{"id":"https://openalex.org/W2065193262","doi":"https://doi.org/10.1371/journal.pcbi.1003586","title":"Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism","display_name":"Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism","publication_year":2014,"publication_date":"2014-05-15","ids":{"openalex":"https://openalex.org/W2065193262","doi":"https://doi.org/10.1371/journal.pcbi.1003586","mag":"2065193262","pmid":"https://pubmed.ncbi.nlm.nih.gov/24830705"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003586","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003586","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003586&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003586&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009256033","display_name":"Vitaly V. Ganusov","orcid":"https://orcid.org/0000-0001-6572-1691"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vitaly V. Ganusov","raw_affiliation_strings":["Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America; Department of Mathematics, University of Tennessee, Knoxville, Tennessee, United States of America","Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America","Department of Mathematics, University of Tennessee, Knoxville, Tennessee, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America; Department of Mathematics, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Microbiology, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"Department of Mathematics, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051636263","display_name":"Jeremy Auerbach","orcid":"https://orcid.org/0000-0003-0061-7943"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremy Auerbach","raw_affiliation_strings":["Department of Mathematics, University of Tennessee, Knoxville, Tennessee, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5009256033","https://openalex.org/A5051636263"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.9461,"has_fulltext":true,"cited_by_count":87,"citation_normalized_percentile":{"value":0.86007367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"10","issue":"5","first_page":"e1003586","last_page":"e1003586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lymph","display_name":"Lymph","score":0.8642065525054932},{"id":"https://openalex.org/keywords/spleen","display_name":"Spleen","score":0.8051356077194214},{"id":"https://openalex.org/keywords/lymphatic-system","display_name":"Lymphatic system","score":0.6761525273323059},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.5455150604248047},{"id":"https://openalex.org/keywords/thoracic-duct","display_name":"Thoracic duct","score":0.5440245866775513},{"id":"https://openalex.org/keywords/residence-time","display_name":"Residence time (fluid dynamics)","score":0.5377030968666077},{"id":"https://openalex.org/keywords/lymphocyte","display_name":"Lymphocyte","score":0.5305557250976562},{"id":"https://openalex.org/keywords/mesenteric-lymph-nodes","display_name":"Mesenteric lymph nodes","score":0.516649067401886},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.5101714134216309},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.47123822569847107},{"id":"https://openalex.org/keywords/kinetics","display_name":"Kinetics","score":0.4565202593803406},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.43129175901412964},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4193882942199707},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3709510564804077},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.34709352254867554},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.25356435775756836},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.19838973879814148},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10490879416465759}],"concepts":[{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.8642065525054932},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.8051356077194214},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.6761525273323059},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5455150604248047},{"id":"https://openalex.org/C2777593132","wikidata":"https://www.wikidata.org/wiki/Q1263629","display_name":"Thoracic duct","level":3,"score":0.5440245866775513},{"id":"https://openalex.org/C2775913793","wikidata":"https://www.wikidata.org/wiki/Q3030793","display_name":"Residence time (fluid dynamics)","level":2,"score":0.5377030968666077},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5305557250976562},{"id":"https://openalex.org/C2779237934","wikidata":"https://www.wikidata.org/wiki/Q7643652","display_name":"Mesenteric lymph