{"id":"https://openalex.org/W2153216949","doi":"https://doi.org/10.1371/journal.pcbi.1003358","title":"Systems Modeling of Anti-apoptotic Pathways in Prostate Cancer: Psychological Stress Triggers a Synergism Pattern Switch in Drug Combination Therapy","display_name":"Systems Modeling of Anti-apoptotic Pathways in Prostate Cancer: Psychological Stress Triggers a Synergism Pattern Switch in Drug Combination Therapy","publication_year":2013,"publication_date":"2013-12-05","ids":{"openalex":"https://openalex.org/W2153216949","doi":"https://doi.org/10.1371/journal.pcbi.1003358","mag":"2153216949","pmid":"https://pubmed.ncbi.nlm.nih.gov/24339759"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003358","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003358","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003358&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003358&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047111777","display_name":"Xiaoqiang Sun","orcid":"https://orcid.org/0000-0002-3399-7260"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]},{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Xiaoqiang Sun","raw_affiliation_strings":["Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America ; School of Mathematical Science, Beijing Normal University, Beijing, P. R. China","Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America","School of Mathematical Science, Beijing Normal University, Beijing, P. R. China"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America ; School of Mathematical Science, Beijing Normal University, Beijing, P. R. China","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I47251452"]},{"raw_affiliation_string":"School of Mathematical Science, Beijing Normal University, Beijing, P. R. China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113579924","display_name":"Jiguang Bao","orcid":"https://orcid.org/0000-0001-5545-1560"},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiguang Bao","raw_affiliation_strings":["School of Mathematical Science, Beijing Normal University, Beijing, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Mathematical Science, Beijing Normal University, Beijing, P. R. China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014501666","display_name":"Kyle C. Nelson","orcid":null},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle C. Nelson","raw_affiliation_strings":["Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063975699","display_name":"King C. Li","orcid":"https://orcid.org/0000-0002-6473-2687"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"King Chuen Li","raw_affiliation_strings":["Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001676288","display_name":"George Kulik","orcid":"https://orcid.org/0000-0001-7838-3847"},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"George Kulik","raw_affiliation_strings":["Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106792514","display_name":"Xiaobo Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaobo Zhou","raw_affiliation_strings":["Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America","institution_ids":["https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5001676288","https://openalex.org/A5047111777","https://openalex.org/A5106792514"],"corresponding_institution_ids":["https://openalex.org/I25254941","https://openalex.org/I47251452"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.3003,"has_fulltext":true,"cited_by_count":46,"citation_normalized_percentile":{"value":0.87881084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"9","issue":"12","first_page":"e1003358","last_page":"e1003358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.7923210263252258},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"Combination therapy","score":0.566415548324585},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5385047197341919},{"id":"https://openalex.org/keywords/prostate","display_name":"Prostate","score":0.5309668779373169},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.47051969170570374},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.46741151809692383},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4495139420032501},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4153040647506714},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3872881233692169},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3754309415817261},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3130970597267151},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2752510905265808},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20412245392799377},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.10810708999633789},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06896859407424927}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7923210263252258},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.566415548324585},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5385047197341919},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5309668779373169},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47051969170570374},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.46741151809692383},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4495139420032501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4153040647506714},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3872881233692169},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3754309415817261},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3130970597267151},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2752510905265808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20412245392799377},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10810708999633789},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06896859407424927}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051025","descriptor_name":"bcl-Associated Death Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051025","descriptor_name":"bcl-Associated Death Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051025","descriptor_name":"bcl-Associated Death Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003358","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003358","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003358&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24339759","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24339759","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.782.2384","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.782.2384","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/f2/1a/pcbi.1003358.PMC3854132.