{"id":"https://openalex.org/W1963572891","doi":"https://doi.org/10.1371/journal.pcbi.1003533","title":"Loads Bias Genetic and Signaling Switches in Synthetic and Natural Systems","display_name":"Loads Bias Genetic and Signaling Switches in Synthetic and Natural Systems","publication_year":2014,"publication_date":"2014-03-27","ids":{"openalex":"https://openalex.org/W1963572891","doi":"https://doi.org/10.1371/journal.pcbi.1003533","mag":"1963572891","pmid":"https://pubmed.ncbi.nlm.nih.gov/24676102"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003533","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003533","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003533&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003533&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033550867","display_name":"Samanthe M. Lyons","orcid":null},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samanthe M. Lyons","raw_affiliation_strings":["School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101398148","display_name":"Wenlong Xu","orcid":"https://orcid.org/0000-0002-2906-4724"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenlong Xu","raw_affiliation_strings":["Chemical and Biological Engineering Department, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Biological Engineering Department, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022381603","display_name":"June I. Medford","orcid":"https://orcid.org/0000-0002-0599-4863"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"June Medford","raw_affiliation_strings":["Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027796280","display_name":"Ashok Prasad","orcid":"https://orcid.org/0000-0002-0832-8153"},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashok Prasad","raw_affiliation_strings":["School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, United States of America; Chemical and Biological Engineering Department, Colorado State University, Fort Collins, Colorado, United States of America","School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, United States of America","Chemical and Biological Engineering Department, Colorado State University, Fort Collins, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, United States of America; Chemical and Biological Engineering Department, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]},{"raw_affiliation_string":"Chemical and Biological Engineering Department, Colorado State University, Fort Collins, Colorado, United States of America","institution_ids":["https://openalex.org/I92446798"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027796280"],"corresponding_institution_ids":["https://openalex.org/I92446798"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.396,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.7984921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"3","first_page":"e1003533","last_page":"e1003533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.7111533880233765},{"id":"https://openalex.org/keywords/modularity","display_name":"Modularity (biology)","score":0.5950679779052734},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.5825390815734863},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5618574619293213},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5117449760437012},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.5111365914344788},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.509393036365509},{"id":"https://openalex.org/keywords/network-motif","display_name":"Network motif","score":0.5037645697593689},{"id":"https://openalex.org/keywords/upstream","display_name":"Upstream (networking)","score":0.451568603515625},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4249681830406189},{"id":"https://openalex.org/keywords/network-topology","display_name":"Network topology","score":0.42250511050224304},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.41982796788215637},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.4124714732170105},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3950847387313843},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3517689108848572},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2563720941543579},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.2559624910354614},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.23455455899238586},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1958363652229309},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.14304900169372559},{"id":"https://openalex.org/keywords/computer-network","display_name":"Computer network","score":0.1357797086238861}],"concepts":[{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.7111533880233765},{"id":"https://openalex.org/C2779478453","wikidata":"https://www.wikidata.org/wiki/Q6889748","display_name":"Modularity (biology)","level":2,"score":0.5950679779052734},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.5825390815734863},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5618574619293213},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5117449760437012},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.5111365914344788},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.509393036365509},{"id":"https://openalex.org/C60723933","wikidata":"https://www.wikidata.org/wiki/Q7001080","display_name":"Network motif","level":3,"score":0.5037645697593689},{"id":"https://openalex.org/C191172861","wikidata":"https://www.wikidata.org/wiki/Q7899321","display_name":"Upstream (networking)","level":2,"score":0.451568603515625},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4249681830406189},{"id":"https://openalex.org/C199845137","wikidata":"https://www.wikidata.org/wiki/Q145490","display_name":"Network topology","level":2,"score":0.42250511050224304},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.41982796788215637},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.4124714732170105},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3950847387313843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3517689108848572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2563720941543579},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2559624910354614},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23455455899238586},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1958363652229309},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.14304900169372559},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.1357797086238861},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1003533","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003533","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003533&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24676102","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24676102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:osti.gov:1904832","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1904832","pdf_url":"https://www.osti.gov/servlets/purl/1904832","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.773.2602","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.773.2602","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f4/6e/pcbi.1003533.PMC3967935.