nodes","level":3,"score":0.516649067401886},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5101714134216309},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47123822569847107},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.4565202593803406},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43129175901412964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4193882942199707},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3709510564804077},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34709352254867554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25356435775756836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19838973879814148},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10490879416465759},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001783","descriptor_name":"Blood Flow Velocity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008208","descriptor_name":"Lymphatic System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003586","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003586","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003586&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24830705","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24830705","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1003586","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003586","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2443936b56cd4baab1187f0f1d376ee3","is_oa":true,"landing_page_url":"https://doaj.org/article/2443936b56cd4baab1187f0f1d376ee3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 5, p e1003586 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3003054","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4022467","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1027716","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Mathematical_Modeling_Reveals_Kinetics_of_Lymphocyte_Recirculation_in_the_Whole_Organism_/1027716","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4022467","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4022467","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003586","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003586","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003586&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2065193262.pdf","grobid_xml":"https://content.openalex.org/works/W2065193262.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W31450529","https://openalex.org/W79874253","https://openalex.org/W201095198","https://openalex.org/W269067557","https://openalex.org/W653537448","https://openalex.org/W1044780602","https://openalex.org/W1411490118","https://openalex.org/W1483127293","https://openalex.org/W1484205257","https://openalex.org/W1490229695","https://openalex.org/W1494888381","https://openalex.org/W1506066152","https://openalex.org/W1506420409","https://openalex.org/W1523040345","https://openalex.org/W1533324097","https://openalex.org/W1593218714","https://openalex.org/W1796426082","https://openalex.org/W1850428701","https://openalex.org/W1899242698","https://openalex.org/W1949682302","https://openalex.org/W1963479673","https://openalex.org/W1964851502","https://openalex.org/W1964942209","https://openalex.org/W1968757602","https://openalex.org/W1968881502","https://openalex.org/W1968960673","https://openalex.org/W1969625579","https://openalex.org/W1969964090","https://openalex.org/W1973988310","https://openalex.org/W1980283637","https://openalex.org/W1981044286","https://openalex.org/W1981764548","https://openalex.org/W1984007659","https://openalex.org/W1992778083","https://openalex.org/W1995497089","https://openalex.org/W1995945562","https://openalex.org/W1999626234","https://openalex.org/W1999752605","https://openalex.org/W2002301651","https://openalex.org/W2009435671","https://openalex.org/W2010284781","https://openalex.org/W2012364722","https://openalex.org/W2013257561","https://openalex.org/W2013685153","https://openalex.org/W2015310734","https://openalex.org/W2018779510","https://openalex.org/W2019962314","https://openalex.org/W2021115043","https://openalex.org/W2029143206","https://openalex.org/W2029329186","https://openalex.org/W2031566809","https://openalex.org/W2034503943","https://openalex.org/W2034750640","https://openalex.org/W2035681961","https://openalex.org/W2042636619","https://openalex.org/W2045455672","https://openalex.org/W2045494155","https://openalex.org/W2046699406","https://openalex.org/W2047624540","https://openalex.org/W2050137292","https://openalex.org/W2051326232","https://openalex.org/W2055589870","https://openalex.org/W2058582950","https://openalex.org/W2059008857","https://openalex.org/W2059033421","https://openalex.org/W2060488986","https://openalex.org/W2063130964","https://openalex.org/W2065114044","https://openalex.org/W2070044081","https://openalex.org/W2070779353","https://openalex.org/W2074167608","https://openalex.org/W2076738925","