{"id":"https://openalex.org/W2057948774","doi":"https://doi.org/10.1371/journal.pcbi.1003477","title":"Optimal Serotype Compositions for Pneumococcal Conjugate Vaccination under Serotype Replacement","display_name":"Optimal Serotype Compositions for Pneumococcal Conjugate Vaccination under Serotype Replacement","publication_year":2014,"publication_date":"2014-02-13","ids":{"openalex":"https://openalex.org/W2057948774","doi":"https://doi.org/10.1371/journal.pcbi.1003477","mag":"2057948774","pmid":"https://pubmed.ncbi.nlm.nih.gov/24550722"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003477","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003477","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003477&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003477&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013120990","display_name":"Markku Nurhonen","orcid":"https://orcid.org/0000-0002-5001-3585"},"institutions":[{"id":"https://openalex.org/I39624965","display_name":"Finnish Institute for Health and Welfare","ror":"https://ror.org/03tf0c761","country_code":"FI","type":"funder","lineage":["https://openalex.org/I39624965"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Markku Nurhonen","raw_affiliation_strings":["Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland","Department of Vaccination and Immune Protection; National Institute for Health and Welfare; Helsinki Finland"],"affiliations":[{"raw_affiliation_string":"Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland","institution_ids":["https://openalex.org/I39624965"]},{"raw_affiliation_string":"Department of Vaccination and Immune Protection; National Institute for Health and Welfare; Helsinki Finland","institution_ids":["https://openalex.org/I39624965"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023905414","display_name":"Kari Auranen","orcid":"https://orcid.org/0000-0002-8162-2260"},"institutions":[{"id":"https://openalex.org/I39624965","display_name":"Finnish Institute for Health and Welfare","ror":"https://ror.org/03tf0c761","country_code":"FI","type":"funder","lineage":["https://openalex.org/I39624965"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kari Auranen","raw_affiliation_strings":["Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland","Department of Vaccination and Immune Protection; National Institute for Health and Welfare; Helsinki Finland"],"affiliations":[{"raw_affiliation_string":"Department of Vaccination and Immune Protection, National Institute for Health and Welfare, Helsinki, Finland","institution_ids":["https://openalex.org/I39624965"]},{"raw_affiliation_string":"Department of Vaccination and Immune Protection; National Institute for Health and Welfare; Helsinki Finland","institution_ids":["https://openalex.org/I39624965"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013120990"],"corresponding_institution_ids":["https://openalex.org/I39624965"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.7921,"has_fulltext":true,"cited_by_count":31,"citation_normalized_percentile":{"value":0.90075724,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"e1003477","last_page":"e1003477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carriage","display_name":"Carriage","score":0.8836801052093506},{"id":"https://openalex.org/keywords/serotype","display_name":"Serotype","score":0.8676263689994812},{"id":"https://openalex.org/keywords/vaccination","display_name":"Vaccination","score":0.787611722946167},{"id":"https://openalex.org/keywords/herd-immunity","display_name":"Herd immunity","score":0.634414792060852},{"id":"https://openalex.org/keywords/pneumococcal-conjugate-vaccine","display_name":"Pneumococcal conjugate vaccine","score":0.6302310228347778},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4980621337890625},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.47162961959838867},{"id":"https://openalex.org/keywords/pneumococcal-infections","display_name":"Pneumococcal infections","score":0.43706077337265015},{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.3669035732746124},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3586697578430176},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31185752153396606},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.15586957335472107},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.10065099596977234},{"id":"https://openalex.org/keywords/antibiotics","display_name":"Antibiotics","score":0.060080915689468384}],"concepts":[{"id":"https://openalex.org/C32762888","wikidata":"https://www.wikidata.org/wiki/Q235356","display_name":"Carriage","level":2,"score":0.8836801052093506},{"id":"https://openalex.org/C10389963","wikidata":"https://www.wikidata.org/wiki/Q848328","display_name":"Serotype","level":2,"score":0.8676263689994812},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.787611722946167},{"id":"https://openalex.org/C106192422","wikidata":"https://www.wikidata.org/wiki/Q736798","display_name":"Herd immunity","level":3,"score":0.634414792060852},{"id":"https://openalex.org/C2778866548","wikidata":"https://www.wikidata.org/wiki/Q7205991","display_name":"Pneumococcal conjugate vaccine","level":4,"score":0.6302310228347778},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4980621337890625},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47162961959838867},{"id":"https://openalex.org/C2776152631","wikidata":"https://www.wikidata.org/wiki/Q4366062","display_name":"Pneumococcal infections","level":4,"score":0.43706077337265015},{"id":"https://openalex.org/C2781253189","wikidata":"https://www.wikidata.org/wiki/Q221179","display_name":"Streptococcus pneumoniae","level":3,"score":0.3669035732746124},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3586697578430176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31185752153396606},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15586957335472107},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10065099596977234},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.060080915689468384},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011008","descriptor_name":"Pneumococcal Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012703","descriptor_name":"Serotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012703","descriptor_name":"Serotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012703","descriptor_name":"Serotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018074","descriptor_name":"Vaccines, Conjugate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018074","descriptor_name":"Vaccines, Conjugate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018074","descriptor_name":"Vaccines, Conjugate","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018074","descriptor_name":"Vaccines, Conjugate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018074","descriptor_name":"Vaccines, Conjugate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018074","descriptor_name":"Vaccines, Conjugate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D022242","descriptor_name":"Pneumococcal Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003477","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003477","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003477&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24550722","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24550722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.774.8573","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.774.8573","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3e/b1/pcbi.1003477.PMC3923658.