{"id":"https://openalex.org/W2022374283","doi":"https://doi.org/10.1371/journal.pcbi.1003483","title":"Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism","display_name":"Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism","publication_year":2014,"publication_date":"2014-02-20","ids":{"openalex":"https://openalex.org/W2022374283","doi":"https://doi.org/10.1371/journal.pcbi.1003483","mag":"2022374283","pmid":"https://pubmed.ncbi.nlm.nih.gov/24586134"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003483","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003483","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003483&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003483&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021074279","display_name":"\u0395lad Noor","orcid":"https://orcid.org/0000-0001-8776-4799"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Elad Noor","raw_affiliation_strings":["Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044028530","display_name":"Arren Bar\u2010Even","orcid":"https://orcid.org/0000-0002-1039-4328"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Arren Bar-Even","raw_affiliation_strings":["Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062382712","display_name":"Avi I. Flamholz","orcid":"https://orcid.org/0000-0002-9278-5479"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Avi Flamholz","raw_affiliation_strings":["Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel ; Department of Molecular and Cellular Biology, University of California, Berkely, Berkely, California, United States of America","Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel","Department of Molecular and Cellular Biology, University of California, Berkely, Berkely, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel ; Department of Molecular and Cellular Biology, University of California, Berkely, Berkely, California, United States of America","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, University of California, Berkely, Berkely, California, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081768872","display_name":"Ed Reznik","orcid":"https://orcid.org/0000-0002-6511-5947"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ed Reznik","raw_affiliation_strings":["Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046914403","display_name":"Wolfram Liebermeister","orcid":"https://orcid.org/0000-0002-2568-2381"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Wolfram Liebermeister","raw_affiliation_strings":["Institut f\u00fcr Biochemie, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Biochemie, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024451873","display_name":"Ron Milo","orcid":"https://orcid.org/0000-0003-1641-2299"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Ron Milo","raw_affiliation_strings":["Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021074279","https://openalex.org/A5024451873","https://openalex.org/A5044028530","https://openalex.org/A5046914403","https://openalex.org/A5062382712","https://openalex.org/A5081768872"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I53964585","https://openalex.org/I7877124"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":8.9341,"has_fulltext":true,"cited_by_count":363,"citation_normalized_percentile":{"value":0.98562323,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"10","issue":"2","first_page":"e1003483","last_page":"e1003483"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12915","display_name":"Biochemical Acid Research Studies","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.6980774402618408},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.6055291295051575},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5839802026748657},{"id":"https://openalex.org/keywords/gibbs-free-energy","display_name":"Gibbs free energy","score":0.5806818008422852},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5348979234695435},{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.5014121532440186},{"id":"https://openalex.org/keywords/kinetic-energy","display_name":"Kinetic energy","score":0.4241403639316559},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.24873319268226624},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.23323002457618713},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20539921522140503},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09432756900787354},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.08622533082962036}],"concepts":[{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.6980774402618408},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.6055291295051575},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5839802026748657},{"id":"https://openalex.org/C146477669","wikidata":"https://www.wikidata.org/wiki/Q334631","display_name":"Gibbs free