https://openalex.org/W2079372567","https://openalex.org/W2083065256","https://openalex.org/W2097553897","https://openalex.org/W2100788374","https://openalex.org/W2100994301","https://openalex.org/W2102826387","https://openalex.org/W2112539486","https://openalex.org/W2113787577","https://openalex.org/W2116959117","https://openalex.org/W2125650988","https://openalex.org/W2126579192","https://openalex.org/W2127141798","https://openalex.org/W2127155176","https://openalex.org/W2127349884","https://openalex.org/W2127921247","https://openalex.org/W2140807362","https://openalex.org/W2141258913","https://openalex.org/W2142654329","https://openalex.org/W2151322257","https://openalex.org/W2152316245","https://openalex.org/W2152730481","https://openalex.org/W2155051381","https://openalex.org/W2155686622","https://openalex.org/W2156864280","https://openalex.org/W2161689282","https://openalex.org/W2164586836","https://openalex.org/W2166269696","https://openalex.org/W2169339684","https://openalex.org/W2187632474","https://openalex.org/W2209290666","https://openalex.org/W2237079524","https://openalex.org/W2268959185","https://openalex.org/W2308223145","https://openalex.org/W2343553122","https://openalex.org/W2403153129","https://openalex.org/W2416535418","https://openalex.org/W2416825735","https://openalex.org/W2423468832","https://openalex.org/W3080153981","https://openalex.org/W3080748832","https://openalex.org/W3106889297","https://openalex.org/W4239156989","https://openalex.org/W4313380763","https://openalex.org/W4388322985","https://openalex.org/W6642457207","https://openalex.org/W6650234803","https://openalex.org/W6684471815","https://openalex.org/W7074193835"],"related_works":["https://openalex.org/W315489838","https://openalex.org/W3207194665","https://openalex.org/W2499845531","https://openalex.org/W2374071147","https://openalex.org/W2275059507","https://openalex.org/W219268239","https://openalex.org/W4225313571","https://openalex.org/W2408120219","https://openalex.org/W1967651981","https://openalex.org/W2420155886"],"abstract_inverted_index":{"The":[0,135],"kinetics":[1,263],"of":[2,4,30,41,53,58,68,71,84,145,158,177,218,229,261,264],"recirculation":[3,262],"naive":[5],"lymphocytes":[6,45,72,109,178,267],"in":[7,55,73,79,127,147,160,181,195,245,268],"the":[8,14,56,74,80,85,102,123,148,173,185,190,232,253,269],"body":[9],"has":[10,242],"important":[11],"implications":[12],"for":[13,252],"speed":[15],"at":[16,65,117],"which":[17],"local":[18],"infections":[19],"are":[20],"detected":[21],"and":[22,50,87,114,152,164,210,234],"controlled":[23],"by":[24],"immune":[25],"responses.":[26],"With":[27],"a":[28,31,139,153,257],"help":[29],"novel":[32],"mathematical":[33],"model,":[34],"we":[35,170,214],"analyze":[36],"experimental":[37],"data":[38],"on":[39,205],"migration":[40,207],"51Cr-labeled":[42],"thoracic":[43,265],"duct":[44,266],"(TDLs)":[46],"via":[47,77,111,208],"major":[48,161],"lymphoid":[49,93],"nonlymphoid":[51],"tissues":[52,94,129],"rats":[54],"absence":[57],"systemic":[59],"antigenic":[60],"stimulation.":[61],"We":[62],"show":[63],"that":[64,108,172,216],"any":[66],"point":[67],"time,":[69],"95%":[70],"blood":[75],"travel":[76,110],"capillaries":[78,113],"lung":[81,112],"or":[82,101,189,194],"sinusoids":[83,116],"liver":[86,115],"only":[88],"5%":[89],"migrate":[90],"to":[91,201,225,237],"secondary":[92],"such":[95],"as":[96,241],"lymph":[97,162,182,212,220],"nodes,":[98],"Peyer's":[99,165,196],"patches,":[100],"spleen.":[103],"Interestingly,":[104],"our":[105,199,250],"analysis":[106,251],"suggests":[107],"an":[118,202],"extremely":[119],"rapid":[120],"rate":[121,228,240],"with":[122],"average":[124,142,155,174],"residence":[125,143,156,175],"time":[126,144,157,176,255],"these":[128],"being":[130],"less":[131],"than":[132],"1":[133],"minute.":[134],"model":[136,200],"also":[137],"predicts":[138],"relatively":[140],"short":[141],"TDLs":[146,159,230],"spleen":[149],"(2.5":[150],"hours)":[151],"longer":[154],"nodes":[163,183,213,221,233],"patches":[166],"(10":[167],"hours).":[168],"Surprisingly,":[169],"find":[171,215],"is":[179],"similar":[180],"draining":[184],"skin":[186],"(subcutaneous":[187],"LNs)":[188,193],"gut":[191],"(mesenteric":[192],"patches.":[197],"Applying":[198],"additional":[203],"dataset":[204],"lymphocyte":[206],"resting":[209],"antigen-stimulated":[211,219],"enlargement":[217],"occurs":[222],"mainly":[223],"due":[224,236],"increased":[226],"entrance":[227],"into":[231],"not":[235],"decreased":[238],"exit":[239],"been":[243],"suggested":[244],"some":[246],"studies.":[247],"Taken":[248],"together,":[249],"first":[254],"provides":[256],"comprehensive,":[258],"systems":[259],"view":[260],"whole":[270],"organism.":[271]},"counts_by_year":[{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}