{"id":"https://openalex.org/W2112251177","doi":"https://doi.org/10.1371/journal.pcbi.1003283","title":"Evidence for Finely-Regulated Asynchronous Growth of Toxoplasma gondii Cysts Based on Data-Driven Model Selection","display_name":"Evidence for Finely-Regulated Asynchronous Growth of Toxoplasma gondii Cysts Based on Data-Driven Model Selection","publication_year":2013,"publication_date":"2013-11-14","ids":{"openalex":"https://openalex.org/W2112251177","doi":"https://doi.org/10.1371/journal.pcbi.1003283","mag":"2112251177","pmid":"https://pubmed.ncbi.nlm.nih.gov/24244117"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003283","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003283","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003283&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003283&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Adam M. Sullivan","orcid":null},"institutions":[{"id":"https://openalex.org/I122345529","display_name":"National Institute for Mathematical and Biological Synthesis","ror":"https://ror.org/04vj69e88","country_code":"US","type":"facility","lineage":["https://openalex.org/I122345529","https://openalex.org/I1311060795"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam M. Sullivan","raw_affiliation_strings":["Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, Tennessee, United States of America ; National Institute of Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee, United States of America","Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, Tennessee, United States of America","National Institute of Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, Tennessee, United States of America ; National Institute of Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I122345529","https://openalex.org/I75027704"]},{"raw_affiliation_string":"Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"National Institute of Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I122345529","https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056442662","display_name":"Xiaopeng Zhao","orcid":"https://orcid.org/0000-0003-1207-5379"},"institutions":[{"id":"https://openalex.org/I122345529","display_name":"National Institute for Mathematical and Biological Synthesis","ror":"https://ror.org/04vj69e88","country_code":"US","type":"facility","lineage":["https://openalex.org/I122345529","https://openalex.org/I1311060795"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaopeng Zhao","raw_affiliation_strings":["Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, Tennessee, United States of America","National Institute of Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical, Aerospace, and Biomedical Engineering, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"National Institute of Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I122345529","https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100749553","display_name":"Yasuhiro Suzuki","orcid":"https://orcid.org/0000-0001-9046-5466"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasuhiro Suzuki","raw_affiliation_strings":["Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024502952","display_name":"Eri Ochiai","orcid":null},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eri Ochiai","raw_affiliation_strings":["Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045858093","display_name":"Stephen Crutcher","orcid":null},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Crutcher","raw_affiliation_strings":["Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, Kentucky, United States of America","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080011508","display_name":"Michael A. Gilchrist","orcid":"https://orcid.org/0000-0002-6936-0771"},"institutions":[{"id":"https://openalex.org/I122345529","display_name":"National Institute for Mathematical and Biological Synthesis","ror":"https://ror.org/04vj69e88","country_code":"US","type":"facility","lineage":["https://openalex.org/I122345529","https://openalex.org/I1311060795"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Gilchrist","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, Tennessee, United States of America","National Institute of Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I75027704"]},{"raw_affiliation_string":"National Institute of Mathematical and Biological Synthesis, University of Tennessee, Knoxville, Tennessee, United States of America","institution_ids":["https://openalex.org/I122345529","https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056442662"],"corresponding_institution_ids":["https://openalex.org/I122345529","https://openalex.org/I75027704"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1057,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.74083634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"11","first_page":"e1003283","last_page":"e1003283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11155","display_name":"Toxoplasma gondii Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9725000262260437,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9460999965667725,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toxoplasma-gondii","display_name":"Toxoplasma gondii","score":0.7535424828529358},{"id":"https://openalex.org/keywords/cyst","display_name":"Cyst","score":0.7482264041900635},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.724551796913147},{"id":"https://openalex.org/keywords/chronic-infection","display_name":"Chronic infection","score":0.6515874266624451},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"Pathogenesis","score":0.6007068157196045},{"id":"https://openalex.org/keywords/akaike-information-criterion","display_name":"Akaike information