{"id":"https://openalex.org/W2601000897","doi":"https://doi.org/10.1371/journal.pcbi.1003503","title":"Modeling Mutual Exclusivity of Cancer Mutations","display_name":"Modeling Mutual Exclusivity of Cancer Mutations","publication_year":2014,"publication_date":"2014-03-27","ids":{"openalex":"https://openalex.org/W2601000897","doi":"https://doi.org/10.1371/journal.pcbi.1003503","mag":"2601000897"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003503","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003503","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003503&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003503&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036326710","display_name":"Ewa Szczurek","orcid":"https://orcid.org/0000-0002-1320-6695"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"funder","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ewa Szczurek","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; SIB Swiss Institute of Bioinformatics, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Basel, Switzerland","Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; SIB Swiss Institute of Bioinformatics, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035497488","display_name":"Niko Beerenwinkel","orcid":"https://orcid.org/0000-0002-0573-6119"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"funder","lineage":["https://openalex.org/I12708293"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Niko Beerenwinkel","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; SIB Swiss Institute of Bioinformatics, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, Basel, Switzerland","Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland"],"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; SIB Swiss Institute of Bioinformatics, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5035497488"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I35440088"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":1841,"currency":"EUR","value_usd":1985},"fwci":5.8562,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.97128316,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"10","issue":"3","first_page":"e1003503","last_page":"e1003503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.6556814312934875},{"id":"https://openalex.org/keywords/statistical-power","display_name":"Statistical power","score":0.5755824446678162},{"id":"https://openalex.org/keywords/mutual-information","display_name":"Mutual information","score":0.5723444223403931},{"id":"https://openalex.org/keywords/ranking","display_name":"Ranking (information retrieval)","score":0.5430547595024109},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5192115902900696},{"id":"https://openalex.org/keywords/permutation","display_name":"Permutation (music)","score":0.5061420798301697},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5032736659049988},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.50154709815979},{"id":"https://openalex.org/keywords/statistical-hypothesis-testing","display_name":"Statistical hypothesis testing","score":0.4993319511413574},{"id":"https://openalex.org/keywords/null-model","display_name":"Null model","score":0.4989163875579834},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.4766736328601837},{"id":"https://openalex.org/keywords/type-i-and-type-ii-errors","display_name":"Type I and type II errors","score":0.46598002314567566},{"id":"https://openalex.org/keywords/statistical-model","display_name":"Statistical model","score":0.4502630829811096},{"id":"https://openalex.org/keywords/dna-microarray","display_name":"DNA microarray","score":0.4381946623325348},{"id":"https://openalex.org/keywords/replicate","display_name":"Replicate","score":0.4359341263771057},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42157602310180664},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3702387511730194},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.31304967403411865},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3049028217792511},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.28614431619644165},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20686200261116028},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.15286904573440552}],"concepts":[{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.6556814312934875},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.5755824446678162},{"id":"https://openalex.org/C152139883","wikidata":"https://www.wikidata.org/wiki/Q252973","display_name":"Mutual information","level":2,"score":0.5723444223403931},{"id":"https://openalex.org/C189430467","wikidata":"https://www.wikidata.org/wiki/Q7293293","display_name":"Ranking (information retrieval)","level":2,"score":0.5430547595024109},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5192115902900696},{"id":"https://openalex.org/C21308566","wikidata":"https://www.wikidata.org/wiki/Q7169365","display_name":"Permutation (music)","level":2,"score":0.5061420798301697},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5032736659049988},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.50154709815979},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.4993319511413574},{"id":"https://openalex.org/C36382193","wikidata":"https://www.wikidata.org/wiki/Q7068966","display_name":"Null model","level":2,"score":0.4989163875579834},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.4766736328601837},{"id":"https://openalex.org/C40696583","wikidata":"https://www.wikidata.org/wiki/Q989120","display_name":"Type I and type II errors","level":2,"score":0.46598002314567566},{"id":"https://openalex.org/C114289077","wikidata":"https://www.wikidata.org/wiki/Q3284399","display_name":"Statistical