{"id":"https://openalex.org/W1983587495","doi":"https://doi.org/10.1371/journal.pcbi.1003472","title":"Integrative Computational and Experimental Approaches to Establish a Post-Myocardial Infarction Knowledge Map","display_name":"Integrative Computational and Experimental Approaches to Establish a Post-Myocardial Infarction Knowledge Map","publication_year":2014,"publication_date":"2014-03-20","ids":{"openalex":"https://openalex.org/W1983587495","doi":"https://doi.org/10.1371/journal.pcbi.1003472","mag":"1983587495","pmid":"https://pubmed.ncbi.nlm.nih.gov/24651374"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003472","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003472","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003472&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003472&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113146842","display_name":"Nguyen T. Nguyen","orcid":null},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nguyen T. Nguyen","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America; San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America; San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":[]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100403831","display_name":"Xiaolin Zhang","orcid":"https://orcid.org/0000-0003-0403-1560"},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolin Zhang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053761444","display_name":"Cathy Wu","orcid":"https://orcid.org/0000-0001-6379-8601"},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cathy Wu","raw_affiliation_strings":["Center for Bioinformatics and Computational Biology and Protein Information Resource, University of Delaware, Newark, Delaware, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Bioinformatics and Computational Biology and Protein Information Resource, University of Delaware, Newark, Delaware, United States of America","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038574422","display_name":"Richard A. Lange","orcid":"https://orcid.org/0000-0002-6493-3913"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard A. Lange","raw_affiliation_strings":["San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":[]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083786375","display_name":"Robert \u0106hilton","orcid":"https://orcid.org/0000-0003-0195-5063"},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Chilton","raw_affiliation_strings":["San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America; Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058202537","display_name":"Merry L. Lindsey","orcid":"https://orcid.org/0000-0002-4090-0391"},"institutions":[{"id":"https://openalex.org/I2802864460","display_name":"Jackson Memorial Hospital","ror":"https://ror.org/02y070a55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802864460","https://openalex.org/I4210089954"]},{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]},{"id":"https://openalex.org/I4210144720","display_name":"G.V. (Sonny) Montgomery VA Medical Center","ror":"https://ror.org/040qrra89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636","https://openalex.org/I4210144720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Merry L. Lindsey","raw_affiliation_strings":["San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America; Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, Mississippi, United States of America; Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, United States of America","San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, Mississippi, United States of America","Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, United States of America"],"affiliations":[{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America; Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, Mississippi, United States of America; Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, United States of America","institution_ids":[]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Mississippi Center for Heart Research, University of Mississippi Medical Center, Jackson, Mississippi, United States of America","institution_ids":["https://openalex.org/I29606459","https://openalex.org/I2802864460"]},{"raw_affiliation_string":"Research Service, G.V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, Mississippi, United States of America","institution_ids":["https://openalex.org/I4210144720"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110694181","display_name":"Yu-Fang Jin","orcid":null},"institutions":[{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yu-Fang Jin","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America; San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America; San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":[]},{"raw_affiliation_string":"San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Texas at San Antonio, San Antonio, Texas, United States of