{"id":"https://openalex.org/W2056413975","doi":"https://doi.org/10.1371/journal.pcbi.1003445","title":"Segregation and Crosstalk of D1 Receptor-Mediated Activation of ERK in Striatal Medium Spiny Neurons upon Acute Administration of Psychostimulants","display_name":"Segregation and Crosstalk of D1 Receptor-Mediated Activation of ERK in Striatal Medium Spiny Neurons upon Acute Administration of Psychostimulants","publication_year":2014,"publication_date":"2014-01-30","ids":{"openalex":"https://openalex.org/W2056413975","doi":"https://doi.org/10.1371/journal.pcbi.1003445","mag":"2056413975","pmid":"https://pubmed.ncbi.nlm.nih.gov/24499932"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003445","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003445","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003445&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003445&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002500835","display_name":"Omar Gutierrez\u2010Arenas","orcid":null},"institutions":[{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Omar Gutierrez-Arenas","raw_affiliation_strings":["School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020483725","display_name":"Olivia Eriksson","orcid":"https://orcid.org/0000-0003-0740-4318"},"institutions":[{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Olivia Eriksson","raw_affiliation_strings":["Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084813027","display_name":"Jeanette Hellgren Kotaleski","orcid":"https://orcid.org/0000-0002-0550-0739"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]},{"id":"https://openalex.org/I161593684","display_name":"Stockholm University","ror":"https://ror.org/05f0yaq80","country_code":"SE","type":"education","lineage":["https://openalex.org/I161593684"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jeanette Hellgren Kotaleski","raw_affiliation_strings":["School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden ; Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden ; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden","School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden","Department of Neuroscience, Karolinska Institute, Stockholm, Sweden","Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden ; Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden ; Department of Neuroscience, Karolinska Institute, Stockholm, Sweden","institution_ids":[]},{"raw_affiliation_string":"School of Computer Science and Communication, KTH Royal Institute of Technology, Stockholm, Sweden","institution_ids":["https://openalex.org/I86987016"]},{"raw_affiliation_string":"Department of Neuroscience, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden","institution_ids":["https://openalex.org/I161593684"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002500835","https://openalex.org/A5020483725","https://openalex.org/A5084813027"],"corresponding_institution_ids":["https://openalex.org/I161593684","https://openalex.org/I28166907","https://openalex.org/I86987016"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.379,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.77426626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"e1003445","last_page":"e1003445"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medium-spiny-neuron","display_name":"Medium spiny neuron","score":0.834945559501648},{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.754193127155304},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.6849179863929749},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6675500869750977},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.6247926950454712},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5241817831993103},{"id":"https://openalex.org/keywords/glutamate-receptor","display_name":"Glutamate receptor","score":0.502842128276825},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.4447345733642578},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4384484589099884},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.419354647397995},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.40903013944625854},{"id":"https://openalex.org/keywords/striatum","display_name":"Striatum","score":0.3390670120716095},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.266401469707489},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14465919137001038},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.07769134640693665}],"concepts":[{"id":"https://openalex.org/C85714458","wikidata":"https://www.wikidata.org/wiki/Q17152690","display_name":"Medium spiny neuron","level":4,"score":0.834945559501648},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.754193127155304},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6849179863929749},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6675500869750977},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6247926950454712},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5241817831993103},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.502842128276825},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.4447345733642578},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4384484589099884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.419354647397995},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.40903013944625854},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.3390670120716095},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.266401469707489},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14465919137001038},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07769134640693665},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000697","descriptor_name":"Central