energy","level":2,"score":0.5806818008422852},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5348979234695435},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.5014121532440186},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.4241403639316559},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.24873319268226624},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23323002457618713},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20539921522140503},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09432756900787354},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08622533082962036},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005285","descriptor_name":"Fermentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008291","descriptor_name":"Malate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008291","descriptor_name":"Malate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008291","descriptor_name":"Malate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003483","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003483","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003483&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24586134","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24586134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:c82b19fb103d429d92d566fddf014399","is_oa":true,"landing_page_url":"https://doaj.org/article/c82b19fb103d429d92d566fddf014399","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 2, p e1003483 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2914714","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3930492","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/939466","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Pathway_Thermodynamics_Highlights_Kinetic_Obstacles_in_Central_Metabolism_/939466","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003483","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003483","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003483&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.4699999988079071}],"awards":[{"id":"https://openalex.org/G6855729192","display_name":null,"funder_award_id":"Ll 1676/2-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2022374283.pdf","grobid_xml":"https://content.openalex.org/works/W2022374283.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W3295651","https://openalex.org/W120247693","https://openalex.org/W263690924","https://openalex.org/W399385914","https://openalex.org/W1492117602","https://openalex.org/W1499996884","https://openalex.org/W1530704185","https://openalex.org/W1534229002","https://openalex.org/W1540594181","https://openalex.org/W1552092570","https://openalex.org/W1561767438","https://openalex.org/W1568735259","https://openalex.org/W1575273684","https://openalex.org/W1585179321","https://openalex.org/W1586778906","https://openalex.org/W1591613693","https://openalex.org/W1626064454","https://openalex.org/W1677343354","https://openalex.org/W1762430620","https://openalex.org/W1884073728","https://openalex.org/W1914467681","https://openalex.org/W1965055109","https://openalex.org/W1967039865","https://openalex.org/W1972990890","https://openalex.org/W1974368517","https://openalex.org/W1981673913","https://openalex.org/W1982799855","https://openalex.org/W1985319478","https://openalex.org/W1987003501","https://openalex.org/W1987104093","https://openalex.org/W1988242255","https://openalex.org/W1990812533","https://openalex.org/W1994575037","https://openalex.org/W1994930272","https://openalex.org/W1997733142","https://openalex.org/W1998783652","https://openalex.org/W1999269740","https://openalex.org/W2000557621","https://openalex.org/W2000605827","https://openalex.org/W2001689758","https://openalex.org/W2003229972","https://openalex.org/W2004235182","https://openalex.org/W2019683970","https://openalex.org/W2026990029","https://openalex.org/W2029335716","https://openalex.org/W2031825920","https://openalex.org/W2034752666","https://openalex.org/W2035612098","https://openalex.org/W2035934220","https://openalex.org/W2038241057","https://openalex.org/W2039374566","https://openalex.org/W2044151730","https://openalex.org/W2044317668","https://openalex.org/W2047075997","https://openalex.org/W2049770693","https://openalex.org/W2050073769","https://openalex.org/W2056756011","https://openalex.org/W2062931536","https://openalex.org/W2069568056","https://openalex.org/W2073354998","https://openalex.org/W2074978715","https://openalex.org/W2081518479","https://openalex.org/W2084374578","https://openalex.org/W2090970630","https://openalex.org/W2094542138","https://openalex.org/W2097346112","https://openalex.org/W2101600488","https://openalex.org/W2102164505","https://openalex.org/W2103795997","https://openalex.org/W2104488216","https://openalex.org/W2104619491","https://openalex.org/W2104724247","https://openalex.org/W2107275175","https://openalex.org/W2109449871","https://openalex.org/W2117745792","https://openalex.org/W2121082646","https://openalex.org/W2123060905","https://openalex.org/W2123875295","https://openalex.org/W2124019798","https://openalex.org/W2125122419","https