{"id":"https://openalex.org/W2024345822","doi":"https://doi.org/10.1371/journal.pcbi.1003448","title":"Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms","display_name":"Mathematical Model of a Telomerase Transcriptional Regulatory Network Developed by Cell-Based Screening: Analysis of Inhibitor Effects and Telomerase Expression Mechanisms","publication_year":2014,"publication_date":"2014-02-13","ids":{"openalex":"https://openalex.org/W2024345822","doi":"https://doi.org/10.1371/journal.pcbi.1003448","mag":"2024345822","pmid":"https://pubmed.ncbi.nlm.nih.gov/24550717"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003448","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003448","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003448&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003448&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028781806","display_name":"Alan Bilsland","orcid":"https://orcid.org/0000-0003-0957-3908"},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alan E. Bilsland","raw_affiliation_strings":["Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001002081","display_name":"Katrina H. Stevenson","orcid":"https://orcid.org/0000-0002-7612-1453"},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Katrina Stevenson","raw_affiliation_strings":["Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345711","display_name":"Yu Liu","orcid":"https://orcid.org/0000-0002-1282-4897"},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yu Liu","raw_affiliation_strings":["Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108420511","display_name":"Stacey F. Hoare","orcid":null},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stacey Hoare","raw_affiliation_strings":["Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088444170","display_name":"Claire J. Cairney","orcid":"https://orcid.org/0000-0001-6531-245X"},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]},{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claire J. Cairney","raw_affiliation_strings":["Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016507822","display_name":"Jon Roffey","orcid":null},"institutions":[{"id":"https://openalex.org/I2801075885","display_name":"Wolfson Foundation","ror":"https://ror.org/0333xzh65","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2801075885"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jon Roffey","raw_affiliation_strings":["Cancer Research Technology Ltd., Wolfson Institute for Biomedical Research, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Cancer Research Technology Ltd., Wolfson Institute for Biomedical Research, London, United Kingdom","institution_ids":["https://openalex.org/I2801075885"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078069273","display_name":"W. Nicol Keith","orcid":"https://orcid.org/0000-0001-7862-3580"},"institutions":[{"id":"https://openalex.org/I4210143228","display_name":"Cancer Research UK Scotland Institute","ror":"https://ror.org/03pv69j64","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801316944","https://openalex.org/I4210143228"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"W. Nicol Keith","raw_affiliation_strings":["Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Cancer Sciences, University of Glasgow, Cancer Research UK Beatson Laboratories, Bearsden, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5078069273"],"corresponding_institution_ids":["https://openalex.org/I4210143228","https://openalex.org/I7882870"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.3917,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.80456159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"2","first_page":"e1003448","last_page":"e1003448"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":0.972000002861023,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase-reverse-transcriptase","display_name":"Telomerase reverse transcriptase","score":0.739435076713562},{"id":"https://openalex.org/keywords/psychological-repression","display_name":"Psychological repression","score":0.6787161827087402},{"id":"https://openalex.org/keywords/telomerase","display_name":"Telomerase","score":0.6339864730834961},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5562515258789062},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5455947518348694},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.4585525691509247},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"Transcriptional