America","institution_ids":["https://openalex.org/I45438204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5110694181"],"corresponding_institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9982,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74426043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"10","issue":"3","first_page":"e1003472","last_page":"e1003472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"Myocardial infarction","score":0.6499494910240173},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5355230569839478},{"id":"https://openalex.org/keywords/uniprot","display_name":"UniProt","score":0.5200304985046387},{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.47319433093070984},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.4489181339740753},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.44472092390060425},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3719289302825928},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3330565094947815},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.320592999458313},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2461133897304535},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.12905049324035645},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.10668408870697021}],"concepts":[{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6499494910240173},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5355230569839478},{"id":"https://openalex.org/C202264299","wikidata":"https://www.wikidata.org/wiki/Q905695","display_name":"UniProt","level":3,"score":0.5200304985046387},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.47319433093070984},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4489181339740753},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.44472092390060425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3719289302825928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3330565094947815},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.320592999458313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2461133897304535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12905049324035645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10668408870697021},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008490","descriptor_name":"Medical Informatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009203","descriptor_name":"Myocardial Infarction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003472","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003472","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003472&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24651374","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24651374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.688.1405","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.688.1405","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961365/pdf/pcbi.1003472.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1860ed925c614e3e8c776aca563f55b1","is_oa":true,"landing_page_url":"https://doaj.org/article/1860ed925c614e3e8c776aca563f55b1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 3, p e1003472 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2941802","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3961365","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/968420","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Integrative_Computational_and_Experimental_Approaches_to_Establish_a_Post_Myocardial_Infarction_Knowledge_Map_/968420","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003472","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003472","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003472&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1229473973","display_name":null,"funder_award_id":"HL075360","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1262960305","display_name":null,"funder_award_id":"HHSN 268201000036C (N01-HV-00244)","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1336385654","display_name":null,"funder_award_id":"N01-HV-00244","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G199696075","display_name":null,"funder_award_id":"HL051971","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2501379408","display_name":null,"funder_award_id":"HL075360","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3034189076","display_name":null,"funder_award_id":"BX000505","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3298056745","display_name":null,"funder_award_id":"R01HL","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3317640553","display_name":null,"funder_award_id":"51971","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3530239307","display_name":null,"funder_award_id":"NHLBI","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4086130786","display_name":null,"funder_award_id":"5I01BX000505","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4386296807","display_name":null,"funder_award_id":"I01BX000505","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4507702226","display_name":null,"funder_award_id":"268201000036C (N01-HV-00244)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5286880059","display_name":null,"funder_award_id":"HHSN 