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a0d057edd42f428387e23f9bce3dbbbd","is_oa":true,"landing_page_url":"https://doaj.org/article/a0d057edd42f428387e23f9bce3dbbbd","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 12, p e1003358 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2843584","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3854132","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/869405","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Systems_Modeling_of_Anti_apoptotic_Pathways_in_Prostate_Cancer_Psychological_Stress_Triggers_a_Synergism_Pattern_Switch_in_Drug_Combination_Therapy_/869405","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003358","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003358","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003358&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"awards":[{"id":"https://openalex.org/G1060346003","display_name":null,"funder_award_id":"R01DE022676","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G13557379","display_name":null,"funder_award_id":"U01 CA166886-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2504770780","display_name":null,"funder_award_id":"1R01DE022676-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2945214297","display_name":null,"funder_award_id":"R01CA118329","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3490116524","display_name":null,"funder_award_id":"W81XWH-11-2-0168","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4066787487","display_name":null,"funder_award_id":"R01DE022676-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4380237420","display_name":null,"funder_award_id":"R01LM010185-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6556760511","display_name":null,"funder_award_id":"U01HL111560","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6836066074","display_name":null,"funder_award_id":"R01LM010185","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7320824963","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G7952760586","display_name":null,"funder_award_id":"U01HL111560-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8523599045","display_name":null,"funder_award_id":"R01DE02267","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8574605435","display_name":null,"funder_award_id":"DE022676","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320309558","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332689","display_name":"Wake Forest School of Medicine","ror":"https://ror.org/0207ad724"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2153216949.pdf","grobid_xml":"https://content.openalex.org/works/W2153216949.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1482646691","https://openalex.org/W1966280575","https://openalex.org/W1969101909","https://openalex.org/W1972699120","https://openalex.org/W1972987774","https://openalex.org/W1977258127","https://openalex.org/W1994663540","https://openalex.org/W1998052292","https://openalex.org/W2001620484","https://openalex.org/W2002304314","https://openalex.org/W2008030719","https://openalex.org/W2019298819","https://openalex.org/W2025845020","https://openalex.org/W2030712926","https://openalex.org/W2030945597","https://openalex.org/W2044025814","https://openalex.org/W2060737851","https://openalex.org/W2061826427","https://openalex.org/W2070119107","https://openalex.org/W2075941967","https://openalex.org/W2077206871","https://openalex.org/W2079183692","https://openalex.org/W2093628776","https://openalex.org/W2095612053","https://openalex.org/W2103919496","https://openalex.org/W2131770017","https://openalex.org/W2135514753","https://openalex.org/W2137626311","https://openalex.org/W2138071274","https://openalex.org/W2140662159","https://openalex.org/W2146998426","https://openalex.org/W2147960762","https://openalex.org/W2151313580","https://openalex.org/W2335854816","https://openalex.org/W2761217954","https://openalex.org/W6703221619"],"related_works":["https://openalex.org/W299695548","https://openalex.org/W3171449477","https://openalex.org/W2384122898","https://openalex.org/W151774199","https://openalex.org/W4281885123","https://openalex.org/W2345040638","https://openalex.org/W2088520467","https://openalex.org/W2075763133","https://openalex.org/W2376423713","https://openalex.org/W1583600832"],"abstract_inverted_index":{"Prostate":[0],"cancer":[1,24,47,80,237],"patients":[2],"often":[3],"have":[4,30],"increased":[5],"levels":[6],"of":[7,75,88,97,103,109,124,135,141,161,178,200,214,226],"psychological":[8,20,205,215,228],"stress":[9,21,42,216,229],"or":[10,93],"anxiety,":[11],"but":[12],"the":[13,17,62,85,95,101,114,122,133,148,159,172,189,212,223],"molecular":[14,182],"mechanisms":[15,183,213],"underlying":[16],"interaction":[18],"between":[19],"and":[22,34,119,139,175,188,221],"prostate":[23,46,79,236],"as":[25,27],"well":[26],"therapy":[28],"resistance":[29,187],"been":[31],"rarely":[32],"studied":[33],"remain":[35],"poorly":[36],"understood.":[37],"Recent":[38],"reports":[39],"show":[40],"that":[41,65,132,168],"inhibits":[43],"apoptosis":[44,76,125],"in":[45,78,106,191,218,230],"cells":[48],"via":[49],"epinephrine/beta2":[50],"adrenergic":[51],"receptor/PKA/BAD":[52],"pathway.":[53],"In":[54],"this":[55],"study,":[56],"we":[57,117,166],"used":[58],"experimental":[59],"data":[60],"on":[61,113],"signaling":[63,170,201,217],"pathways":[64,202],"control":[66],"BAD":[67,142],"phosphorylation":[68,143],"to":[69],"build":[70],"a":[71,197],"dynamic":[72],"network":[73,198],"model":[74,199],"regulation":[77],"cells.":[81],"We":[82,130],"then":[83],"compared":[84],"predictive":[86,163],"power":[87],"two":[89],"different":[90],"models":[91],"with":[92],"without":[94],"role":[96,102],"Mcl-1,":[98],"which":[99],"justified":[100],"Mcl-1":[104],"stabilization":[105],"anti-apoptotic":[107],"effects":[108],"emotional":[110],"stress.":[111,206],"Based":[112],"selected":[115],"model,":[116],"examined":[118],"quantitatively":[120],"evaluated":[121],"induction":[123],"by":[126,195,204],"drug":[127],"combination":[128,134,179],"therapies.":[129],"predicted":[131],"PI3K":[136],"inhibitor":[137],"LY294002":[138],"inhibition":[140],"at":[144],"S112":[145],"would":[146],"produce":[147],"best":[149],"synergistic":[150],"effect":[151],"among":[152],"8":[153],"interventions":[154],"examined.":[155],"Experimental":[156],"validation":[157],"confirmed":[158],"effectiveness":[160],"our":[162],"model.":[164],"Moreover,":[165],"found":[167],"epinephrine":[169],"changes":[171],"synergism":[173,192],"pattern":[174],"decreases":[176],"efficacy":[177],"therapy.":[180],"The":[181],"responsible":[184],"for":[185,235],"therapeutic":[186],"switch":[190],"were":[193],"explored":[194],"analyzing":[196],"affected":[203],"These":[207],"results":[208],"provide":[209],"insights":[210],"into":[211],"therapy-resistant":[219],"cancer,":[220],"indicate":[222],"potential":[224],"benefit":[225],"reducing":[227],"designing":[231],"more":[232],"effective":[233],"therapies":[234],"patients.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":3}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
