{"id":"https://openalex.org/W2076508626","doi":"https://doi.org/10.1371/journal.pcbi.1003451","title":"Correlation between Oncogenic Mutations and Parameter Sensitivity of the Apoptosis Pathway Model","display_name":"Correlation between Oncogenic Mutations and Parameter Sensitivity of the Apoptosis Pathway Model","publication_year":2014,"publication_date":"2014-01-23","ids":{"openalex":"https://openalex.org/W2076508626","doi":"https://doi.org/10.1371/journal.pcbi.1003451","mag":"2076508626","pmid":"https://pubmed.ncbi.nlm.nih.gov/24465201"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003451","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003451","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003451&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003451&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101998869","display_name":"Jia Chen","orcid":"https://orcid.org/0000-0002-9256-7121"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Chen","raw_affiliation_strings":["Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210160507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007669972","display_name":"Haicen Yue","orcid":"https://orcid.org/0000-0002-6771-9074"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haicen Yue","raw_affiliation_strings":["Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China ; School of Physics and the State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, Peking University, Beijing, China","Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China","School of Physics and the State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China ; School of Physics and the State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210160507"]},{"raw_affiliation_string":"School of Physics and the State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056459691","display_name":"Qi Ouyang","orcid":"https://orcid.org/0000-0003-1585-7368"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210160507","display_name":"Center for Life Sciences","ror":"https://ror.org/05kje8j93","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570","https://openalex.org/I4210160507","https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Ouyang","raw_affiliation_strings":["Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China ; School of Physics and the State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, Peking University, Beijing, China","Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China","School of Physics and the State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, Peking University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China ; School of Physics and the State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences at Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210160507"]},{"raw_affiliation_string":"School of Physics and the State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, Peking University, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5056459691"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210160507"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":1.4416,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81119721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"1","first_page":"e1003451","last_page":"e1003451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.700628399848938},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6989695429801941},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5854164361953735},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.5651251077651978},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.564263105392456},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.551414966583252},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4876497983932495},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.48281607031822205},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.474059522151947},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.4169424772262573},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2712317109107971}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.700628399848938},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6989695429801941},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5854164361953735},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.5651251077651978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.564263105392456},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.551414966583252},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4876497983932495},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.48281607031822205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.474059522151947},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.4169424772262573},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2712317109107971}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003451","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003451","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003451&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24465201","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24465201","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2885759","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3900373","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2dcd05acd58f400bb858b894caa09e8f","is_oa":true,"landing_page_url":"https://doaj.org/article/2dcd05acd58f400bb858b894caa09e8f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 