268201000036C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G581947752","display_name":null,"funder_award_id":"51971","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6178253440","display_name":null,"funder_award_id":"1SC2 HL101430","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6408202313","display_name":null,"funder_award_id":"5I01BX000505","funder_id":"https://openalex.org/F4320309037","funder_display_name":"Office of Research and Development"},{"id":"https://openalex.org/G7480745220","display_name":null,"funder_award_id":"268201000036C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G752354275","display_name":null,"funder_award_id":"N01-HV-00244","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7695129055","display_name":null,"funder_award_id":"HL051971","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7841121199","display_name":null,"funder_award_id":"268201000036C","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7862281814","display_name":null,"funder_award_id":"HL051971","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320309883","display_name":"Foundation for Cardiovascular Research","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1983587495.pdf","grobid_xml":"https://content.openalex.org/works/W1983587495.grobid-xml"},"referenced_works_count":172,"referenced_works":["https://openalex.org/W11304534","https://openalex.org/W27716746","https://openalex.org/W200771712","https://openalex.org/W229097380","https://openalex.org/W950821216","https://openalex.org/W1485388354","https://openalex.org/W1834954709","https://openalex.org/W1873594494","https://openalex.org/W1901628168","https://openalex.org/W1943882442","https://openalex.org/W1956694423","https://openalex.org/W1964263044","https://openalex.org/W1965907761","https://openalex.org/W1966619356","https://openalex.org/W1967416148","https://openalex.org/W1968100401","https://openalex.org/W1968356216","https://openalex.org/W1974718993","https://openalex.org/W1977111128","https://openalex.org/W1977432718","https://openalex.org/W1982612556","https://openalex.org/W1983002549","https://openalex.org/W1987546980","https://openalex.org/W1989769844","https://openalex.org/W1990147753","https://openalex.org/W1992024672","https://openalex.org/W1992304830","https://openalex.org/W1994225520","https://openalex.org/W1995213405","https://openalex.org/W1996190606","https://openalex.org/W2000042664","https://openalex.org/W2001895872","https://openalex.org/W2002771205","https://openalex.org/W2003870338","https://openalex.org/W2008207929","https://openalex.org/W2009143323","https://openalex.org/W2009780680","https://openalex.org/W2015840376","https://openalex.org/W2015949632","https://openalex.org/W2018753710","https://openalex.org/W2019277066","https://openalex.org/W2019831264","https://openalex.org/W2021163282","https://openalex.org/W2021688285","https://openalex.org/W2022206202","https://openalex.org/W2024708909","https://openalex.org/W2027341612","https://openalex.org/W2027952464","https://openalex.org/W2029146061","https://openalex.org/W2031638186","https://openalex.org/W2033549658","https://openalex.org/W2035729423","https://openalex.org/W2038862814","https://openalex.org/W2040177576","https://openalex.org/W2040990410","https://openalex.org/W2041963174","https://openalex.org/W2047035960","https://openalex.org/W2048091528","https://openalex.org/W2050856345","https://openalex.org/W2053060883","https://openalex.org/W2053154970","https://openalex.org/W2054030668","https://openalex.org/W2054153086","https://openalex.org/W2054990405","https://openalex.org/W2056944867","https://openalex.org/W2057626690","https://openalex.org/W2057943460","https://openalex.org/W2061252559","https://openalex.org/W2061901927","https://openalex.org/W2061963189","https://openalex.org/W2064898260","https://openalex.org/W2065784560","https://openalex.org/W2066402685","https://openalex.org/W2067103740","https://openalex.org/W2068498734","https://openalex.org/W2069769149","https://openalex.org/W2069786094","https://openalex.org/W2072444809","https://openalex.org/W2075282559","https://openalex.org/W2076735582","https://openalex.org/W2077760260","https://openalex.org/W2079950215","https://openalex.org/W2082973968","https://openalex.org/W2084045815","https://openalex.org/W2084671075","https://openalex.org/W2086140631","https://openalex.org/W2086736448","https://openalex.org/W2088253237","https://openalex.org/W2090351364","https://openalex.org/W2094286678","https://openalex.org/W2096454162","https://openalex.org/W2096653406","https://openalex.org/W2097675424","https://openalex.org/W2099647647","https://openalex.org/W2101490763","https://openalex.org/W2103540952","https://openalex.org/W2104905716","https://openalex.org/W2105074761","https://openalex.org/W2105504284","https://openalex.org/W2106528482","https://openalex.org/W2106557745","https://openalex.org/W2106605816","https://openalex.org/W2107359871","https://openalex.org/W2107432046","https://openalex.org/W2108323385","https://openalex.org/W2109894063","https://openalex.org/W2115242847","https://openalex.org/W2115762367","https://openalex.org/W2115821400","https://openalex.org/W2116398954","https://openalex.org/W2117439758","https://openalex.org/