{"id":"https://openalex.org/W2078208725","doi":"https://doi.org/10.1371/journal.pcbi.1003481","title":"Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers","display_name":"Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers","publication_year":2014,"publication_date":"2014-03-06","ids":{"openalex":"https://openalex.org/W2078208725","doi":"https://doi.org/10.1371/journal.pcbi.1003481","mag":"2078208725","pmid":"https://pubmed.ncbi.nlm.nih.gov/24603301"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003481","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003481","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003481&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003481&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078178163","display_name":"Alexandra Jilkine","orcid":"https://orcid.org/0000-0001-5896-5962"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Jilkine","raw_affiliation_strings":["Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, Indiana, United States of America","Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America","Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, Indiana, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America; Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, Indiana, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, Indiana, United States of America","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056381387","display_name":"Ryan N. Gutenkunst","orcid":"https://orcid.org/0000-0002-8659-0579"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan N. Gutenkunst","raw_affiliation_strings":["Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona, United States of America","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056381387"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.541,"has_fulltext":true,"cited_by_count":66,"citation_normalized_percentile":{"value":0.89166204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"3","first_page":"e1003481","last_page":"e1003481"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.8279937505722046},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.7423288822174072},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7034742832183838},{"id":"https://openalex.org/keywords/cancer-stem-cell","display_name":"Cancer stem cell","score":0.6855721473693848},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.6256451606750488},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.6231936812400818},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5095889568328857},{"id":"https://openalex.org/keywords/stem-cell-theory-of-aging","display_name":"Stem cell theory of aging","score":0.4801335036754608},{"id":"https://openalex.org/keywords/progenitor","display_name":"Progenitor","score":0.4344397485256195},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.37863409519195557},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.28288403153419495},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.21389225125312805},{"id":"https://openalex.org/keywords/stem-cell-factor","display_name":"Stem cell factor","score":0.176846444606781},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.08209991455078125}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8279937505722046},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7423288822174072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7034742832183838},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.6855721473693848},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6256451606750488},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6231936812400818},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5095889568328857},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.4801335036754608},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.4344397485256195},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37863409519195557},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28288403153419495},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21389225125312805},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.176846444606781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08209991455078125},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1003481","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003481","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003481&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24603301","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24603301","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1308.6808","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1308.6808","pdf_url":"https://arxiv.org/pdf/1308.6808","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.665.4783","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.665.4783","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://gutengroup.mcb.arizona.edu/Publications/Jilkine2014.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.765.1636","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.765.1636","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://arxiv.org/pdf/1308.6808.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:24c758b893494bc1adfaac3f3555f4bd","is_oa":true,"landing_page_url":"https://doaj.org/article/24c758b893494bc1adfaac3f3555f4bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 3, p e1003481 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2932594","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3945168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/954808","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Effect_of_Dedifferentiation_on_Time_to_Mutation_Acquisition_in_Stem_Cell_Driven_Cancers_/954808","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3945168","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3945168","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003481","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003481","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003481&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1197312516","display_name":null,"funder_award_id":"DEB-1146074","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5792073655","display_name":"Demographic History Inference from Genomic Linkage and Allele Frequency Spectra","funder_award_id":"1146074","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078208725.pdf","grobid_xml":"https://content.openalex.org/works/W2078208725.