Nervous System Stimulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016739","descriptor_name":"Behavior, Addictive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017447","descriptor_name":"Receptors, Dopamine D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017447","descriptor_name":"Receptors, Dopamine D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017447","descriptor_name":"Receptors, Dopamine D1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003445","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003445","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003445&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24499932","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24499932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.806.6434","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.806.6434","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3d/85/pcbi.1003445.PMC3907292.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a1acc9afde134d679e81a4344d9bcdcb","is_oa":true,"landing_page_url":"https://doaj.org/article/a1acc9afde134d679e81a4344d9bcdcb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 1, p e1003445 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2898382","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3907292","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/919617","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Segregation_and_Crosstalk_of_D1_Receptor_Mediated_Activation_of_ERK_in_Striatal_Medium_Spiny_Neurons_upon_Acute_Administration_of_Psychostimulants/919617","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003445","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003445","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003445&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"awards":[{"id":"https://openalex.org/G1783795302","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G5921281487","display_name":null,"funder_award_id":"number","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320317161","display_name":"Swedish e-Science Research Centre","ror":"https://ror.org/01e59yk92"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056413975.pdf","grobid_xml":"https://content.openalex.org/works/W2056413975.grobid-xml"},"referenced_works_count":129,"referenced_works":["https://openalex.org/W628847457","https://openalex.org/W1519847602","https://openalex.org/W1551845545","https://openalex.org/W1556750912","https://openalex.org/W1596786601","https://openalex.org/W1609834322","https://openalex.org/W1623155147","https://openalex.org/W1656928430","https://openalex.org/W1681161665","https://openalex.org/W1823711977","https://openalex.org/W1896569873","https://openalex.org/W1907647691","https://openalex.org/W1917554980","https://openalex.org/W1941795588","https://openalex.org/W1965030220","https://openalex.org/W1971462812","https://openalex.org/W1971626394","https://openalex.org/W1972107254","https://openalex.org/W1974311066","https://openalex.org/W1974931223","https://openalex.org/W1977486844","https://openalex.org/W1978625035","https://openalex.org/W1979532884","https://openalex.org/W1980418696","https://openalex.org/W1982138808","https://openalex.org/W1982624291","https://openalex.org/W1982976081","https://openalex.org/W1983285634","https://openalex.org/W1983445937","https://openalex.org/W1983504883","https://openalex.org/W1984008642","https://openalex.org/W1984057909","https://openalex.org/W1985308724","https://openalex.org/W1989475543","https://openalex.org/W1991449336","https://openalex.org/W1993798909","https://openalex.org/W1995088614","https://openalex.org/W1995682111","https://openalex.org/W1995692874","https://openalex.org/W1995906542","https://openalex.org/W1998152406","https://openalex.org/W1999135159","https://openalex.org/W1999377902","https://openalex.org/W2002965952","https://openalex.org/W2004024823","https://openalex.org/W2004152813","https://openalex.org/W2007251619","https://openalex.org/W2011736950","https://openalex.org/W2012753124","https://openalex.org/W2013607259","https://openalex.org/W2014408809","https://openalex.org/W2017279410","https://openalex.org/W2017559332","https://openalex.org/W2019435757","https://openalex.org/W2020065445","https://openalex.org/W2020116618","https://openalex.org/W2022286642","https://openalex.org/W2023187275","https://openalex.org/W2023508127","https://openalex.org/W2023680694","https://openalex.org/W2024624930","https://openalex.org/W2030756376","https://openalex.org/W2030852918","https://openalex.org/W2032192786","https://openalex.org/W2042950885","https://openalex.org/W2043820536","https://openalex.org/W2045074917","https://openalex.org/W2046314965","https://openalex.org/W2047604907","https://openalex.org/W2048061342","https://openalex.org/W2049367666","https://openalex.org/W2049529883","https