regulation","score":0.45551151037216187},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.41025710105895996},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4020983874797821},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3605240285396576},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.32517683506011963},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3130679130554199},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1920674443244934}],"concepts":[{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.739435076713562},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.6787161827087402},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.6339864730834961},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5562515258789062},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5455947518348694},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4585525691509247},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.45551151037216187},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.41025710105895996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4020983874797821},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3605240285396576},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32517683506011963},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3130679130554199},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1920674443244934},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050787","descriptor_name":"Proto-Oncogene Protein c-ets-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050787","descriptor_name":"Proto-Oncogene Protein c-ets-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050787","descriptor_name":"Proto-Oncogene Protein c-ets-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003448","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003448","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003448&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24550717","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24550717","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:eprints.gla.ac.uk:94092","is_oa":false,"landing_page_url":"https://eprints.gla.ac.uk/view/author/1799.html>","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":false,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:doaj.org/article:12af634056c54dc780e056ce775e8e7b","is_oa":true,"landing_page_url":"https://doaj.org/article/12af634056c54dc780e056ce775e8e7b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 2, p e1003448 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2909825","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3923661","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3923661","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3923661","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003448","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003448","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003448&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G6537522628","display_name":null,"funder_award_id":"C301/A12962","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G8700781023","display_name":null,"funder_award_id":"C301/A14762","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"}],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2024345822.pdf","grobid_xml":"https://content.openalex.org/works/W2024345822.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W110846516","https://openalex.org/W1270834676","https://openalex.org/W1523522456","https://openalex.org/W1526999767","https://openalex.org/W1547608553","https://openalex.org/W1599424389","https://openalex.org/W1844218774","https://openalex.org/W1860239833","https://openalex.org/W1952959444","https://openalex.org/W1967626444","https://openalex.org/W1967899825","https://openalex.org/W1972709515","https://openalex.org/W1972778624","https://openalex.org/W1973603971","https://openalex.org/W1978426642","https://openalex.org/W1980223730","https://openalex.org/W1980986084","https://openalex.org/W1985770207","https://openalex.org/W1987976359","https://openalex.org/W1988099693","https://openalex.org/W1989375763","https://openalex.org/W1991440608","https://openalex.org/W1992247552","https://openalex.org/W1993524190","https://openalex.org/W1993653578","https://openalex.org/W2000817203","https://openalex.org/W2001548272","https://openalex.org/W2001757458","https://openalex.org/W2002340616","https://openalex.org/W2003800304","https://openalex.org/W2009132290","https://openalex.org/W2010972289","https://openalex.org/W2014141863","https://openalex.org/W2018000037","https://openalex.org/W2019642531","https://openalex.org/W2020329784","https://openalex.org/W2025487619","https://openalex.org/W2027022789","https://openalex.org/W2030209169","https://openalex.org/W2031049138","https://openalex.org/W2031162955","https://openalex.org/W2033637309","https://openalex.org/W2033918201","https://openalex.org/W2035385264","https://openalex.org/W2036877110","https://openalex.org/W2037324207","https://openalex.org/W2038296520","https://openalex.org/W2039375942","https://openalex.org/W2039709545","https://openalex.org/W2046881634","https://openalex.org/W2047697085","https://openalex.org/W2052853256","https://openalex.org/W2054383392","https://openalex.org/W2059075951","https://openalex.org/W2066737222","https://openalex.org/W2066961854","https://openalex.org/W2068900887","https://openalex.org/W2071141381","https://openalex.org/W2072424337","https://openalex.org/W2075941967","https://openalex.org/W2076130704","https://openalex.org/W2079727164","https://openalex.org/W2084647824","https://openalex.org/W2085116222","https://openalex.org/W2086911602","https://openalex.org/W2088853482","https://openalex.org/W2092324565","https://openalex.org/W2093669704","https://openalex.org/W2094872845","https://openalex.org/W2104329724","https://openalex