://openalex.org/W2127771683","https://openalex.org/W2131272473","https://openalex.org/W2133657715","https://openalex.org/W2135386829","https://openalex.org/W2141650231","https://openalex.org/W2141776893","https://openalex.org/W2142717577","https://openalex.org/W2145516650","https://openalex.org/W2151109749","https://openalex.org/W2151999472","https://openalex.org/W2152954594","https://openalex.org/W2153560677","https://openalex.org/W2153572376","https://openalex.org/W2154126596","https://openalex.org/W2159715570","https://openalex.org/W2161227644","https://openalex.org/W2169678694","https://openalex.org/W2171090044","https://openalex.org/W2171901564","https://openalex.org/W2250496884","https://openalex.org/W2339493109","https://openalex.org/W2482371382","https://openalex.org/W2944782266","https://openalex.org/W3025652231","https://openalex.org/W6703695517"],"related_works":["https://openalex.org/W1974744264","https://openalex.org/W2255699127","https://openalex.org/W2317273365","https://openalex.org/W2364598349","https://openalex.org/W2359412950","https://openalex.org/W2041310076","https://openalex.org/W1984013971","https://openalex.org/W2153909955","https://openalex.org/W4245647349","https://openalex.org/W2030669860"],"abstract_inverted_index":{"In":[0],"metabolism":[1,226],"research,":[2],"thermodynamics":[3,35],"is":[4,28,60,183],"usually":[5],"used":[6],"to":[7,31,63,70,129,147,179,207,211,222,251],"determine":[8],"the":[9,15,21,38,43,49,52,55,64,88,96,112,116,121,125,145,177,194,212,216,285,296],"directionality":[10],"of":[11,17,33,40,51,84,174,196,224,231,246,256,266,283,290],"a":[12,18,71,79,82,131,141,161,280],"reaction":[13,72,80,122],"or":[14],"feasibility":[16],"pathway.":[19],"However,":[20],"relationship":[22],"between":[23,54],"thermodynamic":[24,152,187,286],"potentials":[25],"and":[26,57,200,204,254,287],"fluxes":[27,59],"not":[29],"limited":[30],"questions":[32],"directionality:":[34],"also":[36],"affects":[37],"kinetics":[39],"reactions":[41],"through":[42],"flux-force":[44],"relationship,":[45],"which":[46,120,148,170,180],"states":[47],"that":[48,294],"logarithm":[50],"ratio":[53],"forward":[56,89],"reverse":[58,97,113],"directly":[61],"proportional":[62],"change":[65],"in":[66,275],"Gibbs":[67],"energy":[68],"due":[69],"(\u0394rG').":[73],"Accordingly,":[74],"if":[75],"an":[76,262],"enzyme":[77,109,126],"catalyzes":[78,111],"with":[81],"\u0394rG'":[83,100],"-5.7":[85],"kJ/mol":[86],"then":[87],"flux":[90,133,182],"will":[91],"be":[92],"roughly":[93],"ten":[94],"times":[95],"flux.":[98,155],"As":[99],"approaches":[101],"equilibrium":[102],"(\u0394rG'":[103],"=":[104],"0":[105],"kJ/mol),":[106],"exponentially":[107],"more":[108],"counterproductively":[110],"reaction,":[114],"reducing":[115],"net":[117],"rate":[118],"at":[119],"proceeds.":[123],"Thus,":[124],"level":[127],"required":[128],"achieve":[130],"given":[132],"increases":[134],"dramatically":[135],"near":[136],"equilibrium.":[137],"Here,":[138],"we":[139,159],"develop":[140],"framework":[142,191],"for":[143,193],"quantifying":[144],"degree":[146,178],"pathways":[149,175,223,239],"suffer":[150],"these":[151],"limitations":[153],"on":[154,229],"For":[156],"each":[157],"pathway,":[158],"calculate":[160],"single":[162],"thermodynamically-derived":[163],"metric":[164],"(the":[165],"Max-min":[166],"Driving":[167],"Force,":[168],"MDF),":[169],"enables":[171],"objective":[172],"ranking":[173],"by":[176,185],"their":[181,232],"constrained":[184],"low":[186],"driving":[188],"force.":[189],"Our":[190],"accounts":[192],"effect":[195],"pH,":[197],"ionic":[198],"strength":[199],"metabolite":[201],"concentration":[202],"ranges":[203],"allows":[205],"us":[206],"quantify":[208],"how":[209],"alterations":[210],"pathway":[213,292],"structure":[214],"affect":[215],"pathway's":[217],"thermodynamics.":[218],"Applying":[219],"this":[220],"methodology":[221],"central":[225],"sheds":[227],"light":[228],"some":[230],"features,":[233],"including":[234],"metabolic":[235,276],"bypasses":[236],"(e.g.,":[237,245,259],"fermentation":[238],"bypassing":[240],"substrate-level":[241],"phosphorylation),":[242],"substrate":[243],"channeling":[244],"oxaloacetate":[247],"from":[248],"malate":[249],"dehydrogenase":[250],"citrate":[252],"synthase),":[253],"use":[255],"alternative":[257],"cofactors":[258],"quinone":[260],"as":[261],"electron":[263],"acceptor":[264],"instead":[265],"NAD).":[267],"The":[268],"methods":[269],"presented":[270],"here":[271],"place":[272],"another":[273],"arrow":[274],"engineers'":[277],"quiver,":[278],"providing":[279],"simple":[281],"means":[282],"evaluating":[284],"kinetic":[288],"quality":[289],"different":[291],"chemistries":[293],"produce":[295],"same":[297],"molecules.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":44},{"year":2024,"cited_by_count":41},{"year":2023,"cited_by_count":43},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":43},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-04T07:58:01.006859","created_date":"2025-10-10T00:00:00"}