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003533","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003533","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:553271851ff44765b4f6312fbedb666c","is_oa":true,"landing_page_url":"https://doaj.org/article/553271851ff44765b4f6312fbedb666c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 3, p e1003533 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2954222","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3967935","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/977355","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Loads_Bias_Genetic_and_Signaling_Switches_in_Synthetic_and_Natural_Systems_/977355","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3967935","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3967935","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003533","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003533","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003533&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.8999999761581421,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G1399744113","display_name":"CAREER: The Landscape of Differentiation: Understanding the Mesenchymal Stem Cell Response to the Topography and Geometry of their Environment","funder_award_id":"1151454","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6671297155","display_name":null,"funder_award_id":"CAREER","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1963572891.pdf","grobid_xml":"https://content.openalex.org/works/W1963572891.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W54389250","https://openalex.org/W1544401280","https://openalex.org/W1645305843","https://openalex.org/W1946177469","https://openalex.org/W1963906834","https://openalex.org/W1966855912","https://openalex.org/W1967728313","https://openalex.org/W1970283086","https://openalex.org/W1970743380","https://openalex.org/W2001722157","https://openalex.org/W2003930585","https://openalex.org/W2012964934","https://openalex.org/W2013330518","https://openalex.org/W2018994057","https://openalex.org/W2027576577","https://openalex.org/W2031952899","https://openalex.org/W2037992356","https://openalex.org/W2041985017","https://openalex.org/W2046649943","https://openalex.org/W2056556558","https://openalex.org/W2056657629","https://openalex.org/W2060350357","https://openalex.org/W2063854986","https://openalex.org/W2063921800","https://openalex.org/W2077206871","https://openalex.org/W2096511406","https://openalex.org/W2108726522","https://openalex.org/W2111759547","https://openalex.org/W2111870329","https://openalex.org/W2114870653","https://openalex.org/W2117136688","https://openalex.org/W2123097315","https://openalex.org/W2124892319","https://openalex.org/W2124977728","https://openalex.org/W2128605063","https://openalex.org/W2130127788","https://openalex.org/W2132405406","https://openalex.org/W2132828256","https://openalex.org/W2134759932","https://openalex.org/W2135541516","https://openalex.org/W2136969641","https://openalex.org/W2142691347","https://openalex.org/W2145225614","https://openalex.org/W2149202606","https://openalex.org/W2153683741","https://openalex.org/W2155560009","https://openalex.org/W2158516169","https://openalex.org/W2166499263","https://openalex.org/W2169360734","https://openalex.org/W2169675068","https://openalex.org/W2172162088","https://openalex.org/W2316378629","https://openalex.org/W2419526123"],"related_works":["https://openalex.org/W2057769265","https://openalex.org/W2796517744","https://openalex.org/W2024161258","https://openalex.org/W1911418903","https://openalex.org/W2338895903","https://openalex.org/W15348386","https://openalex.org/W4212865750","https://openalex.org/W2509687359","https://openalex.org/W2362023034","https://openalex.org/W2135602072"],"abstract_inverted_index":{"Biological":[0],"protein":[1],"interactions":[2,60],"networks":[3,11,256],"such":[4],"as":[5,15,237],"signal":[6,109,191],"transduction":[7,110,192],"or":[8],"gene":[9,106],"transcription":[10,107],"are":[12,48,242],"often":[13],"treated":[14],"modular,":[16],"allowing":[17],"motifs":[18,47],"to":[19,122,154,209,238,257],"be":[20],"analyzed":[21],"in":[22,36,105,142,149,172,183,244],"isolation":[23],"from":[24],"the":[25,28,59,70,74,81,87,99,112,123,134,145,155,179,216,220,227,235],"rest":[26],"of":[27,86,101,144,218,222,229],"network.":[29],"Modularity":[30],"is":[31,41,250],"also":[32,159,188],"a":[33,62,102,184,197,210],"key":[34],"assumption":[35],"synthetic":[37,255],"biology,":[38],"where":[39],"it":[40,141],"similarly":[42],"expected":[43],"that":[44,61,116,165,196],"when":[45,207,225,253],"network":[46,63,231],"combined":[49],"together,":[50],"they":[51],"do":[52],"not":[53],"lose":[54,203],"their":[55],"essential":[56],"characteristics.":[57],"However,":[58],"module":[64,76],"has":[65],"with":[66],"downstream":[67,120,211,223],"elements":[68],"change":[69,80],"dynamical":[71,130],"equations":[72],"describing":[73],"upstream":[75,88],"and":[77,83,108,139,148,194,233],"thus":[78],"may":[79],"dynamic":[82],"static":[84],"properties":[85,131,206],"circuit":[89],"even":[90],"without":[91],"explicit":[92],"feedback.":[93],"In":[94],"this":[95],"work":[96],"we":[97],"analyze":[98,189],"behavior":[100],"ubiquitous":[103,198],"motif":[104,170],"circuits:":[111],"switch.":[113],"We":[114,163,187],"show":[115,195],"adding":[117,152],"an":[118,166],"additional":[119,167],"component":[121],"simple":[124],"genetic":[125,156],"toggle":[126,175],"switch":[127,157,201],"changes":[128],"its":[129,204],"by":[132],"changing":[133],"underlying":[135],"potential":[136,180],"energy":[137,181],"landscape,":[138],"skewing":[140],"favor":[143],"unloaded":[146],"side,":[147],"some":[150],"situations":[151],"loads":[153],"can":[158,202],"abrogate":[160],"bistable":[161],"behavior.":[162],"find":[164],"positive":[168,199],"feedback":[169,200],"found":[171],"naturally":[173],"occurring":[174],"switches":[176,193],"could":[177],"tune":[178],"landscape":[182],"desirable":[185],"manner.":[186],"autocatalytic":[190],"switch-like":[205],"connected":[208],"load.":[212],"Our":[213],"analysis":[214,249],"underscores":[215],"necessity":[217],"incorporating":[219],"effects":[221,241],"components":[224],"understanding":[226],"physics":[228],"biochemical":[230],"motifs,":[232],"raises":[234],"question":[236],"how":[239],"these":[240],"managed":[243],"real":[245],"biological":[246],"systems.":[247],"This":[248],"particularly":[251],"important":[252],"scaling":[254],"more":[258],"complex":[259],"organisms.":[260]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-07-11T18:08:03.149640","created_date":"2025-10-10T00:00:00"}