{"id":"https://openalex.org/W2000183570","doi":"https://doi.org/10.1371/journal.pcbi.1003479","title":"A Virtual Infection Model Quantifies Innate Effector Mechanisms and Candida albicans Immune Escape in Human Blood","display_name":"A Virtual Infection Model Quantifies Innate Effector Mechanisms and Candida albicans Immune Escape in Human Blood","publication_year":2014,"publication_date":"2014-02-20","ids":{"openalex":"https://openalex.org/W2000183570","doi":"https://doi.org/10.1371/journal.pcbi.1003479","mag":"2000183570","pmid":"https://pubmed.ncbi.nlm.nih.gov/24586131"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003479","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003479","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003479&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003479&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087512061","display_name":"Kerstin H\u00fcnniger","orcid":"https://orcid.org/0000-0002-7071-0484"},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kerstin H\u00fcnniger","raw_affiliation_strings":["Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074051193","display_name":"Teresa Lehnert","orcid":null},"institutions":[{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]},{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Teresa Lehnert","raw_affiliation_strings":["Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany ; Friedrich Schiller University Jena, Jena, Germany","Friedrich Schiller University Jena, Jena, Germany","Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany ; Friedrich Schiller University Jena, Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Friedrich Schiller University Jena, Jena, Germany","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017440218","display_name":"Kristin Bieber","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kristin Bieber","raw_affiliation_strings":["Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019221390","display_name":"Ronny Martin","orcid":"https://orcid.org/0000-0002-2212-1511"},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ronny Martin","raw_affiliation_strings":["Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048137901","display_name":"Marc Thilo Figge","orcid":"https://orcid.org/0000-0002-4044-9166"},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]},{"id":"https://openalex.org/I76198965","display_name":"Friedrich Schiller University Jena","ror":"https://ror.org/05qpz1x62","country_code":"DE","type":"education","lineage":["https://openalex.org/I76198965"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Marc Thilo Figge","raw_affiliation_strings":["Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany ; Friedrich Schiller University Jena, Jena, Germany","Friedrich Schiller University Jena, Jena, Germany","Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany ; Friedrich Schiller University Jena, Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Friedrich Schiller University Jena, Jena, Germany","institution_ids":["https://openalex.org/I76198965"]},{"raw_affiliation_string":"Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044917199","display_name":"Oliver Kurzai","orcid":"https://orcid.org/0000-0002-7277-2646"},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Oliver Kurzai","raw_affiliation_strings":["Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology - Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":[]},{"raw_affiliation_string":"Septomics Research Center, Friedrich Schiller University and Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans-Kn\u00f6ll-Institute (HKI), Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044917199","https://openalex.org/A5048137901"],"corresponding_institution_ids":["https://openalex.org/I4210162077","https://openalex.org/I76198965"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.449,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.92801033,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"10","issue":"2","first_page":"e1003479","last_page":"e1003479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.8727512359619141},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.8134859800338745},{"id":"https://openalex.org/keywords/corpus-albicans","display_name":"Corpus albicans","score":0.7550227642059326},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6757150888442993},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6334437131881714},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.5937833786010742},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"Phagocytosis","score":0.553675651550293},{"id":"https://openalex.org/keywords/effector","display_name":"Effector","score":0.5323463082313538},{"id":"https://openalex.org/keywords/immunity","display_name":"Immunity","score":0.45138177275657654},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4018753170967102}],"concepts":[{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.8727512359619141},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.8134859800338745},{"id":"https://openalex.org/C145081991","wikidata":"https://www.wikidata.org/wiki/Q2576388","display_name":"Corpus albicans","level":3,"score":0.7550227642059326},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6757150888442993},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6334437131881714},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5937833786010742},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.553675651550293},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5323463082313538},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.45138177275657654},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4018753170967102}],"mesh":[{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D002176","descriptor_name":"Candida albicans","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014584","descriptor_name":"User-Computer Interface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003479","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003479","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003479&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24586131","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24586131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1003479","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003479","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:10bfabb2d1fe45d09027a5aa2d1b3332","is_oa":true,"landing_page_url":"https://doaj.org/article/10bfabb2d1fe45d09027a5aa2d1b3332","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 2, p e1003479 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2914718","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3930496","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/939860","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/A_Virtual_Infection_Model_Quantifies_Innate_Effector_Mechanisms_and_Candida_albicans_Immune_Escape_in_Human_Blood/939860","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003479","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003479","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003479&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"awards":[{"id":"https://openalex.org/G498519350","display_name":null,"funder_award_id":"BMBF 03Z2JN21","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G8154738156","display_name":null,"funder_award_id":"CRC124","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2000183570.pdf","grobid_xml":"https://content.openalex.org/works/W2000183570.