model","level":2,"score":0.4502630829811096},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.4381946623325348},{"id":"https://openalex.org/C2781162219","wikidata":"https://www.wikidata.org/wiki/Q26250693","display_name":"Replicate","level":2,"score":0.4359341263771057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42157602310180664},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3702387511730194},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31304967403411865},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3049028217792511},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.28614431619644165},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20686200261116028},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.15286904573440552},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003503","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003503","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003503&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003503","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003503","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:eebe33cddb254673a37e91f7a83ddf60","is_oa":true,"landing_page_url":"https://doaj.org/article/eebe33cddb254673a37e91f7a83ddf60","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 3, p e1003503 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2954210","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3967923","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/976650","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Modeling_Mutual_Exclusivity_of_Cancer_Mutations_/976650","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003503","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003503","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003503&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2601000897.pdf","grobid_xml":"https://content.openalex.org/works/W2601000897.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1582541231","https://openalex.org/W1756618264","https://openalex.org/W1830719945","https://openalex.org/W1974681499","https://openalex.org/W1985035689","https://openalex.org/W1985923121","https://openalex.org/W2017283085","https://openalex.org/W2025183726","https://openalex.org/W2042851051","https://openalex.org/W2042994628","https://openalex.org/W2070166919","https://openalex.org/W2108643617","https://openalex.org/W2109816625","https://openalex.org/W2112495642","https://openalex.org/W2116798163","https://openalex.org/W2119313610","https://openalex.org/W2120010359","https://openalex.org/W2121443461","https://openalex.org/W2122769974","https://openalex.org/W2126172213","https://openalex.org/W2129873928","https://openalex.org/W2138601221","https://openalex.org/W2144940507","https://openalex.org/W2148883613","https://openalex.org/W2149441684","https://openalex.org/W2168303063","https://openalex.org/W2601000897"],"related_works":["https://openalex.org/W4386773228","https://openalex.org/W3003558595","https://openalex.org/W2752163332","https://openalex.org/W3195675344","https://openalex.org/W2044363112","https://openalex.org/W2130566053","https://openalex.org/W2018863440","https://openalex.org/W2146983240","https://openalex.org/W2137338763","https://openalex.org/W2982103160"],"abstract_inverted_index":{"In":[0,94],"large":[1],"collections":[2],"of":[3,12,40,65,108,122,155,216,229,248],"tumor":[4,204],"samples,":[5],"it":[6],"has":[7],"been":[8],"observed":[9],"that":[10,14,49,78,166,211],"sets":[11,35],"genes":[13],"are":[15,212],"commonly":[16],"involved":[17],"in":[18,29,43,196,199,245],"the":[19,30,63,67,84,163,174,246],"same":[20,31],"cancer":[21,44,239],"pathways":[22,240],"tend":[23],"not":[24,88,219],"to":[25,162,179,191,237],"occur":[26],"mutated":[27],"together":[28],"patient.":[32],"Such":[33],"gene":[34,41,53,169],"form":[36],"mutually":[37,51],"exclusive":[38,52],"patterns":[39,60,195,210],"alterations":[42,77],"genomic":[45,242],"data.":[46],"Computational":[47],"approaches":[48,86],"detect":[50,192,238],"sets,":[54],"rank":[55],"and":[56,70,98,106,136,143,198,235],"test":[57,154,176,186],"candidate":[58],"alteration":[59,109,243],"by":[61,71,158,222],"rewarding":[62],"number":[64],"samples":[66],"pattern":[68,144],"covers":[69],"punishing":[72],"its":[73,160],"impurity,":[74,128],"i.e.,":[75],"additional":[76],"violate":[79],"strict":[80],"mutual":[81,123,156,193,230],"exclusivity.":[82],"However,":[83],"extant":[85],"do":[87],"account":[89],"for":[90,140],"possible":[91],"observation":[92],"errors.":[93],"practice,":[95],"false":[96,100],"negatives":[97],"especially":[99],"positives":[101],"can":[102],"severely":[103],"bias":[104],"evaluation":[105],"ranking":[107],"patterns.":[110],"To":[111],"address":[112],"these":[113],"limitations,":[114],"we":[115,150,206],"develop":[116],"a":[117,152,184],"fully":[118],"probabilistic,":[119],"generative":[120],"model":[121,165],"exclusivity,":[124],"explicitly":[125],"taking":[126],"coverage,":[127],"as":[129,131],"well":[130],"error":[132],"rates":[133],"into":[134],"account,":[135],"devise":[137],"efficient":[138],"algorithms":[139],"parameter":[141],"estimation":[142],"ranking.":[145],"Based":[146],"on":[147],"this":[148],"model,":[149],"derive":[151],"statistical":[153,226],"exclusivity":[157,194,231],"comparing":[159],"likelihood":[161],"null":[164],"assumes":[167],"independent":[168],"alterations.":[170],"Using":[171],"extensive":[172],"simulations,":[173],"new":[175],"is":[177],"shown":[178],"be":[180,220],"more":[181],"powerful":[182],"than":[183],"permutation":[185],"applied":[187,190],"previously.":[188],"When":[189],"glioblastoma":[197],"pan-cancer":[200],"data":[201,244],"from":[202,241],"twelve":[203],"types,":[205],"identify":[207],"several":[208],"significant":[209],"biologically":[213],"relevant,":[214],"most":[215],"which":[217],"would":[218],"detected":[221],"previous":[223],"approaches.":[224],"Our":[225],"modeling":[227],"framework":[228],"provides":[232],"increased":[233],"flexibility":[234],"power":[236],"presence":[247],"noise.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}