://openalex.org/W2052585711","https://openalex.org/W2053070706","https://openalex.org/W2054528757","https://openalex.org/W2055584145","https://openalex.org/W2059968977","https://openalex.org/W2061817263","https://openalex.org/W2063225331","https://openalex.org/W2064111585","https://openalex.org/W2065138156","https://openalex.org/W2067175577","https://openalex.org/W2069380892","https://openalex.org/W2069579672","https://openalex.org/W2071700722","https://openalex.org/W2073300307","https://openalex.org/W2075742505","https://openalex.org/W2076090607","https://openalex.org/W2079862834","https://openalex.org/W2080666574","https://openalex.org/W2080834373","https://openalex.org/W2081788716","https://openalex.org/W2083875726","https://openalex.org/W2086015992","https://openalex.org/W2086543171","https://openalex.org/W2091061305","https://openalex.org/W2094212507","https://openalex.org/W2096595244","https://openalex.org/W2104036010","https://openalex.org/W2104649539","https://openalex.org/W2104783138","https://openalex.org/W2110048510","https://openalex.org/W2114481572","https://openalex.org/W2114899976","https://openalex.org/W2117136688","https://openalex.org/W2119084501","https://openalex.org/W2120218847","https://openalex.org/W2125236560","https://openalex.org/W2127442322","https://openalex.org/W2131751421","https://openalex.org/W2136259428","https://openalex.org/W2136969641","https://openalex.org/W2137563167","https://openalex.org/W2146439993","https://openalex.org/W2147023594","https://openalex.org/W2149067866","https://openalex.org/W2150626351","https://openalex.org/W2154343843","https://openalex.org/W2155372661","https://openalex.org/W2156927636","https://openalex.org/W2157092518","https://openalex.org/W2158691076","https://openalex.org/W2159891593","https://openalex.org/W2161304688","https://openalex.org/W2161812595","https://openalex.org/W2163334673","https://openalex.org/W2166499263","https://openalex.org/W2170205898","https://openalex.org/W6947478522"],"related_works":["https://openalex.org/W2038754384","https://openalex.org/W2094568064","https://openalex.org/W1974963742","https://openalex.org/W2965899752","https://openalex.org/W2976995946","https://openalex.org/W2023637370","https://openalex.org/W3093917743","https://openalex.org/W3138727255","https://openalex.org/W4247786827","https://openalex.org/W3116707624"],"abstract_inverted_index":{"The":[0,31,69],"convergence":[1],"of":[2,41,51,62,87,97,101,105,164,182,204,222,229,239,245],"corticostriatal":[3],"glutamate":[4],"and":[5,24,124,166,189,249],"dopamine":[6,35],"from":[7,129],"the":[8,11,38,52,63,85,94,103,108,130,134,158,197,202,205,220,227,237,258],"midbrain":[9],"in":[10,33,93,170,187,190,211,280],"striatal":[12,34],"medium":[13],"spiny":[14],"neurons":[15,186],"(MSN)":[16],"triggers":[17],"synaptic":[18],"plasticity":[19],"that":[20,116,125,160,226],"underlies":[21],"reinforcement":[22],"learning":[23],"pathological":[25],"conditions":[26],"such":[27,56,66],"as":[28,57,67],"psychostimulant":[29],"addiction.":[30],"increase":[32],"produced":[36],"by":[37,78,91,231],"acute":[39],"administration":[40],"psychostimulants":[42],"has":[43],"been":[44],"found":[45,225],"to":[46,81,133,195,209,219,251,256,272],"activate":[47],"not":[48,100,218],"only":[49],"effectors":[50,61],"AC5/cAMP/PKA":[53,131,206],"signaling":[54,149,173,207,274],"cascade":[55,65,132,136,208],"GluR1,":[58],"but":[59,83,99],"also":[60],"NMDAR/Ca(2+)/RAS":[64,135],"ERK.":[68,223],"dopamine-triggered":[70],"effects":[71],"on":[72,157,242],"both":[73],"these":[74],"cascades":[75],"are":[76,215,254],"mediated":[77],"D1R":[79,165,212],"coupled":[80],"Golf":[82,98,118,167,214],"while":[84],"phosphorylation":[86,253],"GluR1":[88],"is":[89,113,127,168],"affected":[90],"reductions":[92,210],"available":[95],"amount":[96,181],"D1R,":[102],"activation":[104,119,221],"ERK":[106,234,246],"follows":[107],"opposite":[109],"pattern.":[110],"This":[111,175,262],"segregation":[112,155],"puzzling":[114],"considering":[115],"D1R-induced":[117],"monotonically":[120],"increases":[121],"with":[122,236],"DA":[123],"there":[126],"crosstalk":[128,198],"via":[137],"a":[138,148,161,178,265],"STEP":[139,230,240],"(a":[140],"tyrosine":[141],"phosphatase).":[142],"In":[143],"this":[144,154],"work,":[145],"we":[146],"developed":[147],"model":[150,176,263],"which":[151,201],"accounts":[152],"for":[153,185,268,276],"based":[156,270],"assumption":[159],"common":[162],"pool":[163],"distributed":[169],"two":[171],"D1R/Golf":[172],"compartments.":[174],"integrates":[177],"relatively":[179],"large":[180],"experimental":[183],"data":[184],"vivo":[188],"vitro.":[191],"We":[192,224],"used":[193],"it":[194],"explore":[196],"topologies":[199],"under":[200],"sensitivities":[203],"or":[213,217],"transferred":[216],"sequestration":[228],"its":[232],"substrate":[233],"together":[235],"insensitivity":[238],"activity":[241],"targets":[243],"upstream":[244],"(i.e.":[247],"Fyn":[248],"NR2B)":[250],"PKA":[252],"able":[255],"explain":[257],"experimentally":[259],"observed":[260],"segregation.":[261],"provides":[264],"quantitative":[266],"framework":[267],"simulation":[269],"experiments":[271],"study":[273],"required":[275],"long":[277],"term":[278],"potentiation":[279],"MSNs.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