1, p e1003451 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/910707","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Correlation_between_Oncogenic_Mutations_and_Parameter_Sensitivity_of_the_Apoptosis_Pathway_Model_/910707","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003451","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003451","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003451&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4699999988079071}],"awards":[{"id":"https://openalex.org/G1143113198","display_name":null,"funder_award_id":"11074009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2458693334","display_name":null,"funder_award_id":"2009CB918500","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5231695628","display_name":null,"funder_award_id":"10721463","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2076508626.pdf","grobid_xml":"https://content.openalex.org/works/W2076508626.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1494567425","https://openalex.org/W1616121322","https://openalex.org/W1835750525","https://openalex.org/W1967334296","https://openalex.org/W1979634817","https://openalex.org/W1979985168","https://openalex.org/W1985911638","https://openalex.org/W1990039929","https://openalex.org/W1992989336","https://openalex.org/W1993371359","https://openalex.org/W1998308376","https://openalex.org/W2002934131","https://openalex.org/W2009970436","https://openalex.org/W2010114834","https://openalex.org/W2011912935","https://openalex.org/W2012322426","https://openalex.org/W2023568503","https://openalex.org/W2023800438","https://openalex.org/W2025183726","https://openalex.org/W2038735546","https://openalex.org/W2040244459","https://openalex.org/W2040827479","https://openalex.org/W2044079387","https://openalex.org/W2054035764","https://openalex.org/W2064330613","https://openalex.org/W2069206405","https://openalex.org/W2075499588","https://openalex.org/W2076650991","https://openalex.org/W2081184407","https://openalex.org/W2085418817","https://openalex.org/W2087877138","https://openalex.org/W2091818021","https://openalex.org/W2094629286","https://openalex.org/W2096606586","https://openalex.org/W2099113454","https://openalex.org/W2101897262","https://openalex.org/W2118691390","https://openalex.org/W2126832141","https://openalex.org/W2126860377","https://openalex.org/W2130698963","https://openalex.org/W2131833681","https://openalex.org/W2138155367","https://openalex.org/W2139349129","https://openalex.org/W2147318282","https://openalex.org/W2152750766","https://openalex.org/W2160345685","https://openalex.org/W2172102031","https://openalex.org/W2313997600","https://openalex.org/W2361838659","https://openalex.org/W6629658836","https://openalex.org/W6679673418"],"related_works":["https://openalex.org/W2320892144","https://openalex.org/W2163262592","https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W249159571","https://openalex.org/W2791736663","https://openalex.org/W2806770614","https://openalex.org/W4385510321","https://openalex.org/W2129949791"],"abstract_inverted_index":{"One":[0],"of":[1,41,49,70,113,147,155,158,166,175],"the":[2,12,39,47,71,81,94,99,105,114,119,133,145,148,156,173],"major":[3],"breakthroughs":[4],"in":[5,8,15,22,59,189],"oncogenesis":[6],"research":[7],"recent":[9],"years":[10],"is":[11,151],"discovery":[13,30],"that,":[14],"most":[16,86],"patients,":[17],"oncogenic":[18,33,56,139],"mutations":[19,57],"are":[20,35,64],"concentrated":[21],"a":[23,152,159],"few":[24],"core":[25],"biological":[26,61,160,180],"functional":[27,50,62],"pathways.":[28,51],"This":[29,141],"indicates":[31],"that":[32,55,97,128,130,144],"mechanisms":[34],"highly":[36],"related":[37,66],"to":[38,67,137,179,184],"dynamics":[40,108],"biologic":[42],"regulatory":[43,95],"networks,":[44],"which":[45],"govern":[46],"behaviour":[48],"Here,":[52],"we":[53,78,126],"propose":[54],"found":[58,127],"different":[60],"pathways":[63],"closely":[65],"parameter":[68],"sensitivity":[69,111],"corresponding":[72],"networks.":[73],"To":[74],"test":[75],"this":[76],"hypothesis,":[77],"focus":[79],"on":[80],"DNA":[82],"damage-induced":[83],"apoptotic":[84],"pathway--the":[85],"important":[87],"safeguard":[88],"against":[89],"oncogenesis.":[90],"We":[91],"first":[92],"built":[93],"network":[96,106,115,161],"governs":[98],"apoptosis":[100],"pathway,":[101],"and":[102,117],"then":[103],"translated":[104],"into":[107],"equations.":[109],"Using":[110],"analysis":[112,178],"parameters":[116,129],"comparing":[118],"results":[120],"with":[121],"cancer":[122],"gene":[123,163],"mutation":[124],"spectra,":[125],"significantly":[131],"affect":[132],"bifurcation":[134,149],"point":[135,150],"correspond":[136],"high-frequency":[138],"mutations.":[140],"result":[142],"shows":[143],"position":[146],"better":[153],"measure":[154],"functionality":[157],"than":[162],"expression":[164],"levels":[165],"certain":[167],"key":[168],"proteins.":[169],"It":[170],"further":[171],"demonstrates":[172],"suitability":[174],"applying":[176],"systems-level":[177],"networks":[181],"as":[182],"opposed":[183],"studying":[185],"genes":[186],"or":[187],"proteins":[188],"isolation.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}