W2117877435","https://openalex.org/W2119209586","https://openalex.org/W2120236378","https://openalex.org/W2120311757","https://openalex.org/W2121481371","https://openalex.org/W2124693576","https://openalex.org/W2124894661","https://openalex.org/W2128049108","https://openalex.org/W2129425642","https://openalex.org/W2129761910","https://openalex.org/W2131541226","https://openalex.org/W2132602690","https://openalex.org/W2133465414","https://openalex.org/W2133523105","https://openalex.org/W2133542546","https://openalex.org/W2133607877","https://openalex.org/W2134237888","https://openalex.org/W2134474051","https://openalex.org/W2136479434","https://openalex.org/W2137518425","https://openalex.org/W2138855865","https://openalex.org/W2142285130","https://openalex.org/W2142803556","https://openalex.org/W2144528399","https://openalex.org/W2144799747","https://openalex.org/W2146250664","https://openalex.org/W2146540624","https://openalex.org/W2148090504","https://openalex.org/W2149008701","https://openalex.org/W2149831851","https://openalex.org/W2150107812","https://openalex.org/W2150420891","https://openalex.org/W2151566330","https://openalex.org/W2154454189","https://openalex.org/W2158217645","https://openalex.org/W2159303573","https://openalex.org/W2159328319","https://openalex.org/W2162562820","https://openalex.org/W2166893514","https://openalex.org/W2167577789","https://openalex.org/W2169017722","https://openalex.org/W2169076729","https://openalex.org/W2171403830","https://openalex.org/W2223937191","https://openalex.org/W2311246384","https://openalex.org/W2336258650","https://openalex.org/W2396297048","https://openalex.org/W2404553872","https://openalex.org/W2418157716","https://openalex.org/W2425921534","https://openalex.org/W2799004609","https://openalex.org/W3103362336","https://openalex.org/W3142570770","https://openalex.org/W3143219376","https://openalex.org/W3144199829","https://openalex.org/W4210949340","https://openalex.org/W4213214460","https://openalex.org/W4233334497","https://openalex.org/W4243574176","https://openalex.org/W4399531681","https://openalex.org/W6793127252"],"related_works":["https://openalex.org/W24553703","https://openalex.org/W4211000692","https://openalex.org/W4212920271","https://openalex.org/W2612240612","https://openalex.org/W4324018414","https://openalex.org/W4211208250","https://openalex.org/W4211054902","https://openalex.org/W2472351724","https://openalex.org/W3145366215","https://openalex.org/W2170381940"],"abstract_inverted_index":{"Vast":[0],"research":[1,32],"efforts":[2],"have":[3],"been":[4],"devoted":[5],"to":[6,16,37,155,185,201,213],"providing":[7,189],"clinical":[8],"diagnostic":[9],"markers":[10],"of":[11,30,82,100,111,130,143,174,197],"myocardial":[12],"infarction":[13],"(MI),":[14],"leading":[15],"over":[17],"one":[18],"million":[19],"abstracts":[20],"associated":[21],"with":[22,136,166],"\"MI\"":[23],"and":[24,39,47,61,74,89,97,119,146,149,203,210],"\"Cardiovascular":[25],"Diseases\"":[26],"in":[27,114,134,169],"PubMed.":[28],"Accumulation":[29],"the":[31,51,59,101,105,131,144,175,180,186,205],"results":[33,168],"imposed":[34],"a":[35,152,190],"challenge":[36],"integrate":[38],"interpret":[40],"these":[41],"results.":[42],"To":[43],"address":[44],"this":[45],"problem":[46],"better":[48],"understand":[49],"how":[50],"left":[52],"ventricle":[53],"(LV)":[54],"remodels":[55],"post-MI":[56,106,187],"at":[57],"both":[58],"molecular":[60,198,206],"cellular":[62,208],"levels,":[63],"we":[64,178],"propose":[65],"here":[66],"an":[67,79,91],"integrative":[68],"framework":[69],"that":[70,104],"couples":[71],"computational":[72],"methods":[73],"experimental":[75],"data.":[76],"We":[77],"selected":[78],"initial":[80],"set":[81,154],"MI-related":[83],"proteins":[84,112,133],"from":[85],"published":[86,167],"human":[87],"studies":[88],"constructed":[90],"MI-specific":[92],"protein-protein-interaction":[93],"network":[94],"(MIPIN).":[95],"Structural":[96],"functional":[98],"analysis":[99],"MIPIN":[102,132,158],"showed":[103],"LV":[107,215],"exhibited":[108],"increased":[109],"representation":[110],"involved":[113],"transcriptional":[115],"activity,":[116],"inflammatory":[117],"response,":[118,188],"extracellular":[120],"matrix":[121],"(ECM)":[122],"remodeling.":[123,216],"Known":[124],"plasma":[125],"or":[126],"serum":[127],"expression":[128],"changes":[129,160],"patients":[135],"MI":[137,202],"were":[138,164],"acquired":[139],"by":[140],"data":[141],"mining":[142],"PubMed":[145],"UniProt":[147],"knowledgebase,":[148],"served":[150],"as":[151],"training":[153],"predict":[156],"unlabeled":[157],"protein":[159],"post-MI.":[161],"The":[162],"predictions":[163],"validated":[165],"PubMed,":[170],"suggesting":[171],"prognosticative":[172],"capability":[173],"MIPIN.":[176],"Further,":[177],"established":[179],"first":[181],"knowledge":[182],"map":[183],"related":[184],"major":[191],"step":[192],"towards":[193],"enhancing":[194],"our":[195],"understanding":[196],"interactions":[199],"specific":[200],"linking":[204],"interaction,":[207],"responses,":[209],"biological":[211],"processes":[212],"quantify":[214]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
