structurally":[82],"homologous":[83],"PDB.":[87],"call":[89],"family":[93,221],"class":[94,226,267],"Pierced":[96,107],"Lasso":[97,108],"Bundle":[98],"(PLB)":[99],"(PL).":[109],"In":[110],"current":[112],"study,":[113],"use":[115,173],"structure-based":[116],"simulation":[117],"to":[118,158,165,242],"investigate":[119],"threading/folding":[121],"mechanisms":[122],"all":[124],"PLBs":[126,239],"along":[127],"with":[128],"three":[129],"unthreaded":[130],"homologs":[131],"covalent":[134,155,169,184],"loop":[135,156,191],"(or":[136],"lasso)":[137],"important":[141],"folding":[143],"dynamics":[144],"activity.":[146,209],"find":[148],"that":[149],"presence":[151],"small":[154],"leads":[157],"mechanism":[160,176],"where":[161,177,270],"elements":[163,260],"slipknot":[164],"thread":[166],"loop.":[170,185],"Larger":[171],"loops":[172],"piercing":[175],"free":[179],"terminal":[180],"plugs":[181],"Remarkably,":[186],"position":[188],"well":[193],"its":[195],"size":[196],"influences":[197],"native":[199],"state":[200],"dynamics,":[201],"can":[203,276],"impact":[204],"receptor":[205],"binding":[206],"biological":[208],"This":[210],"previously":[211],"unrecognized":[212],"comprises":[222],"completely":[224],"knot":[229],"family,":[230],"hidden":[233,280],"unraveled":[236],"expected":[241],"be":[243,277,284],"found":[244],"protein":[247,295],"structures":[248],"outside":[249],"bundles.":[252],"The":[253],"insights":[254],"gained":[255],"here":[256],"provide":[257],"critical":[258],"future":[262],"investigation":[263],"emerging":[266],"proteins,":[269],"function":[271],"energetic":[274],"landscape":[275],"controlled":[278],"topology,":[281],"should":[283],"take":[285],"into":[286],"account":[287],"ab":[289],"initio":[290],"predictions":[291],"newly":[293],"identified":[294],"targets.":[296]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