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W94976983","https://openalex.org/W198080268","https://openalex.org/W1483639472","https://openalex.org/W1559752786","https://openalex.org/W1574913997","https://openalex.org/W1676917713","https://openalex.org/W1935457495","https://openalex.org/W1969726211","https://openalex.org/W1973344767","https://openalex.org/W1974620207","https://openalex.org/W1975633805","https://openalex.org/W1988360777","https://openalex.org/W1989386278","https://openalex.org/W1990474165","https://openalex.org/W1992994480","https://openalex.org/W1999340863","https://openalex.org/W2007164727","https://openalex.org/W2009527638","https://openalex.org/W2012600634","https://openalex.org/W2021009407","https://openalex.org/W2024135111","https://openalex.org/W2024755223","https://openalex.org/W2026054345","https://openalex.org/W2030072837","https://openalex.org/W2030827652","https://openalex.org/W2030898901","https://openalex.org/W2038753879","https://openalex.org/W2057549505","https://openalex.org/W2061860088","https://openalex.org/W2063145009","https://openalex.org/W2064433533","https://openalex.org/W2065033987","https://openalex.org/W2074758124","https://openalex.org/W2080363965","https://openalex.org/W2081928829","https://openalex.org/W2089031488","https://openalex.org/W2102809922","https://openalex.org/W2107299271","https://openalex.org/W2111240123","https://openalex.org/W2113648585","https://openalex.org/W2114602085","https://openalex.org/W2114844963","https://openalex.org/W2116830693","https://openalex.org/W2143564701","https://openalex.org/W2148258556","https://openalex.org/W2149806222","https://openalex.org/W2150428940","https://openalex.org/W2152466791","https://openalex.org/W2153104382","https://openalex.org/W2157673764","https://openalex.org/W2161872635","https://openalex.org/W2163998860","https://openalex.org/W2168222429","https://openalex.org/W2169831223","https://openalex.org/W2171423689","https://openalex.org/W2171796570","https://openalex.org/W2313875412","https://openalex.org/W2407405722","https://openalex.org/W2480907039","https://openalex.org/W3036294205","https://openalex.org/W3152335208","https://openalex.org/W4235389068"],"related_works":["https://openalex.org/W2027633987","https://openalex.org/W2411734508","https://openalex.org/W2102861863","https://openalex.org/W2367173716","https://openalex.org/W2247003880","https://openalex.org/W4362508968","https://openalex.org/W3029732278","https://openalex.org/W2778267304","https://openalex.org/W2742010288","https://openalex.org/W4309514212"],"abstract_inverted_index":{"Candida":[0],"albicans":[1,38,179,201,209,248,264],"bloodstream":[2,265],"infection":[3,73,86],"is":[4],"increasingly":[5],"frequent":[6],"and":[7,42,91,129,149,213,216,230,233,280],"can":[8],"result":[9],"in":[10,70,164,187,202,262,282],"disseminated":[11],"candidiasis":[12],"associated":[13],"with":[14,45,111],"high":[15,258],"mortality":[16],"rates.":[17],"To":[18,78],"analyze":[19],"the":[20,71,95,112,132,155,196,257,276],"innate":[21,241],"immune":[22,197,224,242],"response":[23,198],"against":[24,199,252],"C.":[25,37,178,200,208,247,263],"albicans,":[26],"fungal":[27,52,231],"cells":[28,53,210,249],"were":[29,64,76,103],"added":[30],"to":[31,40,56,66,119,130,220,236],"human":[32,203,287],"whole-blood":[33,72],"samples.":[34],"After":[35],"inoculation,":[36],"started":[39],"filament":[41],"predominantly":[43],"associate":[44],"neutrophils,":[46,145],"whereas":[47],"only":[48],"a":[49,84,106,124,141,283],"minority":[50],"of":[51,61,97,116,135,144,157,177,207,228,240,246,260,275],"became":[54],"attached":[55],"monocytes.":[57],"While":[58],"many":[59],"parameters":[60],"host-pathogen":[62,98],"interaction":[63],"accessible":[65],"direct":[67],"experimental":[68],"quantification":[69],"assay,":[74],"others":[75],"not.":[77],"overcome":[79],"these":[80],"limitations,":[81],"we":[82],"generated":[83],"virtual":[85],"model":[87],"that":[88,183],"allowed":[89,272],"detailed":[90],"quantitative":[92,121,273],"predictions":[93,122],"on":[94,123],"dynamics":[96],"interaction.":[99],"Experimental":[100],"time-resolved":[101],"data":[102],"simulated":[104,117],"using":[105],"state-based":[107],"modeling":[108],"approach":[109],"combined":[110],"Monte":[113],"Carlo":[114],"method":[115],"annealing":[118],"obtain":[120],"priori":[125],"unknown":[126],"transition":[127],"rates":[128],"identify":[131],"main":[133],"axis":[134],"antifungal":[136,158],"immunity.":[137],"Results":[138],"clearly":[139,181],"demonstrated":[140],"predominant":[142],"role":[143],"mediated":[146],"by":[147],"phagocytosis":[148,212,253],"intracellular":[150],"killing":[151],"as":[152,154],"well":[153],"release":[156],"effector":[159],"molecules":[160],"upon":[161],"activation,":[162],"resulting":[163],"extracellular":[165,215],"fungicidal":[166],"activity.":[167],"Both":[168],"mechanisms":[169],"together":[170],"account":[171,255],"for":[172,218,256],"almost":[173],"[Formula:":[174],"see":[175],"text]":[176],"killing,":[180],"proving":[182],"beside":[184],"being":[185,250],"present":[186],"larger":[188],"numbers":[189],"than":[190],"other":[191],"leukocytes,":[192],"neutrophils":[193],"functionally":[194],"dominate":[195],"blood.":[204,288],"A":[205],"fraction":[206],"escaped":[211],"remained":[214],"viable":[217],"up":[219],"four":[221],"hours.":[222],"This":[223],"escape":[225],"was":[226],"independent":[227],"filamentation":[229],"activity":[232],"not":[234],"linked":[235],"exhaustion":[237],"or":[238],"inactivation":[239],"cells.":[243],"The":[244],"occurrence":[245],"resistant":[251],"may":[254],"proportion":[259],"dissemination":[261],"infection.":[266],"Taken":[267],"together,":[268],"iterative":[269],"experiment-model-experiment":[270],"cycles":[271],"analyses":[274],"interplay":[277],"between":[278],"host":[279],"pathogen":[281],"complex":[284],"environment":[285],"like":[286]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":3}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