.org/W2104337990","https://openalex.org/W2104500293","https://openalex.org/W2107031745","https://openalex.org/W2109110326","https://openalex.org/W2109278577","https://openalex.org/W2111123076","https://openalex.org/W2113544380","https://openalex.org/W2113655514","https://openalex.org/W2114445658","https://openalex.org/W2114840351","https://openalex.org/W2117692326","https://openalex.org/W2123106337","https://openalex.org/W2123421061","https://openalex.org/W2130410032","https://openalex.org/W2130522879","https://openalex.org/W2131117209","https://openalex.org/W2137961581","https://openalex.org/W2139151268","https://openalex.org/W2141817193","https://openalex.org/W2142839601","https://openalex.org/W2145833524","https://openalex.org/W2149421377","https://openalex.org/W2151041413","https://openalex.org/W2151724377","https://openalex.org/W2154601808","https://openalex.org/W2157445042","https://openalex.org/W2158107632","https://openalex.org/W2159130719","https://openalex.org/W2161234257","https://openalex.org/W2165857364","https://openalex.org/W2167031279","https://openalex.org/W2171322586","https://openalex.org/W2171590707","https://openalex.org/W2171968985","https://openalex.org/W2314018338","https://openalex.org/W2419215310","https://openalex.org/W3101174921","https://openalex.org/W4239293914","https://openalex.org/W6676698813"],"related_works":["https://openalex.org/W2184345139","https://openalex.org/W3149534788","https://openalex.org/W2044473828","https://openalex.org/W1549402393","https://openalex.org/W2114551234","https://openalex.org/W2141515497","https://openalex.org/W2121324028","https://openalex.org/W2102536676","https://openalex.org/W2735616874","https://openalex.org/W2148335564"],"abstract_inverted_index":{"Cancer":[0],"cells":[1,262],"depend":[2],"on":[3,26,173],"transcription":[4,11,38,93,114],"of":[5,20,36,63,112,129,143,154,163,177,207,221,232,279],"telomerase":[6,27],"reverse":[7],"transcriptase":[8],"(TERT).":[9],"Many":[10],"factors":[12,94],"affect":[13],"TERT,":[14],"though":[15,33],"regulation":[16,28,281],"occurs":[17,235],"in":[18,48,72,99,158,190,193,202,213,236,260],"context":[19],"a":[21,40,109,118,183,290],"broader":[22],"network.":[23],"Network":[24],"effects":[25,128,162],"have":[29],"not":[30,52],"been":[31],"investigated,":[32],"deeper":[34],"understanding":[35],"TERT":[37,91,113,135,156,170,191,204,211,237,255,280,296],"requires":[39],"systems":[41,65,73],"view.":[42],"However,":[43],"control":[44],"over":[45],"individual":[46],"interactions":[47,88],"complex":[49,64],"networks":[50],"is":[51,188],"easily":[53,226],"achievable.":[54],"Mathematical":[55],"modelling":[56],"provides":[57],"an":[58],"attractive":[59],"approach":[60],"for":[61,297],"analysis":[62,153],"and":[66,95,115,141,175,263],"some":[67],"models":[68],"may":[69,294],"prove":[70],"useful":[71],"pharmacology":[74],"approaches":[75],"to":[76,86,107,116],"drug":[77],"discovery.":[78],"In":[79],"this":[80],"report,":[81],"we":[82],"used":[83,106],"transfection":[84],"screening":[85],"test":[87],"among":[89],"14":[90],"regulatory":[92],"their":[96],"respective":[97],"promoters":[98],"ovarian":[100],"cancer":[101],"cells.":[102,160],"The":[103,272],"results":[104,149],"were":[105,125],"generate":[108],"network":[110],"model":[111,121,273],"implement":[117],"dynamic":[119],"Boolean":[120],"whose":[122],"steady":[123],"states":[124],"analysed.":[126],"Modelled":[127,161],"signal":[130],"transduction":[131],"inhibitors":[132],"successfully":[133,275],"predicted":[134,168,276],"repression":[136,144,171],"by":[137,145,151,219],"Src-family":[138],"inhibitor":[139,147,165],"SU6656":[140],"lack":[142],"ERK":[146],"FR180204,":[148],"confirmed":[150],"RT-QPCR":[152],"endogenous":[155,203,254],"expression":[157,176,187,224,256],"treated":[159],"GSK3":[164],"6-bromoindirubin-3'-oxime":[166],"(BIO)":[167],"unstable":[169],"dependent":[172],"noise":[174],"JUN,":[178,243],"corresponding":[179],"with":[180,197],"observations":[181],"from":[182],"previous":[184],"study.":[185],"MYC":[186,208,258],"critical":[189],"activation":[192],"the":[194],"model,":[195,215],"consistent":[196],"its":[198],"well":[199],"known":[200],"function":[201],"regulation.":[205],"Loss":[206],"caused":[209],"complete":[210],"suppression":[212,251],"our":[214],"substantially":[216],"rescued":[217,227],"only":[218],"co-suppression":[220],"AR.":[222],"Interestingly":[223],"was":[225],"under":[228],"modelled":[229],"Ets-factor":[230],"gain":[231],"function,":[233],"as":[234],"promoter":[238],"mutation.":[239],"RNAi":[240],"targeting":[241],"AR,":[242],"MXD1,":[244],"SP3,":[245],"or":[246,265],"TP53,":[247],"showed":[248],"that":[249,289],"AR":[250],"does":[252],"rescue":[253],"following":[257],"knockdown":[259],"these":[261],"SP3":[264],"TP53":[266],"siRNA":[267],"also":[268],"cause":[269],"partial":[270],"recovery.":[271],"therefore":[274],"several":[277],"aspects":[278],"including":[282],"previously":[283],"unknown":[284],"mechanisms.":[285],"An":[286],"extrapolation":[287],"suggests":[288],"dominant":[291],"stimulatory":[292],"system":[293],"programme":[295],"transcriptional":[298],"stability.":[299]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}