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:58294dfcbca34622bc1ebef046964ec1","is_oa":true,"landing_page_url":"https://doaj.org/article/58294dfcbca34622bc1ebef046964ec1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 2, p e1003477 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2909822","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3923658","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/934933","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Optimal_Serotype_Compositions_for_Pneumococcal_Conjugate_Vaccination_under_Serotype_Replacement_/934933","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3923658","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3923658","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:www.julkari.fi:10024/116603","is_oa":false,"landing_page_url":"http://www.julkari.fi/handle/10024/116603","pdf_url":null,"source":{"id":"https://openalex.org/S4306402058","display_name":"STM:n Hallinnonalan avoin julkaisuarkisto (Julkari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WOS","raw_type":"A1"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003477","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003477","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003477&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G6877960042","display_name":null,"funder_award_id":"138068","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320314363","display_name":"European Society for Paediatric Infectious Diseases","ror":"https://ror.org/00jvfh371"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2057948774.pdf","grobid_xml":"https://content.openalex.org/works/W2057948774.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1991373559","https://openalex.org/W1991389919","https://openalex.org/W1998204843","https://openalex.org/W2000499723","https://openalex.org/W2041461093","https://openalex.org/W2053889461","https://openalex.org/W2077913253","https://openalex.org/W2078465859","https://openalex.org/W2079547451","https://openalex.org/W2090760434","https://openalex.org/W2093931806","https://openalex.org/W2128684438","https://openalex.org/W2130492588","https://openalex.org/W2149176649","https://openalex.org/W2150562212","https://openalex.org/W2157583453","https://openalex.org/W2160040448","https://openalex.org/W2160332563","https://openalex.org/W2164754521","https://openalex.org/W2165364652","https://openalex.org/W2171726487"],"related_works":["https://openalex.org/W2808407520","https://openalex.org/W4236759531","https://openalex.org/W2053512666","https://openalex.org/W2218750465","https://openalex.org/W1977910742","https://openalex.org/W2107556453","https://openalex.org/W2171675135","https://openalex.org/W2002790873","https://openalex.org/W1921011725","https://openalex.org/W2783876038"],"abstract_inverted_index":{"Pneumococcal":[0],"conjugate":[1,31],"vaccination":[2,32,57,276],"has":[3,231],"proved":[4],"highly":[5,203],"effective":[6],"in":[7,66,115,179,207,213,218,251,277,289],"eliminating":[8],"vaccine-type":[9,90],"pneumococcal":[10,30,60,79,267],"carriage":[11,80,105,184,256],"and":[12,63,81,83,97,171,181,185,198,246,272,294],"disease.":[13],"However,":[14,139],"the":[15,47,53,67,111,127,146,149,165,173,193,228,237,242,247,255,259,273,278,290],"potential":[16],"adverse":[17],"effects":[18],"of":[19,49,56,69,89,102,131,135,167,175,196,241,249,258,264,275],"serotype":[20,50,72,121,169,189,230,262],"replacement":[21,51,93,142],"remain":[22],"a":[23,35,41,161,232],"major":[24],"concern":[25],"when":[26],"implementing":[27],"routine":[28],"childhood":[29],"programmes.":[33],"Applying":[34],"concise":[36],"predictive":[37],"model,":[38],"we":[39],"present":[40],"ready-to-use":[42],"quantitative":[43],"tool":[44],"to":[45,64,141,154,177],"investigate":[46],"implications":[48],"on":[52,78,192,254],"net":[54,221],"effectiveness":[55,222,252,274],"against":[58],"invasive":[59],"disease":[61],"(IPD)":[62],"guide":[65],"selection":[68],"optimal":[70,168,188,271],"vaccine":[71,120,205,291],"compositions.":[73],"We":[74,159],"utilise":[75],"pre-vaccination":[76],"data":[77,180],"IPD":[82,103,113],"assume":[84],"partial":[85],"or":[86],"complete":[87],"elimination":[88],"carriage,":[91,96],"its":[92],"by":[94,137,285],"non-vaccine-type":[95],"stable":[98],"case-to-carrier":[99,234,239],"ratios":[100],"(probability":[101],"per":[104],"episode).":[106],"The":[107,187,220,261],"model":[108],"predicts":[109],"that":[110],"post-vaccination":[112],"incidences":[114],"Finland":[116],"for":[117,164],"currently":[118,265],"available":[119,266],"compositions":[122,170,263],"can":[123],"eventually":[124],"decrease":[125,147],"among":[126,148],"target":[128],"age":[129,136,194,209],"group":[130,195],"children":[132],"<5":[133],"years":[134],"75%.":[138],"due":[140],"through":[143],"herd":[144],"effects,":[145],"older":[150],"population":[151,279],"is":[152],"predicted":[153],"be":[155,202,224,283],"much":[156],"less":[157],"(20-40%).":[158],"introduce":[160],"sequential":[162],"algorithm":[163],"search":[166],"assess":[172],"robustness":[174],"inferences":[176],"uncertainties":[178],"assumptions":[182],"about":[183],"IPD.":[186],"composition":[190],"depends":[191,253],"interest":[197],"some":[199],"serotypes":[200,288],"may":[201],"beneficial":[204],"types":[206,245],"one":[208],"category":[210],"(e.g.":[211,292],"6B":[212],"children),":[214],"while":[215],"being":[216],"disadvantageous":[217],"another.":[219],"will":[223],"improved":[225,284],"only":[226],"if":[227],"added":[229],"higher":[233],"ratio":[235,240],"than":[236],"average":[238],"current":[243],"non-vaccine":[244],"degree":[248],"improvement":[250],"incidence":[257],"serotype.":[260],"vaccines":[268],"are":[269],"not":[270],"at":[280],"large":[281],"could":[282],"including":[286],"new":[287],"22":[293],"9N).":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-22T08:38:42.863108","created_date":"2025-10-10T00:00:00"}