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W133959735","https://openalex.org/W349368958","https://openalex.org/W1537236879","https://openalex.org/W1595296482","https://openalex.org/W1964154017","https://openalex.org/W1964562290","https://openalex.org/W1965766641","https://openalex.org/W1970847438","https://openalex.org/W1971916129","https://openalex.org/W1974841785","https://openalex.org/W1977821962","https://openalex.org/W1977905227","https://openalex.org/W1978168667","https://openalex.org/W1982650853","https://openalex.org/W1983199521","https://openalex.org/W1984133324","https://openalex.org/W1985399917","https://openalex.org/W1987088302","https://openalex.org/W1989019426","https://openalex.org/W1997404722","https://openalex.org/W1998196049","https://openalex.org/W2000362335","https://openalex.org/W2009031936","https://openalex.org/W2009465554","https://openalex.org/W2011334551","https://openalex.org/W2012962381","https://openalex.org/W2014600438","https://openalex.org/W2021307759","https://openalex.org/W2024997496","https://openalex.org/W2026295302","https://openalex.org/W2026721712","https://openalex.org/W2061445495","https://openalex.org/W2061965920","https://openalex.org/W2062594085","https://openalex.org/W2063673453","https://openalex.org/W2065111801","https://openalex.org/W2065220128","https://openalex.org/W2069064270","https://openalex.org/W2070672434","https://openalex.org/W2072193332","https://openalex.org/W2072612668","https://openalex.org/W2073302269","https://openalex.org/W2076933987","https://openalex.org/W2077393203","https://openalex.org/W2081620485","https://openalex.org/W2083521569","https://openalex.org/W2086149372","https://openalex.org/W2094413841","https://openalex.org/W2094698810","https://openalex.org/W2097116261","https://openalex.org/W2101624484","https://openalex.org/W2102085111","https://openalex.org/W2105670702","https://openalex.org/W2106154018","https://openalex.org/W2109336877","https://openalex.org/W2109860416","https://openalex.org/W2112789125","https://openalex.org/W2117577687","https://openalex.org/W2118077148","https://openalex.org/W2124082414","https://openalex.org/W2124505818","https://openalex.org/W2125291586","https://openalex.org/W2127553277","https://openalex.org/W2129118821","https://openalex.org/W2129375080","https://openalex.org/W2132373340","https://openalex.org/W2138157271","https://openalex.org/W2140817080","https://openalex.org/W2143292535","https://openalex.org/W2143447139","https://openalex.org/W2145281784","https://openalex.org/W2146489738","https://openalex.org/W2151948621","https://openalex.org/W2153010521","https://openalex.org/W2153051750","https://openalex.org/W2158195820","https://openalex.org/W2162336396","https://openalex.org/W2163235555","https://openalex.org/W2168901267","https://openalex.org/W2168989497","https://openalex.org/W2169602834","https://openalex.org/W2171412952","https://openalex.org/W2547292717","https://openalex.org/W2581071829","https://openalex.org/W3098092026","https://openalex.org/W3102642837","https://openalex.org/W3123922469","https://openalex.org/W4235776389","https://openalex.org/W4238417967","https://openalex.org/W4242285942","https://openalex.org/W4246469391","https://openalex.org/W4249259387","https://openalex.org/W4285719527","https://openalex.org/W4300820761"],"related_works":["https://openalex.org/W2084533426","https://openalex.org/W2043337239","https://openalex.org/W2019260118","https://openalex.org/W2026748421","https://openalex.org/W2578732716","https://openalex.org/W2057870358","https://openalex.org/W2889893284","https://openalex.org/W2762443209","https://openalex.org/W2949376870","https://openalex.org/W2966060845"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"suggests":[2],"that":[3,23,120,155,195],"many":[4],"tumors":[5],"have":[6],"a":[7,27,68,87,159,198,214,238],"hierarchical":[8],"organization,":[9],"with":[10,102,183],"the":[11,14,60,97,111,138,164,173,206,217],"bulk":[12],"of":[13,17,30,62,72,83,96,99,205,221,243],"tumor":[15,100],"composed":[16],"relatively":[18],"differentiated":[19],"short-lived":[20],"progenitor":[21,52,84],"cells":[22,43,48,78,85],"are":[24],"maintained":[25],"by":[26],"small":[28],"population":[29,141,167,176,225],"undifferentiated":[31],"long-lived":[32],"cancer":[33,41],"stem":[34,42,47,77,88,132,139,165,174,207,223,244],"cells.":[35,53],"It":[36],"is":[37,135,143,178],"unclear,":[38],"however,":[39],"whether":[40],"originate":[44],"from":[45,50],"normal":[46],"or":[49],"dedifferentiated":[51],"To":[54],"address":[55],"this,":[56],"we":[57,106,153,193],"mathematically":[58],"modeled":[59],"effect":[61],"dedifferentiation":[63,82,121,156,196,211],"on":[64,130],"carcinogenesis.":[65,171],"We":[66,91],"considered":[67],"hybrid":[69],"stochastic-deterministic":[70],"model":[71],"mutation":[73],"accumulation":[74],"in":[75,127,163,234],"both":[76,188],"and":[79,105,168,190,231],"progenitors,":[80],"including":[81],"to":[86,115,148,180,202],"cell-like":[89],"state.":[90],"performed":[92],"exact":[93],"computer":[94],"simulations":[95],"emergence":[98],"subpopulations":[101],"two":[103],"mutations,":[104],"derived":[107],"semi-analytical":[108],"estimates":[109],"for":[110],"waiting":[112],"time":[113],"distribution":[114],"fixation.":[116],"Our":[117],"results":[118],"suggest":[119],"may":[122,212,227],"play":[123,213],"an":[124],"important":[125],"role":[126],"carcinogenesis,":[128],"depending":[129],"how":[131],"cell":[133,140,166,175,208,224,245],"homeostasis":[134],"maintained.":[136],"If":[137,172],"size":[142,177,226],"held":[144],"strictly":[145],"constant":[146,222],"(due":[147],"all":[149],"divisions":[150],"being":[151],"asymmetric),":[152],"found":[154,194],"acts":[157],"like":[158],"positive":[160],"selective":[161],"force":[162],"thus":[169],"speeds":[170],"allowed":[179],"vary":[181],"stochastically":[182],"density-dependent":[184],"reproduction":[185],"rates":[186],"(allowing":[187],"symmetric":[189],"asymmetric":[191],"divisions),":[192],"beyond":[197],"critical":[199],"threshold":[200],"leads":[201],"exponential":[203],"growth":[204],"population.":[209],"Thus,":[210],"crucial":[215],"role,":[216],"common":[218],"modeling":[219],"assumption":[220],"not":[228],"be":[229],"adequate,":[230],"further":[232],"progress":[233],"understanding":[235,242],"carcinogenesis":[236],"demands":[237],"more":[239],"detailed":[240],"mechanistic":[241],"homeostasis.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":3}],"updated_date":"2026-07-03T08:13:44.112507","created_date":"2025-10-10T00:00:00"}