criterion","score":0.5014526844024658},{"id":"https://openalex.org/keywords/toxoplasmosis","display_name":"Toxoplasmosis","score":0.4629249572753906},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.43537914752960205},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4098852276802063},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.26544255018234253},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13202178478240967},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08036506175994873},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.07322162389755249}],"concepts":[{"id":"https://openalex.org/C2778128430","wikidata":"https://www.wikidata.org/wiki/Q131003","display_name":"Toxoplasma gondii","level":3,"score":0.7535424828529358},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.7482264041900635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.724551796913147},{"id":"https://openalex.org/C3019392825","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic infection","level":3,"score":0.6515874266624451},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6007068157196045},{"id":"https://openalex.org/C126674687","wikidata":"https://www.wikidata.org/wiki/Q1662573","display_name":"Akaike information criterion","level":2,"score":0.5014526844024658},{"id":"https://openalex.org/C2778062946","wikidata":"https://www.wikidata.org/wiki/Q154878","display_name":"Toxoplasmosis","level":2,"score":0.4629249572753906},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43537914752960205},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4098852276802063},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26544255018234253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13202178478240967},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08036506175994873},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.07322162389755249},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D014122","descriptor_name":"Toxoplasma","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003283","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003283","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003283&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24244117","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24244117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:uknowledge.uky.edu:microbio_facpub-1024","is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/microbio_facpub/25","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbiology, Immunology, and Molecular Genetics Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a4f08755b93f4883ba81f32989c7f37e","is_oa":false,"landing_page_url":"https://doaj.org/article/a4f08755b93f4883ba81f32989c7f37e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 9, Iss 11, p e1003283 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2815896","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3828147","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/851026","is_oa":true,"landing_page_url":"https://figshare.com/articles/Evidence_for_Finely_Regulated_Asynchronous_Growth_of_Toxoplasma_gondii_Cysts_Based_on_Data_Driven_Model_Selection/851026","pdf_url":null,"source":{"id":"https://openalex.org/S4306402621","display_name":"INDIGO (University of Illinois at Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39422238","host_organization_name":"University of Illinois Chicago","host_organization_lineage":["https://openalex.org/I39422238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003283","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003283","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003283&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.4300000071525574}],"awards":[{"id":"https://openalex.org/G1012483139","display_name":null,"funder_award_id":"EF-0832858","funder_id":"https://openalex.org/F4320306110","funder_display_name":"U.S. Department of Homeland Security"},{"id":"https://openalex.org/G1471804637","display_name":null,"funder_award_id":"AI077887","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1933260551","display_name":"IFN-gamma production by microglia for prevention of toxoplasmic encephalitis","funder_award_id":"5r01ai078756-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2099971737","display_name":"Cooperation of CD8+ T cells and phagocytes to eliminate Toxoplasma cysts","funder_award_id":"5r01ai095032-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2264049340","display_name":null,"funder_award_id":"CMMI-0845753","funder_id":"https://openalex.org/F4320306110","funder_display_name":"U.S. Department of Homeland Security"},{"id":"https://openalex.org/G2268172677","display_name":null,"funder_award_id":"CMMI-0845753","funder_id":"https://openalex.org/F4320315068","funder_display_name":"University of Tennessee, Knoxville"},{"id":"https://openalex.org/G229045238","display_name":null,"funder_award_id":"AI 095032","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2877504876","display_name":null,"funder_award_id":"EF-0832858","funder_id":"https://openalex.org/F4320315068","funder_display_name":"University of Tennessee, Knoxville"},{"id":"https://openalex.org/G3571701802","display_name":null,"funder_award_id":"R01AI095032","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G420829736","display_name":null,"funder_award_id":"U01 AI077887","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4517923230","display_name":null,"funder_award_id":"EF-0832858","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4650149314","display_name":null,"funder_award_id":"MCB-1120370","funder_id":"https://openalex.org/F4320315068","funder_display_name":"University of Tennessee, Knoxville"},{"id":"https://openalex.org/G5329369612","display_name":"National Institute for Mathematical and Biological Synthesis (NIMBioS)","funder_award_id":"0832858","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5406454118","display_name":"Employing Models of Evolution and Protein Translation to Infer Protein Production Rates from Genomic Data","funder_award_id":"1120370","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G55638240","display_name":null,"funder_award_id":"EF-0832858","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G6172874901","display_name":null,"funder_award_id":"AI078756","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6245417858","display_name":"CAREER: Integrated Research and Education in Nonlinear Dynamics in Biological Systems","funder_award_id":"0845753","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G705847031","display_name":null,"funder_award_id":"R01 AI078756","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7569934672","display_name":null,"funder_award_id":"EF-0832858","funder_id":"https://openalex.org/F4320310889","funder_display_name":"National Institute for Mathematical and Biological Synthesis"},{"id":"https://openalex.org/G8053149267","display_name":null,"funder_award_id":"CMMI-0845753","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306110","display_name":"U.S. Department of Homeland Security","ror":"https://ror.org/00jyr0d86"},{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320309530","display_name":"Stanley Medical Research Institute","ror":"https://ror.org/01pj5nn22"},{"id":"https://openalex.org/F4320310889","display_name":"National Institute for Mathematical and Biological Synthesis","ror":"https://ror.org/04vj69e88"},{"id":"https://openalex.org/F4320315068","display_name":"University of Tennessee, Knoxville","ror":"https://ror.org/020f3ap87"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337391","display_name":"Division of Civil, Mechanical and Manufacturing Innovation","ror":"https://ror.org/028yd4c30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2112251177.pdf","grobid_xml":"https://content.openalex.org/works/W2112251177.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W182198429","https://openalex.org/W1511806896","https://openalex.org/W1549251788","https://openalex.org/W1596619759","https://openalex.org/W1848937020","https://openalex.org/W1934326843","https://openalex.org/W1966464635","https://openalex.org/W1975028446","https://openalex.org/W1988676138","https://openalex.org/W1995866519","https://openalex.org/W1998047654","https://openalex.org/W2014517913","https://openalex.org/W2019667781","https://openalex.org/W2054442227","https://openalex.org/W2065563527","https://openalex.org/W2085683193","https://openalex.org/W2088117125","https://openalex.org/W2090085993","https://openalex.org/W2102709432","https://openalex.org/W2107829724","https://openalex.org/W2130913778","https://openalex.org/W2131915744","https://openalex.org/W2146081698","https://openalex.org/W2146771667","https://openalex.org/W2209894880","https://openalex.org/W2321090951","https://openalex.org/W2323096252","https://openalex.org/W2335141002","https://openalex.org/W2478738321","https://openalex.org/W3152507489","https://openalex.org/W3182730020"],"related_works":["https://openalex.org/W2179426006","https://openalex.org/W2906567361","https://openalex.org/W1967728126","https://openalex.org/W2416997590","https://openalex.org/W3039690148","https://openalex.org/W2078785198","https://openalex.org/W4386365074","https://openalex.org/W2552604312","https://openalex.org/W2088164381","https://openalex.org/W2112251177"],"abstract_inverted_index":{"Toxoplasma":[0],"gondii":[1,121],"establishes":[2],"a":[3,77,125,147,187],"chronic":[4,14,42],"infection":[5,15,43],"by":[6,52,58],"forming":[7],"cysts":[8,48,122],"preferentially":[9],"in":[10,24,35,118,173,177],"the":[11,19,41,47,59,69,92,100,107,130,136,142,154,163,192],"brain.":[12],"This":[13],"is":[16,65,138],"one":[17],"of":[18,46,71,81,102,109,135,144,153,194],"most":[20],"common":[21,73],"parasitic":[22],"infections":[23,195],"humans":[25],"and":[26,49,56,84,94,182],"can":[27],"be":[28],"reactivated":[29],"to":[30,90,141,161],"develop":[31],"life-threatening":[32],"toxoplasmic":[33],"encephalitis":[34],"immunocompromised":[36],"patients.":[37],"Host-pathogen":[38],"interactions":[39,64],"during":[40],"include":[44],"growth":[45,83,93,133],"their":[50],"removal":[51,95,167],"both":[53],"natural":[54],"rupture":[55],"elimination":[57],"immune":[60],"system.":[61],"Analyzing":[62],"these":[63],"important":[66],"for":[67,190],"understanding":[68,191],"pathogenesis":[70,193],"this":[72],"infection.":[74],"We":[75],"developed":[76],"differential":[78],"equation":[79],"framework":[80,184],"cyst":[82,103,166,178,198],"employed":[85],"Akaike":[86],"Information":[87],"Criteria":[88],"(AIC)":[89],"determine":[91],"functions":[96],"that":[97,129],"best":[98],"describe":[99],"distribution":[101],"sizes":[104],"measured":[105],"from":[106],"brains":[108],"chronically":[110],"infected":[111],"mice.":[112],"The":[113,180],"AIC":[114],"strongly":[115],"support":[116],"models":[117,164],"which":[119],"T.":[120],"grow":[123],"at":[124],"constant":[126],"rate":[127,134,168],"such":[128],"per":[131],"capita":[132],"parasite":[137],"inversely":[139],"proportional":[140],"number":[143],"parasites":[145],"within":[146],"cyst,":[148],"suggesting":[149],"finely-regulated":[150],"asynchronous":[151],"replication":[152],"parasites.":[155,200],"Our":[156],"analyses":[157],"were":[158],"also":[159],"able":[160],"reject":[162],"where":[165],"increases":[169],"linearly":[170],"or":[171],"quadratically":[172],"association":[174],"with":[175,196],"increase":[176],"size.":[179],"modeling":[181],"analysis":[183],"may":[185],"provide":[186],"useful":[188],"tool":[189],"other":[197],"producing":[199]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}